ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases
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Title
ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases
Authors
Keywords
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Journal
Science Signaling
Volume 9, Issue 415, Pages ra18-ra18
Publisher
American Association for the Advancement of Science (AAAS)
Online
2016-02-17
DOI
10.1126/scisignal.aac4374
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Note: Only part of the references are listed.- ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies
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