Article
Biochemistry & Molecular Biology
An-nan Zhang, Nan Li, Zhuo-chang Chen, Ya-li Guo, Cui-jie Tian, Dong-jun Cheng, Xue-yi Tang, Xiao-yu Zhang
Summary: Objective of this study was to investigate the effect of amygdalin, an active ingredient in bitter almonds, on TGF-beta-induced EMT in bronchial epithelial cells and elucidate the underlying mechanisms. The results showed that amygdalin treatment relieved airway wall remodeling and decreased the expressions of EMT markers. Furthermore, amygdalin inhibited TGF-beta-induced EMT through regulating the expression of HPSE.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Medicine, Research & Experimental
Xiaobo Zhang, Jun Xie, Hongmei Sun, Qin Wei, Guangmin Nong
Summary: Research on neutrophilic asthma (NA) suggests that decreased miR-29a-3p and elevated SPARC levels are associated with EMT in the mouse model, where SPARC induces EMT in 16HBE cells and miR-29a-3p can regulate this process.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Critical Care Medicine
Xingnan Li, Stefano Guerra, Julie G. Ledford, Monica Kraft, Huashi Li, Annette T. Hastie, Mario Castro, Loren C. Denlinger, Serpil C. Erzurum, John Fahy, Benjamin Gaston, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, David T. Mauger, Wendy C. Moore, Joe Zein, Naftali Kaminski, Sally E. Wenzel, Prescott G. Woodruff, Deborah A. Meyers, Eugene R. Bleecker
Summary: This study investigated the association between CC16 mRNA expression levels in nonciliated bronchial epithelial cells (BECs) and asthma severity. The results showed that low CC16 mRNA expression levels were significantly associated with asthma susceptibility, severity, exacerbations, and T2 inflammation biomarkers. Additionally, CC16 mRNA expression levels were correlated with the expression levels of Th2, Th1, and inflammation genes. A combination of CC16 and IL-6 could identify different asthma endotypes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Nutrition & Dietetics
Shu-Ju Wu, Wen-Chung Huang, Ching-Yi Cheng, Meng-Chun Wang, Shu-Chen Cheng, Chian-Jiun Liou
Summary: The study shows that fisetin can reduce the inflammatory response and oxidative stress in bronchial epithelial cells, and improve airway hyperresponsiveness in asthmatic mice. Fisetin decreases the levels of inflammatory cytokines and chemokines, as well as intercellular adhesion molecule-1 expression. It also suppresses monocyte adhesion and reduces eosinophil numbers. Moreover, fisetin promotes glutathione levels and decreases malondialdehyde levels in the lungs.
Article
Immunology
Yimin Guo, Xiaoqing Yuan, Luna Hong, Qiujie Wang, Shanying Liu, Zhaolin Li, Linjie Huang, Shanping Jiang, Jianting Shi
Summary: This study found that miR-23b-3p is upregulated in chronic asthma, promoting airway remodeling and migration. The expression of miR-23b-3p is regulated by DNA methylation. These findings provide potential therapeutic targets for airway remodeling.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Scott P. Ginebaugh, Matthias Hagner, Anuradha Ray, Serpil C. Erzurum, Suzy A. A. Comhair, Loren C. Denlinger, Nizar N. Jarjour, Mario Castro, Prescott G. Woodruff, Stephanie A. Christenson, Eugene R. Bleecker, Deborah A. Meyers, Annette T. Hastie, Wendy C. Moore, David T. Mauger, Elliot Israel, Bruce D. Levy, Sally E. Wenzel, Matthew J. Camiolo
Summary: This study investigated the transcriptional response of bronchial epithelial cells to inhaled corticosteroids. It was found that a subset of asthma patients with poor hormone treatment response had worse lung function and quality of life. Furthermore, the response to hormone treatment could be predicted using blood samples.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Xiaoyan Liu, Yongjun Li, Zhuo Li, Tian Hou
Summary: The study revealed that miR-155 may serve as a potential diagnostic and therapeutic target for breast cancer. High levels of miR-155 were found in breast cancer tissues and were associated with tumor size, TNM stage, and metastasis status. Inhibitors of miR-155 reduced cell proliferation and suppressed the epithelial-mesenchymal transition process in MCF-7 cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sihui Zhao, Yunfang Ning, Na Qin, Nan Ping, Yong Yu, Guoyan Yin
Summary: The GAS5/miR-217/HDAC4 axis plays a crucial role in regulating TGF-beta 1-induced injury of bronchial epithelial cells, affecting cell viability and apoptosis. These findings contribute to a better understanding of the pathogenesis of asthma.
Article
Immunology
Ji Young Kim, Patrick Stevens, Manjula Karpurapu, Hyunwook Lee, Joshua A. A. Englert, Pearlly Yan, Tae Jin Lee, Navjot Pabla, Maciej Pietrzak, Gye Young Park, John W. W. Christman, Sangwoon Chung
Summary: By utilizing a mouse model and studying clinical patients, we discovered the important role of ETs in asthma, with miR-155 inhibition showing therapeutic benefits in severe asthma. Targeting dsDNA release may be a potential therapeutic target for mitigating neutrophilic asthma phenotype.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Junwei Zhao, Tianci Jiang, Pengfei Li, Lingling Dai, Guang Shi, Xiaogang Jing, Shuhui Gao, Liuqun Jia, Shujun Wu, Yu Wang, Youmei Peng, Zhe Cheng
Summary: The study showed that TF promotes airway pathological features by enhancing the EMT of bronchial epithelial cells in asthma, while downregulation of TF reduces airway hyperresponsiveness, eosinophil inflammation, and EMT process. TF downregulation also inhibits migration and invasion, and decreases fibronectin 1 and TGF-β1 expression while increasing E-cadherin expression in stimulated 16HBE cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Bo Zhou, Gulinigaer Tuerhong Jiang, Hui Liu, Manyun Guo, Junhui Liu, Jianqing She
Summary: This study revealed dysregulated serum metabolic profiles enriched in arginine metabolism among young patients with chronic persistent asthma. L-citrulline could potentially restore airway NO production and exhibit therapeutic benefits in young patients with chronic asthma.
Article
Biotechnology & Applied Microbiology
Pedro Paranhos Tanaka, Ernna Herida Oliveira, Mayara Cristina Vieira-Machado, Max Jordan Duarte, Amanda Freire Assis, Karina Fittipaldi Bombonato-Prado, Geraldo Aleixo Passos
Summary: This study found that miR-155 may posttranscriptionally regulate Aire mRNA, reducing Aire protein levels and affecting the mRNA levels of tissue-restricted antigens. Additionally, miR-155 regulates a crucial process of chemotaxis, allowing thymocyte migration through mTECs.
Article
Multidisciplinary Sciences
Juliette Delhove, Moayed Alawami, Matthew Macowan, Susan E. Lester, Phan T. Nguyen, Hubertus P. A. Jersmann, Paul N. Reynolds, Eugene Roscioli
Summary: Differentiated air-liquid interface models are widely used for assessing mucociliary phenotype, but obtaining airway epithelial cells invasively and resource-intensively. This study used a tissue engineering approach to generate sinonasal airway epithelial cells and found that they were predictive of bronchial airway epithelial cells in terms of barrier function, mucociliary architecture, and autophagy gene activity. However, there were significant differences in inflammatory marker expression, possibly due to the immunological surveillance of sinonasal epithelium.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Qing Yin, Ya-Jie Zhao, Wei-Jie Ni, Tao-Tao Tang, Yao Wang, Jing-Yuan Cao, Di Yin, Yi Wen, Zuo-Lin Li, Yi-Lin Zhang, Wei Jiang, Yue Zhang, Xiao-Yu Lu, Ai-Qing Zhang, Wei-Hua Gan, Lin-Li Lv, Bi-Cheng Liu, Bin Wang
Summary: This study found that miR-155 overexpression was associated with cisplatin-induced acute kidney injury (cAKI), and inhibition of miR-155 expression could attenuate cAKI-induced renal damage and apoptosis. The study also revealed that miR-155 inhibition increased the expression of TRF1 and CDK12, thereby limiting telomeric dysfunction and genomic DNA damage.
Article
Immunology
Jiayi Dong, Lindsey M. Warner, Ling-Li Lin, Mei-Chi Chen, Ryan M. O'Connell, Li-Fan Lu
Summary: miR-155 plays a crucial role in promoting tT reg cell differentiation by promoting mTEC maturation in the thymus. RANKL stimulation induces miR-155 expression to target molecules within the TGF beta signaling pathway, safeguarding thymic medulla integrity.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Fumihiro Yamaguchi, Takao Minakata, Sakiko Miura, Takashi Suzuki, Hironori Sagara
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2020)
Article
Medicine, Research & Experimental
Ayaka Mase, Fumihiro Yamaguchi, Toshitaka Funaki, Yohei Yamazaki, Yusuke Shikama, Kunihiko Fukuchi
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2020)
Letter
Allergy
Kuniaki Hirai, Akihiko Tanaka, Tetsuya Homma, Tomoko Kawahara, Naruhito Oda, Hatsuko Mikuni, Yoshitaka Uchida, Tomoki Uno, Yoshito Miyata, Hideki Inoue, Shin Ohta, Fumihiro Yamaguchi, Shintaro Suzuki, Hironori Sagara
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Respiratory System
Kaho Akimoto, Kuniaki Hirai, Tomohiro Matsunaga, Keisuke Kaneko, Hatsuko Mikuni, Tomoko Kawahara, Tomoki Uno, Akiko Fujiwara, Yoshito Miyata, Shin Ohta, Tetsuya Homma, Hideki Inoue, Fumihiro Yamaguchi, Sojiro Kusumoto, Shintaro Suzuki, Akihiko Tanaka, Hironori Sagara
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2020)
Article
Gastroenterology & Hepatology
Kuniyo Gomi, Takayoshi Ito, Fumihiro Yamaguchi, Yoshito Kamio, Yoshinori Sato, Hiroyoshi Mori, Kei Endo, Takashi Abe, Shunsuke Sakakura, Kouji Kobayashi, Ken Shimada, Jun Noda, Tarou Hibiki, Shin Ohta, Hironori Sagara, Akihiko Tanaka, Megumi Jinno, Masataka Yamawaki, Fumiya Nishimoto, Kazuaki Inoue, Masatsugu Nagahama
Summary: This study found that an AST-predominant elevation of AST/ALT/LDH peaking 8-9 days after symptom onset and not accompanied by elevated alkaline phosphatase or gamma-glutamyl transferase may be a useful clinical feature for differentiating COVID-19 from other diseases. Patients with a high lymphocyte-to-white blood cell ratio and high LDH/AST ratio may require admission to the ICU.
Article
Biotechnology & Applied Microbiology
Haruka Kitano, Fumihiro Yamaguchi, Kenji Atarashi, Mina Hiraiwa, Yo Shiratori, Shota Onozaki, Yusuke Shikama
Summary: Good syndrome is a rare condition characterized by thymoma and adult-onset hypogammaglobulinemia. The immunological features of this syndrome include various immunodeficiencies and hypogammaglobulinemia. Interestingly, a patient with advanced-stage thymoma showed a decrease in serum sIL-2R level after effective chemotherapy, suggesting sIL-2R as a potential prognostic biomarker in some Good syndrome patients.
ONCOTARGETS AND THERAPY
(2021)
Article
Substance Abuse
Kuniaki Hirai, Akihiko Tanaka, Tetsuya Homma, Tomoko Kawahara, Naruhito Oda, Hatsuko Mikuni, Yoshitaka Uchida, Haruhisa Saito, Yosuke Fukuda, Akiko Fujiwara, Yoko Sato, Tomoki Uno, Hideki Inoue, Shin Ohta, Fumihiro Yamaguchi, Shintaro Suzuki, Tsukasa Ohnishi, Hironori Sagara
Summary: The study found that COPD patients who continue smoking tend to have lower appetite and display unsafe smoking behaviors. Additionally, younger age and higher education level were associated with the use of HTP among COPD patients.
TOBACCO INDUCED DISEASES
(2021)
Article
Oncology
Yizhuo Zhao, Qiming Wang, Li Zhang, Jianhua Shi, Zhehai Wang, Ying Cheng, Jianxing He, Yuankai Shi, Weiqiang Chen, Yi Luo, Lin Wu, Xiuwen Wang, Kejun Nan, Faguang Jin, Jian Dong, Baolan Li, Fumihiro Yamaguchi, Daniel Breadner, Tatsuya Nagano, Fumihiro Tanaka, Hatim Husain, Kai Li, Baohui Han
Summary: This subgroup analysis demonstrated that the efficacy of anlotinib as a third-line therapy for NSCLC patients is independent of EGFR mutation status.
TRANSLATIONAL LUNG CANCER RESEARCH
(2022)
Article
Oncology
Yiruo Zhang, Xin Huang, Ruiqi Niu, Chenghui Li, Jingdan Pang, Pingping Liu, Hiroyuki Adachi, Akikazu Kawase, Fumihiro Yamaguchi, Yingying Du
Summary: This study found that the occurrence of T790M mutation after resistance to first-generation EGFR-TKI treatment may be related to the expression of EGFR mutant protein in patients with EGFR gene mutation. Patients with exon 19 deletion and L858R mutation who had positive protein expression had a higher rate of T790M mutation.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Takashi Abe, Fumihiro Yamaguchi, Shunsuke Sakakura, Yohei Yamazaki, Yusuke Shikama
Summary: This study aimed to investigate the effect of tocilizumab treatment combined with remdesivir, dexamethasone, and heparin on obese Japanese patients with COVID-19. The results showed that single-dose treatment of tocilizumab in combination with other drugs is beneficial for obese patients with COVID-19. The study suggests that the severity of obesity is related to the sensitivity of anti-IL-6 treatment in COVID-19 patients.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Infectious Diseases
Ayako Suzuki, Fumihiro Yamaguchi, Masayuki Maeda, Miyuki Hashiguchi, Nobuyuki Kabasawa, Jun Sasaki, Tokutada Sato, Masaki Fuyama, Yohei Yamazaki, Kei Endo, Kae Iwata, Sei Kobayashi, Hisato Fujihara
Summary: As antibiotic resistance is a global problem, the intervention of an antimicrobial stewardship team is necessary. This study evaluated the effect of antimicrobial stewardship interventions on carbapenem therapy in the department of hematology. The analysis showed that the number of days of therapy decreased with the intervention. Factors associated with long-term carbapenem therapy were also investigated.
Article
Respiratory System
Takuya Iwasaki, Fumihiro Yamaguchi, Makoto Hayashi, Hitoshi Kobayashi, Kento Hirata, Kenta Miyo, Chika Kondo, Mamiko Kanzaki, Kazusawa Tei, Takashi Abe, Shunsuke Sakakura, Daisuke Inoue, Yohei Yamazaki, Hidetsugu Tateno, Takuya Yokoe, Yusuke Shikama
Summary: The combination of anti-Mycobacterium avium complex (MAC) antibodies and clinical findings is effective in diagnosing non-tuberculous mycobacterium pulmonary disease (NTM-PD). Positive anti-MAC antibodies, low body mass index, absence of malignancy, and cavity-forming lung lesions are significantly associated with NTM-PD. The positive rates of the anti-MAC antibody test may also be low in patients harboring different components in glycopeptidolipids (GPLs).
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2022)
Article
Respiratory System
Yuki Osakabe, Fumihiro Yamaguchi, Ayako Suzuki, Haruka Kitano, Mina Hiraiwa, Yo Shiratori, Shota Onozaki, Mari Nakamoto, Saori Kawamura, Miku Kosuge, Kenji Atarashi, Hidekazu Cho, Shohei Shimizu, Akira Fujishima, Yusuke Shikama
Summary: 8.2% of the results from the QFT-plus test were indeterminate, mainly due to low levels of IFN-gamma production. Age, sex, corticosteroid use, autoimmune disease, and inpatient setting were significantly associated with indeterminate results.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2022)
Article
Respiratory System
Kuniaki Hirai, Akihiko Tanaka, Tetsuya Homma, Tomoko Kawahara, Naruhito Oda, Hatsuko Mikuni, Yoshitaka Uchida, Haruhisa Saito, Keisuke Kaneko, Akiko Fujiwara, Yuiko Goto, Tomoki Uno, Yoshito Miyata, Shin Ohta, Fumihiro Yamaguchi, Shintaro Suzuki, Tsukasa Ohnishi, Hironori Sagara
Summary: The study found that a high percentage of patients and their families were dissatisfied with the current respiratory status of COPD patients. The COPD Assessment Test (CAT) was the most sensitive marker of dissatisfaction, and a CAT score of 11 or higher was predictive of patient dissatisfaction. Treatment strategies targeting CAT may contribute to improved patient satisfaction, in line with the Global Initiative for Chronic Obstructive Lung Disease recommendation to enhance treatment in patients with a CAT score >= 10.
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Article
Respiratory System
Fumihiro Yamaguchi, Haruka Yoda, Mina Hiraiwa, Yo Shiratori, Shota Onozaki, Mari Ito, Saori Kashima, Miku Kosuge, Kenji Atarashi, Hidekazu Cho, Shohei Shimizu, Akira Fujishima, Ayaka Mase, Yuki Osakabe, Toshitaka Funaki, Daisuke Inoue, Yohei Yamazaki, Hidetsugu Tateno, Takuya Yokoe, Yusuke Shikama
JOURNAL OF THORACIC DISEASE
(2020)