Article
Chemistry, Physical
Hao Zhang, Zhijia Lv, Dongzhi Xue, Tianqi Zhang, Longhai Jin, Yue Cao, Shuai Zhang, Yinghui Wang, Hongjie Zhang
Summary: A TME-responsive theranostic nanoagent was fabricated using a layer-by-layer synthesis method, which can achieve enhanced chemotherapy within tumor cells without collateral damage to normal tissues. The nanoagent efficiently kills tumor cells in both in vitro and in vivo experiments.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Applied
Hamed Nosrati, Marziyeh Salehiabar, Faezeh Mozafari, Jalil Charmi, Nuri Erdogan, Mohammadreza Ghaffarlou, Fatemeh Abhari, Hossein Danafar, Ali Ramazani, Yavuz Nuri Ertas
Summary: Early diagnosis and treatment of cancer is crucial, and theranostic systems play a significant role in this aspect. In this study, bi-functional nanoparticles were developed as dual MRI/CT contrast agent and carrier of natural anticancer drug. These nanoparticles showed good performance in both MRI and CT imaging contrast, while also demonstrating high biocompatibility and anticancer activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jin Wang, Yinhang Jia, Qiyue Wang, Zeyu Liang, Guangxu Han, Zejun Wang, Jiyoung Lee, Meng Zhao, Fangyuan Li, Ruiliang Bai, Daishun Ling
Summary: The article introduces a T-1-T-2 dual-mode contrast agent designed for ultrahigh-field MRI, which not only improves resolution and signal-to-noise ratio, but also effectively displays microvasculature structures with high sensitivity and accuracy in detecting tumor vascular permeability.
ADVANCED MATERIALS
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Faraz Ahmad, Lee Treanor, Trevor A. McGrath, Daniel Walker, Matthew D. F. McInnes, Nicola Schieda
Summary: The study found that the adverse event rate of ferumoxytol as an MRI contrast agent is 2%, with a mix of mild, moderate, and severe adverse events reported. There were no deaths related to ferumoxytol administration, but the safety of ferumoxytol as an alternative to gadolinium-based contrast agents in patients with prior hypersensitivity reactions remains unexplored.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Pharmacology & Pharmacy
Dongsik Park, Su Jin Lee, Dong Kyu Choi, Jee-Woong Park
Summary: Tissue engineering integrates multiple disciplines to repair or regenerate damaged tissues and organs. Fibrous scaffolds loaded with therapeutic agents have shown great potential in this field. This comprehensive review examines methods for fabricating bioactive molecule-loaded fibrous scaffolds, their biomedical applications, and aims to contribute to the development of new technologies or improvements to existing ones.
Article
Chemistry, Physical
Davino M. A. Neto, Luelc S. da Costa, Fernando L. de Menezes, Lillian M. U. D. Fechine, Rafael M. Freire, Juliano C. Denardin, Manuel Banobre-Lopez, Igor F. Vasconcelos, Thiago S. Ribeiro, Luzia Kalyne A. M. Leal, Joao A. C. de Sousa, Juan Gallo, Pierre B. A. Fechine
Summary: The study demonstrates the successful functionalization of Fe3O4 NPs with DTPMP for potential use as an MRI contrast agent, showing non-cytotoxicity and high transverse relaxivity values. This novel material presents an excellent alternative magnetic option for biological and technological applications, particularly for MRI contrast imaging.
APPLIED SURFACE SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Li Xu, Zhanying Ren, Guolin Li, Danni Xu, Jiaqian Miao, Jingxuan Ju, Xuan Mo, Xianghui Wang, Hongping Deng, Min Xu
Summary: A liver-targeting gadolinium-based MRI contrast agent was developed using galactose functionalized o-carboxymethyl chitosan, which exhibited higher hepatocyte uptake, excellent biocompatibility, and better T1-weighted signal enhancement in the liver. The agent showed good safety in vivo at a specific dose.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Ji Hye Jin, Hyeji Um, Ji Hyeon Oh, Youngbuhm Huh, Yuna Jung, Dokyoung Kim
Summary: A new nano-formulation based on gadolinium silicate-coated porous silicon nanoparticles (pSiNPs) is introduced as an MRI contrast agent and drug delivery carrier. The newly developed surface coating method using gadolinium ions (Gd3+) resulted in nanoparticles (named pSiNPs-Gd) that exhibited T-1-type MR responses and high drug encapsulation efficacy. The nanoparticle characterization, MR signal, cytotoxicity, and drug release profile were systematically analyzed. These findings contribute to the development of multi-functional pSiNPs-based nanotherapeutics and their applications in various fields.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Sedigheh Cheraghali, Ghasem Dini, Isabella Caligiuri, Michele Back, Flavio Rizzolio
Summary: In this study, hierarchical MnZn ferrite nanoparticles were synthesized and their surface characteristics were improved by PEGylation. In vitro MRI studies confirmed the ability of the synthesized nanoparticles as a contrast agent. Results were compared with normal structured MnZn ferrite nanoparticles.
Article
Chemistry, Multidisciplinary
Hamidreza Saeidi, Morteza Mozaffari, Serhat Ilbey, Silvio Dutz, Diana Zahn, Gholamhassan Azimi, Michael Bock
Summary: This work provides a detailed description of the synthesis and characterizations of europium-substituted Mn-Zn ferrite magnetic nanoparticles. The europium substitution significantly affects the crystallite size, saturation magnetization, and relaxivity. The results show that the europium-substituted nanoparticles have potential as dual-mode MRI contrast agents with enhanced contrast and improved biocompatibility.
Article
Pharmacology & Pharmacy
Jiali Li, Xue Jiang, Lihuan Shang, Zhen Li, Conglian Yang, Yan Luo, Daoyu Hu, Yaqi Shen, Zhiping Zhang
Summary: The study successfully synthesized L-epigallocatechin gallate complexed Mn2+ nanoparticles with good biocompatibility, stability, pH sensitivity, and anti-tumor properties, potentially serving as an MRI contrast agent.
Article
Nanoscience & Nanotechnology
Vidumin Dahanayake, Trevor Lyons, Brendan Kerwin, Olga Rodriguez, Christopher Albanese, Erika Parasido, Yichien Lee, Edward Van Keuren, Luxi Li, Evan Maxey, Tatjana Paunesku, Gayle Woloschak, Sarah L. Stoll
Summary: The study focused on enhancing the relaxivity of a manganese and iron-oxo cluster grafted within porous polystyrene nanobeads with increased surface area. The synthesis of the cluster-nanocarrier under miniemulsion conditions resulted in porous nanobeads approximately 70 nm in diameter, leading to higher relaxivity. The stability assessment and synchrotron X-ray fluorescence microscopy showed promising results for in vivo applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Paolo Arosio, Davide Cicolari, Amedea Manfredi, Francesco Orsini, Alessandro Lascialfari, Elisabetta Ranucci, Paolo Ferruti, Daniela Maggioni
Summary: In this study, a linear polyamidoamine (PAA) named BAC-EDDS was successfully synthesized and showed stable nanoaggregates with negative charge, demonstrating good performance as a contrast agent in magnetic resonance imaging.
Article
Engineering, Biomedical
Shuai Guo, Wei Xiong, Jiaoyang Zhu, Jie Feng, Ruilong Zhou, Qingdeng Fan, Qianqian Zhang, Zongheng Li, Jing Yang, Huimin Zhou, Peiwei Yi, Yanqiu Feng, Sugeun Yang, Xiaozhong Qiu, Yikai Xu, Zheyu Shen
Summary: In this study, a STING pathway-activatable contrast agent was developed for magnetic resonance imaging (MRI)-guided tumor immunoferroptosis synergistic therapy. The effectiveness and biosafety of this therapy were demonstrated by in vivo investigations, and the mechanisms of action were studied using various indicators.
Article
Chemistry, Multidisciplinary
Sellamuthu Anbu, Sabrina H. L. Hoffmann, Fabio Carniato, Lawrence Kenning, Thomas W. Price, Timothy J. Prior, Mauro Botta, Andre F. Martins, Graeme J. Stasiuk
Summary: Manganese-based contrast agents have emerged as potential alternatives to gadolinium-based ones, but their clinical application is limited due to synthetic challenges. This study successfully developed a MnCA with optimized relaxivity, MnLMe, through an innovative synthetic strategy, demonstrating promising performance in both in vitro and in vivo studies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Nanoscience & Nanotechnology
Daniel Escobar Hernandez, Angelica Perez Magallon, Gregorio Guadalupe Carbajal Arizaga
MICRO & NANO LETTERS
(2019)
Article
Green & Sustainable Science & Technology
Alexandre Amado de Moura, Luciane Effting, Murilo Pereira Moises, Gregorio Guadalupe Arizaga Carbajal, Cesar Ricardo Teixeira Tarley, Everlei Camara, Angelo Gracioli, Alesandro Bail
JOURNAL OF CLEANER PRODUCTION
(2019)
Article
Environmental Sciences
F. Lopez-Herrera y Cairo, H. D. Jimenez-Torres, I. D. Barcelo-Quintal, P. F. Zarate-Del Valle, G. G. Carbajal-Arizaga, W. de la Cruz-Hernandez, S. Gomez-Salazar
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2019)
Article
Engineering, Electrical & Electronic
Carlos R. Michel, Miguel A. Lopez-Alvarez, Alma H. Martinez-Preciado, Gregorio G. Carbajal-Arizaga
JOURNAL OF SENSORS
(2019)
Article
Chemistry, Multidisciplinary
Pedro Ivan Hernandez-Velazquez, Jose A. Gutierrez-Ortega, Gregorio Guadalupe Carbajal-Arizaga, Ricardo Manriquez-Gonzalez, Wencel De la Cruz-Hernandez, Sergio Gomez-Salazar
JOURNAL OF THE MEXICAN CHEMICAL SOCIETY
(2019)
Review
Chemistry, Physical
Karina Nava Andrade, Ana Maria Puebla Perez, Gregorio Guadalupe Carbajal Arizaga
APPLIED CLAY SCIENCE
(2019)
Article
Pharmacology & Pharmacy
Filiberto Gutierrez-Gutierrez, Cecilia Sanchez-Jimenez, Itzia Azucena Rangel-Castaneda, Gregorio Guadalupe Carbajal-Arizaga, Adriana Macaria Macias-Lamas, Araceli Castillo-Romero, Karina Jeanette Parra-Saavedra
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2020)
Article
Chemistry, Physical
Jose Eduardo Casillas, Jorge Campa-Molina, Francisco Tzompantzi, Gregorio Guadalupe Carbajal Arizaga, Alejandro Lopez-Gaona, Sandra Ulloa-Godinez, Mario Eduardo Cano, Arturo Barrera
Article
Engineering, Chemical
Karina Nava Andrade, Gregorio Guadalupe Carbajal Arizaga, Jose Antonio Rivera Mayorga
Article
Chemistry, Physical
Karina Nava Andrade, Peter Knauth, Zaira Lopez, Gustavo A. Hirata, Santiago Jose Guevara Martinez, Gregorio Guadalupe Carbajal Arizaga
APPLIED CLAY SCIENCE
(2020)
Article
Environmental Sciences
Felipe do Casal de Paula, Luciane Effting, Gregorio Guadalupe Carbajal Arizaga, Renata Mello Giona, Andre Luiz Tessaro, Fabricio Maesta Bezerra, Alesandro Bail
Summary: Mesoporous silica spheres were synthesized using solvothermal method and modified by thermal treatment for the removal of cationic dyes under strong acidic conditions. The adsorption kinetics followed a pseudo-second-order model, indicating physical forces as the driving mechanism. The adsorbents showed significant removal efficiency in a fast-contact system.
ENVIRONMENTAL TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Andrei Gurinov, Benedikt Sieland, Andrey Kuzhelev, Hossam Elgabarty, Thomas D. Kuehne, Thomas Prisner, Jan Paradies, Marc Baldus, Konstantin L. Ivanov, Svetlana Pylaeva
Summary: A novel set of polarizing agents - mixed-valence compounds have been investigated through theoretical and experimental methods, showcasing their performance in high-field dynamic nuclear polarization (DNP) NMR experiments in the solid state. These compounds, with molecular mobility persisting even in solids, can be used to conduct Overhauser-DNP experiments in the solid state, providing favorable conditions for dynamic nuclear polarization formation at ultra-high magnetic fields.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Nanoscience & Nanotechnology
Dayne Kassandra Gutierrez Galan, Fermin P. Pacheco-Moises, Frank Silva Bezerra, Natalia Alves de Matos, Norma Alejandra Gonzalez Rojas, Jenny Arratia-Quijada, Gregorio Guadalupe Carbajal Arizaga
Summary: A composite of lycopene and LDH nanoparticles was prepared, with magnesium-based composites maintaining the antioxidant capability of lycopene and zinc-containing LDHs synergizing its antioxidant capacity. The improved hydrodispersability of the composites allowed for assessment of antioxidant capacity and oxidative stress protection beyond traditional oily lycopene formulations. The cation composition of the LDH influenced antioxidant capacity, with magnesium-containing composites showing non-toxic performance in oxidative stress assays.
APPLIED NANOSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Norma Alejandra Gonzalez Rojas, Fermin Paul Pacheco Moises, Jose Alfonso Cruz-Ramos, Frank Silva Bezerra, Gregorio Guadalupe Carbajal Arizaga
Summary: Lycopene is a powerful natural antioxidant that can protect against diseases. Researchers have developed a composite material containing layered double hydroxides and 54% lycopene to improve its hydrophobicity and release. This composite material has a high release of lycopene in simulated stomach, small intestine, and large intestine conditions, and shows similar antioxidant capacity to pure lycopene. It can be used as a supplement and antioxidant additive.
Article
Multidisciplinary Sciences
Cecilia Sanchez Jumenez, Fermin Paul Pacheco Moises, M. E. Cano, Karina Nava Andrade, Ana Laura Briones Torres, Gregorio Guadalupe Carbajal Arizaga
