Article
Biotechnology & Applied Microbiology
Yue Ke, Yu Ye, Jintao Wu, Yanxia Ma, Yuxin Fang, Fei Jiang, Jinhua Yu
Summary: A phosphoserine-loaded chitosan membrane was synthesized to improve the osteogenic effect of chitosan membranes. The incorporation of phosphoserine into chitosan membranes was confirmed and the phosphoserine-chitosan membranes significantly stimulated bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Leila Gholami, Vajihe Taghdiri Nooshabadi, Shiva Shahabi, Marzieh Jazayeri, Rana Tarzemany, Zohreh Afsartala, Khatereh Khorsandi
Summary: Oral mesenchymal stem cells (MSCs) and their secretomes play a crucial role in medical tissue engineering and cell free biotherapy due to their accessibility and therapeutic outcomes. Recent studies have focused on the regenerative ability of EVs and CM from MSCs in bone and periodontal defects.
CELL AND BIOSCIENCE
(2021)
Article
Cell Biology
Santhosh Kacham, Tejal Sunil Bhure, Sindhuja D. Eswaramoorthy, Gaurav Naik, Subha Narayan Rath, Sreenivasa Rao Parcha, Sayan Basu, Virender Singh Sangwan, Sachin Shukla
Summary: Umbilical cord-derived mesenchymal stem cells promote the repair of injured corneal epithelium by stimulating the proliferation of corneal epithelial cells, potentially serving as a non-ocular source of stem cells for treating injury-induced bilateral corneal diseases.
Article
Orthopedics
Shipin Zhang, Keng Lin Wong, Xiafei Ren, Kristeen Ye Wen Teo, Hassan Afizah, Andre Boon Hwa Choo, Ruenn Chai Lai, Sai Kiang Lim, James Hoi Po Hui, Wei Seong Toh
Summary: This study validates the safety and efficacy of human mesenchymal stem cell (MSC) exosomes combined with hyaluronic acid (HA) for osteochondral repair in a clinically relevant micropig model. The results show that the combination treatment promotes functional cartilage and subchondral bone repair, with significantly improved morphological, histological, and biomechanical outcomes. No adverse response or major systemic alterations were observed, indicating the potential of this therapy for clinical applications.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Engineering, Biomedical
Jiang-Shan Gong, Guo-Qiang Zhu, Yu Zhang, Bei Chen, Yi-Wei Liu, Hong-Ming Li, Ze-Hui He, Jing-Tao Zou, Yu-Xuan Qian, Sheng Zhu, Xin-Yue Hu, Shan-Shan Rao, Jia Cao, Hui Xie, Zhen-Xing Wang, Wei Du
Summary: This study developed a novel BMSC-aptamer functionalized hydrogel and demonstrated its effectiveness in recruiting BMSCs and promoting bone regeneration.
MATERIALS TODAY BIO
(2023)
Article
Biochemistry & Molecular Biology
Victor J. B. van Santen, Angela P. Bastidas Coral, Jolanda M. A. Hogervorst, Jenneke Klein-Nulend, Astrid D. Bakker
Summary: A new, biologically relevant in vitro 3D-model was developed to study the bone regeneration potential of MSCs. This model is likely more suitable for the screening of novel factors to enhance bone regeneration than standard cell cultures.
Review
Endocrinology & Metabolism
Xiaofeng Wang, Fanyuan Yu, Ling Ye
Summary: Recent studies have shown that MSCs play a vital role in bone regeneration, including osteogenic differentiation and providing seed cells. However, factors like drug intake and body senescence can affect MSCs' functions in bone regeneration. Epigenetic regulation has received attention for its heritable nature and involvement in bone metabolism disorders. This review focuses on the effects of epigenetic regulation on osteogenic differentiation, proliferation, and cellular senescence in MSCs and its role in bone regeneration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Che-Chang Tu, Zhao-Cheng Zheng, Nai-Chen Cheng, Jiashing Yu, Wei-Chiu Tai, Yi-Xuan Pan, Po-Chun Chang
Summary: This study evaluated the potential of alveolar mucosal cell (AMC) spheroids for promoting extraction socket healing and calvarial osseous defect regeneration. The results showed that AMC spheroids can accelerate wound healing and bone tissue regeneration. The effects of socket healing and bone defect regeneration can be further enhanced by promoting osteogenesis of AMC.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Multidisciplinary Sciences
Jingjing Shang, Zhentang Yu, Chengwei Xiong, Junjie Zhang, Jinhong Gong, Changlin Yu, Yong Huang, Xindie Zhou
Summary: Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a crucial role in bone defect regeneration. Resistin, an adipose tissue-specific secretory factor, has diverse functions including metabolism, inflammation, cancer, and bone remodeling. However, the effects and mechanisms of resistin on BMSCs' osteogenic differentiation are still unclear.
Article
Dentistry, Oral Surgery & Medicine
Carina Lantmann Cabreira, Roberta Limeira Fulginiti, Patricia Sesterheim, Rosemary Sadami Arai Shinkai, Eduardo Rolim Teixeira
Summary: This study evaluated different molecular weight hyaluronic acids as potential matrices for tissue-engineered bone grafting, with results showing higher expression of growth factors in the high/low molecular weight group. Differentiated cells secreted fewer cytokines compared to undifferentiated cells, with IGF-1 showing the highest expression in the low molecular weight group.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Chemistry, Medicinal
Yanran Yang, Daiyun Chen, Yilin Li, Jinghua Zou, Ruiqi Han, Hongkun Li, Jun Zhang
Summary: Puerarin has a positive impact on the proliferation and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells, and promotes new bone formation. In a rat RME model, puerarin solution enhances osteogenesis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Situo Wang, Ziwei Liu, Shuo Yang, Na Huo, Bo Qiao, Tong Zhang, Juan Xu, Quan Shi
Summary: In this study, the benefits of EVs secreted by human gingival mesenchymal stem cells (hGMSC-derived EVs) in promoting bone regeneration were researched. The study showed that hGMSC-derived EVs could enhance the osteogenic ability of rat bone marrow mesenchymal stem cells and the angiogenic capability of human umbilical vein endothelial cells. The combination of hGMSC-derived EVs and nHAC materials significantly promoted new bone formation and neovascularization in rat models, indicating their potential in bone regeneration treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Physiology
Sara Petrillo, Tullio Genova, Giorgia Chinigo, Ilaria Roato, Giorgia Scarpellino, Joanna Kopecka, Fiorella Altruda, Emanuela Tolosano, Chiara Riganti, Federico Mussano, Luca Munaron
Summary: This study reveals the molecular mechanism underlying the interaction between endothelial cells and osteodifferentiating stem cells during bone tissue renewal. Specifically, endothelial cells induce osteodifferentiation in stem cells through the secretion of soluble factors, while stem cells promote vascular network formation by recruiting endothelial cells. Moreover, endothelial cells enhance anaerobic glycolysis in stem cells without compromising their oxidative metabolic shift required for osteodifferentiation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Hanghang Liu, Shibo Liu, Huanzhong Ji, Qiucheng Zhao, Yao Liu, Pei Hu, En Luo
Summary: The study found that using the newly discovered specific activator for adiponectin receptor, AdipoRon, can regulate bone-fat balance and promote bone regeneration. AdipoRon not only promotes cell migration and osteogenesis, but also inhibits adipogenesis and osteoclastogenesis, leading to faster bone regeneration and reduced adipogenesis in mice.
CELL PROLIFERATION
(2021)
Article
Biotechnology & Applied Microbiology
Yu Zhu, Shi-min Wei, Kai-xiao Yan, Ying-xin Gu, Hong-chang Lai, Shi-chong Qiao
Summary: The study demonstrated that ADSCs had better osteogenic differentiation potential than DPSCs, and the combined treatment with ADSCs and xenografts was more effective in enhancing bone repair processes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Polymer Science
Kata Cseko, Peter Maroti, Zsuzsanna Helyes, Roland Told, Fanni Riegler, Jozsef Szalma, Zsuzsanna Gurdan
Summary: This study investigated the effects of mouthwashes, toothbrushing, and smoking on the force decay of orthodontic elastomers. The findings suggest that external factors can influence the force decay of different types of elastomers.
Article
Dentistry, Oral Surgery & Medicine
Sachin Chhatwani, Ouafaa Kouji-Diehl, Kristian Kniha, Ali Modabber, Frank Hoelzle, Jozsef Szalma, Gholamreza Danesh, Stephan Christian Moehlhenrich
Summary: This study evaluated the primary stability of orthodontic mini-implants at different implant sites with varying morphologies and qualities. The results showed that bone defects and bone quality affected the stability of the implants.
JOURNAL OF OROFACIAL ORTHOPEDICS-FORTSCHRITTE DER KIEFERORTHOPADIE
(2023)
Article
Polymer Science
Kinga Dorottya Nemeth, Dora Haluszka, Laszlo Seress, Balint Viktor Lovasz, Jozsef Szalma, Edina Lempel
Summary: The effects of calcium carbonate air-abrasion on the surface roughness of enamel, nanofill, and microhybrid resin composites were investigated in this study. Post-polishing with rubber- or brush polisher was also examined to restore the surface smoothness. The results showed that air-abrasion increased the surface roughness of resin composites, and the post-polishing methods had varying effects on different materials.
Article
Immunology
Zsolt Matula, Marton Gonczi, Gabriella Beko, Bela Kadar, Eva Ajzner, Ferenc Uher, Istvan Valyi-Nagy
Summary: The study compared the immune responses elicited by BBIBP-CorV and BNT162b2 vaccines after 6 months of immunization. It was found that the T cell responses were similar, but there were differences in humoral immunity. Administering a third dose of BNT162b2 after BBIBP-CorV significantly enhanced the immune response.
Article
Multidisciplinary Sciences
Edina Lempel, Dora Kincses, Donat Szebeni, Dora Jordaki, Balint Viktor Lovasz, Jozsef Szalma
Summary: The adhesive cementation of ceramic veneers can lead to an increase in pulpal temperature, potentially causing damage to the pulp. The heat generated by the curing unit and the exothermic reaction of the luting agent contribute to this increase. The temperature change is influenced by the composition of the luting agent and the thickness of the ceramic veneers.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jozsef Szalma, Kata Janovics, Ana Pacheco, Balint Kaszas, Edina Lempel
Summary: This article presents cases of deeply impacted high-risk third molars with pre-eruptive intracoronal resorption (PEIR) defects and emphasizes the importance of preoperative imaging in the diagnosis and management of such cases.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Erika Dunavari, Gergely Berta, Tamas Kiss, Jozsef Szalma, Mark Frater, Katalin Boeddi, Edina Lempel
Summary: This study investigated the effect of pre-heating on monomer elution and closed porosity in dental resin-based composites. The results showed that pre-heating significantly reduced monomer elution in bulk-filled composites, but increased it in layered composites. However, pre-heating was unfavorable in terms of closed porosity for most composites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Edina Lempel, Donat Szebeni, Zsuzsanna Ori, Tamas Kiss, Jozsef Szalma, Balint Viktor Lovasz, Sandor Kunsagi-Mate, Katalin Boddi
Summary: This study aimed to compare the degree of conversion, monomer elution, polymerization shrinkage, and porosity of two AFCT modified resin-based composites under rapid, turbo, or conventional polymerization settings. The results showed that curing time affected the degree of conversion and monomer elution, suggesting a longer exposure time is recommended in a clinical situation.
Article
Biochemistry & Molecular Biology
Dora Kincses, Dora Jordaki, Donat Szebeni, Sandor Kunsagi-Mate, Jozsef Szalma, Edina Lempel
Summary: The adhesive cementation of ceramic inlays can cause increased pulpal temperature and damage due to heat generated by the curing unit and the exothermic reaction of the luting agent. This study aimed to measure the temperature rise during ceramic inlay cementation by testing different combinations of dentin and ceramic thicknesses and luting agents. The results showed that dentin thickness had the greatest influence on temperature changes, followed by the luting agent and ceramic thickness. Adhesive inlay cementation significantly increased pulpal temperature, especially when the remaining dentin thickness was less than 2 mm.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zsolt Matula, Ferenc Uher, Istvan Valyi-Nagy, Gabor Mikala
Summary: Belantamab mafodotin (belamaf) is an afucosylated monoclonal antibody that targets B cell maturation antigen (BCMA) and can eliminate myeloma cells through multiple mechanisms. However, primary myeloma cells can exhibit widely varying levels of BCMA expression, and low expression is associated with high resistance to belamaf. Additionally, we found that increasing concentrations of belamaf can lead to enhanced incorporation of mitochondria from bone marrow stromal cells, resulting in increased resistance to belamaf, similar to other medications like carfilzomib or venetoclax. The observed resistance to belamaf suggests the need for combination therapies to overcome the risk of antigen escape.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Anita Marx, Magdolna Osvath, Bence Szikora, Orsolya Pipek, Istvan Csabai, Akos Nagy, Csaba Bodor, Zsolt Matula, Ginette Nagy, Andras Bors, Ferenc Uher, Gabor Mikala, Istvan Valyi-Nagy, Imre Kacskovics
Summary: The study aimed to optimize a highly sensitive molecular system using next-generation sequencing and droplet digital PCR to monitor minimal/measurable residual disease (MRD) in multiple myeloma patients. The methods showed significant correlation with clinical parameters and yielded complementary information for MRD evaluation. Early indications of relapse before clinical signs were also detected.
Article
Biochemistry & Molecular Biology
Kinga Dorottya Nemeth, Roland Told, Peter Szabo, Peter Maroti, Reka Szenai, Zsolt Balazs Pinter, Balint Viktor Lovasz, Jozsef Szalma, Edina Lempel
Summary: The purpose of this study was to compare the effect of sodium bicarbonate (SB) and aluminum oxide (AO) surface treatments on the microtensile bond strength (μTBS) of repaired, aged resin-based composite (RBC). Different surface treatments and adhesive applications were used prior to the application of the repair RBC. AO-PA-UA showed the most significant increase in μTBS, followed by SB-EDTA-UA, suggesting that both could be viable alternatives in the RBC repair protocol.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Thomas Starch-Jensen, Bojan Gacic, Vitomir S. Konstantinovic, Adaia Valls Ontanon, Angel Sapundzhiev, Nikolay Pavlov, Petia Pechalova, Jozsef Szalma, Radovan Mottl, Tiia Tamme, Janne Tiigimae-Saar, Oksana Ivask, Veronika Bozic, Trajche Jovanovski, Tadej Dovsak, Paul Andrei Tent, Matteo Brucoli, Vincenzo Rocchetti, Paolo Boffano
Summary: This study evaluated the patient's perception of recovery and potential risk factors associated with impaired recovery following surgical removal of mandibular third molars (SRM3s). The results showed that preoperative symptoms, dental anxiety level, and prolonged surgical time were associated with increased pain and swelling. In addition, impaired sensation of the lower lip and chin was associated with Pell and Gregory classification.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2023)
Article
Chemistry, Multidisciplinary
Laszlo Pinter, Karoly Krajczar, Fanni Ory, Jozsef Szalma, Edina Lempel
Summary: Endodontic preparation with ultrasonic instruments can cause temperature rise on the external root surface, which may be harmful to the periodontium. Rinsing between preparation phases can reduce the temperature rise, and high-energy treatment exceeding 60 seconds has potential risks.
APPLIED SCIENCES-BASEL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ana Pacheco, Balazs Soos, Edina Lempel, Imre Simon, Peter Maroti, Stephan Christian Moehlhenrich, Jozsef Szalma
Summary: This in vitro study evaluated the effect of a 3D-printed drill sleeve on the precision and duration of coronectomy sections. The results showed that the use of a drill sleeve significantly reduced the occurrence of too deep and too superficial cuts and shortened the surgical time.
CLINICAL ORAL INVESTIGATIONS
(2023)
