Article
Clinical Neurology
Paul C. C. Donaghy, Calum Hamilton, Rory Durcan, Sarah Lawley, Sally Barker, Joanna Ciafone, Nicola Barnett, Kirsty Olsen, Michael Firbank, Gemma Roberts, Jim Lloyd, Louise M. M. Allan, Ranjan Saha, Ian G. G. McKeith, John T. T. O'Brien, John-Paul Taylor, Alan J. J. Thomas
Summary: Through the investigation of patients with mild cognitive impairment with Lewy bodies (MCI-LB), it was found that MCI-LB patients have more symptoms, and a 10-point symptom scale can effectively differentiate MCI-LB and MCI-AD. These findings are important for clinicians to diagnose and treat MCI.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Psychology, Clinical
Paul C. Donaghy, Joanna Ciafone, Rory Durcan, Calum A. Hamilton, Sally Barker, Jim Lloyd, Michael Firbank, Louise M. Allan, John T. O'Brien, John-Paul Taylor, Alan J. Thomas
Summary: MCI-LB is characterized by more neuropsychiatric symptoms compared to MCI-AD. The presence of two or more neuropsychiatric supportive symptoms as defined by MCI-LB diagnostic criteria is highly specific and moderately sensitive for a diagnosis of MCI-LB. The cognitive profile of MCI-LB differs from MCI-AD.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Clinical Neurology
Paul C. Donaghy, Claudia Carrarini, Daniel Ferreira, Annegret Habich, Dag Aarsland, Claudio Babiloni, Ece Bayram, Joseph P. M. Kane, Simon J. G. Lewis, Andrea Pilotto, Alan J. Thomas, Laura Bonanni
Summary: This study conducted a systematic review and meta-analysis of the diagnostic clinical features and biomarkers in MCI-LB, supporting the inclusion of current clinical features in the diagnostic criteria and finding promise in FDG-PET and quantitative EEG as diagnostic biomarkers.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychology, Clinical
Alan J. Thomas, Calum A. Hamilton, Sally Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Michael Firbank, Gemma Roberts, Louise M. Allan, John O'Brien, John-Paul Taylor, Paul C. Donaghy
Summary: Impaired olfaction may serve as a potential biomarker for early Lewy body disease, particularly in cases of mild cognitive impairment with Lewy bodies (MCI-LB). Olfactory function was significantly worse in individuals with probable MCI-LB compared to those with MCI-AD and healthy controls. A lower cutoff score of ≤ 7 on the SS-16 is recommended for identifying early LB disease in memory services.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Clinical Neurology
Alan J. Thomas, Calum A. Hamilton, Amanda Heslegrave, Sally Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Debbie Lett, Michael Firbank, Gemma Roberts, John-Paul Taylor, Paul C. Donaghy, Henrik Zetterberg, John O'Brien
Summary: The study found that plasma pTau181 can serve as a blood-based biomarker for AD co-pathology and is associated with cognitive decline in patients with dementia with Lewy bodies and MCI with AD. pTau181 partially discriminated probable MCI-LB from controls and MCI-AD from controls, but was not useful in distinguishing probable MCI-LB from MCI-AD.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Alice Tisserand, Benjamin Cretin, Mary Mondino, Anne Botzung, Lea Sanna, Catherine Demuynck, Pierre Anthony, Candice Muller, Olivier Bousiges, Nathalie Philippi, Frederic Blanc
Summary: This study aimed to investigate the association between photophobia and dementia with Lewy bodies (DLB). The study found that photophobia was more frequent in DLB patients and was associated with decreased gray matter in the right precentral cortex and the eyelid motor region. This finding is important for understanding the pathological mechanism of DLB.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Calum A. Hamilton, Fiona E. Matthews, Paul C. Donaghy, John-Paul Taylor, John T. O'Brien, Nicola Barnett, Kirsty Olsen, Jim Lloyd, George Petrides, Ian G. McKeith, Alan J. Thomas
Summary: The study found differences in cognitive profiles and progression between probable MCI-LB and MCI-AD, with MCI-LB patients showing less impaired recognition memory, greater initial impairments in verbal fluency and perception of line orientation, and an expedited decline in visuo-constructional functions. However, no clear diagnostic group differences were found in deterioration speeds for global cognition, language, overall memory, attention or other executive functions.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Calum A. Hamilton, James Frith, Paul C. Donaghy, Sally A. H. Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Michael Firbank, Gemma Roberts, John-Paul Taylor, Louise M. Allan, John O'Brien, Alison J. Yarnall, Alan J. Thomas
Summary: This study aimed to compare the autonomic symptoms between the cognitive prodrome of Lewy body dementia (MCI-LB) and healthy older adults, as well as mild cognitive impairment due to Alzheimer's disease (MCI-AD). The study found that MCI-LB had more severe autonomic symptoms compared to normal aging and MCI-AD, but the autonomic symptoms were not specific to MCI-LB. The COMPASS-31 scale may have value as a sensitive screening test for early-stage Lewy body disease.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Calum A. Hamilton, Fiona E. Matthews, Louise M. Allan, Sally Barker, Joanna Ciafone, Paul C. Donaghy, Rory Durcan, Michael J. Firbank, Sarah Lawley, John T. O'Brien, Gemma Roberts, John-Paul Taylor, Alan J. Thomas
Summary: In the early stage of mild cognitive impairment (MCI), individuals with Lewy bodies (MCI-LB) show more frequent pareidolic responses compared to MCI due to Alzheimer's disease (MCI-AD). However, the sensitivity of the pareidolia test in classifying MCI-LB and visual hallucinations is poor, with lower rates of manifestation at this earlier stage. Despite this, the test's high specificity and ease of use may be beneficial in specialist clinics without imaging biomarkers.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Clinical Neurology
James E. Galvin, Stephanie Chrisphonte, Iris Cohen, Keri K. Greenfield, Michael J. Kleiman, Claudia Moore, Mary Lou Riccio, Amie Rosenfeld, Niurka Shkolnik, Marcia Walker, Lun-Ching Chang, Magdalena I. Tolea
Summary: The study tested the performance of the LBD-MOD module in characterizing Lewy body dementia (DLB) and distinguishing it from Alzheimer's disease (AD). Results showed differences between DLB and AD in various symptoms, as well as differences between MCI-DLB and MCI-AD. The LBD-MOD module provided excellent characterization of core features and supportive features to differentiate DLB from AD and also characterize features of MCI-DLB.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neuroimaging
Julia Schumacher, John-Paul Taylor, Calum A. Hamilton, Michael Firbank, Ruth A. Cromarty, Paul C. Donaghy, Gemma Roberts, Louise Allan, Jim Lloyd, Rory Durcan, Nicola Barnett, John T. O'Brien, Alan J. Thomas
Summary: The study found that cholinergic degeneration in the MCI-LB stage is related to cognitive impairment severity. Early EEG slowing in MCI-LB might be partly cholinergically driven. These findings suggest an early cholinergic deficit in MCI-LB.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Manon Querry, Frederic Blanc, Olivier Bousiges, Nathalie Philippi, Benjamin Cretin, Catherine Demuynck, Candice Muller, Anne Botzung
Summary: The aim of this study was to describe the characteristics and evolution of the long-term memory profile of patients with prodromal and mild DLB and AD. The study found that DLB patients performed better than AD patients in terms of total recall, delayed total recall, recognition, and loss of information over time. The memory performance of DLB patients remained stable over 48 months, unlike that of AD patients. Four indicators were relevant to distinguish between DLB and AD patients in terms of memory performance.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Psychology, Clinical
Calum A. Hamilton, Fiona E. Matthews, Paul C. Donaghy, John-Paul Taylor, John T. O'Brien, Nicola Barnett, Kirsty Olsen, Ian G. McKeith, Alan J. Thomas
Summary: The study identified three distinct cognitive trajectories in individuals with MCI: slow/stable progression, intermediate progressive decline, and a small group with rapid decline. The presence of LB symptoms, particularly visual hallucinations, predicted decline in cognitive function. Identifying individuals with rapid decline is important for early intervention, although further research with larger cohorts is needed.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Clinical Neurology
Kurt A. Jellinger
Summary: PDD and DLB are two major neurocognitive disorders in the spectrum of Lewy body diseases with overlapping clinical and neuropathological features. DLB has higher Braak LB scores and neuritic Braak stages, as well as more severe neuropathological features like Thal A beta phases and neuritic Braak stages. Worse prognosis in DLB is linked to increased Braak neuritic stages and more severe cerebral amyloid angiopathy.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Clinical Neurology
Melissa J. Armstrong
Summary: Dementia with Lewy bodies (DLB) is a specific presentation of a pathological alpha-synucleinopathy, with recent advances including updated diagnostic criteria and recognition of prodromal states. Research shows common co-occurrence of Alzheimer's disease pathology in individuals with DLB, impacting biomarker use and progression. Identifying biomarkers and effective therapies remain key areas of focus for future research in DLB.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Article
Gerontology
Rachel Collins, Anna Hunt, Catherine Quinn, Anthony Martyr, Claire Pentecost, Linda Clare
Summary: This study aims to identify methods, tools, and approaches to facilitate meaningful communication with people with moderate-to-severe dementia and include their perspectives. The findings suggest that a person-centred approach and the use of meaningful pictures, photographs, or objects can help facilitate conversations with dementia patients.
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2022)
Article
Geriatrics & Gerontology
Anthony Martyr, Laura D. Gamble, Sharon M. Nelis, Rachel Collins, Catherine M. Alexander, Robin G. Morris, Catherine Quinn, Claire Pentecost, Jennifer M. Rusted, Christina Victor, Jeanette M. Thom, Fiona E. Matthews, Linda Clare
Summary: The study investigates the awareness of functional ability in people with dementia through the examination of ADL discrepancy scores. Factors such as depression, neuroticism, neuropsychiatric symptoms, comorbidity, caregiver stress, and amount of daily care received were found to be associated with smaller discrepancy scores.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2022)
Article
Geriatrics & Gerontology
Catherine M. Alexander, Anthony Martyr, Linda Clare
Summary: This study found that awareness of difficulties in people with mild-to-moderate dementia can change and may increase over time. The study also revealed that there may be individual reasons for ongoing low awareness, not explained by cognitive or functional ability. These findings challenge the notion that low awareness in dementia is a fixed symptom and highlight the complex and individual nature of awareness.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Catherine Quinn, Laura D. Gamble, Sophie Parker, Anthony Martyr, Rachel Collins, Christina Victor, Eleanor Dawson, Anna Hunt, Claire Pentecost, Louise Allan, Linda Clare
Summary: This study explores the impact of the COVID-19 pandemic on carers for community-dwelling people with dementia. The findings indicate that the pandemic has negatively affected carers' healthcare needs, increased their feelings of loneliness, and decreased life satisfaction. However, the caregiving experience remained relatively unaffected, and most carers coped well during the pandemic. There were no significant differences in the experiences of spousal/partner carers and the full sample.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Neurosciences
Laura D. Gamble, Sophie Parker, Catherine Quinn, Holly Q. Bennett, Anthony Martyr, Serena Sabatini, Claire Pentecost, Rachel Collins, Eleanor Dawson, Anna Hunt, Louise Allan, Alistair Burns, Rachael Litherland, Christina Victor, Fiona E. Matthews, Linda Clare
Summary: The study found that despite initial reports of negative impacts on carers during the pandemic, it actually had little negative longer-term effects on carers of people with dementia. In fact, several months into the pandemic, they appeared to have a more positive attitude towards coping.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Aaron Choi, Anthony Martyr, Linda Clare, Jane Fossey, Zunera Khan, Joanne McDermid, Clive Ballard
Summary: Delusions and hallucinations in people with dementia living in nursing homes are associated with poorer quality of life. The effects remain significant even after controlling for other factors. Agitation, anxiety, and depression partially mediate the relationship between each psychotic symptom and quality of life.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Geriatrics & Gerontology
Laura D. Gamble, Fiona E. Matthews, Ian R. Jones, Alex E. Hillman, Bob Woods, Catherine A. Macleod, Anthony Martyr, Rachel Collins, Claire Pentecost, Jennifer M. Rusted, Linda Clare
Summary: The study found that people with dementia who have better cognition, more years of education, or live in more deprived areas are less likely to be diagnosed. Additionally, depression and sleep problems were associated with being undiagnosed.
Article
Geriatrics & Gerontology
Serena Sabatini, Anthony Martyr, Laura D. Gamble, Ian R. Jones, Rachel Collins, Fiona E. Matthews, Christina R. Victor, Catherine Quinn, Claire Pentecost, Jeanette M. Thom, Linda Clare
Summary: This study explored the social, cultural, and economic capital of spousal carers of people with dementia, and the profiles of carers with different levels of capital. The results showed that carers with lower capital experienced less stress and reported more positive experiences in caring over time. However, compared to carers with better capital, those with poorer capital were more likely to be depressed over time.
AGING & MENTAL HEALTH
(2023)
Article
Gerontology
Serena Sabatini, Anthony Martyr, Laura D. Gamble, Rachel Collins, Fiona E. Matthews, Robin G. Morris, Jennifer M. Rusted, Claire Pentecost, Catherine Quinn, Linda Clare
Summary: This study examines the involvement of people with dementia in everyday decision-making and the factors that explain the variability in their involvement. The results show that female, single, and younger people with dementia tend to have greater involvement in everyday decision-making. Factors such as better cognition, fewer functional difficulties, fewer neuropsychiatric symptoms, less caregiver stress, and better relationship quality are associated with higher involvement in everyday decision-making.
JOURNAL OF APPLIED GERONTOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Serena Sabatini, Anthony Martyr, Laura D. Gamble, Ian R. Jones, Rachel Collins, Fiona E. Matthews, Martin Knapp, Jeanette M. Thom, Catherine Henderson, Christina Victor, Claire Pentecost, Linda Clare, IDEAL Programme Team
Summary: This study describes the levels of social, cultural, and economic capital among people with dementia and examines the differences in personal characteristics and quality of life over time based on different combinations of capital. The results show that people with dementia have relatively lower levels of social, cultural, and economic capital, although they are not significantly lower compared to older adults in the UK. The study identifies four groups of people with dementia based on their capital levels and finds that higher levels of capital are associated with higher quality of life and well-being. Therefore, efforts from the government and society are needed to address the social, cultural, and economic disadvantages among people with dementia.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Geriatrics & Gerontology
Anna Hunt, Anthony Martyr, Laura D. Gamble, Robin G. Morris, Jeanette M. Thom, Claire Pentecost, Linda Clare
Summary: This study aimed to explore whether each of the Five-Factor personality traits were associated with change over two years in perceptions of 'living well' for people with dementia and their caregivers. The results showed that neuroticism was negatively associated with 'living well' scores for people with dementia, while conscientiousness, extraversion, openness, and agreeableness were positively associated. For caregivers, neuroticism was negatively associated with 'living well' scores, while conscientiousness and extraversion were positively associated. Personality traits had no significant impact on changes in 'living well' scores over time.
Article
Clinical Neurology
Anthony Martyr, Madhumathi Ravi, Laura D. Gamble, Robin G. Morris, Jennifer M. Rusted, Claire Pentecost, Fiona E. Matthews, Linda Clare, DEAL study team
Summary: This study compared the trajectories of cognition and instrumental activities of daily living (iADL) in people with dementia. The results showed that cognition and self-rated iADL declined at a similar rate, while informant-rated iADL declined at a significantly higher rate than cognition. This suggests that either cognition and self-rated iADL decline at different rates or informants overestimate iADL difficulties compared to both cognition and self-ratings.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychology
Anthony Martyr, Sharon M. Nelis, Robin G. Morris, Ivana S. Markova, Ilona Roth, Robert T. Woods, Linda Clare
Summary: The aim of the study was to investigate responses to dementia-relevant words in healthy older people and changes in response over 20 months in people with early-stage dementia. The study used an emotional Stroop task to measure implicit awareness of dementia. Results showed longer response times to dementia-relevant words compared to neutral words for healthy older people and people with dementia, but this effect declined over time for people with dementia. Implicit awareness of dementia is present in early-stage dementia, even when explicit awareness is reduced.
JOURNAL OF NEUROPSYCHOLOGY
(2023)
Article
Gerontology
Linda Clare, Claire Pentecost, Rachel Collins, Anthony Martyr, Rachael Litherland, Robin G. Morris, Catherine Quinn, Laura D. Gamble, Serena Sabatini, Christina Victor
Summary: This study aimed to co-produce and validate an accessible questionnaire to measure 'living well' with dementia for people with mild-to-moderate dementia. Through a series of workshops and testing with IDEAL cohort participants, a 10-item version of the questionnaire was developed and found to have good reliability and validity.
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2023)
Review
Geriatrics & Gerontology
Rachel Collins, Anthony Martyr, Anna Hunt, Catherine Quinn, Claire Pentecost, Julian C. Hughes, Linda Clare
Summary: This systematic review explores methods and approaches for including the perspectives and preferences of people with moderate-to-severe dementia in research. The review identified five specific communication tools and five general approaches to optimize communication. The findings provide guidance for researchers and practitioners on how to facilitate communication with people with moderate-to-severe dementia.
INTERNATIONAL JOURNAL OF OLDER PEOPLE NURSING
(2023)