Coupling an EML4-ALK-centric interactome with RNA interference identifies sensitizers to ALK inhibitors
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Title
Coupling an EML4-ALK-centric interactome with RNA interference identifies sensitizers to ALK inhibitors
Authors
Keywords
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Journal
Science Signaling
Volume 9, Issue 450, Pages rs12-rs12
Publisher
American Association for the Advancement of Science (AAAS)
Online
2016-10-19
DOI
10.1126/scisignal.aaf5011
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Note: Only part of the references are listed.- A framework for understanding and targeting residual disease in oncogene-driven solid cancers
- (2016) Trever G Bivona et al. NATURE MEDICINE
- Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition
- (2016) Aaron N Hata et al. NATURE MEDICINE
- Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells
- (2016) Michael Ramirez et al. Nature Communications
- A Functional Landscape of Resistance to ALK Inhibition in Lung Cancer
- (2015) Frederick H. Wilson et al. CANCER CELL
- Akt Kinase-Interacting Protein 1 Signals through CREB to Drive Diffuse Malignant Mesothelioma
- (2015) T. Yamada et al. CANCER RESEARCH
- RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK–positive lung cancer
- (2015) Gorjan Hrustanovic et al. NATURE MEDICINE
- Phthalimide conjugation as a strategy for in vivo target protein degradation
- (2015) G. E. Winter et al. SCIENCE
- Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells
- (2015) Azusa Tanimoto et al. Oncotarget
- Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy
- (2014) Jihye Kim et al. BIOINFORMATICS
- Tyrosine Phosphoproteomics Identifies Both Codrivers and Cotargeting Strategies for T790M-Related EGFR-TKI Resistance in Non-Small Cell Lung Cancer
- (2014) T. Yoshida et al. CLINICAL CANCER RESEARCH
- Rationale for co-targeting IGF-1R and ALK in ALK fusion–positive lung cancer
- (2014) Christine M Lovly et al. NATURE MEDICINE
- Ceritinib in ALK-Rearranged Non–Small-Cell Lung Cancer
- (2014) Alice T. Shaw et al. NEW ENGLAND JOURNAL OF MEDICINE
- PhosphoSitePlus, 2014: mutations, PTMs and recalibrations
- (2014) Peter V. Hornbeck et al. NUCLEIC ACIDS RESEARCH
- The BioGRID interaction database: 2015 update
- (2014) Andrew Chatr-aryamontri et al. NUCLEIC ACIDS RESEARCH
- Patient-derived models of acquired resistance can identify effective drug combinations for cancer
- (2014) Adam S. Crystal et al. SCIENCE
- Clust&See: A Cytoscape plugin for the identification, visualization and manipulation of network clusters
- (2013) Lionel Spinelli et al. BIOSYSTEMS
- Activity of EGFR-tyrosine kinase and ALK inhibitors for EML4–ALK-rearranged non–small–cell lung cancer harbored coexisting EGFRmutation
- (2013) Akihiko Miyanaga et al. BMC CANCER
- Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells
- (2013) Kamaraj Sattu et al. FEBS Journal
- Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
- (2013) J. Li et al. Molecular Systems Biology
- Structure and dynamics of molecular networks: A novel paradigm of drug discovery
- (2013) Peter Csermely et al. PHARMACOLOGY & THERAPEUTICS
- Targeted Inhibition of the Molecular Chaperone Hsp90 Overcomes ALK Inhibitor Resistance in Non–Small Cell Lung Cancer
- (2013) Jim Sang et al. Cancer Discovery
- Tankyrase and the Canonical Wnt Pathway Protect Lung Cancer Cells from EGFR Inhibition
- (2012) Matias Casás-Selves et al. CANCER RESEARCH
- Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition
- (2012) Mikko Taipale et al. CELL
- Activation of HER Family Signaling as a Mechanism of Acquired Resistance to ALK Inhibitors in EML4-ALK-Positive Non-Small Cell Lung Cancer
- (2012) J. Tanizaki et al. CLINICAL CANCER RESEARCH
- Detection of EML4-ALK fusion genes in non-small cell lung cancer patients with clinical features associated with EGFR mutations
- (2012) Zhou Shaozhang et al. GENES CHROMOSOMES & CANCER
- Akt kinase-interacting protein1, a novel therapeutic target for lung cancer with EGFR-activating and gatekeeper mutations
- (2012) T Yamada et al. ONCOGENE
- Comparative Analysis of Dynamic Cell Viability, Migration and Invasion Assessments by Novel Real-Time Technology and Classic Endpoint Assays
- (2012) Ridha Limame et al. PLoS One
- Complementary Fe3+- and Ti4+-immobilized metal ion affinity chromatography for purification of acidic and basic phosphopeptides
- (2012) Alan Chuan-Ying Lai et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers
- (2012) R. Katayama et al. Science Translational Medicine
- CH5424802, a Selective ALK Inhibitor Capable of Blocking the Resistant Gatekeeper Mutant
- (2011) Hiroshi Sakamoto et al. CANCER CELL
- Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase
- (2011) Tingting Sun et al. CELL
- Ras-Induced and Extracellular Signal-Regulated Kinase 1 and 2 Phosphorylation-Dependent Isomerization of Protein Tyrosine Phosphatase (PTP)-PEST by PIN1 Promotes FAK Dephosphorylation by PTP-PEST
- (2011) Y. Zheng et al. MOLECULAR AND CELLULAR BIOLOGY
- PSICQUIC and PSISCORE: accessing and scoring molecular interactions
- (2011) Bruno Aranda et al. NATURE METHODS
- g:Profiler—a web server for functional interpretation of gene lists (2011 update)
- (2011) Jüri Reimand et al. NUCLEIC ACIDS RESEARCH
- PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse
- (2011) P. V. Hornbeck et al. NUCLEIC ACIDS RESEARCH
- Survival and Death Signals Can Predict Tumor Response to Therapy After Oncogene Inactivation
- (2011) P. T. Tran et al. Science Translational Medicine
- Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
- (2011) Richard Marcotte et al. Cancer Discovery
- Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene
- (2010) Z. Chen et al. CANCER RESEARCH
- Involvement of Grb2 Adaptor Protein in Nucleophosmin-Anaplastic Lymphoma Kinase (NPM-ALK)-mediated Signaling and Anaplastic Large Cell Lymphoma Growth
- (2010) Ludovica Riera et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Proteolysis-induced N-terminal Ectodomain Shedding of the Integral Membrane Glycoprotein CUB Domain-containing Protein 1 (CDCP1) Is Accompanied by Tyrosine Phosphorylation of Its C-terminal Domain and Recruitment of Src and PKCδ
- (2010) Yaowu He et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An Integrated Phosphoproteomics Work Flow Reveals Extensive Network Regulation in Early Lysophosphatidic Acid Signaling
- (2010) Thiemo B. Schreiber et al. MOLECULAR & CELLULAR PROTEOMICS
- EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors
- (2010) Young Lim Choi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer
- (2010) Eunice L. Kwak et al. NEW ENGLAND JOURNAL OF MEDICINE
- Synthetic Lethal Screen of an EGFR-Centered Network to Improve Targeted Therapies
- (2010) I. Astsaturov et al. Science Signaling
- Proteome-Wide Identification of Novel Binding Partners to the Oncogenic Fusion Gene Protein, NPM-ALK, using Tandem Affinity Purification and Mass Spectrometry
- (2009) Fang Wu et al. AMERICAN JOURNAL OF PATHOLOGY
- Thrombin Induces EGF Receptor Expression and Cell Proliferation via a PKC(δ)/c-Src-Dependent Pathway in Vascular Smooth Muscle Cells
- (2009) Hsi-Lung Hsieh et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome
- (2009) Alastair J. Barr et al. CELL
- Clinical Features and Outcome of Patients With Non–Small-Cell Lung Cancer Who Harbor EML4-ALK
- (2009) Alice T. Shaw et al. JOURNAL OF CLINICAL ONCOLOGY
- Role of PKCβII and PKCδ in blood–brain barrier permeability during aglycemic hypoxia
- (2009) Young-Ae Kim et al. NEUROSCIENCE LETTERS
- Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
- (2009) Ben Langmead et al. GENOME BIOLOGY
- PhosphoPOINT: a comprehensive human kinase interactome and phospho-protein database
- (2008) Chia-Ying Yang et al. BIOINFORMATICS
- The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL
- (2008) F. E. Boccalatte et al. BLOOD
- EML4-ALK Fusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung Cancer
- (2008) J. P. Koivunen et al. CLINICAL CANCER RESEARCH
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