Journal
STEM CELL REVIEWS AND REPORTS
Volume 13, Issue 1, Pages 24-34Publisher
SPRINGER
DOI: 10.1007/s12015-016-9697-x
Keywords
Direct conversion; Induced pluripotent stem cells; Reprogramming.; Reprogramming efficiency; Reprogramming enhancer; Somatic cell nuclear transfer
Funding
- NRF [2016R1C1B1010742, 2016K1A3A1A61006001]
- National Research Foundation of Korea [2016R1C1B1010742, 2016K1A3A1A61006001] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Direct conversion of cell fate is a core technology for future regenerative medicine. However, the low reprogramming efficiency and low reproducibility are the largest obstacles blocking translational research of direct conversion technology. This review lists the major reprogramming enhancers verified in the representative reprogramming technologies of somatic cell nuclear transfer, induced pluripotent stem cell technology, and direct conversion, and categorizes them according to their functions. Ultimately, we strive to provide a practical plan to overcome the low reprogramming efficiency and low reproducibility of direct conversion.
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