Article
Immunology
Aleksei Parshenkov, Thierry Hennet
Summary: Altered surface glycosylation is a major characteristic of tumor cells and can be recognized by lectins, which can distinguish tumor cells from healthy cells based on the expression of glycosylation-dependent markers. Lectins induce cell death through various pathways, and their broad cytotoxic response makes them potential candidates for therapies targeting tumor cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Dongming Guo, Xinlei Huang, Tianqing Xiong, Xingyi Wang, Jingwen Zhang, Yingge Wang, Jingyan Liang
Summary: Methamphetamine, commonly known as METH, is a highly addictive drug that can lead to addiction and various health issues. This review discusses the molecular mechanisms of neuronal damage caused by METH and identifies potential therapeutic targets.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Xue Yu, Yan Yang, Tianzuo Chen, Yuqin Wang, Tianwei Guo, Yujun Liu, Hong Li, Liming Yang
Summary: Homeostatic regulation of cardiomyocytes is crucial for normal cardiac function. New cancer therapies have improved patient survival but can cause serious cardiac adverse effects. Mitochondrial targeting is a major mechanism of chemotherapy-induced cardiotoxicity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yawen Xie, Xianli Lei, Guoyu Zhao, Ran Guo, Na Cui
Summary: Mechanistic target of rapamycin (mTOR), a highly conserved serine/threonine kinase, plays crucial roles in cellular metabolism, protein synthesis, and cell death, including programmed cell death (PCD). mTOR can regulate PCD through autophagy-dependent and autophagy-independent pathways, affecting reactive oxygen species production, protein degradation, and gene expression. However, the underlying mechanisms of mTOR-mediated regulation of PCD, such as ferroptosis, are still not fully understood.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Review
Cell Biology
Fajuan Tang, Lin Chen, Hu Gao, Dongqiong Xiao, Xihong Li
Summary: This review summarizes the functions of m(6)A in programmed cell death, including its role in RNA translation, decay, and stability, as well as its importance in promoting the maturation of miRNA, translation and degradation of circRNA, and stability of lncRNA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Li Liu, Hui Li, Dingyu Hu, Yanyan Wang, Wenjun Shao, Jing Zhong, Shudong Yang, Jing Liu, Ji Zhang
Summary: This review explores the complex relationship between m6A methylation and different types of programmed cell death pathways, which are closely associated with the initiation, progression, and resistance of cancer. Clarifying the relationship between m6A and cell death is of great significance for the development of novel strategies for cancer treatment.
Review
Cell Biology
Juntao Cui, Suhan Zhao, Yinghui Li, Danyang Zhang, Bingjing Wang, Junxia Xie, Jun Wang
Summary: Regulated cell death (RCD) is a crucial process in maintaining tissue homeostasis and restoring biological balance, involving various forms of cell death with complex interactions. Understanding of the role of RCD in evolution, development, physiology, and disease is improving, with a focus on key mechanisms of RCD and its critical role in neurodegenerative diseases.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Immunology
Ruoyu Gao, Haiying Tang, Jingwei Mao
Summary: Programmed cell death (PCD) is a crucial process in the pathogenesis of liver fibrosis, involving various forms of cell death. PCD eliminates aberrant cells, particularly activated hepatic stellate cells (HSCs), which contribute to the production of extracellular matrix (ECM). Understanding the mechanisms and effects of PCD in liver fibrosis is important for developing therapeutic strategies.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Immunology
Erandi Perez-Figueroa, Pablo Alvarez-Carrasco, Enrique Ortega, Carmen Maldonado-Bernal
Summary: Neutrophils play a crucial role in innate immune response by executing various effector functions. When activated, they undergo cell death processes to ensure the proper elimination of pathogens and damaged cells, contributing to timely resolution of inflammation. Neutrophils' cell death mechanisms include apoptosis, pyroptosis, necrosis, and others, ultimately maintaining homeostasis in the organism.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Cheng-long Zhu, Yi Wang, Qiang Liu, Hui-ru Li, Chang-meng Yu, Peng Li, Xiao-ming Deng, Jia-feng Wang
Summary: Sepsis is a common disease with high mortality rates and long-term morbidity. Neutrophil cell death, including various types like necrosis, apoptosis, necroptosis, pyroptosis, NETosis, and autophagy, plays a crucial role in the development and progression of sepsis. However, the exact role and mechanisms of neutrophil cell death in sepsis still need further investigation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Yuan Xiao, Yang Cheng, Wen-Jie Liu, Kun Liu, Yan Wang, Feng Xu, De-Ming Wang, Yi Yang
Summary: Neutrophils play a crucial role in the innate immune response by rapidly and efficiently identifying and clearing infectious agents. They are the first immune cells to reach the site of tissue injury or pathogen invasion and participate in the inflammatory response.
INFLAMMATION RESEARCH
(2023)
Article
Oncology
Hector Katifelis, Maria-Paraskevi Nikou, Iuliia Mukha, Nadiia Vityuk, Nefeli Lagopati, Christina Piperi, Ammad Ahmad Farooqi, Natassa Pippa, Efstathios P. Efstathopoulos, Maria Gazouli
Summary: Nanoparticles composed of a gold and silver alloy can induce multiple cell death pathways, including necroptosis and pyroptosis, which have promising anticancer effects. These nanoparticles also trigger the release of danger signals, which may play a beneficial role in cancer.
Review
Clinical Neurology
Haogang Sun, Xinxin Li, Qi Guo, Songyan Liu
Summary: Prolonged and repeated epileptic seizures can lead to various changes in the brain, ultimately resulting in neuronal death. Oxidative stress plays a critical role in neuronal death induced by epileptic seizures. The research aims to elucidate the molecular mechanism of neuronal death and explore the moderating effect of oxidative stress on neuronal death.
NEUROLOGICAL SCIENCES
(2022)
Review
Immunology
Jing Liu, Minjing Hong, Yijia Li, Dan Chen, Yangzhe Wu, Yi Hu
Summary: Cell death plays a crucial role in modulating the tumor microenvironment and determining the outcomes of cancer therapy. It can have dual roles in promoting or inhibiting tumor growth and also regulates the accumulation of immune cells, contributing to fine-tuning tumor immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jianan Zhao, Ping Jiang, Shicheng Guo, Steven J. Schrodi, Dongyi He
Summary: Rheumatoid arthritis is a chronic inflammatory joint disease characterized by chronic synovial inflammation and degeneration of bones and joints. Despite the variety of treatment options available, some patients still have a poor prognosis due to the complex mechanism of the disease. Programmed cell death has been identified as one of the essential pathological mechanisms of RA, contributing to its development through dysregulation in various cell types.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Liangjiao Chen, Pengyan Qiao, Hongchen Liu, Longquan Shao
Summary: The study found that ACP NPs are safe for macrophages, but at high concentrations, they promote autophagy and induce ROS production. ACP NPs change the morphology of macrophages and induce polarization into M1 type, thus promoting the expression of inflammatory cytokines. ACP NPs/macrophage-modulated environments weaken the osteogenic ability of BMSCs.
Review
Toxicology
Xiaoli Feng, Yaqing Zhang, Chao Zhang, Xuan Lai, Yanli Zhang, Junrong Wu, Chen Hu, Longquan Shao
PARTICLE AND FIBRE TOXICOLOGY
(2020)
Review
Chemistry, Multidisciplinary
Yanli Zhang, Yulin Zhang, Junrong Wu, Jia Liu, Yiyuan Kang, Chen Hu, Xiaoli Feng, Wenjing Liu, Haiyun Luo, Aijie Chen, Lili Chen, Longquan Shao
Summary: The potential of carbon nanomaterials in the biomedical field is significant, however, their interaction with vascular endothelium can affect biomedical efficiency. This study focused on the impact of CBNs on physiological endothelial barriers, discussed factors influencing CBN-endothelium interaction, and highlighted the importance of balancing therapeutic efficacy and biocompatibility.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell & Tissue Engineering
Haiyun Luo, Wenjing Liu, Yanli Zhang, Yeqing Yang, Xiao Jiang, Shiqing Wu, Longquan Shao
Summary: This study explored the biological effect of m(6)A methylation in DPSCs, revealing m(6)A methylated hallmarks and a regulatory role of METTL3 in cell cycle control. METTL3 depletion associated with cell cycle, mitosis, and alteration of METTL3 resulted in cell cycle arrest, with Polo-like kinase 1 (PLK1) identified as the target of METTL3-mediated m(6)A methylation in DPSCs.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Yajie Yang, Yaokun Zhang, Yiyuan Kang, Chen Hu, Yanli Zhang, Huimin Liang, Jie You, Longquan Shao
Summary: The study found that the biological safety of tantalum particles was within clinically acceptable levels, with no significant impact on cell apoptosis and inflammatory cytokine release. Additionally, the phosphorylation levels of NF-kappa B and ERK were lower in cells exposed to tantalum compared to the control groups.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Engineering, Environmental
Xuan Lai, Menglei Wang, Yixia Zhu, Xiaoli Feng, Huimin Liang, Junrong Wu, Li Nie, Li Li, Longquan Shao
Summary: This study found that zinc oxide nanoparticles can enter psoriasis-like skin lesions and promote inflammation and keratinocyte apoptosis through nuclear translocation of p-NFicB p65 and cysteine deficiency. The research serves as a reminder to the public that ZnO NPs have harmful effects on the recovery of inflammatory skin diseases.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Biotechnology & Applied Microbiology
Ting Sun, Yiyuan Kang, Jia Liu, Yanli Zhang, Lingling Ou, Xiangning Liu, Renfa Lai, Longquan Shao
Summary: This review provides an overview of the toxicokinetics of nanomaterials (NMs) and their potential risks to the liver, including inducing liver diseases and enhancing toxic effects. The article highlights the various liver diseases that NMs may cause, while summarizing the potential risks of NMs in susceptible liver individuals.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yiyuan Kang, Jia Liu, Yanping Jiang, Suhan Yin, Zhendong Huang, Yanli Zhang, Junrong Wu, Lili Chen, Longquan Shao
Summary: The interactions between inorganic-based nanomaterials (NMs) and biological membranes are crucial for developing NM-based therapeutics and addressing nanotoxicology issues. Biological membranes act as platforms mediating NM-immune system contacts, and the challenges and potential applications in these areas are discussed in the overview. Understanding these concepts will enhance the design of therapeutic NM for drug delivery systems by leveraging NMs-membrane interactions and functions.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Nanoscience & Nanotechnology
Yunhui Liao, Ruolan Wang, Shaozhen Wang, Yifan Xie, Huanhao Chen, Runjia Huang, Longquan Shao, Qiuhua Zhu, Yanshan Liu
Summary: The new AIE-active Schiff base TBTDC NPs exhibit good biocompatibility, impressive two-photon bioimaging capability, high O-1(2) generation quantum yield, specific targeting, and photostability in PDT. They also show remarkable cytotoxicity for tumor cells and potential for suppressing tumor growth in nude mice.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Medicine, Research & Experimental
Haiyun Luo, Wenjing Liu, Yachuan Zhou, Yanli Zhang, Junrong Wu, Ruolan Wang, Longquan Shao
Summary: This study reveals the important role of m(6)A in dental pulp stem cell differentiation and the key role of METTL3 in this process. The results demonstrate that dynamic m(6)A signaling plays a crucial role in the temporal control of dental pulp stem cell differentiation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Engineering, Biomedical
Aijie Chen, Ruolan Wang, Yiyuan Kang, Jia Liu, Junrong Wu, Yanli Zhang, Yulin Zhang, Longquan Shao
Summary: This study found that zinc oxide nanoparticles can enter the brain through the tongue-brain pathway and cause a decrease in taste sensitivity and taste aversion learning ability by reducing synaptic transmission and inducing neuroinflammation. The neuroinflammation originates from neurons and is mediated by the activation of the JAK-STAT signaling pathway, which inhibits the Neurexin1-PSD95-Neurologigin1 pathway. Blocking the activation of the JAK-STAT pathway prevents neuroinflammation and the reduction in Neurexin1-PSD95-Neurologigin1. These findings reveal the impact of zinc oxide nanoparticles on neuronal function and provide a novel mechanism.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Yingjing Pan, Tianci Lin, Longquan Shao, Yulin Zhang, Qiao Han, Liyuan Sheng, Rui Guo, Ting Sun, Yanli Zhang
Summary: In this study, a puerarin-attached lignin nanoparticle-incorporated hydrogel was found to promote angiogenesis, possibly through puerarin-mediated autophagy activation and increase in PPAR beta/delta. This research is of great significance for the treatment of ischemic diseases.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Engineering, Environmental
Yanli Zhang, Yulin Zhang, Ye Lei, Junrong Wu, Yiyuan Kang, Shuo Zheng, Longquan Shao
Summary: During pregnancy, the human body is vulnerable to external stimuli, including zinc oxide nanoparticles (ZnO-NPs). This study investigates the effects of prenatal ZnO-NP exposure on fetal brain tissue development. The findings suggest that ZnO-NPs can cross the blood-brain barrier and enter fetal brain tissue, causing mitochondrial damage, autophagosome overaccumulation, microglial inflammation, and neuronal damage. These findings highlight the importance of understanding the effects of prenatal ZnO-NP exposure on fetal brain development and raising awareness of the use of ZnO-NPs among pregnant women.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Materials Science, Biomaterials
Ziyi Liu, Ruijie Wang, Wenjing Liu, Yushan Liu, Xiaoli Feng, Fujian Zhao, Pei Chen, Longquan Shao, Mingdeng Rong
Summary: Silicon nitride is an emerging bioceramic material that promotes osteogenesis due to its unique surface chemistry and excellent mechanical properties. The mechanisms of osteogenesis promotion and the optimization of molding process are important for its clinical applications.
BIOMATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Chenguang Zhang, Wenliang Wang, Xiaodong Hao, Yong Peng, Yulin Zheng, Jia Liu, Yiyuan Kang, Fujian Zhao, Zhengtang Luo, Junjie Guo, Bingshe Xu, Longquan Shao, Guoqiang Li
Summary: This study utilized GaN/AlGaN materials with controlled polarity to induce endogenous electrical stimulation for bone regeneration, finding that Ga-polarity GaN/AlGaN nanofilms showed superior bone repair in vivo and promoted osteogenic differentiation of bone mesenchymal stem cells in vitro. Additionally, the study revealed that bone morphogenetic protein-6 (BMP6) may be an electrically sensitive osteogenic protein.
ADVANCED FUNCTIONAL MATERIALS
(2021)
