Increased expression of the PI3K catalytic subunit p110δ underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family

Toward an immune-mediated subtype of autism spectrum disorder

(2015) Christopher J. McDougle et al.   BRAIN RESEARCH

Recent Advances in the Genetics of Autism Spectrum Disorder

(2015) Silvia De Rubeis et al.   Current Neurology and Neuroscience Reports

Drugging PI3K in cancer: refining targets and therapeutic strategies

(2015) Timothy A Yap et al.   CURRENT OPINION IN PHARMACOLOGY

Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy

(2015) Jae Seok Lim et al.   NATURE MEDICINE

The association between autism and schizophrenia spectrum disorders: A review of eight alternate models of co-occurrence

(2015) Katharine Chisholm et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Selective Role of the Catalytic PI3K Subunit p110β in Impaired Higher Order Cognition in Fragile X Syndrome

(2015) Christina Gross et al.   Cell Reports

Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome

(2015) Christina Gross et al.   Cell Reports

Integrated analysis of whole-exome sequencing and transcriptome profiling in males with autism spectrum disorders

(2015) Marta Codina-Solà et al.   Molecular Autism

Identification of Fragile X Syndrome Specific Molecular Markers in Human Fibroblasts: A Useful Model to Test the Efficacy of Therapeutic Drugs

(2014) Daman Kumari et al.   HUMAN MUTATION

The Familial Risk of Autism

(2014) Sven Sandin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Most genetic risk for autism resides with common variation

(2014) Trent Gaugler et al.   NATURE GENETICS

The Neurology of mTOR

(2014) Jonathan O. Lipton et al.   NEURON

PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model

(2014) Pei Ching Low et al.   Nature Communications

Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders

(2014) Christina Gross et al.   Frontiers in Molecular Neuroscience

The Genetic Landscapes of Autism Spectrum Disorders

(2013) Guillaume Huguet et al.   Annual Review of Genomics and Human Genetics

Adjusting Head Circumference for Covariates in Autism: Clinical Correlates of a Highly Heritable Continuous Trait

(2013) Pauline Chaste et al.   BIOLOGICAL PSYCHIATRY

Recent advances in psychoneuroimmunology relevant to schizophrenia therapeutics

(2013) Monojit Debnath et al.   CURRENT OPINION IN PSYCHIATRY

PTEN Inhibition to Facilitate Intrinsic Regenerative Outgrowth of Adult Peripheral Axons

(2013) K. J. Christie et al.   JOURNAL OF NEUROSCIENCE

Targeting the endocannabinoid system in the treatment of fragile X syndrome

(2013) Arnau Busquets-Garcia et al.   NATURE MEDICINE

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

Mechanism-Based Treatment in Tuberous Sclerosis Complex

(2013) Kristina Jülich et al.   PEDIATRIC NEUROLOGY

Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and induciblePIK3CDpromoter

(2012) Maria A. Whitehead et al.   BIOCHEMICAL JOURNAL

Molecular Therapies for Tuberous Sclerosis and Neurofibromatosis

(2012) David Neal Franz et al.   Current Neurology and Neuroscience Reports

Integrative gene network analysis provides novel regulatory relationships, genetic contributions and susceptible targets in autism spectrum disorders

(2012) Tin-Lap Lee et al.   GENE

Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome

(2012) C. A. Hoeffer et al.   GENES BRAIN AND BEHAVIOR

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(2012) Christina Gross et al.   MOLECULAR MEDICINE

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

(2012) Peter T. Tsai et al.   NATURE

Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

(2012) Aditi Bhattacharya et al.   NEURON

Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy

(2012) Amanda J. Law et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local infusion of ghrelin enhanced hippocampal synaptic plasticity and spatial memory through activation of phosphoinositide 3-kinase in the dentate gyrus of adult rats

(2011) Liang Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Phosphatase and Tensin Homolog (PTEN) Gene Mutations and Autism: Literature Review and a Case Report of a Patient With Cowden Syndrome, Autistic Disorder, and Epilepsy

(2011) Sara Conti et al.   JOURNAL OF CHILD NEUROLOGY

Phosphoinositide 3-Kinase Enhancer Regulates Neuronal Dendritogenesis and Survival in Neocortex

(2011) C. Bun Chan et al.   JOURNAL OF NEUROSCIENCE

Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome

(2010) C. Gross et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of mTOR Signaling in Fragile X Syndrome

(2010) A. Sharma et al.   JOURNAL OF NEUROSCIENCE

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autism-specific copy number variants further implicate the phosphatidylinositol signaling pathway and the glutamatergic synapse in the etiology of the disorder

(2009) I. Cusco et al.   HUMAN MOLECULAR GENETICS

The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders

(2009) Pat Levitt et al.   JOURNAL OF CLINICAL INVESTIGATION

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

Regulation of p110δ PI 3-Kinase Gene Expression

(2009) Klaartje Kok et al.   PLoS One

Inhibition of PI3K-Akt Signaling Blocks Exercise-Mediated Enhancement of Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus

(2009) Elodie Bruel-Jungerman et al.   PLoS One

The Autistic Neuron: Troubled Translation?

(2008) Raymond J. Kelleher et al.   CELL

Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex

(2008) L. Sui et al.   LEARNING & MEMORY

Reversal of learning deficits in a Tsc2 +/− mouse model of tuberous sclerosis

(2008) Dan Ehninger et al.   NATURE MEDICINE