Gastrointestinal Dysfunctions in Parkinson’s Disease: Symptoms and Treatments

Multicenter Assessment of Immunohistochemical Methods for Pathological Alpha-Synuclein in Sigmoid Colon of Autopsied Parkinson’s Disease and Control Subjects

(2016) Thomas G. Beach et al.   Journal of Parkinsons Disease

Evaluation of alpha-synuclein immunohistochemical methods for the detection of Lewy-type synucleinopathy in gastrointestinal biopsies

(2016) Anne-Gaëlle Corbillé et al.   Acta Neuropathologica Communications

Rate of aspiration pneumonia in hospitalized Parkinson’s disease patients: a cross-sectional study

(2015) Daniel Martinez-Ramirez et al.   BMC Neurology

Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy

(2015) Davor Ivankovic et al.   JOURNAL OF NEUROCHEMISTRY

A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication

(2015) Cristina Guardia-Laguarta et al.   MOVEMENT DISORDERS

Colonic bacterial composition in Parkinson's disease

(2015) Ali Keshavarzian et al.   MOVEMENT DISORDERS

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Inflammatory dysregulation of blood monocytes in Parkinson’s disease patients

(2014) Veselin Grozdanov et al.   ACTA NEUROPATHOLOGICA

Non-motor symptoms: the core of multi-morbid Parkinson's disease

(2014) Anna Sauerbier et al.   BRITISH JOURNAL OF HOSPITAL MEDICINE

Premotor and nonmotor features of Parkinsonʼs disease

(2014) Jennifer G. Goldman et al.   CURRENT OPINION IN NEUROLOGY

Swallowing Outcomes Following Unilateral STN vs. GPi Surgery: A Retrospective Analysis

(2014) Michelle S. Troche et al.   DYSPHAGIA

Clinical implications of irregular ADMET properties with levodopa and other antiparkinson's drugs

(2014) Livia Dézsi et al.   Expert Opinion on Drug Metabolism & Toxicology

Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease

(2014) Daniela Berg et al.   MOVEMENT DISORDERS

Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders

(2014) Ellen Gelpi et al.   MOVEMENT DISORDERS

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Randomized, placebo-controlled trial of trimethobenzamide to control nausea and vomiting during initiation and continued treatment with subcutaneous apomorphine injection

(2014) Robert A. Hauser et al.   PARKINSONISM & RELATED DISORDERS

Drooling in Parkinson's disease: A review

(2014) Prachaya Srivanitchapoom et al.   PARKINSONISM & RELATED DISORDERS

Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease

(2013) David Hilton et al.   ACTA NEUROPATHOLOGICA

Unravelling mitochondrial pathways to Parkinson's disease

(2013) I Celardo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Emerging drugs for autonomic dysfunction in Parkinson's disease

(2013) Santiago Perez-Lloret et al.   EXPERT OPINION ON EMERGING DRUGS

Parkinson disease: from pathology to molecular disease mechanisms

(2013) David T. Dexter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Delayed gastric emptying in Parkinson's disease

(2013) Sarah Marrinan et al.   MOVEMENT DISORDERS

Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease

(2013) Andrea Gold et al.   MOVEMENT DISORDERS

Surgical Treatment of Parkinson’s Disease: Patients, Targets, Devices, and Approaches

(2013) Aparna Wagle Shukla et al.   Neurotherapeutics

Subcutaneous apomorphine and non-motor symptoms in Parkinson's disease

(2013) Antoniya Todorova et al.   PARKINSONISM & RELATED DISORDERS

Swallowing and deep brain stimulation in Parkinson's disease: A systematic review

(2013) Michelle S. Troche et al.   PARKINSONISM & RELATED DISORDERS

Where are we with surgical therapies for Parkinson's disease?

(2013) Ido Strauss et al.   PARKINSONISM & RELATED DISORDERS

Malnutrition in a Sample of Community-Dwelling People with Parkinson’s Disease

(2013) Jamie M. Sheard et al.   PLoS One

Hypometabolism in the supplementary and anterior cingulate cortices is related to dysphagia in Parkinson's disease: a cross-sectional and 3-year longitudinal cohort study

(2013) Akio Kikuchi et al.   BMJ Open

Linaclotide: new mechanisms and new promise for treatment in constipation and irritable bowel syndrome

(2013) Ruchit Sood et al.   Therapeutic Advances in Chronic Disease

Parkinson’s disease is not associated with gastrointestinal myenteric ganglion neuron loss

(2012) Dana M. Annerino et al.   ACTA NEUROPATHOLOGICA

Clinical Guideline: Management of Gastroparesis

(2012) Michael Camilleri et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Intrajejunal Levodopa Versus Conventional Therapy in Parkinson Disease

(2012) Prashanth Reddy et al.   CLINICAL NEUROPHARMACOLOGY

Glycopyrrolate for Chronic Drooling in Children

(2012) Lea S. Eiland   CLINICAL THERAPEUTICS

Impact of Progression of Parkinson’s Disease on Drooling in Various Ethnic Groups

(2012) Abdul Qayyum Rana et al.   EUROPEAN NEUROLOGY

The impact of deep brain stimulation on the nonmotor symptoms of Parkinson’s disease

(2012) Keyoumars Ashkan et al.   JOURNAL OF NEURAL TRANSMISSION

Premotor Parkinson's disease: Concepts and definitions

(2012) Andrew Siderowf et al.   MOVEMENT DISORDERS

Toward a redefinition of Parkinson's disease

(2012) Matthew B. Stern et al.   MOVEMENT DISORDERS

Colonic inflammation in Parkinson's disease

(2012) David Devos et al.   NEUROBIOLOGY OF DISEASE

A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson’s disease

(2012) H. Pouclet et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Nonmotor Manifestations in Parkinson Disease

(2012) Oscar Bernal-Pacheco et al.   NEUROLOGIST

Placebo-controlled trial of lubiprostone for constipation associated with Parkinson disease

(2012) W. G. Ondo et al.   NEUROLOGY

Treatment of recurrent sigmoid volvulus in Parkinson's disease by percutaneous endoscopic colostomy

(2012) Susan Toebosch   WORLD JOURNAL OF GASTROENTEROLOGY

The critical role of the MyD88-dependent pathway in non-CNS MPTP-mediated toxicity

(2011) M. Côté et al.   BRAIN BEHAVIOR AND IMMUNITY

Gastrointestinal Features of Parkinson’s Disease

(2011) Leslie J. Cloud et al.   Current Neurology and Neuroscience Reports

Absence of Excretion of the Active Moiety of Bisacodyl and Sodium Picosulfate into Human Breast Milk: an Open-label Parallel-group, Multiple-dose Study in Healthy Lactating Women

(2011) Christian Friedrich et al.   Drug Metabolism and Pharmacokinetics

Nonmotor Symptoms in Parkinson's Disease

(2011) Mark Stacy   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Gastrointestinal Dysfunction in a Parkinson’s Disease Rat Model and the Changes of Dopaminergic, Nitric Oxidergic, and Cholinergic Neurotransmitters in Myenteric Plexus

(2011) Hong Can Zhu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A double-blind, placebo-controlled, randomized, crossover pilot study of the safety and efficacy of multiple doses of intra-oral tropicamide films for the short-term relief of sialorrhea symptoms in Parkinson's disease patients

(2011) Santiago Perez Lloret et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Do nonmotor symptoms in Parkinson's disease differ from normal aging?

(2011) Syam Krishnan et al.   MOVEMENT DISORDERS

The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson's disease

(2011) Klaus Seppi et al.   MOVEMENT DISORDERS

Neuropathology of sporadic Parkinson's disease: Evaluation and changes of concepts

(2011) Kurt A. Jellinger   MOVEMENT DISORDERS

Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease

(2011) Kathleen M. Shannon et al.   MOVEMENT DISORDERS

A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease

(2011) Hélène Pouclet et al.   NEUROBIOLOGY OF DISEASE

Pathological correlates of gastrointestinal dysfunction in Parkinson's disease

(2011) Maria G. Cersosimo et al.   NEUROBIOLOGY OF DISEASE

Parkinson disease: The enteric nervous system spills its guts

(2011) P. Derkinderen et al.   NEUROLOGY

Two Randomized Trials of Linaclotide for Chronic Constipation

(2011) Anthony J. Lembo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gastroparesis and Parkinson’s disease: A systematic review

(2011) Zaid S. Heetun et al.   PARKINSONISM & RELATED DISORDERS

Prevalence of oropharyngeal dysphagia in Parkinson’s disease: A meta-analysis

(2011) J.G. Kalf et al.   PARKINSONISM & RELATED DISORDERS

Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

(2011) Christopher B. Forsyth et al.   PLoS One

Linaclotide, a synthetic guanylate cyclase C agonist, for the treatment of functional gastrointestinal disorders associated with constipation

(2011) Maria Vazquez Roque et al.   Expert Review of Gastroenterology & Hepatology

Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

(2010) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson’s disease

(2010) Kelly Del Tredici et al.   ACTA NEUROPATHOLOGICA

Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes

(2010) Yien-Ming Kuo et al.   HUMAN MOLECULAR GENETICS

Autonomic and sensory symptoms and signs in incident, untreated Parkinson's disease: Frequent but mild

(2010) Bernd Müller et al.   MOVEMENT DISORDERS

What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them?

(2010) David A. Gallagher et al.   MOVEMENT DISORDERS

Gum chewing improves swallow frequency and latency in Parkinson patients: A preliminary study

(2010) A. R. South et al.   NEUROLOGY

Practice Parameter: Treatment of nonmotor symptoms of Parkinson disease: Report of the Quality Standards Subcommittee of the American Academy of Neurology

(2010) T. A. Zesiewicz et al.   NEUROLOGY

Glycopyrrolate for sialorrhea in Parkinson disease: A randomized, double-blind, crossover trial

(2010) M. E. L. Arbouw et al.   NEUROLOGY

The impact of and the factors associated with drooling in Parkinson's disease

(2010) Joshua Leibner et al.   PARKINSONISM & RELATED DISORDERS

Determinants of health-related quality of life in Parkinson’s disease: A systematic review

(2010) Sze-Ee Soh et al.   PARKINSONISM & RELATED DISORDERS

Colonic Biopsies to Assess the Neuropathology of Parkinson's Disease and Its Relationship with Symptoms

(2010) Thibaud Lebouvier et al.   PLoS One

Effects of Therapy in Oropharyngeal Dysphagia by Speech and Language Therapists: A Systematic Review

(2009) Renée Speyer et al.   DYSPHAGIA

The second brain and Parkinson’s disease

(2009) Thibaud Lebouvier et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease

(2009) James G. Greene et al.   EXPERIMENTAL NEUROLOGY

Oxidative damage in Parkinson disease: Measurement using accurate biomarkers

(2009) Raymond C.S. Seet et al.   FREE RADICAL BIOLOGY AND MEDICINE

Long-lasting benefits of botulinum toxin type B in Parkinson’s disease-related drooling

(2009) Giovanni Lagalla et al.   JOURNAL OF NEUROLOGY

Non-motor symptoms in Parkinson’s disease

(2009) Ariane Park et al.   JOURNAL OF NEUROLOGY

Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment

(2009) K Ray Chaudhuri et al.   LANCET NEUROLOGY

Intrajejunal levodopa infusion in Parkinson's disease: A pilot multicenter study of effects on nonmotor symptoms and quality of life

(2009) Holger Honig et al.   MOVEMENT DISORDERS

Dysautonomia rating scales in Parkinson's disease: Sialorrhea, dysphagia, and constipation-Critique and recommendations by movement disorders task force on rating scales for Parkinson's disease

(2009) Marian L. Evatt et al.   MOVEMENT DISORDERS

The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease

(2009) Paolo Barone et al.   MOVEMENT DISORDERS

Influence of 5-HT4receptor activation on acetylcholine release in human large intestine with endometriosis

(2009) r. a. lefebvre et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Routine colonic biopsies as a new tool to study the enteric nervous system in living patients

(2009) t. lebouvier et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Incidence of and risk factors for cognitive impairment in an early Parkinson disease clinical trial cohort

(2009) E. Y. Uc et al.   NEUROLOGY

Functional and neurochemical changes of the gastrointestinal tract in a rodent model of Parkinson's disease

(2009) F. Blandini et al.   NEUROSCIENCE LETTERS

Clinical trial: single- and multiple-dose pharmacokinetics of polyethylene glycol (PEG-3350) in healthy young and elderly subjects

(2008) R. W. PELHAM et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pharmacologic treatment of constipation: what is new?

(2008) D POHL et al.   CURRENT OPINION IN PHARMACOLOGY

Pathological lesions in colonic biopsies during Parkinson's disease

(2008) T Lebouvier et al.   GUT

Bladder and bowel dysfunction in Parkinson’s disease

(2008) R. Sakakibara et al.   JOURNAL OF NEURAL TRANSMISSION

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

(2008) Edward D. Plowey et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Subcutaneous Methylnaltrexone for the Treatment of Opioid-Induced Constipation in Patients with Advanced Illness: A Double-Blind, Randomized, Parallel Group, Dose-Ranging Study

(2008) Russell K. Portenoy et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Non-dopaminergic treatments in development for Parkinson's disease

(2008) Susan H Fox et al.   LANCET NEUROLOGY

Enteric neurodegeneration in ageing

(2008) m. camilleri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental Parkinsonism

(2008) t. chaumette et al.   NEUROGASTROENTEROLOGY AND MOTILITY

IN DEMENTIA WITH LEWY BODIES, BRAAK STAGE DETERMINES PHENOTYPE, NOT LEWY BODY DISTRIBUTION

(2008) K. A. Jellinger   NEUROLOGY

Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease?

(2008) R.J. Phillips et al.   NEUROSCIENCE

The 6-hydroxydopamine model: News from the past

(2008) Fabio Blandini et al.   PARKINSONISM & RELATED DISORDERS

Nonmotor symptoms of Parkinson's disease: Prevalence and awareness of patients and families

(2007) Sang-Myung Cheon et al.   PARKINSONISM & RELATED DISORDERS

Is drooling secondary to a swallowing disorder in patients with Parkinson's disease?

(2007) Ana Caline Nóbrega et al.   PARKINSONISM & RELATED DISORDERS