Article
Neurosciences
Xin Xu, Xue Li, Xu Qi, Xi Jiang, Haoyang Xing, Xiaoqi Huang, Qiyong Gong
Summary: Resting-state functional magnetic resonance imaging (RS-FMRI) was used to evaluate the effects of intermittent theta burst stimulation (iTBS) and continuous theta burst stimulation (cTBS) on intrinsic brain activity in the precuneus. The results showed that iTBS decreased functional connectivity in the bilateral precuneus, while cTBS decreased functional connectivity in the bilateral insula and increased it in the thalamus.
HUMAN BRAIN MAPPING
(2023)
Article
Behavioral Sciences
Remy Cohan, Sara A. A. Rafique, Karlene S. S. Stoby, Diana J. J. Gorbet, Jennifer K. E. Steeves
Summary: In this study, the immediate and short-term effects of iTBS and cTBS on V1 were investigated using a sham-controlled design. The results showed that neither iTBS nor cTBS had any effect on functional connectivity or cortical excitability in V1. This suggests that a single session of cTBS or iTBS using a standard protocol may not effectively modulate FC in V1, especially in clinical settings targeting pathological networks.
BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
Xinping Deng, Jue Wang, Yufeng Zang, Yang Li, Wenjin Fu, Yanyan Su, Xiongying Chen, Boqi Du, Qi Dong, Chuansheng Chen, Jun Li
Summary: This study identified the crucial role of the parietal cortex in working memory storage and found that repeated parietal intermittent theta-burst stimulation (iTBS) can improve neural indicators of working memory. However, further optimization is needed to produce a behavioral effect.
HUMAN BRAIN MAPPING
(2022)
Article
Behavioral Sciences
Yali Feng, Jack Jiaqi Zhang, Jiaqi Zhu, Xiaobing Tan, Sanyue Huang, Zhongfei Bai, Ying Yin
Summary: This study aimed to investigate the effects of intermittent theta burst stimulation (iTBS) on working memory performance in healthy adults, specifically focusing on the left dorsolateral prefrontal cortex (LDLPFC) and right dorsolateral prefrontal cortex (RDLPFC). The results showed significant time effects on overall accuracy in both 2-back and 3-back tasks, as well as on total reaction time in 3-back tasks. However, there were no significant interaction effects between time and group.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Clinical Neurology
Carl Johan Ekman, Katarzyna Popiolek, Robert Boden, Axel Nordenskjold, Johan Lundberg
Summary: This study investigated the effectiveness and tolerability of intermittent Theta-burst stimulation (iTBS) in a clinical setting. The results showed that iTBS was safe and well-tolerated, and the response rate was similar to that reported in clinical trials. Older age and milder illness predicted a better treatment response.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Qian Ding, Shunxi Zhang, Songbin Chen, Jixiang Chen, Xiaotong Li, Junhui Chen, Yuan Peng, Yujie Chen, Kang Chen, Guiyuan Cai, Guangqing Xu, Yue Lan
Summary: Using resting-state EEG, this study found that active iTBS significantly increased interhemispheric functional connectivity and global efficiency in stroke survivors, suggesting its potential to normalize brain network functioning after stroke, which can be utilized in stroke rehabilitation.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Marco K. Wittmann, Nadescha Trudel, Hailey A. Trier, Miriam C. Klein-Flugge, Alejandra Sel, Lennart Verhagen, Matthew F. S. Rushworth
Summary: In social environments, people estimate others' abilities based on their own and others' past performance, with specific neural patterns in the dmPFC associated with self-other mergence behavior. Research shows that neurostimulation of the dmPFC can silence these neural signatures, leading to increased self-other mergence behavior and projection of self-assessments onto others. This suggests a tendency to form interdependent social representations and highlights the role of the dmPFC in separating self and other representations.
Article
Anatomy & Morphology
Brenton Hordacre, Mitchell R. Goldsworthy, Lynton Graetz, Michael C. Ridding
Summary: This research investigated the impact of baseline resting state functional connectivity on responses to continuous theta burst stimulation (cTBS). The results showed that a low beta frequency band model of connectivity played a crucial role in determining responses to spaced cTBS, suggesting that M1-frontocentral networks may have an important role in the effects of cTBS on corticospinal excitability.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Biology
Adrian Ponce-Alvarez, Morten L. Kringelbach, Gustavo Deco
Summary: Human fMRI and dMRI data were used to test the phenomenological renormalization group (PRG) method and found that the scale invariance of rs-fMRI activity may emerge from criticality and exponentially decaying connectivity between brain regions.
COMMUNICATIONS BIOLOGY
(2023)
Article
Clinical Neurology
Tobias Hebel, Alina Goellnitz, Stefan Schoisswohl, Franziska C. Weber, Mohamed Abdelnaim, Thomas C. Wetter, Rainer Rupprecht, Berthold Langguth, Martin Schecklmann
Summary: The study found that using neuronavigation for positioning did not show significant superiority over the non-neuronavigated F3 guided method. While the add-on iTBS treatment showed high antidepressive effect in inpatient treatment, the difference between neuronavigated and non-neuronavigated approaches may not justify the additional efforts of navigation. Further prospective studies are needed to compare neuronavigation with surface-based approaches in clinical settings.
Article
Neurosciences
Shuang Qiu, Shengpei Wang, Weiwei Peng, Weibo Yi, Chuncheng Zhang, Jing Zhang, Huiguang He
Summary: Continuous theta-burst stimulation (cTBS) induces long-lasting inhibitory effects on cortical excitability and leads to improvements in motor function. Changes in microstate B were found to be associated with improvements in motor function, indicating a specific modulation by cTBS on motor network connectivity.
COGNITIVE NEURODYNAMICS
(2022)
Article
Neurosciences
Yi Chen, Qing-Chuan Wei, Ming-Zhi Zhang, Yun-Juan Xie, Ling-Yi Liao, Hui-Xin Tan, Qi-Fan Guo, Qiang Gao
Summary: Cerebellar intermittent theta-burst stimulation shows promising efficacy in improving upper limb spasticity in subacute stroke patients, with better outcomes compared to sham stimulation group.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Neurosciences
Yixuan Wang, Jian Liu, Yanping Hui, Zhongheng Wu, Ling Wang, Xiang Wu, Yihua Bai, Qiaojun Zhang, Libo Li
Summary: This study found that multiple blocks of iTBS have dose and time-dependent effects on hippocampus-dependent memory in PD, which may be related to changes in hippocampal c-Fos expression and theta rhythm.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Carolina Seybert, Goncalo Cotovio, Daniel Rodrigues da Silva, Francisco Faro Viana, Patricia Pereira, Albino J. Oliveira-Maia
Summary: This study aimed to test the temporal stability of cortical-excitability modulation and study the impact of individual and methodological factors in determining within-and between-subject variability. The results found modulatory effects on the left motor cortex immediately after intermittent theta burst stimulation (iTBS), but not on the right hemisphere. Delta-MEPs were stable immediately after iTBS and were not impacted by different individual factors. The findings suggest that motor cortex excitability modulation may be further explored as a potential biomarker for neuropsychiatric diseases.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Engineering, Biomedical
Nevine El Nahas, Fatma Fathalla Kenawy, Eman Hamid Abd Eldayem, Tamer M. Roushdy, Shahinaz M. Helmy, Ahmed Zaki Akl, Aya Ahmed Ashour, Tamer H. Emara, Marwa Mohamed Moawad, Randa M. Amin, Ahmed M. Elbokl
Summary: The study demonstrated that peripheral intermittent theta burst stimulation (piTBS) can significantly reduce spasticity, especially when applied directly on spastic muscles. It has shown promising results in reducing spasticity and Botulinum toxin dose without compromising treatment efficacy, thus providing a potential alternative to current therapeutic options.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2022)
Article
Clinical Neurology
H. Rasoanandrianina, S. Demortiere, A. Trabelsi, J. P. Ranjeva, O. Girard, G. Duhamel, M. Guye, J. Pelletier, B. Audoin, V. Callot
AMERICAN JOURNAL OF NEURORADIOLOGY
(2020)
Article
Neurosciences
Jonathan Wirsich, Anne-Lise Giraud, Sepideh Sadaghiani
Article
Neurosciences
Diego Lombardo, Catherine Casse-Perrot, Jean-Philippe Ranjeva, Arnaud Le Troter, Maxime Guye, Jonathan Wirsich, Pierre Payoux, David Bartres-Faz, Regis Bordet, Jill C. Richardson, Olivier Felician, Viktor Jirsa, Olivier Blin, Mira Didic, Demian Battaglia
Article
Neurosciences
Arzu C. Has Silemek, Jean-Philippe Ranjeva, Bertrand Audoin, Christoph Heesen, Stefan M. Gold, Simone Kuhn, Martin Weygandt, Jan-Patrick Stellmann
Summary: The study found that patients with multiple sclerosis have slower conscious access to visual stimulus material, with a complex pattern of functional and structural alterations. Compared to healthy controls, patients showed decreased brain activation during unconscious processing.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Jonathan Wirsich, Joao Jorge, Giannina Rita Iannotti, Elhum A. Shamshiri, Frederic Grouiller, Rodolfo Abreu, Francois Lazeyras, Anne-Lise Giraud, Rolf Gruetter, Sepideh Sadafhiani, Serge Vulliemoz
Summary: EEG and fMRI are non-invasive methods to show complementary aspects of human brain activity, with indirectly coupled blood-oxygenation and neurophysiological recordings. The reliability of the resting-state functional connectivity involves complex factors between different setups.
Article
Multidisciplinary Sciences
Maximillian K. Egan, Ryan Larsen, Jonathan Wirsich, Brad P. Sutton, Sepideh Sadaghiani
Summary: This study compared heating and EEG data quality between multi-band (MB) fMRI sequences and standard single-band (SB) sequences, finding that MB sequences induced lower heating and EEG data quality was acceptable after traditional artifact removal techniques.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucas Soustelle, Thomas Troalen, Andreea Hertanu, Samira Mchinda, Jean-Philippe Ranjeva, Maxime Guye, Gopal Varma, David C. Alsop, Guillaume Duhamel, Olivier M. Girard
Summary: Concentrating RF saturation energy in ihMT-GRE sequences mitigates the sensitivity of ihMTR to B1+ variations, allowing for clinical-ready ihMT imaging at 3 T. Under optimal conditions, 73% of WM voxels presented delta(ihMTR) below 10%. Reproducibility analysis showed minimal systematic bias and high correlation between test and retest experiments.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Clinical Neurology
M. M. El Mendili, A. -M. Grapperon, R. Dintrich, J. -P Stellmann, J. -P. Ranjeva, M. Guye, A. Verschueren, S. Attarian, W. Zaaraoui
Summary: This study aimed to investigate the topography of brain regions showing combined microstructural and sodium homeostasis alterations in amyotrophic lateral sclerosis subgroups according to their disease-progression rates. The results showed that fast progressors demonstrated more widespread abnormalities, primarily in the frontal areas, while slow progressors only exhibited abnormalities in fractional anisotropy.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Clinical Neurology
Adil Maarouf, Bertrand Audoin, Soraya Gherib, Mohamed Mounir El Mendili, Patrick Viout, Fanelly Pariollaud, Clemence Boutiere, Audrey Rico, Maxime Guye, Jean-Philippe Ranjeva, Wafaa Zaaraoui, Jean Pelletier
Summary: The study aimed to compare grey-matter sodium abnormalities (GMSAs) in patients with benign multiple sclerosis (BMS) and non-benign multiple sclerosis (NBMS). The results showed that GMSAs were detected in both BMS and NBMS patients, especially in those with relapsing-remitting and secondary progressive multiple sclerosis. Thalamic volume was independently associated with BMS status, and the absence of GMSAs was independently associated with BMS when excluding patients with significant cognitive alteration.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Neurosciences
Mikhael Azilinon, Julia Makhalova, Wafaa Zaaraoui, Samuel Medina Villalon, Patrick Viout, Tangi Roussel, Mohamed M. El Mendili, Ben Ridley, Jean-Philippe Ranjeva, Fabrice Bartolomei, Viktor Jirsa, Maxime Guye
Summary: Whole brain ionic and metabolic imaging is a potential tool for brain disease characterization. This study used sodium MRI and H-1-MR spectroscopic imaging to evaluate changes in epileptogenic networks. The study found a significant increase in sodium signal and a decrease in NAA levels in the epileptogenic zone.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Andreea Hertanu, Lucas Soustelle, Julie Buron, Julie Le Priellec, Myriam Cayre, Arnaud Le Troter, Valentin H. Prevost, Jean-Philippe Ranjeva, Gopal Varma, David C. Alsop, Pascale Durbec, Olivier M. Girard, Guillaume Duhamel
Summary: This study investigated the association of ihMT signals with demyelination and remyelination in the acute cuprizone mouse model using multimodal MRI. The results showed that the ihMT high-pass T1D-filters were sensitive markers of demyelination and remyelination, and correlated well with histology. The ihMT band-pass T1D-filter was less sensitive to myelin changes and may be influenced by other pathological processes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucas Soustelle, Thomas Troalen, Andreea Hertanu, Jean-Philippe Ranjeva, Maxime Guye, Gopal Varma, David C. Alsop, Guillaume Duhamel, Olivier M. Girard
Summary: The purpose of this study is to demonstrate the bias in quantitative MT (qMT) measures caused by dipolar order and on-resonance saturation (ONRS) effects in MT spoiled gradient-recalled (SPGR) acquisitions. The researchers propose changes to the acquisition and analysis strategies to remove these biases and improve the accuracy and reproducibility of qMT-SPGR studies.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Neurosciences
Roy A. M. Haast, Benoit Testud, Julia Makhalova, Hugo Dary, Alexandre Cabane, Arnaud Le Troter, Jean-Philippe Ranjeva, Fabrice Bartolomei, Maxime Guye
Summary: This study used 7T MRI T-1 data to describe subcortical morphological and longitudinal relaxation changes in focal epilepsy patients and evaluated the influence of clinical characteristics. Results showed variable levels of atrophy across thalamic nuclei, with the most prominent changes in the temporal lobe epilepsy group. T-1 measures in the thalamus appeared to differentiate patients based on epileptogenic zone localization.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Jonathan Wirsich, Enrico Amico, Anne-Lise Giraud, Joaquin Goni, Sepideh Sadaghiani
NETWORK NEUROSCIENCE
(2020)
Review
Neurosciences
Sepideh Sadaghiani, Jonathan Wirsich
NETWORK NEUROSCIENCE
(2020)