Review
Cell Biology
Giulia Alloisio, Chiara Ciaccio, Giovanni Francesco Fasciglione, Umberto Tarantino, Stefano Marini, Massimo Coletta, Magda Gioia
Summary: The complex skeletal organization adapts to external contexts and demonstrates excellent self-renewal capacity. Cells respond to mechanical cues and external stimuli to regulate bone anabolism. Exogenous stimuli can promote mineral apposition, bone formation, and fracture repair, while mechanical forces and signaling factors play a crucial role in modulating bone synthesis.
Article
Biochemistry & Molecular Biology
Alessio Malacrida, Roberta Rigolio, Luigi Celio, Silvia Damian, Guido Cavaletti, Vincenzo Mazzaferro, Mariarosaria Miloso
Summary: Cholangiocarcinoma is the most common cancer of the biliary tract, and surgical resection is currently the only potentially curative option with low survival rates. Research shows that Rigosertib may be a potential therapeutic option for nonresectable patients with cholangiocarcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Jie Yu, Sarah L. Berga, Qingying Meng, Mingjing Xia, Trudy A. Kohout, Marcel van Duin, Robert N. Taylor
Summary: The study demonstrated the important regulatory role of dopamine receptor type 2 in endometrial tissue and cells, showing that dopamine agonists like cabergoline can promote decidualization in vitro, potentially serving as therapeutic agents for infertility due to inflammation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Toxicology
B. S. Cagle, M. L. Sturgeon, J. B. O'Brien, J. C. Wilkinson, R. A. Cornell, D. L. Roman, J. A. Doorn
Summary: Disruption of DA metabolism and cell trafficking can lead to toxic products and neurological conditions like PD. In vitro models that replicate DA metabolism and trafficking are crucial for studying pathogenic mechanisms involving DA neurons.
TOXICOLOGY IN VITRO
(2021)
Article
Multidisciplinary Sciences
Jun Jie Tan, Jacques P. Guyette, Kenji Miki, Ling Xiao, Gurbani Kaur, Tong Wu, Liye Zhu, Katrina J. Hansen, King-Hwa Ling, David J. Milan, Harald C. Ott
Summary: The study demonstrates the generation of premature PECs using BVR stimulation, co-culturing PECs with cardiomyocytes leads to cardiomyocyte aggregation, proliferation and the formation of more mature structures with improved beating/contractility.
NATURE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
El-Mustapha Haddouti, Nina Reinhardt, Robert Ossendorff, Christof Burger, Dieter C. Wirtz, Matias de la Fuente, Frank A. Schildberg
Summary: Extracorporeal shock wave therapy is a non-invasive and effective treatment for musculoskeletal disorders. Research indicates that the optimal parameters for shock wave therapy are still undetermined. This study examined the effects of shock wave application on primary MSCs and osteoblastic cell lines in vitro, establishing conditions that enhance the osteogenic differentiation of MSCs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kojiro Matsushita, Chiharu Nakahara, Shun Kimura, Naoya Sakamoto, Satoshi Ii, Hiromi Miyoshi
Summary: Cell nuclei exhibit viscoelastic properties, with the mesoscale viscoelasticity within the nuclei of stem cells changing during differentiation. This change in viscoelasticity affects force transmission efficiency, gene expression pattern, and mechanosensitivity in the nucleus, with chromatin condensation playing a critical role in modulating these properties during stem cell differentiation.
Article
Biochemistry & Molecular Biology
Orie Adachi, Hideki Sugii, Tomohiro Itoyama, Shoko Fujino, Hiroshi Kaneko, Atsushi Tomokiyo, Sayuri Hamano, Daigaku Hasegawa, Junko Obata, Shinichiro Yoshida, Masataka Kadowaki, Risa Sugiura, Mhd Safwan Albougha, Hidefumi Maeda
Summary: The study aims to clarify the biological functions of decorin in the healing and regeneration of wounded periodontal tissue. The results demonstrate that decorin promotes osteoblastic differentiation of periodontal ligament stem cells and contributes to bone healing through ERK1/2 signaling pathway.
Article
Nutrition & Dietetics
Simone Donati, Gaia Palmini, Cecilia Romagnoli, Cinzia Aurilia, Francesca Miglietta, Irene Falsetti, Francesca Marini, Roberto Zonefrati, Gianna Galli, Gemma Marcucci, Teresa Iantomasi, Maria Luisa Brandi
Summary: Recent studies have shown that 25(OH)D-3 can activate rapid non-genomic pathways by binding to VDR, leading to an increase in intracellular Ca2+ levels similar to the biologically active form of vitamin D-3. This work demonstrates for the first time the ability of 25(OH)D-3 to induce a rapid increase in intracellular Ca2+ levels in hADMSCs in vitro.
Article
Materials Science, Multidisciplinary
Alexander J. Steeves, David J. Lomboni, Mohan Vijay, Andrew Tieu, Fabio Variola
Summary: Pulsed-waterjet (PWJ) technology shows potential for biologically effective surface treatment of dental titanium implants. The study demonstrates that different treatment conditions can promote cell proliferation and osteogenic differentiation on titanium surfaces, indicating the potential for surface modification and incorporation of novel bioactive properties into implants.
Article
Biochemistry & Molecular Biology
Ngoc Nguyen Lunde, Nimo Mukhtar Mohamud Osoble, Andrea Dalmao Fernandez, Alfreda S. Antobreh, Abbas Jafari, Sachin Singh, Tuula A. Nyman, Arild C. Rustan, Rigmor Solberg, G. Hege Thoresen
Summary: The mechanical interaction between skeletal muscle and bone is complemented by biochemical crosstalk mediated by secreted factors. This study shows that conditioned medium from osteoblasts enhances glucose metabolism and decreases fatty acid metabolism in skeletal muscle cells, while conditioned medium from myotubes has similar effects on energy metabolism in bone marrow stromal cells. Proteomic analyses reveal common proteins in both conditioned media, suggesting a general pattern of communication between these tissues.
Article
Chemistry, Medicinal
Beiwei Liang, Chunlai Li, Zhan Zhou, Yubo Xie
Summary: This study aimed to investigate the effect of hydromorphone on the growth of human gastric cancer cells. The results showed that within a certain concentration range, hydromorphone can suppress the growth of human gastric cancer cells, and the inhibitory effect is enhanced with longer incubation time and higher concentrations. Hydromorphone inhibits the growth of human gastric cancer cells through cell cycle arrest and induction of apoptosis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Jason Hou, Yukihiko Tamura, Hsin-Ying Lu, Yuta Takahashi, Shohei Kasugai, Hidemi Nakata, Shinji Kuroda
Summary: Selenium nanoparticles (SeNPs) have potential for the treatment of peri-implantitis. At appropriate concentrations, SeNPs do not exhibit cytotoxicity and promote mineralization and calcification. Additionally, SeNPs inhibit inflammation caused by peri-implantitis and suppress the growth of pathogenic bacteria.
Article
Biochemistry & Molecular Biology
Cristiane Oliveira Reno, Grazielle Aparecida Silva Maia, Leilismara Sousa Nogueira, Melina de Barros Pinheiro, Danyelle Romana Alves Rios, Vanessa Faria Cortes, Leandro Augusto de Oliveira Barbosa, Herica de Lima Santos
Summary: Hydroxyurea has significant effects on the biochemical parameters of red blood cells, especially at a concentration of 0.8 mM where enzyme activity and lipid peroxidation levels are notably affected.
Article
Biochemistry & Molecular Biology
Yuan Gao, Jun Yang, Yaru Zhang, Ying Zhao, Xin Zhao, Xining Zhang, Jing Zhang, Li Mao, Hongjun Wang, Huimei Wang, Lianyan Wang
Summary: This study evaluated the immune response of poly(lactic acid) (PLA) nanoparticles with different end groups. In vitro experiments showed that carboxyl (COOH) end group nanoparticles could promote the activation of bone marrow dendritic cells with lower cytotoxicity. In vivo experiments demonstrated that both COOH and ester (COOR) end group nanoparticles could elicit immune responses, but COOH end group nanoparticles induced stronger T cell and B cell activation as well as central memory T cell response, and significantly enhanced splenocyte proliferation and cytokine secretion.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Endocrinology & Metabolism
Adeline H. Ng, Sidney Omelon, Fabio Variola, Bedilu Allo, Thomas L. Willett, Benjamin A. Alman, Marc D. Grynpas
JOURNAL OF BONE AND MINERAL RESEARCH
(2016)
Article
Chemistry, Analytical
Helene Fortier, Fabio Variola, Chen Wang, Shan Zou
ANALYTICAL METHODS
(2016)
Article
Water Resources
Baisha Ren, Bradley Young, Fabio Variola, Robert Delatolla
WATER QUALITY RESEARCH JOURNAL OF CANADA
(2016)
Article
Chemistry, Applied
Francesca Tana, Massimo Messori, Davide Contini, Alberto Cigada, Teodoro Valente, Fabio Variola, Luigi De Nardo, Federica Bondioli
PROGRESS IN ORGANIC COATINGS
(2017)
Article
Nanoscience & Nanotechnology
Marianne B. Ariganello, Dainelys Guadarrama Bello, Alejandra Rodriguez-Contreras, Shayan Sadeghi, Gaetano Isola, Fabio Variola, Antonio Nanci
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2018)
Article
Nanoscience & Nanotechnology
Alexander J. Steeves, William Ho, Maria Chiara Munisso, David J. Lomboni, Enara Larranaga, Sidney Melon, Elena Martinez, Davide Spinello, Fabio Variola
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Materials Science, Multidisciplinary
Lorenzo Bonetti, Luigi De Nardo, Fabio Variola, Silvia Fare
Review
Materials Science, Biomaterials
Alp Ozgun, David Lomboni, Hallie Arnott, William A. Staines, John Woulfe, Fabio Variola
Summary: In vitro models play a crucial role in understanding the physiological mechanisms and pathological disorders of the nervous system, as well as evaluating the safety and efficacy of therapeutic candidates. Recent advancements in materials science, fabrication techniques, and cell culture systems have allowed for the development of more sophisticated in vitro technologies that can bridge the gap between animal and clinical studies. This review provides a comprehensive overview of commonly used biomaterials and fabrication techniques for designing neural tissue models, and discusses the key parameters for developing functional platforms for studying brain functions, pathological processes, and drug discovery/development.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Physical
David J. Lomboni, Alexander Steeves, Sarah Schock, Lorenzo Bonetti, Luigi De Nardo, Fabio Variola
Summary: This study explored the cellular response to micro-engineered surfaces for neuronal tissue engineering, using chitosan substrates and citric acid crosslinking method. It was found that microtopography, roughness, and substrate's stiffness play key roles in governing the activity of cells.
Article
Chemistry, Analytical
Helene Fortier, Valerie Gies, Fabio Variola, Chen Wang, Shan Zou
ANALYTICAL METHODS
(2020)
Article
Chemistry, Physical
Lorenzo Bonetti, Luigi De Nardo, Fabio Variola, Silvia Fare'
Article
Materials Science, Biomaterials
Alexander J. Steeves, Fabio Variola
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Materials Science, Biomaterials
Maidy Rehder Wimmers Ferreira, Roger Rodrigo Fernandes, Amanda Freire Assis, Janaina A. Dernowsek, Geraldo A. Passos, Fabio Variola, Karina Fittipaldi Bombonato-Prado
INTERNATIONAL JOURNAL OF BIOMATERIALS
(2016)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)