Article
Pharmacology & Pharmacy
Afnan Harb, Mahmoud H. Elbatreek, Ahmed Elshahat, Nadia El-Akabawy, Waleed Barakat, Nesreen MIM. Elkomy
Summary: This study reveals the potential of alagebrium in the treatment of diabetic foot ulcer (DFU), as it promotes wound healing, improves sensory function and gait, reduces inflammation, and enhances angiogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
Andreas Kerstan, Kathrin Dieter, Elke Niebergall-Roth, Sabrina Klingele, Michael Junger, Christoph Hasslacher, Georg Daeschlein, Lutz Stemler, Ulrich Meyer-Pannwitt, Kristin Schubert, Gerhard Klausmann, Titus Raab, Matthias Goebeler, Korinna Kraft, Jasmina Esterlechner, Hannes M. Schroder, Samar Sadeghi, Seda Ballikaya, Martin Gasser, Ana M. Waaga-Gasser, George F. Murphy, Dennis P. Orgill, Natasha Y. Frank, Christoph Ganss, Karin Scharffetter-Kochanek, Markus H. Frank, Mark A. Kluth
Summary: This study suggests that GMP-manufactured ABCB5(+) dermal mesenchymal stem cells might be a safe adjunctive therapy for incurable diabetic foot ulcers. The results from mouse models and clinical trials demonstrate the efficacy of these stem cells in promoting wound healing and restoring blood perfusion.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Kyeong Mi Kim, Hyun-Ju An, Sang-Hoon Kim, JuHee Kim, Changgon Sim, Jaemin Lee, Sin Hyung Park, Hyun Il Lee, Inseok Jang, Soonchul Lee
Summary: This study aimed to investigate the angiogenic potential of pericytes in diabetes-induced wounds. The results showed that pericytes enhanced vascularization and promoted wound healing. Therefore, pericyte transplantation may be a suitable treatment option for ischemic foot ulcers.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Multidisciplinary Sciences
Suriadi Jais, Kharisma Pratama
Summary: Indonesia is facing challenges in controlling the burden of diabetic foot ulcers, and a nursing care management approach is needed to accurately monitor wound healing progress. This literature review identified five assessment tools for chronic wounds, with the DMIST tool receiving sufficient rating for its predictive validity and responsiveness.
Article
Medicine, General & Internal
Yu-Chi Wang, Hsiao-Chen Lee, Chien-Lin Chen, Ming-Chun Kuo, Savitha Ramachandran, Rong-Fu Chen, Yur-Ren Kuo
Summary: The study found that silver-releasing foam dressings were more effective in promoting wound healing of diabetic foot ulcers compared to silver-containing cream, particularly in the initial three weeks of treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Golnaz Mahmoudvand, Arian Karimi Rouzbahani, Zahra Sadat Razavi, Mohamad Mahjoor, Hamed Afkhami
Summary: Diabetic foot ulcer (DFU) is a severe complication of diabetes mellitus (DM) that can lead to amputation. The wound-healing process is impaired in diabetic patients, making conventional treatments ineffective. Mesenchymal stem cells (MSCs) have gained attention for their potential in improving wound healing. MSC therapy improves healing in DFU through immunomodulation, differentiation, and angiogenesis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jessica Da Silva, Ermelindo C. Leal, Eugenia Carvalho, Eduardo A. Silva
Summary: The imbalance of local and systemic factors in individuals with diabetes mellitus delays wound healing and leads to diabetic foot ulceration. Biomaterial-based wound dressings with unique properties may be used as a therapeutic strategy for chronic wound healing and DFU management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Lisa J. Gould, Dennis P. Orgill, David G. Armstrong, Robert D. Galiano, Paul M. Glat, Charles M. Zelen, Lawrence A. DiDomenico, Marissa J. Carter, William W. Li
Summary: This study demonstrated the benefits of processed microvascular tissue allograft in promoting wound closure, reducing time to healing, and improving local neuropathy in diabetic foot ulcer patients. Further exploration of its effects on regional neuropathy and perfusion endpoints is warranted.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Frank P. P. Guerriero, Robyn A. A. Clark, Michelle Miller, Christopher L. L. Delaney
Summary: This single-center prospective observational study assesses the impact of bilayer biodegradable synthetic matrix technology (NovoSorb BTM) on the healing and amputation rates of patients with diabetes-related foot ulceration. The results suggest that NovoSorb BTM is a safe and effective treatment for moderate to severe diabetes-related foot ulceration.
Article
Biochemistry & Molecular Biology
Changhong Chen, Qinghua Wang, Daibin Li, Zhijian Qi, Yaofei Chen, Shanzheng Wang
Summary: This study found that exosomes isolated from platelet-rich plasma (PRP-exos) can serve as an optimized therapeutic strategy in treating diabetic foot ulcers (DFUs). The researchers aimed to investigate the role of MALAT1 in DFU wound healing through PRP-exos treatment and explore the underlying mechanism.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Endocrinology & Metabolism
Mona Mohamed Ibrahim Abdalla, Jaiprakash Mohanraj, Sushela Devi Somanath
Summary: The global burden of diabetic foot ulcers (DFUs) is a significant public health concern, affecting millions of people worldwide. One promising therapeutic approach is the use of adiponectin, a hormone primarily produced and secreted by adipose tissue, which has demonstrated anti-inflammatory and anti-atherogenic properties and potential therapeutic applications in the treatment of DFUs.
WORLD JOURNAL OF DIABETES
(2023)
Article
Endocrinology & Metabolism
Tangtang He, Pengfei Sun, Bo Liu, Shiwei Wan, Penghua Fang, Jun Chen, Guicheng Huang, Wen Min
Summary: The study found that puffball spores can accelerate diabetic wound healing by activating the Akt/Nrf2 signaling pathway, promoting the expression of antioxidant genes, and enhancing angiogenesis and collagen deposition. This provides a theoretical basis for the treatment of diabetic and refractory wounds.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ching-Wen Lin, Chien-Min Hung, Wan-Jiun Chen, Jui-Ching Chen, Wen-Yen Huang, Chia-Sing Lu, Ming-Liang Kuo, Shyi-Gen Chen
Summary: Diabetic foot ulcers are costly and problematic complications of diabetes. The chronicity of these ulcers presents a challenge in treatment. Modulating the activity of M1 and M2 macrophages seems to be an effective approach in improving the healing process of DFUs.
Article
Computer Science, Information Systems
Angela Shin-Yu Lien, Chen-Yao Lai, Jyh-Da Wei, Hui-Mei Yang, Jiun-Ting Yeh, Hao-Chih Tai
Summary: An AI detection model was developed to identify the growth of granulation tissue in DM foot ulcers, showing promising results in accurately detecting granulation tissue areas and serving as an important indicator for assessing wound healing progress.
Review
Dermatology
Louise Hitchman, Joshua Totty, George E. Smith, Daniel Carradice, Maureen Twiddy, Cynthia Iglesias, David Russell, Ian C. Chetter
Summary: Emerging evidence suggests that ESWT may improve time to DFU healing, but the certainty of its effectiveness is low, limiting its translation into routine clinical practice.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Endocrinology & Metabolism
Zexu Dang, Davide Maselli, Gaia Spinetti, Elena Sangalli, Franco Carnelli, Francesco Rosa, Elena Seganfreddo, Fabio Canal, Anna Furlan, Agostino Paccagnella, Emanuela Paiola, Bruno Lorusso, Claudia Specchia, Mattia Albiero, Roberta Cappellari, Angelo Avogaro, Angela Falco, Federico Quaini, Kepeng Ou, Iker Rodriguez-Arabaolaza, Costanza Emanueli, Maria Sambataro, Gian Paolo Fadini, Paolo Madeddu
Article
Cell Biology
Letizia Ferroni, Chiara Gardin, Andrea De Pieri, Maria Sambataro, Elena Seganfreddo, Elisabetta Iacopi, Chiara Goretti, Barbara Zavan, Alberto Piaggesi
EUROPEAN JOURNAL OF HISTOCHEMISTRY
(2017)
Article
Endocrinology & Metabolism
David Ferland-McCollough, Davide Maselli, Gaia Spinetti, Maria Sambataro, Niall Sullivan, Ashley Blom, Paolo Madeddu
Article
Biochemistry & Molecular Biology
Maria Sambataro, Luisa Sambado, Enrica Trevisiol, Matilde Cacciatore, Anna Furlan, Piero Maria Stefani, Elena Seganfreddo, Elisabetta Durante, Stefania Conte, Silvia Della Bella, Agostino Paccagnella, Angelo Paolo dei Tos
Correction
Endocrinology & Metabolism
Giuseppe Mangialardi, David Ferland-McCollough, Davide Maselli, Marianna Santopaolo, Andrea Cordaro, Gaia Spinetti, Maria Sambataro, Niall Sullivan, Ashley Blom, Paolo Madeddu
Article
Endocrinology & Metabolism
Giuseppe Mangialardi, David Ferland-McCollough, Davide Maselli, Marianna Santopaolo, Andrea Cordaro, Gaia Spinetti, Maria Sambataro, Niall Sullivan, Ashley Blom, Paolo Madeddu
Article
Endocrinology & Metabolism
Marianna Santopaolo, Maria Sambataro, Gaia Spinetti, Paolo Madeddu
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2020)
Article
Endocrinology & Metabolism
Gaia Spinetti, Elena Sangalli, Elena Tagliabue, Davide Maselli, Ornella Colpani, David Ferland-McCollough, Franco Carnelli, Patrizia Orlando, Agostino Paccagnella, Anna Furlan, Piero Maria Stefani, Luisa Sambado, Maria Sambataro, Paolo Madeddu
Article
Pediatrics
Alessandra Mauri, Susanna Schmidt, Valentina Sosero, Maria Sambataro, Laura Nollino, Francesco Fabris, Anna Coro, Antonella Scantamburlo, Maria L. Marcon, Michela Cazziola-Merlotto, Tania Ciani, Michele Tessarin, Agostino Paccagnella
Summary: The Pediatric Education for Type 1 Diabetes (PED) project, tailored for children and adolescents aged 6 to 16, showed positive impact on improving knowledge, self-management, and wellbeing for young patients with Type 1 diabetes. The collaborative model between pediatric and adult diabetologists seemed to be effective in addressing transitional care.
MINERVA PEDIATRICS
(2021)
Article
Pharmacology & Pharmacy
M. Persano, L. Nollino, M. Sambataro, M. Rigato, I Negro, S. Marchetto, A. Paccagnella
Summary: This study examined the efficacy of degludec/liraglutide combination therapy in type 2 diabetes patients, finding that it significantly lowered HbA1c and body weight after 6 months while reducing total daily insulin units and improving patients' quality of life satisfaction.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Health Care Sciences & Services
Laura Nollino, Maria Lisa Marcon, Edward Kiwanuka, Michela Merlotto-Cazziola, Maria Sambataro, Luisa Sambado, Enrica Trevisiol, Antonella Scantamburlo, Alessandra Mauri, Enrico Busato, Roberta Pirolo, Massimo Boaretto, Licia Turolla, Pietro Paolo Faronato, Marco Cadamuro-Morgante, Roberta Migot, Agostino Paccagnella
QUALITY MANAGEMENT IN HEALTH CARE
(2019)
Article
Gastroenterology & Hepatology
Agostino Paccagnella, Maria L. Marcon, Carla Baruffi, Marta Giometto, Alessandra Mauri, Claudia Vigo, Antonella Scantamburlo, Luisa Sambado, Maria Sambataro, Enrica Trevisiol, Daniela Zanin, Helena Salvat Heras, Maria C. De Marco
MINERVA GASTROENTEROLOGICA E DIETOLOGICA
(2016)
Article
Endocrinology & Metabolism
Yaling Tang, Hetal Shah, Carlos Roberto Bueno Junior, Xiuqin Sun, Joanna Mitri, Maria Sambataro, Luisa Sambado, Hertzel C. Gerstein, Vivian Fonseca, Alessandro Doria, Rodica Pop-Busui
Summary: This study confirmed the benefits of intensive glycemic therapy and for the first time demonstrated a similar benefit of intensive blood pressure control in preventing CAN in T2D patients. Patients with no history of CVD particularly benefit from intensive glycemic control for CAN prevention.
Article
Peripheral Vascular Disease
Maria Sambataro, Elena Seganfreddo, Fabio Canal, Anna Furlan, Laura del Pup, Monia Niero, Agostino Paccagnella, Filippo Gherlinzoni, Angelo Paolo dei Tos
INTERNATIONAL JOURNAL OF VASCULAR MEDICINE
(2014)