Journal
SCIENCE SIGNALING
Volume 9, Issue 430, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scisignal.aaf4630
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Funding
- Crohn's & Colitis Foundation of America [3332, 2570174]
- National Institutes of Health (NIH)/National Center for Advancing Translational Sciences and Colorado Clinical and Translational Science Award [KL2 TR001080]
- Parker B. Francis Foundation Scholarship
- NIH [R01 DK097075, R01-HL092188, R01HL098294, POI-HL114457, R01-HL119837]
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In this issue of Science Signaling, Bullen et al. demonstrate that protein kinase A (PKA) phosphorylates and stimulates the transcriptional activity of hypoxia-inducible transcription factor-1 alpha (HIF-1 alpha). This finding may have implications in diseases processes that occur at the interface of hypoxia and inflammation, where HIF-1 alpha stabilization can function to dampen hypoxia-driven inflammation.
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