ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

AXL kinase as a novel target for cancer therapy

(2015) Xiaoliang Wu et al.   Oncotarget

AXL Mediates TRAIL Resistance in Esophageal Adenocarcinoma

(2015) Jun Hong et al.   NEOPLASIA

Molecular Mechanisms of Bone Metastasis and Associated Muscle Weakness

(2014) D. L. Waning et al.   CLINICAL CANCER RESEARCH

Geminin Overexpression Promotes Imatinib Sensitive Breast Cancer: A Novel Treatment Approach for Aggressive Breast Cancers, Including a Subset of Triple Negative

(2014) Zannel Blanchard et al.   PLoS One

Cholesterol and breast cancer pathophysiology

(2014) Erik R. Nelson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

TAZ Expression as a Prognostic Indicator in Colorectal Cancer

(2013) Hiu-Fung Yuen et al.   PLoS One

Abl Family Kinases Regulate Endothelial Barrier Function In Vitro and in Mice

(2013) Elizabeth M. Chislock et al.   PLoS One

Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival

(2013) E. M. Chislock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer

(2012) Adrian Britschgi et al.   CANCER CELL

Role of TAZ as Mediator of Wnt Signaling

(2012) Luca Azzolin et al.   CELL

SnapShot: Bone Metastasis

(2012) Brian Ell et al.   CELL

Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population

(2012) Hasan Korkaya et al.   MOLECULAR CELL

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo

(2012) H Gil-Henn et al.   ONCOGENE

An Approach for the Identification of Targets Specific to Bone Metastasis Using Cancer Genes Interactome and Gene Ontology Analysis

(2012) Shikha Vashisht et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

(2011) Nilay Sethi et al.   CANCER CELL

Nilotinib and MEK Inhibitors Induce Synthetic Lethality through Paradoxical Activation of RAF in Drug-Resistant Chronic Myeloid Leukemia

(2011) Leisl M. Packer et al.   CANCER CELL

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo

(2010) Lei Gu et al.   ENDOCRINE-RELATED CANCER

Interleukin-6 in bone metastasis and cancer progression

(2010) Tasnim Ara et al.   EUROPEAN JOURNAL OF CANCER

Abl Kinases Are Required for Invadopodia Formation and Chemokine-induced Invasion

(2010) Pameeka S. Smith-Pearson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

(2010) Jianming Zhang et al.   NATURE

ABL Tyrosine Kinases: Evolution of Function, Regulation, and Specificity

(2010) J. Colicelli   Science Signaling

Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo

(2009) Roland Axmann et al.   ARTHRITIS AND RHEUMATISM

Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals

(2009) Xiang H.-F. Zhang et al.   CANCER CELL

ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis

(2009) X. Lu et al.   GENES & DEVELOPMENT

N-Myristoylated c-Abl Tyrosine Kinase Localizes to the Endoplasmic Reticulum upon Binding to an Allosteric Inhibitor

(2009) Yongmun Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts

(2009) W. D. Bradley et al.   JOURNAL OF CELL SCIENCE

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

(2009) C. Gjerdrum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imatinib mesylate (Gleevec(R)) in advanced breast cancer-expressing C-Kit or PDGFR- : clinical activity and biological correlations

(2008) M. Cristofanilli et al.   ANNALS OF ONCOLOGY

Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage

(2008) Dan Levy et al.   MOLECULAR CELL