Article
Multidisciplinary Sciences
Cristovao Antunes de lanna, Beatriz Nascimento Monteiro da Silva, Andreia Cristina de Melo, Martin H. Bonamino, Lisia Daltro Borges Alves, Luis Felipe Ribeiro Pinto, Abel Silveira Cardoso, Heliton Spindola Antunes, Mariana Boroni, Daniel Cohen Goldemberg
Summary: By comparing the gene expression profiles of Oral Lichen Planus and Oral Squamous Cell Carcinoma, similarities were found in processes such as keratinization, cell proliferation, and immune response. Key tumor suppressors and oncogenes were dysregulated in both diseases.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Xibo Li, Liwei Liu, Na Li, Qingquan Jia, Xiaoshuang Wang, Lihua Zuo, Jianglan Long, Peng Xue, Zhi Sun, Hongyu Zhao
Summary: This study identified biomarkers associated with oral squamous cell carcinoma (OSCC) and oral erosive lichen planus (OELP) by analyzing plasma samples. The biomarkers were found to be closely related to cholic acid metabolism and amino acid metabolism. By establishing a diagnostic panel, it was possible to predict the malignant transformation of OELP and diagnose OSCC in its early stages.
Article
Cell Biology
Qing-Mei Wang, Xue-Ying Huang, Wei-Qun Guan
Summary: This study aimed to investigate the expression of interleukin-27 (IL-27) in tissues of oral lichen planus (OLP), oral leukoplakia (OLK), and oral squamous cell carcinoma (OSCC) and its possible role in the development of these diseases. The study found that the expression of IL-27 was significantly higher in OLP, OLK, and OSCC tissues compared to the healthy group. The expression of IL-27 was correlated with lymphocyte infiltration and basal cell liquefaction in OLP, abnormal epithelial cell proliferation in OLK, and squamous cell differentiation in OSCC. These findings suggest that IL-27 may be involved in the development of these diseases and play a role in the carcinogenesis of oral precancerous lesions.
Article
Dentistry, Oral Surgery & Medicine
Xiaotang Wang, Xiaocui Nie, Guoqiang Xu, Jiping Gao, Binhong Wang, Junting Yang, Guohua Song
Summary: miR-450b plays a crucial role in the tumorigenesis of oral squamous cell carcinoma (OSCC) by regulating the migration, invasion, and epithelial-mesenchymal transition (EMT) of OSCC cells through its target gene SERPINB2.
Article
Anatomy & Morphology
Xiao-Qin Liu, Yao Yao, Jing-Wen Mu, Feng-Ying Yang
Summary: This study found that high cytoplasmic expression of Sema4A is related to T classification, clinical stage, and nodal metastasis of OSCC patients. Patients with low cytoplasmic Sema4A expression showed higher microvessel density (MVD) and poorer prognosis in OSCC. Over-expression of Sema4A can inhibit the invasion, migration, and angiogenesis abilities of oral squamous cell carcinoma cells.
Article
Endocrinology & Metabolism
Yuanxin Chen, Zhijie Huang, Jianjiang Zhao, Bo Jia
Summary: This study verified the effect of Fusobacterium nucleatum (F. nucleatum) in oral squamous cell carcinoma (OSCC) and explored the possible molecular mechanism. The abundance of F. nucleatum was found to be higher in OSCC compared to paracancerous tissues. F. nucleatum can regulate cell proliferation, migration, and invasion, and promote the progression of OSCC through CCL20.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Rakefet Czerninski, Zinat Awadieh, Svetlana Feldman, Naama Keshet, Abraham Zlotogorski, Yuval Ramot
Summary: This study describes familial OLP in 20 families, predominantly Jewish. The high prevalence of hypothyroidism and oral squamous cell carcinoma in familial OLP patients suggests a potential predisposition to malignant transformation in this high-risk group.
Article
Multidisciplinary Sciences
Wenli Zang, Junchao Liu, Fengxue Geng, Dongjuan Liu, Shuwei Zhang, Yuchao Li, Yaping Pan
Summary: This study found that butyrate can promote the migration and invasion of oral squamous cell carcinoma (OSCC) cells by inducing epithelial-mesenchymal transition (EMT), indicating that butyrate may contribute to the metastasis of OSCC.
Article
Dentistry, Oral Surgery & Medicine
Masoumeh Mehdipour, Minoo Shahidi, Fahimeh Anbari, Homa Mirzaei, Soudeh Jafari, Azam Kholghi, Ehsan Lotfi, Soheila Manifar, Fatemeh Mashhadiabbas
Summary: This study aimed to assess the salivary level of microRNA-146a and microRNA-155 in patients with OLP and OSCC. The results showed significant alterations in the expression of these biomarkers in dysplastic OLP and OSCC patients, suggesting their potential as warning signs for malignancy.
Article
Immunology
Ying Lin, Ying Qi, Mingjing Jiang, Wei Huang, Bo Li
Summary: There is metabolic interaction between tumor cells and macrophages in oral squamous cell carcinoma (OSCC), which is associated with tumor cell migration, invasion, and epithelial-mesenchymal transition (EMT). GPNMB and CD44 are involved in this process and may serve as potential targets for treating OSCC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Xinjia Cai, Jianyun Zhang, Heyu Zhang, Tiejun Li
Summary: This study investigated the association between oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC) in a retrospective cohort of 3568 patients. The findings suggest that not all cases of OSCC are transformed from OLP, indicating that the previous understanding of OLP transformation may have been overestimated. Strict diagnostic criteria for OLP and close surveillance are important in correctly identifying the origin of OSCC and avoiding overestimation of the risk of OLP transformation.
Article
Biochemistry & Molecular Biology
Xiaoyu Hu, Xin Shen, Jiangxue Tian
Summary: The research found that periodontitis positive correlated microbiota promotes the development of oral squamous cell carcinoma, while periodontitis negative correlated microbiota inhibits its development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Gianluca Tenore, Ahmed Mohsen, Federica Rocchetti, Giulia Rossi, Andrea Cassoni, Andrea Battisti, Marco Della Monaca, Cira Rosaria Tiziana Di Gioia, Francesca De Felice, Andrea Botticelli, Valentino Valentini, Carlo Della Rocca, Marco De Vincentiis, Antonella Polimeni, Umberto Romeo
Summary: This study retrospectively assessed the potential risk of malignant transformation in patients with diagnosed oral lichen planus (OLP) between 2015 and 2022 and evaluated the influence of different risk factors. The analysis revealed a statistically significant difference in age, tobacco status, and radiotherapy as risk factors for malignant transformation. Heavy ex-smoker patients, alcohol-drinker patients, and alcohol-drinker patients with a history of smoking (ex-smokers) had an elevated risk of malignant transformation.
Article
Pharmacology & Pharmacy
Danni Wang, Mei Tian, Yong Fu, Yawei Sun, Liang Ding, Xiaoxin Zhang, Yue Jing, Guowen Sun, Yanhong Ni, Yuxian Song
Summary: The study found that Halofuginone can inhibit the migration and invasion of oral squamous cell carcinoma (OSCC) by targeting cancer-associated fibroblasts (CAFs), and is involved in this process through inhibiting MMP2 secretion and the TGF-beta/Smad2/3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Qionghua Li, Fei Wang, Yujie Shi, Liang Zhong, Shumin Duan, Wenjing Kuang, Na Liu, En Luo, Yu Zhou, Lu Jiang, Hongxia Dan, Xiaobo Luo, Dunfang Zhang, Qianming Chen, Xin Zeng, Taiwen Li
Summary: This study characterized the mucosal immune microenvironment of oral lichen planus (OLP) using single-cell RNA sequencing and immune repertoire sequencing. Activated tissue-resident memory CD8+ T cells were found in OLP tissues, along with clonal expansion of T cell receptor repertoires and BCR clonal expansion. Fibroblasts were identified as potential promoters of immune cell recruitment into connective tissue in OLP.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Xinyuan Zhao, Li Cui
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Cell Biology
Xinyuan Zhao, Xianwen Liu, Li Cui
Article
Medicine, General & Internal
Li Cui, Huan Chen, Xinyuan Zhao
Article
Endocrinology & Metabolism
Li Cui, Xinyuan Zhao, Zhenning Jin, Hailin Wang, Shun-Fa Yang, Shen Hu
Summary: Metabolic remodeling is a hallmark of cancer, and in this study, it was found that melatonin inhibits the folate cycle through downregulation of MTHFD1L, thereby halting HNSCC progression.
JOURNAL OF PINEAL RESEARCH
(2021)
Review
Microbiology
Yi Huang, Xinyuan Zhao, Li Cui, Shaohong Huang
Summary: The oral microbiome is closely related to oral and systemic health, with dental plaque biofilms being the primary factor of periodontitis. Analyzing the composition and functional characteristics of microbial communities is crucial for understanding the pathogenesis of periodontitis.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Genetics & Heredity
Zizhao Mai, Huan Chen, Yu Ye, Ziyu Hu, Wenjuan Sun, Li Cui, Xinyuan Zhao
Summary: Mesenchymal stem cells exert biological functions through secreting exosomes, which play important roles in regenerative medicine and possess various advantages. Exosomes derived from dental stem cells actively participate in multiple biological processes and demonstrate promising clinical application potential.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Zizhao Mai, Huan Chen, Mingshu Huang, Xinyuan Zhao, Li Cui
Summary: This study identified differentially expressed metabolic enzymes (DEMEs) in head and neck squamous cell carcinoma (HNSCC) tissues and constructed a prognostic signature and nomogram model for predicting the clinical outcome of HNSCC. The results showed that the DEME-based signature can effectively predict the prognosis of HNSCC and the nomogram model can provide personalized therapeutic guidance. In vitro experiments also demonstrated that the knockdown of one of the DEMEs suppressed malignant activities of HNSCC cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xinyuan Zhao, Huan Chen, Yu Qiu, Li Cui
Summary: The expression of FAM64A is significantly elevated in HNSCC tissues and cell lines, and is strongly associated with an unfavorable prognosis. Depletion of FAM64A suppresses the malignant activities of HNSCC cells both in vitro and in vivo. Mechanistically, FAM64A enhances the transcriptional activity of FOXM1 and modulates its expression through an autoregulation loop. These findings reveal a previously unknown mechanism behind the activation of FOXM1 in HNSCC and suggest that FAM64A could be a promising molecular therapeutic target.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Li Cui, Xiang Wang, Xinyuan Zhao, Bingbing Sun, Tian Xia, Shen Hu
Summary: In this study, a mass spectrometry-based global metabolomic analysis was conducted to investigate the metabolomic changes in BEAS-2B cells exposed to CeO2 nanoparticles (NPs) with different aspect ratios. The study revealed subtle changes in metabolic activities that traditional functional assays might have missed and discovered a previously unknown molecular mechanism underlying CeO2 NP-induced lung fibrosis with different aspect ratios.
Article
Cell & Tissue Engineering
Xinyuan Zhao, Wenjuan Sun, Bing Guo, Li Cui
Summary: This study found that downregulation of circBIRC6 can enhance the osteogenic potential of PDLSCs under inflammatory conditions, and circBIRC6 regulates the osteogenic differentiation of PDLSCs through miR-543. Furthermore, the circBIRC6/miR-543 axis regulates the mineralization capacity of PDLSCs in the inflammatory microenvironment via the PTEN/PI3K/AKT/mTOR signaling pathway. These findings may provide new targets and treatment strategies for bone loss in periodontitis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Xinyuan Zhao, Dalong Shu, Wenjuan Sun, Shanshan Si, Wei Ran, Bing Guo, Li Cui
Summary: In this study, it was found that PLEK2 expression was significantly increased in HNSCC tissues, and PLEK2 overexpression was strongly associated with poor overall survival and therapeutic resistance. PLEK2 played an important role in maintaining the malignant behaviors of HNSCC cells, altering cellular metabolism, and enhancing c-Myc signaling in HNSCC.
CANCER COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Xin Liao, Yudong Liu, Jiarong Zheng, Xinyuan Zhao, Li Cui, Shen Hu, Tian Xia, Shanshan Si
Summary: With the rapid development of engineered nanomaterials (ENMs) in biomedical applications, evaluating their biocompatibility and cytotoxicity has become crucial. Recent studies have shown that inflammasome activation, particularly the NLRP3 inflammasome's interaction with ENMs, plays a significant role in inducing inflammatory responses. Understanding the pathways linking ENMs to NLRP3 inflammasome activation is essential for safer nanomaterial designs and mitigating ENM-induced adverse health effects.
Review
Cell & Tissue Engineering
Ye Lu, Zizhao Mai, Li Cui, Xinyuan Zhao
Summary: Mesenchymal stem cell-based therapy is effective for bone regeneration, but clinical translation has limitations. The secretome of mesenchymal stem cells, especially exosomes, has a critical role in bone repair and regeneration. Exosomes, with their nanosized structures and cargo of proteins, lipids, RNAs, growth factors, and cytokines, are being investigated for their potential in bone regenerative medicine. Preconditioning of parental cells and exosome engineering can enhance their regenerative potential, and biomaterial-assisted exosomes have emerged as a promising strategy for bone regeneration. This review discusses the roles of exosomes in bone regeneration, the use of engineered exosomes and biomaterial-assisted exosomes, and the current challenges in translating exosomes to clinical applications.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Xinyuan Zhao, Zizhao Mai, Ye Lu, Li Cui, Jinhua Yu
Summary: This study found that KLF9 is a crucial transcription factor that controls the osteogenic differentiation of human dental stem cells (DSCs) by negatively regulating the Notch1 signaling pathway.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Article
Chemistry, Multidisciplinary
Xinyuan Zhao, Bing Guo, Wenjuan Sun, Jinhua Yu, Li Cui
Summary: Cisplatin resistance in head and neck squamous cell carcinoma (HNSCC) is driven by squalene epoxidase (SQLE), which operates through a cholesterol-dependent pathway. SQLE stabilizes c-Myc protein and prevents its degradation, leading to the activation of c-Myc transcriptional activity. Inhibition of SQLE disrupts the binding of Akt to lipid rafts, deactivates Akt, and destabilizes c-Myc. In a mouse model, SQLE is found to be critical for HNSCC initiation and progression. The combination of terbinafine and cisplatin shows promising synergistic effects in arresting tumor growth. These findings provide insights into SQLE-mediated cisplatin resistance and propose a potential therapeutic avenue for HNSCC patients.