Theoretical and Practical Issues That Are Relevant When Scaling Up hMSC Microcarrier Production Processes

The translation of cell-based therapies: clinical landscape and manufacturing challenges

(2015) Thomas RJ Heathman et al.   Regenerative Medicine

Effect of sustained heparin release from PCL/chitosan hybrid small-diameter vascular grafts on anti-thrombogenic property and endothelialization

(2014) Yao Yao et al.   Acta Biomaterialia

Scale-up of adipose tissue-derived mesenchymal stem cell production in stirred single-use bioreactors under low-serum conditions

(2014) Carmen Schirmaier et al.   ENGINEERING IN LIFE SCIENCES

Allogeneic cell therapy bioprocess economics and optimization: Single-use cell expansion technologies

(2013) Ana S. Simaria et al.   BIOTECHNOLOGY AND BIOENGINEERING

Culture of human mesenchymal stem cells on microcarriers in a 5 l stirred-tank bioreactor

(2013) Qasim A. Rafiq et al.   BIOTECHNOLOGY LETTERS

Gastro-intestinal autoimmunity: preclinical experiences and successful therapy of fistulizing bowel diseases and gut Graft versus host disease by mesenchymal stromal cells

(2013) Jan Voswinkel et al.   IMMUNOLOGIC RESEARCH

Scale-up of human mesenchymal stem cell culture: current technologies and future challenges

(2013) Qasim A Rafiq et al.   Current Opinion in Chemical Engineering

Closed system isolation and scalable expansion of human placental mesenchymal stem cells

(2012) N.E. Timmins et al.   BIOTECHNOLOGY AND BIOENGINEERING

Limiting cell aggregation during mesenchymal stem cell expansion on microcarriers

(2012) Caroline Ferrari et al.   BIOTECHNOLOGY PROGRESS

The Global Cell Therapy Industry Continues to Rise during the Second and Third Quarters of 2012

(2012) Chris Mason et al.   Cell Stem Cell

hMSC Production in Disposable Bioreactors with Regards to GMP and PAT

(2012) Katharina Cierpka et al.   CHEMIE INGENIEUR TECHNIK

Fluid Flow and Cell Proliferation of Mesenchymal Adipose-Derived Stem Cells in Small-Scale, Stirred, Single-Use Bioreactors

(2012) Stephan Kaiser et al.   CHEMIE INGENIEUR TECHNIK

Stem cell cultivation in bioreactors

(2011) Carlos A.V. Rodrigues et al.   BIOTECHNOLOGY ADVANCES

Expansion of human mesenchymal stem cells on microcarriers

(2011) Christopher J. Hewitt et al.   BIOTECHNOLOGY LETTERS

Clinical trials for stem cell therapies

(2011) Alan Trounson et al.   BMC Medicine

Mesenchymal stem cells

(2011) Marieke Roemeling-van Rhijn et al.   Current Opinion in Organ Transplantation

Toward a Clinical-Grade Expansion of Mesenchymal Stem Cells from Human Sources: A Microcarrier-Based Culture System Under Xeno-Free Conditions

(2011) Francisco dos Santos et al.   TISSUE ENGINEERING PART C-METHODS

Experimental characterization of flow conditions in 2- and 20-l bioreactors with wave-induced motion

(2010) Andreas Kalmbach et al.   BIOTECHNOLOGY PROGRESS

Axial impeller selection for anchorage dependent animal cell culture in stirred bioreactors: Methodology based on the impeller comparison at just-suspended speed of rotation

(2010) Marie-Laure Collignon et al.   CHEMICAL ENGINEERING SCIENCE

Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties

(2010) T. J. Bartosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shear stress induces osteogenic differentiation of human mesenchymal stem cells

(2010) Gregory Yourek et al.   Regenerative Medicine

Characterization of flow conditions in 2 L and 20 L wave bioreactors® using computational fluid dynamics

(2009) Alper A. Öncül et al.   BIOTECHNOLOGY PROGRESS

Can shear stress direct stem cell fate?

(2009) Sarah Stolberg et al.   BIOTECHNOLOGY PROGRESS

Influence of lactic acid on the proliferation, metabolism, and differentiation of rabbit mesenchymal stem cells

(2009) Ting Chen et al.   CELL BIOLOGY AND TOXICOLOGY

Growth, Metabolism, and Growth Inhibitors of Mesenchymal Stem Cells

(2009) Deborah Schop et al.   TISSUE ENGINEERING PART A