A mega-analysis of fixed-dose trials reveals dose-dependency and a rapid onset of action for the antidepressant effect of three selective serotonin reuptake inhibitors

Systematic Review and Meta-Analysis: Dose-Response Relationship of Selective Serotonin Reuptake Inhibitors in Major Depressive Disorder

(2016) Ewgeni Jakubovski et al.   AMERICAN JOURNAL OF PSYCHIATRY

Depression sum-scores don’t add up: why analyzing specific depression symptoms is essential

(2015) Eiko I Fried et al.   BMC Medicine

Consistent superiority of selective serotonin reuptake inhibitors over placebo in reducing depressed mood in patients with major depression

(2015) F Hieronymus et al.   MOLECULAR PSYCHIATRY

Putting the efficacy of psychiatric and general medicine medication into perspective: review of meta-analyses

(2012) Stefan Leucht et al.   BRITISH JOURNAL OF PSYCHIATRY

Neurogenesis and affective disorders

(2011) Benjamin A. Samuels et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Is bigger better? An argument for very low starting doses

(2010) J. P. McCormack et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Placebo, Prozac and PLoS: significant lessons for psychopharmacology

(2010) Jamie Horder et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Are typical starting doses of the selective serotonin reuptake inhibitors sub-optimal? A meta-analysis of randomized, double-blind, placebo-controlled, dose-finding studies in major depressive disorder

(2010) George I. Papakostas et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2000 British Association for Psychopharmacology guidelines

(2008) IM Anderson et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Serotonin and emotional processing: Does it help explain antidepressant drug action?

(2008) Catherine J. Harmer   NEUROPHARMACOLOGY

Evidence Why Paroxetine Dose Escalation is Not Effective in Major Depressive Disorder: A Randomized Controlled Trial With Assessment of Serotonin Transporter Occupancy

(2008) Henricus G Ruhé et al.   NEUROPSYCHOPHARMACOLOGY

Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy

(2008) Erick H. Turner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

(2008) Irving Kirsch et al.   PLOS MEDICINE