Article
Nanoscience & Nanotechnology
Shan He, Huangding Wen, Nannan Yao, Lu Wang, Junqun Huang, Zhiqing Li
Summary: The composite nano-sustained release system, TTO-NL@PCS, has potential for accelerating the healing of diabetic and MRSA-infected wounds. It disperses biofilms and kills MRSA through the stable and slow release of tea tree oil. Additionally, it improves inflammatory response and wound healing.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hanif Haidari, Richard Bright, Sanjay Garg, Krasimir Vasilev, Allison J. Cowin, Zlatko Kopecki
Summary: The development of highly potent ultrasmall AgNPs combined with a biocompatible hydrogel has shown promising results in eliminating mature biofilm infections in vivo and promoting wound healing. The treatment exhibited superior antibacterial efficacy and improved wound closure, re-epithelization, and collagen deposition compared to conventional silver-based treatments.
Article
Infectious Diseases
Ilaria Cavallo, Ilaria Lesnoni La Parola, Francesca Sivori, Luigi Toma, Tatiana Koudriavtseva, Isabella Sperduti, Daniela Kovacs, Giovanna D'Agosto, Elisabetta Trento, Norma Cameli, Anna Mussi, Alessandra Latini, Aldo Morrone, Fulvia Pimpinelli, Enea Gino Di Domenico
Summary: This study analyzed clinical data and laboratory parameters of patients with infected and noninfected chronic venous leg ulcers (VU). The results showed that infected ulcers had increased size and depth and higher levels of inflammatory cytokines. Hyperhomocysteinemia was more common in infected ulcers, and Gram-negative bacteria and strong biofilm producers were predominant in the infection.
Article
Engineering, Environmental
Junyao Song, Haoyu Chen, Yaqian Lv, Wanqun Yang, Fenglang Zhang, Tianyi Wang, Danping Liu, Yingshan Qu, Lei Han, Jun Fu, Xiaoying Kong
Summary: This study developed a hybrid single atom nanozyme material composed of Zn single-atom catalysts and copper peroxide, which exhibited superior antibacterial properties and therapeutic effects for the treatment of biofilm-infected wounds.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Tara Pourseif, Robabehbeygom Ghafelehbashi, Mohammadreza Abdihaji, Niloufar Radan, Ehsan Kaffash, Maryam Heydari, Maryam Naseroleslami, Neda Mousavi-Niri, Iman Akbarzadeh, Qun Ren
Summary: This study aims to develop a niosomal platform for the delivery of TCH to treat bacterial infections in wounds. Chitosan was used to obtain controlled drug release and antibacterial activity. The optimized TCH-Nio showed a controlled release rate, and TCH-Nio@CS, with chitosan coating, exhibited 2-fold higher antibacterial activity compared to TCH-Nio. The formulated niosomes showed no in vitro toxicity towards human cells and down-regulated biofilm genes in tested bacteria.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Endocrinology & Metabolism
Nicole Lafontaine, Jane Jolley, Mervyn Kyi, Sophie King, Laura Iacobaccio, Eva Staunton, Brent Wilson, Catherine Seymour, Sonja Rogasch, Paul Wraight
Summary: This study aimed to assess whether silver dressings in acute diabetes-related foot ulcers increased the proportion of ulcers healed. The results showed that silver dressings did not improve wound healing or reduce the need for antibiotics compared with non-silver dressings.
Article
Pharmacology & Pharmacy
Nashath Kalangadan, Aarcha Shanmugha Mary, Kaushik Mani, Biplab Nath, Jayalalitha Kondapalli, Swati Soni, Vikram Srinivasa Raghavan, Rajesh Parsanathan, Meganathan Kannan, David Jenkins, Sai Siva Gorthi, Kaushik Rajaram
Summary: Microbial colonization is a common cause of delayed or non-healing wounds. Researchers have developed composite nanofibers using the repurposed drugs ivermectin and ciprofloxacin, and found that these nanofibers can effectively control wound infections and promote wound healing in vitro and in ovo models. The composite nanofibers disintegrate biofilms and enhance fibroblast cell migration and angiogenesis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Savannah M. Aitcheson, Francesca D. Frentiu, Sheree E. Hurn, Katie Edwards, Rachael Z. Murray
Summary: Macrophages play a crucial role in wound healing, but in individuals with diabetes, these cells are dysfunctional, hindering the healing process and potentially leading to the formation of diabetic foot ulcers. Understanding macrophage dysregulation in DFUs and developing better therapies can improve healing rates in these patients.
Article
Endocrinology & Metabolism
Tangtang He, Pengfei Sun, Bo Liu, Shiwei Wan, Penghua Fang, Jun Chen, Guicheng Huang, Wen Min
Summary: The study found that puffball spores can accelerate diabetic wound healing by activating the Akt/Nrf2 signaling pathway, promoting the expression of antioxidant genes, and enhancing angiogenesis and collagen deposition. This provides a theoretical basis for the treatment of diabetic and refractory wounds.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Yen-Hsi Lin, Yen-Chin Chen, Kuo-Sheng Cheng, Po-Jui Yu, Jiun-Ling Wang, Nai-Ying Ko
Summary: This study found a positive correlation between higher periwound temperatures and better wound healing, as well as a link between higher malnutrition scores and poor wound healing. Multivariate analysis showed that changes in periwound temperature can be a useful indicator for predicting pressure ulcer healing outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biophysics
Karan Razdan, Shashi Kanta, Ekta Chaudhary, Seema Kumari, Deepak Kumar Rahi, Ashok Kumar Yadav, Vivek Ranjan Sinha
Summary: The study developed and characterized levofloxacin-loaded clove oil nanoscale emulgel and evaluated its therapeutic efficacy in Pseudomonas aeruginosa biofilm-infected burn wounds in mice. The results showed that the emulgel dispersed biofilms, closed wounds, promoted re-epithelialization and collagen deposition, and cleared the infection within 7 days, indicating its effectiveness in treating biofilm-infected burn wounds.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Pharmacology & Pharmacy
Thambirajoo Maheswary, Asma Abdullah Nurul, Mh Busra Fauzi
Summary: The diversity of normal flora on human skin varies between individuals and parts of the skin. A symbiotic relationship has been formed over time between humans and normal flora. In chronic wounds, particularly in patients with diabetes, the conditions become favorable for microbes to colonize and establish infections within the skin. Antibiotics and wound dressings are the targeted therapy to treat chronic wounds, although prolonged usage may lead to ineffectiveness or resistance. Further studies are needed to comprehensively understand the role of human skin normal flora in chronic injuries at the cellular and molecular level.
Article
Engineering, Environmental
Mingming Qin, Yanqiu Guo, Feifei Su, Xiaopeng Huang, Qiuping Qian, Yunlong Zhou, Jingye Pan
Summary: The development of functional medical dressings with mechanical designability is essential for tissue repair. However, existing liquid or gel dressings have limitations in terms of mechanical properties and antimicrobial biofilm, hindering their applications in emergency cases. In this study, a nanocomposite hydrogel dressing was developed, incorporating gold nanorods and Ca2+ into polyacrylic acid and polyvinyl alcohol, resulting in a double network structure with high toughness and excellent fatigue resistance. The hydrogel dressings exhibited good biocompatibility, self-healing function, and efficient elimination of bacterial biofilm. Moreover, the dressing was found to promote wound healing in vivo.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Microbiology
Mei Li, Hong Xiao, Yongmei Su, Danlin Cheng, Yan Jia, Yingli Li, Qi Yin, Jieying Gao, Yong Tang, Qunhua Bai
Summary: Prevention and control of infections have become a formidable challenge due to the increasing resistance of pathogens to antibiotics. Probiotics have been discovered to have positive effects on the host, and it is well-known that some Lactobacilli are effective in treating and preventing inflammatory and infectious diseases. The study developed an antibacterial formulation consisting of honey and Lactobacillus plantarum. The formulation showed antimicrobial effects and mechanisms in vitro, as well as a healing effect on skin infections in rats.
Article
Biology
Zhuang Liu, Letian Zhang, Maria A. Toma, Dongqing Li, Xiaowei Bian, Irena Pastar, Marjana Tomic-Canic, Pehr Sommar, Ning Xu Landen
Summary: This study identified 17 pathologically relevant miRNAs that are involved in chronic wound pathology and showed their high cooperativity. By targeting these miRNAs, innovative wound treatments with higher efficacy and specificity could be developed.
Article
Surgery
Agata Janowska, Giovanni Papa, Marco Romanelli, Giulia Davini, Teresa Oranges, Chiara Stocco, Zoran Marji Arnez, Valentina Dini
Summary: Treatment with 5% Lidocaine Cream for 14 days resulted in reduced pain intensity in painful wounds, showing high safety and tolerability.
JOURNAL OF INVESTIGATIVE SURGERY
(2022)
Article
Dermatology
Francesco Faita, Teresa Oranges, Nicole Di Lascio, Francesco Ciompi, Saverio Vitali, Giacomo Aringhieri, Agata Janowska, Marco Romanelli, Valentina Dini
Summary: This study presented a potential new method for the differential diagnosis of malignant melanoma from melanocytic naevi using ultra-high-frequency ultrasound and machine learning techniques. The combination of PCA and a weighted k-nearest neighbour classifier achieved a high accuracy rate of 76.9% and promising results in terms of sensitivity and specificity.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Agata Janowska, Giulia Davini, Marco Romanelli, Oranges Teresa, Iannone Michela, Valentina Dini
Summary: This study aimed to evaluate the bacterial environment on wound beds using fluorescence and color captured by MolecuLight i:X device and correlate them with average pH values and wound bed scores. Significant associations were found between fluorescence and pH values, and MolecuLight i:X was able to objectively detect bacterial proliferation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2023)
Article
Dermatology
Alessandra Michelucci, Flavia Manzo Margiotta, Salvatore Panduri, Annalisa Tonini, Marco Romanelli, Riccardo Morganti, Agata Janowska, Valentina Dini
Summary: Guselkumab, a monoclonal antibody that blocks the p19 subunit of IL-23, has demonstrated high efficacy and safety in the treatment of psoriasis. This retrospective cohort study confirms the long-term effectiveness and tolerability of Guselkumab in improving psoriasis symptoms.
DERMATOLOGIC THERAPY
(2022)
Letter
Infectious Diseases
Angelo Massimiliano D'Erme, Cristian Fidanzi, Agata Janowska, Valentina Dini, Marco Romanelli, Vanna Zucchi, Paolo Viacava, Giovanni Bagnoni
SEXUALLY TRANSMITTED INFECTIONS
(2022)
Letter
Infectious Diseases
Angelo Massimiliano D'Erme, Cristian Fidanzi, Giovanni Bagnoni, Simone Pardossi, Flavia Manzo Margiotta, Agata Janowska, Valentina Dini, Marco Romanelli
SEXUALLY TRANSMITTED INFECTIONS
(2022)
Article
Dermatology
Cristian Fidanzi, Giulia Davini, Valentina Dini, Giammarco Granieri, Antonella Vietina, Marco Romanelli, Agata Janowska
Summary: Squamous cell carcinoma is a rare and malignant skin cancer, with bone infiltration and invasion of the dura mater being uncommon. This article describes the management of advanced scalp squamous cell carcinoma involving bones and meninges. The patient received palliative care and various dressings were used to control wound exudate and infection.
WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
(2022)
Article
Parasitology
Teresa Oranges, Stefano Veraldi, Giammarco Granieri, Cristian Fidanzi, Agata Janowska, Valentina Dini, Marco Romanelli
Summary: A wide range of parasites can infect wounds or cause wounds through infection. Proper wound treatment is essential to reduce pathological scars and prevent complications, and the use of appropriate debridement, topical antiseptics, and dressings can help control infection, moisture, inflammation, and promote wound edge proliferation.
Article
Dermatology
Michela Iannone, Agata Janowska, Salvatore Panduri, Riccardo Morganti, Giulia Davini, Marco Romanelli, Valentina Dini
Summary: The interaction between the immunological and nervous system in the skin has a significant impact on patients with psoriasis, atopic dermatitis, and hidradenitis suppurativa. Psychodermatological interventions can improve quality of life, disease flare-ups, and long-term management for these patients.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Raimondo Arena, Maria Grazia Strazzeri, Tommaso Bianchi, Angela Peghetti, Yuri Merli, Diego Abbenante, Diletta Olivari
Summary: This study evaluated the clinical efficacy of a hypericum and neem oil dressing in patients with dehiscence of surgical wounds with critical colonisation/infection. The results showed similar outcomes in terms of resolution of inflammatory/infective symptoms between the experimental group and the control group. However, the experimental group demonstrated significant pain reduction compared to the control group.
JOURNAL OF WOUND CARE
(2022)
Review
Public, Environmental & Occupational Health
Vincenzo Puro, Nicola Coppola, Andrea Frasca, Ivan Gentile, Francesco Luzzaro, Angela Peghetti, Gabriele Sganga
Summary: Healthcare-associated infections are a significant problem for healthcare facilities, and can be prevented through effective Infection Prevention and Control measures. This article provides a practical guide for healthcare organizations, physicians, and nursing staff on implementing these measures to improve the quality and safety of care and protect patients, facilities, and healthcare providers.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Review
Dermatology
Marco Romanelli, Flavia Manzo Margiotta, Alessandra Michelucci, Giammarco Granieri, Agata Janowska, Valentina Dini
Summary: Compression therapy provides valuable support for vascular and inflammatory lower leg skin disorders. Recent findings show its potential benefits in treating atypical wounds and improvements in adherence to treatment. Physicians should be aware of the advantages of compression therapy in managing skin diseases.
CURRENT DERMATOLOGY REPORTS
(2023)
Article
Medicine, General & Internal
Alessandra Michelucci, Valentina Dini, Giorgia Salvia, Giammarco Granieri, Flavia Manzo Margiotta, Salvatore Panduri, Riccardo Morganti, Marco Romanelli
Summary: This study used ultra-high-frequency ultrasound to monitor the changes in nail bed and matrix in patients with psoriatic onychopathy during monoclonal antibody treatment. The results showed a significant decrease in some parameters after treatment. Therefore, ultra-high-frequency ultrasound could be a valuable technique for evaluating and monitoring psoriatic onychopathy.
Article
Dermatology
Michela Iannone, Giorgia Salvia, Cristian Fidanzi, Matteo Bevilacqua, Agata Janowska, Riccardo Morganti, Marco Romanelli, Valentina Dini
Summary: This study aimed to assess the correlation between serum amyloid A (SAA) levels and various factors in Hidradenitis suppurativa (HS) patients. The results showed that SAA levels were associated with number of nodules, abscesses, fistulas, and severe IHS4. Gluteal localization was also correlated with high values of mSartorius and severe IHS4. Therefore, monitoring SAA levels in HS patients is recommended to prevent disease flare-ups and potential complications.
SKIN APPENDAGE DISORDERS
(2023)
Letter
Dermatology
Christos C. Zouboulis, Errol P. Prens, Christopher J. Sayed, Alejandro Molina-Leyva, Vincenzo Bettoli, Marco Romanelli, Jacek C. Szepietowski, Angela Llobet Martinez, Torben Kasparek, Iryna Lobach, Magdalena B. Wozniak, Christine-Elke Ortmann, Nicolas Thomas, Teresa Bachhuber, Shoba Ravichandran, Thrasyvoulos Tzellos
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)