Article
Cardiac & Cardiovascular Systems
Kevin M. Wheelock, Anna Kratz, Sangeeta Lathkar-Pradhan, Kayvan Najarian, Jonathan Gryak, Zhi Li, Hakan Oral, Daniel J. Clauw, Brahmajee K. Nallamothu, Hamid Ghanbari
Summary: This study found that negative affect in patients with atrial fibrillation predicted more severe symptom reporting to a greater extent than heart rhythm.
AMERICAN HEART JOURNAL
(2021)
Article
Medicine, General & Internal
Meaghann S. Weaver, Shana S. Jacobs, Janice S. Withycombe, Jichuan Wang, Katie A. Greenzang, Justin N. Baker, Pamela S. Hinds
Summary: The results of this cohort study suggest that there is alignment between proxy caregiver reports and children's self-reports of symptoms. Proxy reports can serve as a guide to care when the child is unable to self-report.
Article
Orthopedics
Josh W. Faulkner, Deborah L. Snell
Summary: Biopsychosocial models are used to explain PPCS after concussion, highlighting the role of psychological factors. However, clinicians face challenges in addressing these factors. This article provides guidance on understanding and applying psychological factors in the clinical management of PPCS.
Article
Neurosciences
Stella B. Legarda, Caroline E. Lahti, Dana McDermott, Andreas Michas-Martin
Summary: Concussion is a growing public health concern. Infralow frequency neuromodulation (ILF) has been found to be effective in treating postconcussion symptoms (PCS) and persistent postconcussion symptoms (PPCS).
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Oncology
Sofia Spampinato, Tiziana Rancati, Justyna Magdalena Waskiewicz, Barbara Avuzzi, Elisabetta Garibaldi, Adriana Faiella, Elisa Villa, Alessandro Magli, Domenico Cante, Giuseppe Girelli, Marco Gatti, Barbara Noris Chiorda, Luciana Rago, Paolo Ferrari, Cristina Piva, Maddalena Pavarini, Riccardo Valdagni, Vittorio Vavassori, Fernando Munoz, Giuseppe Sanguineti, Nadia Di Muzio, Kathrin Kirchheiner, Claudio Fiorino, Cesare Cozzarini
Summary: This study aimed to evaluate the persistence of symptoms after radiotherapy for localized prostate cancer and its association with quality of life. The results showed that urinary and gastrointestinal symptoms persisted after radiotherapy, and were associated with differences in quality of life. Fatigue was the most common symptom and had the largest impact on quality of life.
Article
Clinical Neurology
Meredith A. Bock, Ethan G. Brown, Li Zhang, Caroline Tanner
Summary: This study found significant correlations between depression, motor symptoms, medical comorbidities, and HRQOL in a large online cohort of Parkinson's disease patients. Neuropsychiatric symptoms and falls had the most negative impact on HRQOL. Motor symptoms may have differential effects on HRQOL in different demographic and clinical subpopulations.
Article
Clinical Neurology
Parisa Hajihashemi, Fahimeh Haghighatdoost, Noushin Mohammadifard, Maryam Maghroun, Firouzeh Sajjadi, Farid Najafi, Hossein Farshidi, Masoud Lotfizadeh, Kamal Solati, Tooba Kazemi, Simin Karimi, Hamidreza Roohafza, Mohammadreza Sabri, Cesar de Oliveira, Erika Aparecida Silveira, Nizal Sarrafzadegan
Summary: This study investigated the potential relationship between Macronutrients' quality and mental health and quality of life among Iranian adults. The results showed that higher protein quality index (PQI) was associated with lower risk of depressive symptoms and low-quality life. However, carbohydrate quality index (CQI) and fat quality index (FQI) were not related to depressive and anxiety symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Kenneth Nilsson, Elisabet Skoog, Viktor Jones, Lisa Labbe Sandelin, Christina Bjorling, Ester Fridenstrom, Marie Edvinsson, Andreas Martensson, Bjorn Olsen
Summary: A study in Sweden found that adults with PTLDS did not show significant differences in medical history and laboratory results compared to patients with similar symptoms but without a PTLDS diagnosis. Most patients exhibited symptoms related to fatigue, musculoskeletal issues, neurological problems, and neurocognitive impairments, with 74% recalling tick bites.
Article
Health Care Sciences & Services
Kendall L. Moody
Summary: This study found that pain and SCD-related symptoms were negatively associated with the health-related quality of life (HRQOL) of pediatric patients diagnosed with SCD. Other SCD-related symptoms, in addition to pain, have the potential to negatively impact youth with SCD.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Review
Endocrinology & Metabolism
Petros Perros, Christina Van der Feltz-Cornelis, Enrico Papini, Endre Nagy, Anthony P. Weetman, Laszlo Hegedus
Summary: A significant minority of patients with hypothyroidism continue to experience symptoms despite normal thyroid biochemistry, and this can be attributed to imperfections in treatment methods, coexistence with somatic symptom and related disorders, autoimmune neuroinflammation, and comorbidities and psychosocial factors. Currently, there is a bias towards pursuing answers related to combination treatment of levothyroxine and liothyronine, while other explanations have been neglected.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Rehabilitation
Leah J. Mercier, Kristina Kowalski, Tak S. Fung, Julie M. Joyce, Keith Owen Yeates, Chantel T. Debert
Summary: The study found that individuals with persistent postconcussive symptoms (PPCS) experienced a significant decrease in physical activity compared to preinjury levels. Patients meeting physical activity guidelines postinjury were associated with better clinical outcomes, while sedentary behavior was negatively correlated with quality of life.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Oncology
Sofia Spampinato, Kari Tanderup, Jacob C. Lindegaard, Maximilian P. Schmid, Alina Sturdza, Barbara Segedin, Ina M. Jurgenliemk-Schulz, Astrid De Leeuw, Kjersti Bruheim, Umesh Mahantshetty, Cyrus Chargari, Bhavana Rai, Rachel Cooper, Elzbieta van der Steen-Banasik, Marit Sundset, Ericka Wiebe, Elena Villafranca, Erik Van Limbergen, Bradley R. Pieters, Li Tee Tan, Ludy C. H. W. Lutgens, Peter Hoskin, Stephanie Smet, Richard Poetter, Remi Nout, Supriya Chopra, Kathrin Kirchheiner
Summary: The purpose of this study was to quantitatively assess the association between persistent morbidity and different aspects of quality of life (QOL) in locally advanced cervical cancer (LACC) survivors. The results showed that persistent symptoms were associated with reductions in QOL, with general symptoms such as fatigue and pain having a greater impact.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Clinical Neurology
Aaron M. Yengo-Kahn, Natalie Hibshman, Christopher M. Bonfield, Eric S. Torstenson, Katherine A. Gifford, Daniil Belikau, Lea K. Davis, Scott L. Zuckerman, Jessica K. Dennis
Summary: This study aims to identify risk factors and generate hypotheses for pediatric persistent postconcussion symptoms (PPCS). The results showed a strong association between preinjury headache disorders and PPCS. Additionally, prior gastritis/duodenitis, sinusitis, and pharyngitis/nasopharyngitis were found to be potentially related to PPCS, suggesting a role for chronic inflammation in the pathophysiology and risk of PPCS. These identified risk factors should be further investigated and considered in the management of pediatric mild traumatic brain injury cases.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2022)
Article
Medicine, General & Internal
Carolyn A. McCarty, Douglas F. Zatzick, Lyscha A. Marcynyszyn, Jin Wang, Robert Hilt, Thomas Jinguji, Celeste Quitiquit, Sara P. D. Chrisman, Frederick P. Rivara
Summary: This randomized clinical trial examined the effectiveness of collaborative care treatment for adolescents with persistent postconcussive symptoms in improving symptoms, quality of life, anxiety, and depressive symptoms over 1 year compared to usual care. The findings suggest that collaborative care intervention led to fewer symptoms and better quality of life for adolescents over the course of 1 year. Additionally, delivering the intervention through telehealth broadened the reach of treatment.
Article
Psychology, Clinical
Pauline A. Hendriksen, Pantea Kiani, Johan Garssen, Gillian Bruce, Joris C. Verster
Summary: The study found that during the COVID-19 lockdown, both individuals living alone and together experienced a decrease in mood, but loneliness significantly increased for those living alone. While both groups reported a decrease in perceived immune fitness, only the group living alone reported a significant increase in COVID-19 symptoms presence and severity. Positive correlations were found between perceived immune fitness and mood outcomes with optimism, being active, and the ability to cope with stress.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2021)
Letter
Emergency Medicine
Laura Simone, Roger Zemek, Damian Roland, Mark D. Lyttle, Simon Craig, Stuart R. Dalziel, Jocelyn Gravel, Yaron Finkelstein, Sarah Curtis, Stephen B. Freedman, Amy C. Plint, Suzanne Schuh
EMERGENCY MEDICINE JOURNAL
(2023)
Article
Neurosciences
Eda Cinar, Bradford J. J. McFadyen, Isabelle Gagnon
Summary: This study investigated the role of resource conflict in the dual-task effects on gait and concurrent tasks in children and adolescents. Gait was evaluated with different concurrent tasks, and the effects of condition and type of task on dual-task performance were analyzed. The results showed significant changes in gait parameters and concurrent task performance between single and dual-task conditions, indicating that resource conflict plays a role in dual-task performance.
JOURNAL OF MOTOR BEHAVIOR
(2023)
Article
Gastroenterology & Hepatology
Keon Ma, Samina Ali, Jianling Xie, Claudia Maki, Bonita Lee, Linda Chui, Xiao-Li Pang, Ran Zhuo, Brendon Parsons, Otto Vanderkooi, Naveen Poonai, Shannon E. MacDonald, Phillip Tarr, Stephen B. Freedman
Summary: This study aimed to explore the correlation between pain severity and specific enteropathogens in children with acute gastroenteritis (AGE). The study found that patients with bacterial infections had higher pain scores compared to those with single virus infections or negative stool tests, both before and during the emergency department visit. The study also found that age and fever had a greater impact on children's pain experiences than etiologic pathogens.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Letter
Pediatrics
Francesca del Giorgio, Merieme Habti, Joanna Merckx, Jay S. Kaufman, Jocelyn Gravel, Nelson Piche, Esli Osmanlliu, Olivier Drouin
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Emergency Medicine
Sriram Ramgopal, Jonathan Rodean, Elizabeth R. Alpern, Matt Hall, Pradip P. Chaudhari, Jennifer R. Marin, Samir S. Shah, Stephen B. Freedman, Mohamed Eltorki, Oluwakemi Badaki-Makun, Daniel J. Shapiro, Tara Rhine, Rustin B. Morse, Mark I. Neuman
Summary: This study found that one-fifth of children discharged from the emergency department had an ambulatory follow-up visit within 7 days, and this follow-up was associated with higher subsequent healthcare utilization. These findings highlight the need for further research on the role and costs of routine post-ED visit follow-up.
ACADEMIC EMERGENCY MEDICINE
(2023)
Review
Sport Sciences
Kathryn J. Schneider, Meghan L. Critchley, Vicki Anderson, Gavin A. Davis, Chantel T. Debert, Nina Feddermann-Demont, Isabelle Gagnon, Kevin M. Guskiewicz, K. Alix Hayden, Stanley Herring, Corson Johnstone, Michael Makdissi, Christina L. Master, Rosemarie Scolaro Moser, Jon S. Patricios, Johna K. Register-Mihalik, Paul E. Ronksley, Noah D. Silverberg, Keith Owen Yeates
Summary: This systematic review evaluated interventions for recovery in children, adolescents, and adults with a sport-related concussion (SRC). The results suggest that individualized cervicovestibular rehabilitation may decrease the time to return to sport for adolescents and adults with dizziness, neck pain, and/or headaches lasting more than 10 days. Vestibular rehabilitation may decrease the time to medical clearance for adolescents with vestibular symptoms/impairments. Active rehabilitation and collaborative care may decrease symptoms for adolescents with persisting symptoms lasting more than 30 days.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Editorial Material
Sport Sciences
Kathryn J. Schneider, Jon S. Patricios
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Marie-Eve Bolduc, Janet E. Rennick, Isabelle Gagnon, Eva Sokol, Annette Majnemer, Marie Brossard-Racine
Summary: This study aimed to explore the perspectives of parents of children and adolescents with complex CHD in Canada regarding developmental follow-up. The results revealed that the current developmental follow-up practices may not timely identify challenges, leading to additional burden on parents and affecting parent-child relationships. Parents emphasized the importance of implementing a universal and systematic approach to developmental follow-up to enable timely identification of challenges and promote positive parent-child relationships.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Medicine, Research & Experimental
Stephen Freedman, David Schnadower, Myka Estes, T. Charles Casper, Stuart L. Goldstein, Silviu Grisaru, Andrew T. Pavia, Benjamin Wilfond, Melissa Metheney, Kadyn Kimball, Phillip I. Tarr
Summary: This study aims to determine whether hyperhydration can improve outcomes for children with high-risk STEC infections. A randomized controlled trial will be conducted in 26 pediatric institutions involving 1040 children, with the primary outcome being major adverse kidney events within 30 days. This study is of great importance in determining the efficacy of hyperhydration therapy in reducing complications associated with HUS.
Article
Pediatrics
Francesca del Giorgio, Jocelyn Gravel, Nelson Piche, Olivier Drouin
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Microbiology
Jianling Xie, Kelly Kim, Byron M. Berenger, Linda Chui, Otto G. Vanderkooi, Silviu Grisaru, Stephen B. Freedman
Summary: Advances in diagnostic microbiology have led to faster identification of enteropathogens, which can reduce testing and provide care. This study compared routine microbiologic approaches with the use of the BioFire FilmArray gastrointestinal panel in pediatric patients with acute bloody diarrhea. The BioFire FilmArray group had a significantly shorter time to test result availability (median 3.0 h) compared to the standard-of-care group (median 42.0 h). The use of BioFire FilmArray did not lead to significant improvements in healthcare utilization or outcomes.
MICROBIOLOGY SPECTRUM
(2023)
Editorial Material
Ethics
Benjamin S. Wilfond, Sinem Toraman Turk, Stephanie A. Kraft, Elliott M. Weiss, Philip I. I. Tarr, David Schnadower, Stephen B. Freedman
AMERICAN JOURNAL OF BIOETHICS
(2023)
Article
Medical Laboratory Technology
Madeleine W. Sumner, Todd A. Florin, Nathan Kuppermann, Jianling Xie, Daniel J. Tancredi, Stephen B. Freedman
Summary: This study aimed to evaluate the relationship between SARS-CoV-2 infection and liver injury by comparing transaminase concentrations among children tested for SARS-CoV-2 and other respiratory viruses. The results showed no significant difference in transaminase concentrations between SARS-CoV-2-positive children and those with a negative respiratory viral panel.
CLINICAL BIOCHEMISTRY
(2023)
Article
Virology
Yuanyuan Qiu, Stephen B. Freedman, Sarah Williamson-Urquhart, Ken J. Farion, Serge Gouin, Naveen Poonai, Suzanne Schuh, Yaron Finkelstein, Jianling Xie, Bonita E. Lee, Linda Chui, Xiaoli Pang
Summary: Acute gastroenteritis (AGE) is a major cause of morbidity and mortality in children under 5 years of age worldwide. Norovirus, rotavirus, and enteric adenovirus are leading viral causes of pediatric AGE. This study found that norovirus had a significantly lower viral load compared to rotavirus and adenovirus on the day of enrollment, but had a higher viral load on days 5 and 28. Norovirus was detected in the stool for the longest duration compared to rotavirus and adenovirus.