Generating Diverse Spinal Motor Neuron Subtypes from Human Pluripotent Stem Cells

Motoneurons Derived from Induced Pluripotent Stem Cells Develop Mature Phenotypes Typical of Endogenous Spinal Motoneurons

(2015) J. S. Toma et al.   JOURNAL OF NEUROSCIENCE

Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes

(2014) Yves Maury et al.   NATURE BIOTECHNOLOGY

Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem Cells

(2013) M. W. Amoroso et al.   JOURNAL OF NEUROSCIENCE

Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity

(2013) Esteban O Mazzoni et al.   NATURE NEUROSCIENCE

Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis

(2012) Rickie Patani et al.   JOURNAL OF NEUROCHEMISTRY

Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons

(2011) Esther Y. Son et al.   Cell Stem Cell

Rapid and Efficient Generation of Functional Motor Neurons From Human Pluripotent Stem Cells Using Gene Delivered Transcription Factor Codes

(2011) Mark E Hester et al.   MOLECULAR THERAPY

Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

(2011) Massimiliano Caiazzo et al.   NATURE

Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state

(2011) R. Patani et al.   Nature Communications

Motor Neuron Diversity in Development and Disease

(2010) Kevin C. Kanning et al.   Annual Review of Neuroscience

Functional Diversity of ESC-Derived Motor Neuron Subtypes Revealed through Intraspinal Transplantation

(2010) Mirza Peljto et al.   Cell Stem Cell

Direct conversion of human fibroblasts to multilineage blood progenitors

(2010) Eva Szabo et al.   NATURE

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Global Control of Motor Neuron Topography Mediated by the Repressive Actions of a Single Hox Gene

(2010) Heekyung Jung et al.   NEURON

Optimal Timing of Inner Cell Mass Isolation Increases the Efficiency of Human Embryonic Stem Cell Derivation and Allows Generation of Sibling Cell Lines

(2009) Alice E. Chen et al.   Cell Stem Cell

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Activin/Nodal Inhibition Alone Accelerates Highly Efficient Neural Conversion from Human Embryonic Stem Cells and Imposes a Caudal Positional Identity

(2009) Rickie Patani et al.   PLoS One

Hox Repertoires for Motor Neuron Diversity and Connectivity Gated by a Single Accessory Factor, FoxP1

(2008) Jeremy S. Dasen et al.   CELL

Pluripotent stem cell lines

(2008) J. Yu et al.   GENES & DEVELOPMENT

Induced pluripotent stem cells from a spinal muscular atrophy patient

(2008) Allison D. Ebert et al.   NATURE

Coordinated Actions of the Forkhead Protein Foxp1 and Hox Proteins in the Columnar Organization of Spinal Motor Neurons

(2008) David L. Rousso et al.   NEURON

Differentiation of Human Embryonic Stem Cells to Regional Specific Neural Precursors in Chemically Defined Medium Conditions

(2008) Slaven Erceg et al.   PLoS One

Directed Differentiation of Ventral Spinal Progenitors and Motor Neurons from Human Embryonic Stem Cells by Small Molecules

(2008) Xue-Jun Li et al.   STEM CELLS

Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm

(2007) Joseph R. Smith et al.   DEVELOPMENTAL BIOLOGY