Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 4, Issue 4, Pages 785-792Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb02011e
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2013-012911, 2013R1A2A2A04015484, 2015R1C1A1A02036404]
- Fusion Technology Development Project - Korean Small and Medium Business Administration [S2175879]
- Korea Technology & Information Promotion Agency for SMEs (TIPA) [S2175879] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [22A20130012537, 2015R1C1A1A02036404, 2013R1A1A2012911, 2013R1A2A2A04015484] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Multifunctional magnetic nanoparticles have gained ample attention in the field of nanomedicine in recent years. Here, novel superparamagnetic core-shell manganese ferrite nanoparticles (MFNP)-encapsulated mesoporous silica nanoparticles (MSMFNPs) loaded with anticancer drug doxorubicin (DOX) for the combined application of hyperthermia and chemotherapy were developed and tested in vitro. Our results indicate that DOX-MSMFNPs achieved a favorable hyperthermic response in an alternating magnetic field in addition to cancer cell-specific cationic DOX release due to the cleavage of amide bonds under acidic pH, and synergistically contributed towards an enhanced tumoricidal effect.
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