Journal
TOXICOLOGY RESEARCH
Volume 5, Issue 4, Pages 1012-1016Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tx00130k
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Funding
- Czech Science Foundation [GA15-16701S]
- MH CZ-DRO (University Hospital Hradec Kralove) [00179906]
- Ministry of Defense (Long Term Organization Development Plan - 1011)
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Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently needed. Herein, we present a novel hybrid compound which is able not only to keep acetylcholinesterase resistant to organophosphate (OP) inhibitors, but also to serve as an enzyme reactivator in the case of OP intoxication.
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