Article
Engineering, Biomedical
Haimei Hu, Han Wang, Shuanghong Liang, Xiaoling Li, Dan Wang
Summary: Poly(amido-amine) (PAMAM) modified by hyaluronic acid (HA) showed reduced cytotoxicity and smaller particle size, with improved DNA delivering capacity in cancer cells line. The transfection efficiency of the modified polymers approached that of unmodified polyplexes, making them potential candidates for targeted gene delivery.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Biotechnology & Applied Microbiology
Friederike Richter, Katharina Leer, Liam Martin, Prosper Mapfumo, Jana Solomun, Maren T. Kuchenbrod, Stephanie Hoeppener, Johannes C. Brendel, Anja Traeger
Summary: Cationic polymers have been extensively studied for non-viral gene delivery, but their charged nature can lead to increased cytotoxicity and limited in vivo application. By utilizing hydrophilic or anionic shielding polymers, the toxicity of cationic polymers can be reduced, improving gene transfection efficiency. The study demonstrated the potential of using layering micelles with shielding polymers for gene delivery applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Nasir Uddin, Logan W. Warriner, Daniel W. Pack, Jason E. DeRouchey
Summary: Gene therapy has advanced significantly, with the use of polymeric materials as gene delivery scaffolds showing increased gene expression and gene editing efficiency in the presence of serum.
MOLECULAR PHARMACEUTICS
(2021)
Article
Nanoscience & Nanotechnology
Erica Quagliarini, Junbiao Wang, Serena Renzi, Lishan Cui, Luca Digiacomo, Gianmarco Ferri, Luca Pesce, Valentina De Lorenzi, Giulia Matteoli, Heinz Amenitsch, Laura Masuelli, Roberto Bei, Daniela Pozzi, Augusto Amici, Francesco Cardarelli, Cristina Marchini, Giulio Caracciolo
Summary: Lipid nanoparticles (LNPs) have shown promise as effective gene delivery vehicles, with a specific formulation (LNP15) demonstrating successful transfection and potential application in cancer vaccines.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Jennifer Lien, Tawni Bull, Richard W. Michelmore, Ting Guo
Summary: Fluorescence titration using magnetic nanoparticles (FTMN) is a rapid, inexpensive, and simple method for quantifying the amount of fluorophore-intercalated plasmid DNA on DNA attractive nanoparticles. By confirming the binding of propidium iodide (PI)-intercalated DNA to polyethylenimine (PEI)-coated monodisperse iron oxide magnetic nanoparticles (PEI-MNs), the FTMN method provides a way to determine the amount of DNA on MNs, the dissociation constant, and binding energy. This method is validated by utilizing quantitative polymerase chain reaction to measure the amount of free PI/DNA in solution.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Xuan Hu, Song Wang, Junjie Xu, Yilong Yang, Zhang Zhang, Xiaolin Wang, Xiaopeng Zhang, Wei Chen
Summary: By designing and synthesizing cationic protein nanocapsules, researchers have discovered that nanocapsules synthesized with hydrolyzable polymers containing tertiary amine groups exhibit the highest gene transfection efficiency, leading to stable protein expression for over four days. This is attributed to the tertiary amine groups facilitating the endosomal escape of nucleic acid-nanocapsule complexes after cell internalization via endocytosis. The subsequent hydrolysis of the polymers triggers the cytosolic release of nucleic acids, promoting gene expression.
Article
Polymer Science
Xinlin Jiang, Jijun Fu, Junyang Zhong, Xin Li, He Wang, Songjing Zhong, Yinhui Wei, Xiaoya Zhao, Xing Chen, Yi Zhou, Lingran Du, Guodong Ye, Jing Zhao, Yugang Huang
Summary: By synthesizing guanidinylated cyclic synthetic polypeptides, it is possible to enhance the efficiency of siRNA delivery. NCs have higher encapsulation efficiency and silencing efficiency, while mimicking the bioactivity of cell-penetrating peptides and nuclear localization signal peptides.
Article
Chemistry, Medicinal
Shuang Wu, Meiyan Liu, Xiang Hu, Chengxi He, Chunyan Zhao, Shuanglin Xiang, Youlin Zeng
Summary: The chemical and physical structure of cationic liposomes significantly affect their gene transfection efficiency; the design of novel cationic liposomes is guided by the structure-function relationship investigation; the study shows that different lipid structures play a crucial role in gene transfection efficiency.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Pharmacology & Pharmacy
Yue Li, Ting Yu, Long-zhe Han, Li-li Jin, Yong Jin, Ji-shan Quan
Summary: In this study, a novel liposome-PEI complex was used to improve the efficiency of gene delivery, which showed high transfection efficiency in various cancer cell lines without causing systemic hematological toxicity. Compared to traditional approaches, the liposome-PEI complex mediated the entry of therapeutic genes into the body without damage to normal organs and enhanced tumor tissue apoptosis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Polymer Science
Mara K. Kuenen, Alexa M. Cuomo, Vincent P. Gray, Rachel A. Letteri
Summary: By modifying the charge, poly(beta-amino ester)s can be transformed into degradable anionic polymers, which can be utilized to create fully degradable polyelectrolyte complexes and delivery vehicles for cationic therapeutics.
Article
Chemistry, Multidisciplinary
Dapeng Zhang, Elena N. Atochina-Vasserman, Devendra S. Maurya, Ning Huang, Qi Xiao, Nathan Ona, Matthew Liu, Hamna Shahnawaz, Houping Ni, Kyunghee Kim, Margaret M. Billingsley, Darrin J. Pochan, Michael J. Mitchell, Drew Weissman, Virgil Percec
Summary: Efficient delivery of nucleic acids is crucial for genetic nanomedicine. While viral vectors are highly efficient, they can also cause severe immune responses, toxicity, and mutations. Nonviral lipid nanoparticles containing specific components show promise for mRNA delivery, but challenges such as stability at low temperatures need to be addressed.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biotechnology & Applied Microbiology
Friederike Richter, Prosper Mapfumo, Liam Martin, Jana I. Solomun, Franziska Hausig, Jochen J. Frietsch, Thomas Ernst, Stephanie Hoeppener, Johannes C. Brendel, Anja Traeger
Summary: Significant progress has been made in gene delivery research, but challenges remain, such as the difficulty in transfecting certain cell types. Incorporating lipoic acid into hydrophobic-cationic micelles shows potential for improving transfection efficiency through a synergistic effect with micellar architecture.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Venkatesh Ravula, Venkanna Muripiti, Shireesha Manthurthi, Srilakshmi Patri
Summary: These sugar-based cationic lipids show promise as carriers for nucleic acids into cells, with the ability to enhance target oriented uptake and biocompatibility. The study synthesized three new cationic lipid analogues, showing that the transfection efficiency of these lipids is cell-dependent. Additionally, the results demonstrate that sugar-mimicking cationic lipids are non-toxic and hold potential applications for liver targeted gene delivery.
Article
Pharmacology & Pharmacy
C. Bellefroid, C. Reusch, A. Lechanteur, B. Evrard, F. Debacq-Chainiaux, D. Mottet, G. Piel
Summary: This study aimed to develop a suitable gene delivery formulation for topical use on skin, and found that different lipid combinations can effectively deliver plasmid DNA into skin cells. Certain formulations showed high transfection rates with limited cytotoxicity, presenting promising potential for gene therapy in treating skin diseases.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Daniel Hachim, Juzhi Zhao, Jash Bhankharia, Raquel Nunez-Toldra, Liliana Brito, Hyejeong Seong, Michele Becce, Liliang Ouyang, Christopher L. Grigsby, Stuart G. Higgins, Cesare M. Terracciano, Molly M. Stevens
Summary: Non-viral vectors provide safe and versatile options for nucleic acid delivery. In this study, nanoneedles were synergistically combined with nanofilms to achieve enhanced transfection efficiency compared to polyplexes in suspension. The results also showed that polysaccharide-based polyanions enhanced transfection efficiency, contrary to previous suggestions that only hyaluronic acid is effective. Additionally, the interaction with the CD44 receptor was found to not play a major role in the enhanced transfection.
Article
Chemistry, Physical
Bin Wu, Wei-Qiang Huang, Xuan Nie, Ze Zhang, Guang Chen, Hai-Li Wang, Fei Wang, Shen-Gang Ding, Zong-Yao Hao, Ye-Zi You
Summary: Polymeric micelles, especially flower micelles with a unique PEG shell, are more stable in the presence of serum and salt compared to traditional micelles. This stability is crucial for drug delivery, as it prevents aggregation and ensures efficient delivery of therapeutic agents to the target area.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2021)
Article
Polymer Science
Peng-Duo Song, Lei Xia, Xuan Nie, Guang Chen, Fei Wang, Ze Zhang, Chun-Yan Hong, Ye-Zi You
Summary: In this study, a ring-opening copolymerization method is reported to synthesize poly(thioester sulfonamide)s with highly alternative structures, high yields, and controlled molecular weights. This method combines the advantages of thioesters and amides, and can also be used to produce novel block copolymers.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Ying-Jie Zhang, Gui-Xiang Huang, Lea R. Winter, Jie-Jie Chen, Lili Tian, Shu-Chuan Mei, Ze Zhang, Fei Chen, Zhi-Yan Guo, Rong Ji, Ye-Zi You, Wen-Wei Li, Xian-Wei Liu, Han-Qing Yu, Menachem Elimelech
Summary: Removal of organic micropollutants from water through advanced oxidation processes is hindered by excessive energy and/or chemical input, as well as the generation of large amounts of residuals. The authors propose a new water purification technology called the direct oxidative transfer process (DOTP) that can achieve complete and efficient decontamination at low oxidant dosage. DOTP differs from traditional methods in pollutant removal behavior and mechanisms, and offers favorable features such as low energy consumption, no residual byproducts, and robust performance in real environmental matrices.
NATURE COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Wei-Qiang Huang, Ya-Qi Zhu, Wei You, Jing Chen, Fan Gao, Xuan Nie, Ze Zhang, Guang Chen, Yue Yu, Lei Xia, Chun-Yan Hong, Long-Hai Wang, Zong-Yao Hao, Ye-Zi You
Summary: Ultrasound-triggered sonodynamic therapy has shown great potential for cancer treatment. However, traditional sonosensitizers have low efficiency, short retention time in cancer cells, and poor tumor selectivity. Therefore, there is a strong need for sonosensitizers with higher efficacy, longer retention in tumor cells, and greater specificity. In this study, we developed a Ti2C(OH)(X) nanosheet, which was transformed into a novel nanofiber structure sonosensitizer in the tumor microenvironment, exhibiting excellent ability to generate reactive oxygen species (ROS) under ultrasound. This nanofiber structure enabled high retention of the sonosensitizer in the tumor and effectively and selectively killed cancer cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Environmental
Kaixiang Yang, Zhiqing Ge, Minhao Zhang, Chengyu Wang, Kang Peng, Haiyang Yang, Yezi You
Summary: We report a simple yet versatile method to fabricate underwater adhesive with time-dependent dynamic adhesion derived from silane-based polymerized deep eutectic solvent (PDES). The adhesive exhibits dynamic adhesion in underwater environments and can be tuned for optimal performance. The introduction of MXene enables near-infrared (NIR)-controlled retrieval property. This alternative strategy opens up new possibilities for designing high-performance underwater adhesive materials.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Xuan Nie, Fan Gao, Wei You, Guang Chen, Qi Shao, Long-Hai Wang, Wei-Qiang Huang, Lei Xia, Ze Zhang, Chun-Yan Hong, Ye-Zi You
Summary: The increasing spread of antimicrobial resistance calls for the urgent need to find new antibiotics that kill bacteria through a novel mechanism to avoid the development of resistance. Researchers have discovered a synthetic cage that tightly surrounds pyrophosphate structures, effectively killing bacteria and preventing the emergence of resistance.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Haili Wang, Wei You, Fan Gao, Lei Zhang, Aizong Shen, Fei Wang, Guang Chen, Xuan Nie, Lei Xia, Wei-Qiang Huang, Wen-Jian Zhang, Long-Hai Wang, Chun-Yan Hong, Ze Zhang, Ye-Zi You
Summary: Delivering exogenous compounds into cells poses a significant challenge in various applications, but a copolymer has been developed that can create targetable holes in cell membranes for direct delivery into the cytosol, bypassing endosome trapping. This copolymer releases absorbed lipids for hole repair, allowing for functional cargo delivery and maintaining cargo functionality. This breakthrough provides a promising method for delivering nanoparticles, DNA, RNA, and proteins directly into cells.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Biomaterials
Chen Zhang, Dan Yang, Tai-Bao Wang, Xuan Nie, Guang Chen, Long-Hai Wang, Ye-Zi You, Qin Wang
Summary: In this study, a biodegradable hydrogel loaded with verteporfin was developed. The hydrogel could effectively treat infected wounds, accelerate healing, and regulate the extracellular matrix. It showed potential for scar healing in infected wounds due to its anti-scarring and antibacterial properties.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Ze Zhang, Yu Xiong, Peng Yang, Yang Li, Rui Tang, Xuan Nie, Guang Chen, Long-Hai Wang, Chun-Yan Hong, Ye-Zi You
Summary: Introduces a thioester-relayed in-chain cascade copolymerization strategy for the preparation of multiblock copolymers with on-demand blocks. The strategy involves building thioester groups in the polymer backbone and using them as initiating centers to trigger the polymerization of episulfides for extending the polymer backbone into multiblock structures. The composition, number of blocks, and block degree of polymerization can be easily regulated.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Biomedical
Xuan Nie, Wei You, Ze Zhang, Fan Gao, Xiao-Hong Zhou, Hai-Li Wang, Long-Hai Wang, Guang Chen, Chang-Hui Wang, Chun-Yan Hong, Qi Shao, Fei Wang, Lei Xia, Yang Li, Ye-Zi You
Summary: Gene therapy is an effective treatment for genetic diseases, but the low gene transfection efficiency in vivo is a major challenge. This study introduces dipicolylamine-zinc ions onto polyplex nanoparticles, creating a strong hydration water layer that reduces protein binding, targets cancer cells, and enhances cellular uptake and endosomal escape. The polyplexes with a strong hydration water layer achieve high gene transfection even in a serum environment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Yiyang Zhou, Qiuyue Meng, Ming Chen, Chenxi Wang, Tao Jiang, Jingsong Zhou, Ping Wang, Lei Xia, Yezi You, Haibing Wei, Yunsheng Ding
Summary: The effects of DIP, a compound containing a xanthate group, on radical reactions and structural evolution of EPDM were investigated. It was found that the structural evolution and long-term stability of EPDM can be achieved by controlling radical reactions during gamma-ray irradiation. The presence of DIP can prevent EPDM deterioration, with the samples containing 1 wt% DIP showing retention rates of elongation at break and tensile strength at about 90% and 160% under irradiation, compared to 33% and 70% for additive-free EPDM. Additionally, DIP can improve the oxidation resistance and maintain the thermal decomposition temperature of EPDM under irradiation.
NPJ MATERIALS DEGRADATION
(2023)
Article
Chemistry, Multidisciplinary
Yulin Jie, Yaolin Xu, Yawei Chen, Miao Xie, Yue Liu, Fanyang Huang, Zdravko Kochovski, Zhanwu Lei, Lei Zheng, Pengduo Song, Chuansheng Hu, Zeming Qi, Xinpeng Li, Shiyang Wang, Yanbin Shen, Liwei Chen, Yezi You, Xiaodi Ren, William A. Goddard, Ruiguo Cao, Yan Lu, Tao Cheng, Kang Xu, Shuhong Jiao
Summary: This study reveals the details of the formation and evolution mechanism of the SEI that affects the stable cycling of the lithium electrode. By using a polymerization inhibitor and a specific initiator, the formation of a polymeric-inorganic composite SEI on the lithium electrode is successfully achieved, demonstrating excellent mechanical properties and self-healing ability.
CELL REPORTS PHYSICAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Guichang Zou, Jing Xia, Heyi Luo, Dan Xiao, Jin Jin, Chenjian Miao, Xin Zuo, Qianqian Gao, Zhi Zhang, Tian Xue, Yezi You, Ye Zhang, Li Zhang, Wei Xiong
Summary: The combined use of cannabis and alcohol leads to greater psychoactive toxicity than using either substance alone, and the underlying mechanisms behind this worsened outcome are still unclear. This study reveals that the synergistic effect of THC and ethanol on motor incoordination in mice is achieved by activating CB1R and potentiating GlyR within cerebellar PCs. Ethanol enhances THC actions by increasing its permeability across the blood-brain barrier and enriching THC in the cell membrane.
Article
Materials Science, Biomaterials
Haili Wang, Wei You, Bin Wu, Xuan Nie, Lei Xia, Changhui Wang, Ye-Zi You
Summary: This study developed a new functional material based on silver nanoparticles and phenylboronic acid, showing significantly enhanced antibacterial activity by disrupting bacterial membranes and high selectivity against a variety of bacteria.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Bin Wu, Wei You, Hai-Li Wang, Ze Zhang, Xuan Nie, Fei Wang, Ye-Zi You
Summary: The study demonstrates that cyclic polycations have enhanced antibacterial activity and penetration compared to linear polycations, effectively killing both planktonic and biofilm bacteria. In a mouse infection model, cyclic polycations also show promising therapeutic effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
