Article
Biochemistry & Molecular Biology
Mohamed Nabil, Mohamed A. El Raey, Walied Abdo, Mohamed A. O. Abdelfattah, Assem M. El-Shazly, Mansour Sobeh, Mona F. Mahmoud
Summary: The leaf extract of Albizia anthelmintica has significant antioxidant, anti-inflammatory, analgesic, and antipyretic properties. It showed gastroprotective effects in an indomethacin-induced ulcer model, preventing gastric lesions and maintaining gastric mucosa integrity through mechanisms involving anti-inflammatory and antioxidant activities, as well as regulation of iNOS levels. These findings suggest that Albizia anthelmintica could be a potential candidate for managing gastric ulcers with antioxidant properties.
Article
Nutrition & Dietetics
Minhee Lee, Dakyung Kim, Hyunji Kim, Sukyung Jo, Ok-Kyung Kim, Jeongmin Lee
Summary: The study demonstrated that Glycine max (L.) Merr. fermented using Lactobacillus delbrueckii ssp. delbrueckii Rosell-187 (Gastro-AD (R)) can alleviate ethanol/HCl-induced gastric damage, with gastro-protective effects such as reducing gastric acid secretion, increasing prostaglandin E2 levels, and decreasing inflammatory factors levels.
Article
Nutrition & Dietetics
Mona S. Almujaydil, Reham M. Algheshairy, Raghad M. Alhomaid, Hend F. Alharbi, Hoda A. Ali
Summary: This study assessed the protective effects of Nigella sativa floral honey (NS floral honey) and multi-floral honey (M-floral honey) compared to Nigella sativa oil (NS oil) against azathioprine-induced testicular degeneration in rats. Both NS floral honey and NS oil partially restored testicular function and improved sperm quality, while the effects of M-floral honey were inconclusive. Further clinical studies are needed to investigate the bioactive constituents of these substances.
Article
Immunology
Mariam I. Gamal El-Din, Fadia S. Youssef, Riham S. Said, Mohamed L. Ashour, Omayma A. Eldahshan, Abdel Nasser B. Singab
Summary: Gastric ulcers are a common global health issue, and the phytochemicals in P. glabra leaf extract show promising potential in treating gastric ulcers through anti-Helicobacter pylori, anti-inflammatory, and anti-apoptotic effects.
INFLAMMOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Klaudia Ciesielska-Figlon, Karolina Wojciechowicz, Anna Wardowska, Katarzyna Aleksandra Lisowska
Summary: Background: Nigella sativa has been traditionally used for medicinal purposes and has known antibacterial, virucidal, fungicidal, and antiparasitic properties. However, studies on its immunomodulatory effects are limited. This review examines in vitro and in vivo research supporting the role of Nigella sativa in modulating immune responses. The results suggest its potential as a therapeutic agent for regulating immune reactions.
Article
Biochemistry & Molecular Biology
Sinem Helvacioglu, Mohammad Charehsaz, Etil Guzelmeric, Mehmet Ali Ockun, Irem Ayran, Hasan Kirmizibekmez, Yuksel Kan, Ahmet Aydin, Erdem Yesilada
Summary: This study compared the antioxidant and mutagenic/antimutagenic activities of Nigella sativa and Nigella damascena fixed oils for the first time. The results showed that Nigella damascena oil exhibited superior antioxidant activity and significant protection against aflatoxin-induced mutagenicity. Additionally, the study identified a possible antimutagenic mechanism of the oils in degrading aflatoxin B1 epoxides.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Veterinary Sciences
Ilknur Undag, Hasan Huseyin Donmez
Summary: This study aimed to evaluate the protective effects of Nigella sativa oil against acrylamide-induced toxicity in the rat hippocampus. The findings showed that Nigella sativa oil supplementation increased the number of neurons in the hippocampus and improved gait abnormalities.
PAKISTAN VETERINARY JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Kannoth Mukundan Geetha, Kondareddypally Nanjundappa Anitha
Summary: The methanolic extract of Nigella sativa seeds has protective effects against ethanol-induced stomach ulcers in rats, by inhibiting soluble epoxide hydrolase activity.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Anatomy & Morphology
Ilknur Birsen, V. Nimet Izgut-Uysal
Summary: The apelin/APJ system plays a vital role in regulating physiological and pathophysiological mechanisms as well as protecting the gastric mucosa from harmful effects in the digestive system.
Article
Medicine, Research & Experimental
Emre Gunay, Erkan Ozkan, Haci Hasan Abuoglu, Asli Aykac, Ayliz Velioglu Ogunc, Buse Karanlik, Sule Cetinel, Ahmet Ozer Sehirli
Summary: The study demonstrated the potent antioxidant and anti-inflammatory effects of Nigella sativa oil in reducing gastrointestinal damage caused by indomethacin-induced ulcers in rats. This suggests that using Nigella sativa oil together with indomethacin may offer a new clinical therapeutic approach for preventing gastrointestinal damage.
CYPRUS JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Plant Sciences
Sadegh Shabab, Zahra Gholamnezhad, Maryam Mahmoudabady
Summary: This study reviewed 81 original English articles on the cardioprotective effects of medicinal plants in diabetes, finding that these plants mainly exert cardioprotective effects through increasing antioxidant effects, inhibiting inflammatory signaling pathways and related cytokines to reduce cardiac remodeling and myocardial cell apoptosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Fisheries
Morteza Yousefi, Hossein Adineh, Miriam Reverter, Mohammad Khademi Hamidi, Yury Anatolyevich Vatnikov, Evgeny Vladimirovich Kulikov, Seyed Hossein Hoseinifar, Hien Van Doan
Summary: The study revealed that glyphosate exposure can have various negative effects on common carp fingerlings, but dietary supplementation with black seed can mitigate these effects. Black seed inclusion in the diet can enhance antioxidant capacity, immune response, and stabilize serum parameters in fish.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Rui Liu, Na Zhu, Yuntao Hao, Xinran Liu, Jiawei Kang, Ruixue Mao, Xiaochen Yu, Yong Li
Summary: The study aimed to investigate the protective effects of walnut oligopeptides on indomethacin-induced gastric ulcers in rats. The results showed that walnut oligopeptides had a significant gastroprotective effect by regulating inflammatory cytokines, oxidative stress, prostaglandins synthesis, and enhancing the expression of COX-1 and COX-2 in gastric tissue. The gastroprotective mechanism may be related to arachidonic acid metabolism and upregulation of tryptophan, phenylalanine, tyrosine, and alpha-Linolenic acid metabolism synthesis in vivo.
Article
Nutrition & Dietetics
Eloise Checkouri, Stephane Ramin-Mangata, Nicolas Diotel, Wildriss Viranaicken, Claude Marodon, Franck Reignier, Christine Robert-Da Silva, Olivier Meilhac
Summary: Medicinal plant decoctions have protective effects on ox-LDL-induced cytotoxicity, reducing macrophage lipid uptake and inhibiting the activation of NF-kappa B, which may be of interest for limiting the atherosclerotic process.
Article
Biochemistry & Molecular Biology
Hussah Abdullah Alshwyeh, Sahar Khamees Aldosary, Muna Abdulsalam Ilowefah, Raheem Shahzad, Adeeb Shehzad, Saqib Bilal, In-Jung Lee, Jannah Ahmed Al Mater, Fatima Najf Al-Shakhoari, Waad Abdulrahman Alqahtani, Nurkhalida Kamal, Ahmed Mediani
Summary: Nigella species, particularly the roasted seeds, have been found to have various health benefits due to the presence of bioactive components. This study investigated the effect of roasting on the composition and biological activities of Nigella arvensis and Nigella sativa seed extracts. The results showed that roasted seeds exhibited strong antimicrobial activities and extracts significantly decreased cancer cell viability.
Review
Neurosciences
Asim Azhar, Mohammad Akram Wali, Qudsia Rashid, Wajihul Hasan Khan, Khaled Al-hosaini, Mohammad Owais, Mohammad Amjad Kamal
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, has become a global concern since March 2020. Initially thought to be limited to the respiratory system, the virus has been found to affect other organs, including the nervous system. Reports indicate that SARS-CoV-2 can penetrate the central nervous system (CNS) and cause neurological symptoms. This comprehensive review examines the entry routes of SARS-CoV-2 into the CNS, the molecular mechanisms involved, clinical symptoms, and associated nervous system diseases.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Neurosciences
Harsh Goel, Keshav Goyal, Avanish Kumar Pandey, Mercilena Benjamin, Fahad Khan, Pratibha Pandey, Sandeep Mittan, Danish Iqbal, Mohammed Alsaweed, Wael Alturaiki, Yahya Madkhali, Mohammad Amjad Kamal, Pranay Tanwar, Tarun Kumar Upadhyay
Summary: Due to environmental contamination, humans are exposed to physical and chemical mutagens, which cause a variety of neurological disorders through neuroinflammation, genetic instability, oxidative stress, and mitochondrial damage. This review summarizes the molecular mechanisms and effects of mutagens in the environment on neurological disorders.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Neurosciences
Md. Mominur Rahman, Sadia Afsana Mim, Md. Rezaul Islam, Nasrin Sultana, Muniruddin Ahmed, Mohammad Amjad Kamal
Summary: G-protein-coupled receptors (GPCRs) are activated by neurotransmitters and play a crucial role in psychiatric and neurological disorders. GPCRs show potential as therapeutic targets for obesity, diabetes, Alzheimer's disease, and other central nervous system disorders. Orphan GPCRs, such as GPR52, GPR6, and GPR8, are of particular interest and may have therapeutic implications for psychiatric disorders.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Biochemistry & Molecular Biology
Aziz Unnisa, Nigel H. H. Greig, Mohammad A. A. Kamal
Summary: Nanotechnology involves manipulating shape and size at the nanoscale to design and create structures, devices, and systems. It has shown great potential in improving drug delivery and overcoming the blood-brain barrier for treating brain disorders such as brain cancer and Alzheimer's disease. The use of nanomaterials in diagnostics and controlled drug delivery systems holds promise for enhancing the efficacy of treatments. However, further research is needed to ensure the safety and effectiveness of nanotechnology-assisted drugs.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Neurosciences
Aziz Unnisa, Nigel H. H. Greig, Mohammad Amjad Kamal
Summary: Traumatic brain injury (TBI) is a major cause of death and morbidity, and is the focus of translational research. Apoptosis is important in the pathophysiology of TBI, and inhibiting it may improve functional recovery. Caspases, such as Caspase-3 and Caspase-9, are key mediators of cell death due to apoptosis in TBI. Understanding these apoptotic pathways and finding ways to inhibit Caspases may have significant treatment implications for TBI.
CURRENT NEUROPHARMACOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Tanima Bhattacharya, Nigel H. Greig, Bairong Shen, Mohammad Amjad Kamal
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Neurosciences
Aziz Unnisa, Nigel H. Greig, Mohammad Amjad Kamal
Summary: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by underdeveloped brain and impaired social interaction. Recent research suggests that disturbances in neuron-glia interactions play a significant role in the pathophysiology of ASD. Glial cells, in addition to neurons, are essential for mental activities, and a new strategy emphasizing neuron-glia interactions should be applied. Dysfunctional neuron-glia connections result in abnormal neural network formation and neurotransmission, leading to the malfunctioning of brain circuits and behavioral issues. Reactive glial cells and dysfunction in microglia have been associated with autism, and various approaches involving glial cell treatment are being explored.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Etimad Huwait, Rehab Almassabi, Sanaa Almowallad, Salma Saddeek, Sajjad Karim, Gauthaman Kalamegam, Zeenat Mirza
Summary: Myricetin, a flavonol found in certain foods, has been found to have anti-inflammatory properties and can prevent the occurrence of macrophage infiltration, lipid deposition, and arterial wall thickening, which are characteristic of atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Mehboob Hoque, Arijit Samanta, Syed Sahajada Mahafujul Alam, Torki A. Zughaibi, Mohammad Amjad Kamal, Shams Tabrez
Summary: Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by the accumulation of amyloid beta (A beta) plaques and hyperphosphorylated tau protein neurofibrillary tangles (NFT). Current AD treatments have limited success and focus on improving cognitive and behavioral symptoms. Developing novel treatment approaches to control/inhibit AD progression, especially in the elderly, is crucial. Immunotherapy, which boosts the patient's immune system, shows promise as a safe treatment option. However, delivering therapeutics to the brain poses a challenge due to the minimal immune surveillance in the brain. The review discusses the use of different nano-formulations to enhance AD immunotherapy.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Zeenat Mirza, Sajjad Karim
Summary: This study aims to predict molecular interactions between cancer biomarker proteins and natural compounds, and identifies tehranolide as a potential anti-cancer phytomolecule with the ability to suppress the expression of AKT1. Docking analyses reveal that tehranolide has the most efficiency in inhibiting AKT1 and shows potential for cancer therapy.
Editorial Material
Behavioral Sciences
Rupesh K. Gautam, Aziz Unnisa, Nigel H. Greig, Mohammad Amjad Kamal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Oncology
Zeenat Mirza, Md Shahid Ansari, Md Shahid Iqbal, Nesar Ahmad, Nofe Alganmi, Haneen Banjar, Mohammed H. H. Al-Qahtani, Sajjad Karim
Summary: Using AI and machine learning, a diagnostic model and a prognostic model for breast cancer classification were constructed based on transcriptomics data. Through experimental validation, a nine-gene signature for diagnosis and an eight-gene signature for prognosis were identified, showing potential in improving the accuracy and cost-effectiveness of breast cancer management.
Article
Pediatrics
Sajjad Karim, Ibtessam Ramzi Hussein, Hans-Juergen Schulten, Saad Alsaedi, Zeenat Mirza, Mohammed Al-Qahtani, Adeel Chaudhary
Summary: This study aimed to investigate the genetic heterogeneity in Saudi children with developmental delay (DD), congenital malformations (CM), and intellectual disability (ID). High-resolution array comparative genomic hybridization (array CGH) was used to detect disease-associated copy number variations (CNVs). The diagnosis rate of array CGH was around two-fold higher than that of standard karyotyping.
Article
Oncology
Amer M. Alanazi, Azmat Ali Khan, Amer Mahmood, Araib Tahir, Mohammad Amjad Kamal
Summary: The aim of this study was to evaluate the effect of different bleaching methods, 40% hydrogen peroxide (HP) and Zinc Phthalocyanine (ZP), activated by photodynamic therapy (PDT) with the utilization of diverse procedures of reversal, on bond values, surface microhardness, and surface roughness of bleached enamel surface. The results showed that Zinc Phthalocyanine activated by PDT with the application of 10% ascorbic acid as the reversal solution had the highest bond values and surface microhardness with acceptable surface roughness for bonding adhesive resin to the enamel surface.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Medicine, General & Internal
Mohammed S. Ziyadah, Eman M. Mansory, Hatem M. Alahwal, Salem M. Bahashwan, Abdullah T. Almohammadi, Osman O. Radhwi, Talal Alghamdi, Shahida A. Khan, Majed N. Almashjary, Ahmed S. Barefah
Summary: This retrospective observational study in Saudi Arabia investigated the incidence and predisposing factors of venous thromboembolism (VTE) in hospitalized sickle cell disease (SCD) patients over a 10-year period. Of the 394 SCD patients analyzed, 3% experienced VTE, with pulmonary embolism being the most common form. Risk factors such as high white blood cell count, length of hospital stay, and presence of additional VTE risk factors were significantly associated with higher VTE risk.
JOURNAL OF CLINICAL MEDICINE
(2023)