Article
Nanoscience & Nanotechnology
Ruyin Lyu, Yuping Chen, Yajun Shuai, Jie Wang, Leihao Lu, Qichao Cheng, Jiangfeng Cai, Chuanbin Mao, Mingying Yang
Summary: We demonstrate a universal strategy for discovering peptides that can bind to and functionalize biomaterials using a Bombyx mori silk fibroin membrane as a model. By fusing two peptides, one screened for binding to the biomaterial and another derived from a growth factor, a new chimeric peptide is created to efficiently bind to the silk fibroin membrane. The chimeric peptide enables the membrane to induce osteogenic differentiation of human mesenchymal stem cells and stimulate bone regeneration in a rat model without causing inflammation.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Xue-Han Xu, Tie-Jun Yuan, Haseeb Anwar Dad, Mu-Yang Shi, Yi-Yu Huang, Zhi-Hong Jiang, Li-Hua Peng
Summary: Exosomes derived from ginseng were shown to efficiently promote neural differentiation of BMSCs by transferring miRNAs, demonstrating potential for neural regenerative medicine both in vitro and in vivo.
Article
Chemistry, Multidisciplinary
Han Liu, Lin Qiu, Hao Liu, Fengji Li, Yaru Fan, Lulu Meng, Xiaoqian Sun, Chaojun Zhan, Rui Luo, Chao Wang, Jun Zhang, Ruixin Li
Summary: This study utilized low-temperature 3D printing technology to construct a silk fibroin/collagen/hydroxyapatite composite scaffold, designed with different fiber cross-angle structures and subjected to various performance tests and cellular experiments. The results indicated that the 90 degrees fiber cross-angle structure significantly enhanced the mechanical properties of the scaffold, promoting cell proliferation and osteogenesis, providing insights into scaffold properties and applications.
Article
Cell Biology
Meng-Yin Yang, Bai-Shuan Liu, Hsiu-Yuan Huang, Yi-Chin Yang, Kai-Bo Chang, Pei-Yeh Kuo, You-Hao Deng, Cheng-Ming Tang, Hsien-Hsu Hsieh, Huey-Shan Hung
Summary: Through studying various nanomaterial combinations and their biological functions and anti-inflammatory abilities, it was found that the combination of pullulan, collagen, and Au nanoparticles had excellent biocompatibility and neuronal differentiation promotion capabilities, which could be used for neuronal repair and skin tissue regeneration.
Article
Cell Biology
Caiyun Wang, Shang Gao, Ran Lu, Xin Wang, Su Chen
Summary: The study suggests that hydrogenated superhydrophilic nanotubes modified titanium implants significantly accelerate bone growth and integration, with the Nano group also exhibiting enhanced osteogenesis at later stages, indicating high clinical potential.
Article
Multidisciplinary Sciences
Ahmed Abdelrahiem Sadek, Mahmoud Abd-Elkareem, Hani Nasser Abdelhamid, Samia Moustafa, Kamal Hussein
Summary: The study investigated the regenerative capacity of g-C3N4 and GO nanomaterials to stimulate critical-sized bone defect regeneration. It was found that both materials promoted bone cell growth and osteogenesis, demonstrating their potential for bone defect treatment.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Faezeh Esmaeili Ranjbar, Saeed Farzad-Mohajeri, Saeed Samani, Jamileh Saremi, Rahele Khademi, Mohammad Mehdi Dehghan, Mahmoud Azami
Summary: This study evaluated the in vitro and in vivo properties of 58S bioactive glass-based scaffolds for bone tissue engineering. Zein-coating improved the mechanical properties of the scaffolds without affecting their bioactivity and cell attachment. In vivo study showed that BMSC-loaded KC.SC promoted significant new bone formation and complete bone regeneration, suggesting a promising strategy for bone regeneration.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Shengying Lou, Ting Huang, Jifeng Qi, Tianyuan Zhang, Jianqing Gao, Sunliang Cui
Summary: The lack of suitable stem cells is currently a limiting factor in the success of stem cell therapy for neurodegenerative diseases, but utilizing mesenchymal stem cells shows potential for treating these diseases. Enhancing the neuronal differentiation capacity of MSCs through bioengineering with small molecules is a promising strategy.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Materials Science, Biomaterials
Yajing Ye, Yaqing Zhou, Zhuoyuan Jing, Yifan Xu, Dachuan Yin
Summary: The application of heparin-loaded sutures made of electrospun nanofibers is an effective strategy for improving tendon healing and health, surpassing traditional commercial sutures. Improving blood supply is crucial for tendon healing, presenting a promising approach for clinical treatment.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biochemistry & Molecular Biology
Francesca Della Sala, Mario di Gennaro, Gianluca Lista, Francesco Messina, Teodoro Valente, Assunta Borzacchiello
Summary: The pulmonary niche plays a crucial role in regulating the signals for MSCs to induce tissue repair. Impaired ECM in lung pathologies affects the attachment and differentiation of MSCs, rendering MSC-based therapies ineffective. To address this issue, a biomimetic niche based on HA and COLL hydrogel is developed to guide the differentiation of MSCs into ATII cells. It is found that low molecular weight HA combined with COLL hydrogel promotes the expression of SPC, a marker for ATII cells.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Engineering, Biomedical
Xiaomeng Li, Shuaibing Liu, Shanshan Han, Qingqing Sun, Jianmin Yang, Yuhang Zhang, Yongchao Jiang, Xiaofeng Wang, Qian Li, Jianglin Wang
Summary: This study develops a dynamic and controllable stiffening 3D biomimetic model to regulate the osteogenic differentiation of MSCs. The findings show that the dynamic hydrogels enhance the osteogenesis of MSCs and promote bone remodeling in vivo. This work highlights the importance of dynamic stiffening microenvironment in modulating stem cell fate and bone restoration.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Yunfang Mo, Zejian Wang, Jian Gao, Yan Yan, Huaijuan Ren, Fengli Zhang, Nianmin Qi, Yantian Chen
Summary: This study aimed to investigate the differentiation ability of three types of adult mesenchymal stem cells into pancreatic beta-like cells in vitro and found that menstrual blood-derived MSCs had the highest differentiation potential, making them a potential cell source for treating TID.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Honorata Kraskiewicz, Piotr Hinc, Agnieszka Krawczenko, Aleksandra Bielawska-Pohl, Maria Paprocka, Danuta Witkowska, Isma Liza Mohd Isa, Abhay Pandit, Aleksandra Klimczak
Summary: A potential treatment for chronic wounds using a hydrogel loaded with secretome from adipose tissue mesenchymal stem cells has been proposed. The biocompatibility and pro-angiogenic activity of the hydrogel-released factors were investigated, showing positive effects on skin-origin cell proliferation and endothelial cell angiogenic properties. Additionally, antimicrobial activity was observed in the secretome, indicating its potential use as an advanced wound-healing dressing in combination with the hydrogel.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Shicheng Sun, Jacky Y. Li, Hieu T. Nim, Adam Piers, Mirana Ramialison, Enzo R. Porrello, Igor E. Konstantinov, Andrew G. Elefanty, Edouard G. Stanley
Summary: This study reveals that human thymic epithelial cells have a hybrid gene expression program of both epithelial and mesenchymal elements. Additionally, it provides a basis for further exploration of thymus development using primary tissues and in vitro differentiation of pluripotent stem cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Jeniffer Farias Dos Santos, Bruna Leticia Freitas-Marchi, Gustavo Roncoli Reigado, Silvia Romano de Assis, Silvya Stuchi Maria Engler, Felipe Santiago Chambergo Alcalde, Viviane Abreu Nunes
Summary: In skin traumas, tissue engineering using mesenchymal stem cells (MSC) from the umbilical cord shows promise for skin regeneration. MSCs can differentiate into keratinocytes and express important epidermal markers, indicating their potential use in producing skin substitutes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)