Review
Endocrinology & Metabolism
Yi Wang, Su-Kang Shan, Bei Guo, Fuxingzi Li, Ming-Hui Zheng, Li-Min Lei, Qiu-Shuang Xu, Muhammad Hasnain Ehsan Ullah, Feng Xu, Xiao Lin, Ling-Qing Yuan
Summary: Diabetic nephropathy is a common complication of diabetes mellitus, which can lead to end-stage renal disease. Mesenchymal stem cells, particularly their secreted exosomes, have shown potential therapeutic effects in the treatment of diabetic kidney disease, with mechanisms including regulation of hyperglycemia, anti-inflammatory properties, anti-fibrotic effects, promotion of angiogenesis, and protection of renal function. The limitations and enhanced therapeutic role of pre-treated MSCs in diabetic nephropathy therapy are also highlighted in this review.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell & Tissue Engineering
Serbay Ozkan, Basak Isildar, Merve Ercin, Selda Gezginci-Oktayoglu, Dildar Konukoglu, Neset Nesetoglu, Mahmut Oncul, Meral Koyuturk
Summary: This study compared the effects of N-CM and DFS-CM, collected from normal and deferoxamine preconditioned umbilical cord-derived MSCs, on a rat diabetic nephropathy model. The results showed that DFS-CM was more effective in reducing podocyte damage and tubular apoptotic cell death, and regulating autophagic activity in DN.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Oncology
Xiuyun Xuan, Chunxia Tian, Mengjie Zhao, Yanhong Sun, Changzheng Huang
Summary: The tumor microenvironment plays a crucial role in cancer progression and therapeutic resistance, with MSCs being a distinct type of cells linked to tumor development. MSCs can both promote and inhibit cancer cell proliferation and metastasis, as well as contribute to therapeutic resistance.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell & Tissue Engineering
Ping Nie, Xue Bai, Yan Lou, Yuexin Zhu, Shan Jiang, Lina Zhang, Na Tian, Ping Luo, Bing Li
Summary: The study found that human umbilical cord mesenchymal stem cells can attenuate renal oxidative damage and apoptosis in type 2 diabetic nephropathy by activating Nrf2. Additionally, activation of the PI3K signaling pathway may help in improving diabetic nephropathy using human umbilical cord mesenchymal stem cells.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Yaqi Zhang, Xi Le, Shuo Zheng, Ke Zhang, Jing He, Mengting Liu, Chengshu Tu, Wei Rao, Hongyuan Du, Yu Ouyang, Changyong Li, Dongcheng Wu
Summary: This study demonstrates that MSCs derived from human umbilical cords can protect renal function in rats with diabetic nephropathy by altering macrophage phenotype. UC-MSCs-derived miR-146a-5p promotes the anti-inflammatory phenotype of macrophages by inhibiting the TRAF6/STAT1 signaling pathway and effectively improves renal function.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Pharmacology & Pharmacy
Heba A. Habib, Gehan H. Heeba, Mohamed M. A. Khalifa
Summary: A study investigated the potential of adipose-derived MSCs in combination with exenatide to improve renal function in diabetic rats, showing superior renoprotective effects through rebalancing inflammatory, fibrotic, and apoptotic markers. This suggests a promising therapy for diabetic nephropathy, warranting further clinical studies to validate these findings.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Cell Biology
Jiali Wang, Yongda Lin, Xiutian Chen, Yiping Liu, Tianbiao Zhou
Summary: Chronic kidney disease has significant impact on public health and requires more effective treatment tools. Mesenchymal stem cells show potential as a new tool for CKD treatment, with the ability to improve renal function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Food Science & Technology
Yu-Teng Chang, Mu-Chi Chung, Chang-Chi Hsieh, Jeng-Jer Shieh, Ming-Ju Wu
Summary: The study showed that protocatechuic aldehyde (PCA) can alleviate diabetic-induced renal dysfunction, reduce glomerular size, restore normal levels of fibrosis markers, decrease oxidative stress and inflammation in the kidneys of db/db mice. This research provides a foundation for using PCA as an alternative therapy for diabetic nephropathy in the future.
Article
Medicine, Research & Experimental
Tie-Jun Yuan, Xue-Han Xu, Nan Zhou, Ge Yan, Ting-Wei Gu, Li-Hua Peng
Summary: This study identified 11 natural compounds from medicinal plants that have both proliferative and anti-senescence abilities in stem cells. Mechanistic analysis revealed their involvement with growth factors and senescence-related pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Christian Savio-Silva, Poliana E. Soinski-Sousa, Antonio Simplicio-Filho, Rosana M. C. Bastos, Stephany Beyerstedt, Erika Bevilaqua Rangel
Summary: The study demonstrated that mesenchymal stem cells (MSCs) have therapeutic potential in treating diabetic kidney disease by inhibiting oxidative stress, apoptosis, regulating autophagy, and maintaining mitochondrial homeostasis to slow down the progression of the disease. In animal experiments, MSC therapy improved kidney function and structure, reduced urinary albumin-to-creatinine ratio, decreased mesangial expansion, upregulated mitochondria-related survival genes, and inhibited excessive autophagy activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yuchen Zhang, Naijun Dong, Huanle Hong, Jingxuan Qi, Shibo Zhang, Jiao Wang
Summary: Due to the aging population, stroke has become more prevalent, leading to increased socioeconomic burden. Stem cell transplantation, particularly using mesenchymal stem cells (MSCs), has shown promise in treating stroke by attenuating inflammation, promoting therapeutic effects, inducing blood vessel formation, promoting neurogenesis, reducing infarct volume, and replacing damaged cells. This review discusses the mechanisms of MSCs and their secreted extracellular vehicles (EVs) in stroke treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Lan Li, Dongqi Cheng, Xingxing An, Guangneng Liao, Ling Zhong, Jingping Liu, Younan Chen, Yujia Yuan, Yanrong Lu
Summary: The study demonstrated that MSCs treatment could reduce elevated levels of uric acid and improve kidney function in hyperuricemic nephropathy rat models. In vitro experiments also showed that MSCs could protect against uric acid-induced cell injury. These findings suggest that MSCs therapy may be a potential treatment for hyperuricemia-related renal diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Peishan Li, Qianmin Ou, Songtao Shi, Changshun Shao
Summary: Mesenchymal stem/stromal cells (MSCs) are widely distributed in the body and can be used for the treatment of autoimmune diseases and other chronic disorders. Dental stem cells (DSCs) have remarkable immunomodulatory properties and have therapeutic effects on systemic inflammatory diseases. MSCs derived from nondental tissues, such as the umbilical cord, also show benefits in the management of periodontitis in preclinical studies.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Cell & Tissue Engineering
Ameneh Shokati, Abdorreza Naser Moghadasi, Mohsen Nikbakht, Mohammad Ali Sahraian, Seyed Asadollah Mousavi, Jafar Ai
Summary: Multiple sclerosis (MS) is a chronic central nervous system disease with limited treatment options, leading researchers to explore new therapies such as mesenchymal stromal cell (MSC) transplantation. Allogeneic MSCs are suggested as a potential novel solution for MS therapy as an alternative to autologous MSCs.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Medicine, Research & Experimental
Qichao Hu, Yuan Chen, Xinyu Deng, Yubing Li, Xiao Ma, Jinhao Zeng, Yanling Zhao
Summary: Diabetic nephropathy is a severe complication of diabetes, but no effective therapeutic methods other than ACEIs and ARBs have been applied due to its complex pathological mechanisms. Recent studies have shown that emerging therapeutics such as novel target-based pharmacotherapy, cell therapies, and dietary regulation are leading to new hopes for DN management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Public, Environmental & Occupational Health
Nadja S. Igarashi, Christiane H. Karam, Rui F. Afonso, Fabiana D. Carneiro, Shirley S. Lacerda, Bento F. Santos, Elisa H. Kozasa, Erika B. Rangel
Summary: The study demonstrated that a short-term meditation protocol for chronic hemodialysis patients led to improvements in depressive symptoms, blood pressure values, self-compassion, and serum phosphorous levels.
PSYCHOLOGY HEALTH & MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Marcella Liciani Franco, Stephany Beyerstedt, erika Bevilaqua Rangel
Summary: Chronic kidney disease (CKD) and acute kidney injury (AKI) are public health problems associated with comorbidities such as diabetes mellitus and hypertension. Klotho has shown promising potential as a therapeutic approach for these kidney conditions. It exerts renoprotective effects by reducing inflammation, oxidative stress, and fibrosis. Mesenchymal stem cells (MSCs) are an important strategy for delivering Klotho.
Article
Endocrinology & Metabolism
Rosana M. C. Bastos, Erika B. Rangel
Summary: The gut microbiota plays a key role in metabolic diseases by producing metabolites that directly target insulin resistance and affect glucose metabolism in skeletal muscle, adipose tissue, and liver. These metabolites have the potential to be targeted for therapeutic intervention to ameliorate hyperglycemia and improve energy expenditure and fat oxidation in the whole body.
WORLD JOURNAL OF DIABETES
(2022)
Article
Biochemistry & Molecular Biology
Rosana M. C. Bastos, Antonio Simplicio-Filho, Christian Savio-Silva, Luiz Felipe Oliveira, Giuliano N. F. Cruz, Eliza H. Sousa, Irene L. Noronha, Cristovao L. P. Mangueira, Heloisa Quaglierini-Ribeiro, Gleice R. Josefi-Rocha, Erika B. Rangel
Summary: This study aimed to investigate the benefits of fecal microbiota transplant (FMT) on type 2 diabetes, obesity, and diabetic kidney disease (DKD). The findings showed that FMT prevented weight gain, reduced albuminuria and tumor necrosis factor-alpha (TNF-alpha) levels, and potentially improved insulin resistance. Intestinal integrity was maintained.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Joao Roberto de Sa, Erika Bevilaqua Rangel, Luis Henrique Canani, Andrea Carla Bauer, Gustavo Monteiro Escott, Themis Zelmanovitz, Marcello Casaccia Bertoluci, Sandra Pinho Silveiro
Summary: The review on Diabetic Kidney Disease by SBD provides evidence-based guidelines for management with recommendations categorized by levels of evidence and degrees of agreement from panelists. Intensive glycemic control, blood pressure management, and the use of specific medications are essential for preventing advanced stages of DKD.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Nursing
Fernanda de Oliveira Procopio, Erika Bevilaqua Rangel, Bartira de Aguiar Roza, Joao Roberto de Sa, Janine Schirmer
Summary: This study investigated medication adherence in type 2 diabetes mellitus among kidney transplant recipients and non-transplant recipients. The results showed that even though patients reported adherence to medication for diabetes control, their glycated hemoglobin levels were still above the recommended range. Additionally, no significant correlation was found between medication adherence, glycated hemoglobin, anxiety, and depression.
ACTA PAULISTA DE ENFERMAGEM
(2023)
Article
Microbiology
Leticia Mello Bezinelli, Luciana Correa, Stephany Beyerstedt, Erika Bevilaqua Rangel, Carlos Benitez, Nelson Hamerschlak, Joao Renato Rebello Pinho, Debora Heller, Fernanda de Paula Eduardo
Summary: This study investigated the effectiveness of an oral hygiene protocol in reducing the SARS-CoV-2 viral load in the oral cavity. The results showed that using chlorhexidine (CHX) and hydrogen peroxide (HP) in the oral rinse immediately after the procedure significantly reduced the viral load.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Alexandre Veronese-Araujo, Debora D. de Lucena, Isabella Aguiar-Brito, Luis Gustavo Modelli de Andrade, Marina P. P. Cristelli, Helio Tedesco-Silva, Jose O. Medina-Pestana, Erika B. Rangel
Summary: Obesity is a component of the cardiometabolic syndrome that worsens the progression and mortality of COVID-19. In this study, the impact of overweight/obesity and kidney transplant on oxygen requirements in COVID-19 patients was investigated. The results showed that obesity was an independent risk factor for oxygen requirements in overweight/obese kidney transplant recipients, particularly in older individuals and smokers.
Meeting Abstract
Immunology
Lucia Alfaro Villanueva, Jose Medina-Pestana, Laila Viana, Marina Cristelli, Erika B. Rangel, Helio Tedesco-Silva, Roberto F. Meirelles
Article
Surgery
Erika B. Rangel, Debora D. de Lucena, Isabella Aguiar-Brito, Luis Gustavo Modelli de Andrade, Alexandre Veronese-Araujo, Marina P. Cristelli, Helio Tedesco-Silva, Jose O. Medina-Pestana
Summary: Kidney transplant recipients with pre-existing comorbidities, such as diabetes mellitus, are at higher risk of COVID-19 progression and mortality. This study found that fasting blood glucose, markers of inflammation (C-reactive protein) and tissue damage (lactate dehydrogenase) were associated with case fatality rate, invasive mechanical ventilation requirement, and acute kidney injury in kidney transplant patients affected by COVID-19. These factors were indicative of COVID-19 burden in this population, independently of diabetes mellitus status.
TRANSPLANT INTERNATIONAL
(2022)
Meeting Abstract
Surgery
L. A. Alfaro, L. A. Viana, M. P. Cristelli, E. B. Rangel, R. Meirelles, H. Tedesco, J. Medina
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Medicine, Research & Experimental
Kleber Goia-Nishide, Lucas Coregliano-Ring, Erika Bevilaqua Rangel
Summary: Diabetes mellitus is associated with comorbidities like heart failure and chronic kidney disease, making diabetic patients susceptible to potassium disorders such as hyperkalemia. This potentially life-threatening condition increases the risk of cardiac arrhythmia and mortality. This review briefly discusses the causes, symptoms, diagnosis, and management of hyperkalemia in diabetic individuals.
Correction
Surgery
Erika Bevillaqua Rangel
ACTA CIRURGICA BRASILEIRA
(2022)
Article
Surgery
Thais Malta Romano, Marcelo Moura Linhares, Karin Romano Posegger, Erika Bevillaqua Rangel, Adriano Miziara Gonzalez, Alcides Augusto Salzedas-Netto, Samantha Mucci, Helio Tedesco Silva-Junior, Gaspar de Jesus Lopes Filho, Jose Osmar Medina-Pestana
Summary: Simultaneous pancreas-kidney transplantation (SPKT) has a positive impact on psychological aspects, specifically in reducing depression levels, for insulin-dependent type-1 diabetic patients with end-stage renal disease (ESRD). However, patients waiting for transplantation are more vulnerable to psychological disorders, and the stressors during the pretransplant stage significantly impact the psychosocial condition of the patient.
ACTA CIRURGICA BRASILEIRA
(2022)
Article
Medicine, General & Internal
Lucas Coregliano-Ring, Kleber Goia-Nishide, Erika Bevilaqua Rangel
Summary: Diabetes mellitus is a global public health problem that can affect individuals regardless of age, sex, and ethnicity. Potassium disorders, particularly hypokalemia, are common in diabetic patients, especially those with acute complications. These potassium disorders are associated with increased all-cause mortality in diabetic individuals, especially those with comorbidities. This article discusses the conditions for the onset of hypokalemia in diabetic individuals, the pathophysiology of acute complications of diabetes mellitus and their association with hypokalemia, the diagnostic signs and symptoms, and the management of hypokalemia, which is one of the most common electrolyte disturbances in clinical practice.
MEDICINA-LITHUANIA
(2022)
