Article
Otorhinolaryngology
Michael J. C. Schachtel, Mitesh Gandhi, James J. Bowman, Sandro Porceddu, Benedict J. Panizza
Summary: This study examined patients with perineural spread of cutaneous squamous cell carcinoma of the head and neck. The results showed that most patients had recurrent disease (89.0%) and simultaneous trigeminal nerve involvement (67.1%). Surgery and post-operative radiotherapy were the main treatments, and early-stage disease and clear surgical margins improved outcomes.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Otorhinolaryngology
Erin R. Cohen, Carly Misztal, Cortney Dable, Carmen Gomez-Fernandez, Rita G. Bhatia, Patrick Roth, Ruixuan Ma, Samuel Trosman, Carlos Green, Elizabeth Nicolli, Christine T. Dinh, Zoukaa B. Sargi
Summary: Perineural invasion (PNI) in head and neck cutaneous squamous cell carcinoma (HNcSCC) has a negative impact on disease-specific survival. Facial weakness and positive margins are high-risk factors for histopathologic PNI, while multiple nerve involvement and advanced tumor stage are associated with worse survival.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Oncology
Nicole N. Scheff, Alexandria L. Harris, Jinhong Li, Nicole L. Horan, Mark W. Kubik, Seungwon W. Kim, Marci L. Nilsen
Summary: This study examined the prevalence and predictors of perineural invasion (PNI) in head and neck cancer (HNC) patients, stratified by tumor site. The results showed that PNI was associated with pretreatment pain and tumor stage, highlighting the importance of considering tumor location in investigating targeted therapies for tumor regression.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Priscila O. de Lima, Natasa Broit, Johnson D. Huang, Jae H. Lim, Damien J. Gardiner, Ian S. Brown, Benedict J. Panizza, Glen M. Boyle, Fiona Simpson
Summary: Cutaneous squamous cell carcinoma of the head and neck (cSCCHN) can metastasize by invading nerves and spread toward the central nervous system. This study describes a complementary whisker pad model for investigating drivers of perineural invasion (PNI) and spread (PNS) in the head and neck environment. The results demonstrate the utility of this model for studying tumor growth and PNI, as well as its potential for use in combination with the established sciatic nerve model.
FRONTIERS IN ONCOLOGY
(2023)
Article
Otorhinolaryngology
James Nightingale, Mitesh Gandhi, Jonathan Helena, James Bowman, Margaret McGrath, Jermaine Coward, Sandro Porceddu, Rahul Ladwa, Benedict Panizza
Summary: This case series demonstrates the efficacy of anti-PD-1 checkpoint inhibitor therapy for perineural spread, supporting the need for future prospective clinical trials in this patient population.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Genetics & Heredity
Pavel Hurnik, Zuzana Chyra, Tereza Sevcikova, Jan Stembirek, Katerina Smesny Trtkova, Daria A. Gaykalova, Marcela Buchtova, Eva Hruba
Summary: Carcinomas of the oral cavity and oropharynx are among the ten most common malignancies in human population, with prognosis determined by invasiveness and metastasis. This article reviews epigenetic changes associated with HNSCC, focusing on perineural invasion, and other factors like tobacco, alcohol, and oral microbiome.
FRONTIERS IN GENETICS
(2022)
Article
Otorhinolaryngology
Theodore A. Gobillot, Matthew Greer, Upendra Parvathaneni, Jay J. Liao, George E. Laramore, Peter Goff, Kent Wallner, Cristina P. Rodriguez, Jeffrey J. Houlton, Brittany R. Barber, Neal D. Futran, Zain H. Rizvi
Summary: In this study, the treatment outcomes of high-risk and low-risk PNI patients with HNSCC were retrospectively reviewed. The results showed that recurrence occurred in 31% of high-risk patients and 17% of low-risk patients. High local control rates of 75% were achieved in high-risk patients who underwent surgery followed by RT or elective neural RT, indicating the efficacy of appropriate radiotherapy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Medicine, Research & Experimental
Michael P. Wu, Katherine L. Reinshagen, Mary B. Cunnane, Sophia Z. Shalhout, Howard L. Kaufman, David Miller, Kevin S. Emerick
Summary: This study retrospectively reviewed cases of patients with head and neck cSCC treated with ICI, showing that ICI therapy is a feasible option for patients with cPNI. The study found a correlation between radiographic and clinical evidence of response, with improvement in neuropathic pain being a sensitive clinical marker of response.
Article
Surgery
Daniel Phung, Navid Ahmadi, Ruta Gupta, Jonathan R. Clark, James Wykes, Sydney Ch'ng, Michael S. Elliott, Carsten E. Palme, Kerwin Shannon, Raymond Wu, Jenny H. Lee, Tsu-Hui (Hubert) Low
Summary: This study retrospectively analyzed the treatment experience and survival outcomes of patients with head and neck cutaneous squamous cell carcinoma and perineural spread. The results showed that surgery combined with adjuvant radiotherapy can improve the survival rate of patients, and surgical treatment with involved margins had similar outcomes to definitive radiotherapy.
ANZ JOURNAL OF SURGERY
(2022)
Review
Ophthalmology
Jessica Y. Tong, Shyamala C. Huilgol, Craig James, Saul Rajak, Dinesh Selva
Summary: This review discusses and summarizes the risks and radiological features of PNI in periocular SCC, and introduces the optimal diagnostic and treatment methods, including surgical excision, radiotherapy, and immunotherapy as a novel treatment alternative.
Article
Oncology
Grace Sora Ahn, Brian Hinds, Frederic Kolb, Amy K. Reisenauer, Seaver L. Soon, Ali R. Sepahdari, Kathryn B. Bollin, Soo J. Park
Summary: For patients with neuropathic symptoms from cutaneous neurotropic carcinomas of the head and neck, an expanded diagnostic evaluation is necessary to ensure timely and appropriate management based on individual priorities, comorbidities, and prognosis. Additionally, when utilizing immune checkpoint inhibitors as a treatment modality, the potential for immune-related adverse events should be taken into consideration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Neslisah Barlak, Gulnur Kusdemir, Rasim Gumus, Betul Gundogdu, Mehmet Hakan Sahin, Arzu Tatar, Michael Ittmann, Omer Faruk Karatas
Summary: This study found that the upregulation of POFUT1 promotes the development and aggression of HNSCC, suggesting its potential as a prognostic marker and therapeutic target for head and neck cancer patients.
CELL BIOLOGY INTERNATIONAL
(2023)
Review
Oncology
Flora Yan, Brittny N. Tillman, Rajiv I. Nijhawan, Divya Srivastava, David J. Sher, Vladimir Avkshtol, Jade Homsi, Justin A. Bishop, Erin M. Wynings, Rebecca Lee, Larry L. Myers, Andrew T. Day
Summary: The current state of high-risk head and neck cutaneous squamous cell carcinoma (HNcSCC) is poorly characterized due to the rapidly evolving nature of the field. Clinical and pathologic risk factors for adverse outcomes are nuanced, leading to challenges in treatment and staging systems. Population-based registries tracking updated, nuanced risk factors and outcomes are needed to guide the development of improved staging systems, along with more randomized controlled trials to evaluate treatment methods.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Moran Amit, Chuan Liu, Jobran Mansour, Frederico O. Gleber-Netto, Samantha Tam, Erez N. Baruch, Mohamed Aashiq, Adel K. El-Naggar, Amy C. Moreno, David I. Rosenthal, Bonnie S. Glisson, Renata Ferrarotto, Michael K. Wong, Kenneth Tsai, Elsa R. Flores, Michael R. Migden, Deborah A. Silverman, Goujun Li, Anshu Khanna, Ryan P. Goepfert, Priyadharsini Nagarajan, Randal S. Weber, Jeffrey N. Myers, Neil D. Gross
Summary: The study showed that elective neck dissection (END) did not improve survival rates for patients with cutaneous squamous cell carcinoma (cSCC) of the head and neck and no evidence of regional metastasis. Further research is needed to clarify the role of END in patients with advanced disease.
Review
Medicine, Research & Experimental
Olga Medvedev, Mihaela Hedesiu, Anca Ciurea, Manuela Lenghel, Horatiu Rotar, Cristian Dinu, Rares Roman, Dragos Termure, Csaba Csutak
Summary: This article reviews the literature on perineural spread in head-and-neck tumors, summarizes important information for diagnostic imaging, and discusses the pathogenesis, clinical signs, prognostic importance, and technical considerations for computer tomography and magnetic resonance imaging. The anatomical pathways of the cranial nerves and main checkpoints are also synthesized, emphasizing the significance of perineural spread as important clues for differential diagnosis.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Otorhinolaryngology
Howard Yu-hao Liu, Christopher P. Daniels, Yuvnik Trada, Anne Bernard, Kyung Ha You, Elizabeth Brown, Matthew Foote, Margaret McGrath, Rahul Ladwa, Benedict James Panizza, Sandro Virgilio Porceddu
Summary: The study found that current smokers with HPV-associated OPC had poorer overall survival and progression-free survival compared to never and former smokers, but smoking status did not predict cancer-specific survival.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Biochemistry & Molecular Biology
James Nightingale, Benedict Lum, Rahul Ladwa, Fiona Simpson, Benedict Panizza
Summary: The natural history of adenoid cystic carcinoma (ACC) is characterized by treatment failure due to locoregional recurrence and distant metastases. Recent research indicates that ACC is resistant to immune checkpoint inhibition. Targeting PSMA and receptor manipulation may be potential directions for future therapeutic approaches in ACC.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Oncology
S. E. Emmett, M. S. Stark, N. Pandeya, B. Panizza, D. C. Whiteman, A. Antonsson
Summary: This study found that certain miRNAs could serve as prognostic tools in patients with mucosal squamous cell carcinomas of the head and neck (HNSCC), particularly those associated with HPV status. These miRNAs have the potential to predict the clinical course of patients with HNSCC.
Article
Surgery
Michael J. C. Schachtel, Mitesh Gandhi, James J. Bowman, Christopher Erian, Sandro V. Porceddu Section, Benedict J. Panizza
Summary: This study reviewed the management of temporal and peritemporal bone malignancies in Queensland, Australia, finding that the majority of cases were secondary cutaneous malignancies. Achieving clear margins of resection through surgery is crucial for optimizing survival outcomes.
ANZ JOURNAL OF SURGERY
(2021)
Article
Oncology
Corey Smith, Margaret McGrath, Michelle A. Neller, Katherine K. Matthews, Pauline Crooks, Laetitia Le Texier, Benedict Panizza, Sandro Porceddu, Rajiv Khanna
Summary: This study presented a novel case report of a patient with metastatic nasopharyngeal carcinoma who was successfully treated with a combination of EBV-specific ACT and PD-1 blockade therapy, resulting in complete resolution of metastatic disease for 22 months. Follow-up immunological analysis showed significant restructuring of the global T-cell repertoire coincident with the clinical response, providing an important platform for further translating these findings to a larger cohort of NPC patients.
NPJ PRECISION ONCOLOGY
(2021)
Article
Otorhinolaryngology
James Nightingale, Mitesh Gandhi, Jonathan Helena, James Bowman, Margaret McGrath, Jermaine Coward, Sandro Porceddu, Rahul Ladwa, Benedict Panizza
Summary: This case series demonstrates the efficacy of anti-PD-1 checkpoint inhibitor therapy for perineural spread, supporting the need for future prospective clinical trials in this patient population.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Otorhinolaryngology
Michael J. C. Schachtel, Mitesh Gandhi, James J. Bowman, Sandro Porceddu, Benedict J. Panizza
Summary: This study examined patients with perineural spread of cutaneous squamous cell carcinoma of the head and neck. The results showed that most patients had recurrent disease (89.0%) and simultaneous trigeminal nerve involvement (67.1%). Surgery and post-operative radiotherapy were the main treatments, and early-stage disease and clear surgical margins improved outcomes.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Annika Antonsson, Marjorie M. A. de Souza, Benedict J. Panizza, David C. Whiteman
Summary: Oropharyngeal cancer is increasingly caused by HPV, possibly due to changing sexual behavior. Sexual intercourse elicits a stronger immune response to HPV compared to oral sex, potentially leading to a weaker immune response in individuals who have their oral sex debut before or at the same time as sexual intercourse, increasing their risk of developing persistent oral HPV infection and oropharyngeal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Amanda Pigott, Bena Brown, Nicole White, Steven McPhail, Sandro Porceddu, Howard Liu, Claire Jeans, Ben Panizza, Jodie Nixon
Summary: This study observed the development of internal and external head and neck lymphedema during the course of treatment for head and neck cancer. The results showed a continuous increase in lymphedema from baseline to 12 weeks after radiotherapy completion, with all participants experiencing internal lymphedema at various sites. These findings highlight the importance of educating head and neck cancer patients about the prolonged duration of this treatment side effect.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Otorhinolaryngology
Michael J. C. Schachtel, Mitesh Gandhi, James J. Bowman, Sandro Porceddu, Benedict J. Panizza
Summary: Accurate epidemiological and outcomes data regarding cutaneous squamous cell carcinoma (cSCC) extending to the temporal bone is lacking. This study found that cSCCs extending to the temporal bone are more common than primary cancers in regions with high sun exposure. Additionally, patients with external ear and pre-auricular tumors, salvage surgery, larger tumor size, nodal disease, and involved margins had lower survival rates.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Surgery
Carly M. Fox, Jo-Lyn C. McKenzie, Helen C. Morris, Yun S. Phua, Stuart A. Bade, James Bowman, Richard J. Theile
Summary: This study describes the use of nasal septal flaps for repair of large or recurrent palatal fistulas. The technique has a high success rate and low incidence of recurrence.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Otorhinolaryngology
Michael J. C. Schachtel, Mitesh Gandhi, Mark J. Midwinter, Benedict J. Panizza
Summary: In our study, we found that the anterior carotid sheath, consisting of several fascial layers, plays a vital role in the dissection of temporal bone region cancers. This sheath can be seen on high-resolution MRI as a hypointense line. Additionally, we discovered that the glossopharyngeal nerve pierces through the sheath and exits near the pharynx. Further research is needed to confirm these findings and understand the role of the anterior carotid sheath in preventing the spread of malignancy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
