Article
Medicine, General & Internal
Nesreen M. Ismail, Eman A. Toraih, Mai H. S. Mohammad, Eida M. Alshammari, Manal S. Fawzy
Summary: The study found that the MIR34A gene rs2666433 variant might confer protection against SLE development, especially in female participants. However, the variant showed no association with disease activity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Genetics & Heredity
Dong-Hwa Lee, Eu-Jeong Ku, Tae-Keun Oh, Hyun-Jeong Jeon
Summary: The A allele of the RANTES gene is associated with obesity and may affect diabetic microvascular complications in patients with T2D for over 15 years.
Article
Medicine, General & Internal
Huijuan Zeng, Meng Li, Jiabin Liu, Jinhong Zhu, Jiwen Cheng, Yong Li, Jiao Zhang, Zhonghua Yang, Li Li, Haixia Zhou, Suhong Li, Huimin Xia, Yan Zou, Jing He, Tianyou Yang
Summary: The YTHDF2 gene rs3738067 A>G polymorphism is associated with decreased neuroblastoma risk, particularly in subgroups such as children, boys, and patients with tumors originating from the retroperitoneal area. The expression quantitative trait locus analysis further confirms this association.
FRONTIERS IN MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Decheng Deng, Ailing Luo, Ming Li, Yaping Yan, Mansi Cai, Shanshan Liu, Xiaodan Liu, Xueliang Wang, Xiaohong Zhang, Hua Jiang, Xiaoping Liu
Summary: This study investigated the relationship between splicing factor-coding gene single nucleotide polymorphisms and the susceptibility of pediatric acute lymphoblastic leukemia (ALL). The results showed that the SFRS1 rs2233911 AG/GG genotype was significantly associated with increased pediatric ALL risk, and had harmful effects in specific subgroups. In addition, rs2233911 AG/GG had a protective effect on MRD in the marrow of Chinese children after 12 weeks of chemotherapy, but had harmful effects at days 15-19 of the South China Children Leukemia Group chemotherapy. In conclusion, SFRS1 gene polymorphism is associated with increased pediatric ALL risk and may serve as a potential biomarker for selecting chemotherapy.
JOURNAL OF GENE MEDICINE
(2023)
Article
Genetics & Heredity
Jian-Yong Wang, Lei Cui, Hong-Yi Shi, Ling-Hao Chen, Ren-Wei Jin, Xiao-Xia Jiang, Zhu-Ling Chen, Jian-Hong Zhu, Xiong Zhang
Summary: This study found that the single nucleotide polymorphisms (SNPs) of the DNMT1 gene are associated with the risk of Parkinson's disease (PD). Among them, rs9305012 is significantly associated with PD risk, and rs9305012/C is a protective allele. The haplotypes of the 4 tag-SNPs show significant differences between PD patients and controls. The ACC module composed of the 3 alleles is the highest-risk haplotype associated with PD.
FRONTIERS IN GENETICS
(2023)
Article
Medical Laboratory Technology
Shaghayegh Saljooghi, Zahra Heidari, Mohsen Saravani, Mahnaz Rezaei, Saeedeh Salimi
Summary: This study found an association between AXIN1 rs12921862 C/A and rs1805105 G/A polymorphisms and PTC susceptibility, with the rs1805105 G/A polymorphism being associated with larger tumor size.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Review
Medicine, General & Internal
Shushu Sun, Xiaotian Li, Bingkun Qu, Kunming Xie, Jinlei Li, Junjie Miao
Summary: A meta-analysis revealed a potential association between the vascular endothelial growth factor receptor 2 rs2305948 gene polymorphism and glioma susceptibility in the Asian population, while the association in non-Asian populations remains unclear.
Article
Genetics & Heredity
Prashant S. Giri, Rasheedunnisa Begum, Mitesh Dwivedi
Summary: The TNFA gene-308 G A polymorphism is associated with vitiligo susceptibility, with varied results among different populations. The study also indicates significant associations between gene genotypes and alleles in active vitiligo patients and those with localized vitiligo in different regions.
Article
Immunology
Minhan Yi, Jiaxin Li, Shijie Jian, Binbin Li, Zini Huang, Li Shu, Yuan Zhang
Summary: The study analyzed the quantitative and causal relationship between inflammatory genes and the risk of Parkinson's disease (PD). It found that polymorphisms in IL-6, TNF-alpha, PON1, CYP2D6, HLA-DRB, BST1, CCDC62 genes were statistically associated with the susceptibility of PD. Additionally, there was evidence of causal relationships between ADP-ribosyl cyclase and PON1 genes with PD risk. These findings contribute to a better understanding of the mechanisms and pathways underlying PD pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Shilin Xue, Wenya Shen, Jianning Cai, Jinhai Jia, Dan Zhao, Shan Zhang, Xiujun Zhao, Ning Ma, Wenjuan Wang, Bingshuang Wang, Xiaolin Zhang, Xuehui Liu
Summary: This meta-analysis aimed to examine the association between rs735482 polymorphism and cancer risk. The results showed that there is no significant association between rs735482 polymorphism and susceptibility to various cancers overall. However, stratified analysis by ethnicity indicated that rs735482 is associated with an increased risk of cancer in the Chinese population and a decreased risk in the Italian population.
Review
Behavioral Sciences
Xi-Yi Hu, Yu-Long Wu, Chao-Hui Cheng, Xiao-Xi Liu, Lan Zhou
Summary: The meta-analysis suggests that the BDNF rs6265 G > A polymorphism is associated with PTSD susceptibility, with an increased risk of A allele mutations. Subgroup analysis showed similar situations in Asian populations and other groups.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Wen-Yi Yang, Si-Si Jiang, Jia-Li Pu, Chong-Yao Jin, Ting Gao, Ran Zheng, Jun Tian, Bao-Rong Zhang
Summary: This study found that single nucleotide polymorphisms rs11655081 (ARSG) and rs61973742 (NALCN) may be associated with Parkinson's disease (PD). The C allele of rs11655081 may increase the risk of PD, whereas the G allele of rs61973742 may be a protective factor.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Vasileios Siokas, Athina-Maria Aloizou, Zisis Tsouris, Ioannis Liampas, Panagiotis Liakos, Daniela Calina, Anca Oana Docea, Aristidis Tsatsakis, Dimitrios P. Bogdanos, Georgios M. Hadjigeorgiou, Efthimios Dardiotis
Summary: The study did not find a significant association between ADORA2A rs5760423 and CYP1A2 rs762551 and PD, suggesting that these polymorphisms may not be major risk factors for Parkinson's disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Zhenlian Zhang, Dilihumaier Duolikun, Tingting Dang, Yuanyuan Wang, Lijuan Ma, Xueyun Ma, Qiaoling Yao
Summary: This meta-analysis suggests that the TNF-α-308A allele may be a risk factor for the development of obstructive sleep apnea (OSA). However, large scale, multi-center, and well-designed case-control studies are needed in the future to validate these findings.
Article
Medicine, General & Internal
Huan Ren, Zhen Guo, Wen-jie Qin, Zhi-ling Yang
Summary: This study investigated the association between IL-6 gene polymorphisms and the risk of essential hypertension in a Chinese population. The results revealed that the rs1800795,-174C > G polymorphism was significantly associated with a reduced risk of essential hypertension development, while the rs1800796,-572G > C polymorphism did not show a substantial association with the risk of essential hypertension. Moreover, eQTL analysis demonstrated that the-174C > G polymorphism affected the gene expression levels of IL-6.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Ophthalmology
Seden Demirci, Alime Gunes, Serpil Demirci, Suleyman Kutluhan, Levent Tok, Ozlem Tok
CUTANEOUS AND OCULAR TOXICOLOGY
(2016)
Article
Clinical Neurology
Seden Demirci, Akif Arslan, Vedat Ali Yurekli, Suleyman Kutluhan, Hasan Rifat Koyuncuoglu, Serpil Demirci
ACTA NEUROLOGICA BELGICA
(2017)
Article
Medicine, General & Internal
N. Komerik, E. Yuce, N. S. Calapoglu, P. A. Kosar, M. Cakir, G. Koparan
NIGERIAN JOURNAL OF CLINICAL PRACTICE
(2017)
Article
Neurosciences
Seden Demirci, Ayse Aynali, Kadir Demirci, Serpil Demirci, Buket Cicioglu Aridogan
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2017)
Article
Respiratory System
Muhammet Yusuf Tepebasi, Nilufer Sahin Calapoglu, Onder Ozturk, Okan Sancer, Taner Gonca
CLINICAL RESPIRATORY JOURNAL
(2018)
Article
Biochemistry & Molecular Biology
Meltem Ozgocmen, Dilek Bayram, Gulcin Yavuz Turel, Vehbi Atahan Togay, Nilufer Sahin Calapoglu
Summary: Research has shown that SDG can inhibit proliferation and induce apoptosis in colorectal cancer cells SW480, affecting both 2D and 3D cultures, with a significant increase in apoptotic cell percentages in the SDG treatment group.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Gulcin Yavuz Turel, Nilufer Sahin Calapoglu, Dilek Bayram, Meltem Ozgocmen, Vehbi Atahan Togay, Eda Evgen Tuluceoglu
Summary: The study demonstrated that curcumin has inhibitory effects on cell proliferation and induces apoptosis in colon carcinoma cells. It suggests that curcumin could be a potential protective or treatment agent against colon cancer, but further research on curcumin-rich diets and bioavailability is needed.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Clinical Neurology
Onder Ozturk, Defne Cebeci, Ugur Sahin, Eda Evgen Tuluceoglu, Nilufer Sahin Calapoglu, Taner Gonca, Mustafa Calapoglu
Summary: The study aimed to evaluate the association of serum levels of orexigenic neuropeptides ghrelin, galanin, and orexin-A with OSAS, finding them to be independent determinants of the presence of OSAS and correlated with the severity of the condition, particularly with moderate OSAS.
SLEEP AND BREATHING
(2022)
Article
Clinical Neurology
Cagla Varol, Fatma Yesim Kirzioglu, Serpil Demirci, Melike Dogan Unlu, Mustafa Calapoglu, Hikmet Orhan
Summary: This study compared the oxidative status in saliva between patients with multiple sclerosis (MS) and systemically healthy controls, and assessed whether salivary oxidative status is correlated with the neutrophil/lymphocyte ratio (NLR). The results showed that MS patients had higher NLRs, lower myeloperoxidase (MPO) levels, higher lactoferrin (LF), total oxidant status (TOS), and oxidative stress index (OSI) levels, as well as decreased total antioxidant capacity (TAOC) levels in saliva. This suggests a prominent ongoing systemic inflammation in MS patients despite altered immune surveillance.
TURKISH JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Melike D. Unlu, Halil Asci, M. Yusuf Tepebasi, Melih Arlioglu, Ibrahim Huseynov, Ozlem Ozmen, Serdar Sezer, Serpil Demirci
Summary: This study aimed to examine the protective effects of Cannabidiol (CBD) treatment in various brain structures from Methotrexate (MTX) damage and evaluate the effect of intracellular pathways involved in apoptosis. The results showed that CBD reversed the pathological changes caused by MTX in the brain and had anti-inflammatory and anti-apoptotic activity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Meeting Abstract
Clinical Neurology
A. H. M. Kurnaz, M. D. Unlu, S. Demirci
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2019)
Meeting Abstract
Clinical Neurology
S. Demirci, C. Yilmaz
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2019)
Meeting Abstract
Clinical Neurology
S. Demirci, M. D. Unlu
MULTIPLE SCLEROSIS JOURNAL
(2018)
Meeting Abstract
Clinical Neurology
S. Demirci, M. D. Unlu
MULTIPLE SCLEROSIS JOURNAL
(2017)
Article
Clinical Neurology
Seden Demirci, Kadir Demirci, Serpil Demirci
NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
(2017)