Article
Nanoscience & Nanotechnology
Justyna Hajtuch, Eliza Iwicka, Anna Szczoczarz, Damian Flis, Elzbieta Megiel, Piotr Cieciorski, Marek Witold Radomski, Maria Jose Santos-Martinez, Iwona Inkielewicz-Stepniak
Summary: In this study, we synthesized eptifibatide-functionalized silver nanoparticles and evaluated their pharmacological activity on platelets and endothelial cells. The results showed that AgNPs-EPI exhibited anti-aggregatory activity by regulating platelet aggregation, blood coagulation, and endothelial cell activity, at concentrations lower than the free drug. These findings provide preliminary evidence that AgNPs can be used as an effective delivery platform for antiplatelet drugs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Engineering, Multidisciplinary
Mohammad Javed Ansari, Mohammed F. Aldawsari, Ameeduzzafar Zafar, Alireza Soltani, Mohd Yasir, Mohammed Asadullah Jahangir, Mohamad Taleuzzaman, Vahid Erfani-Moghadam, Leila Daneshmandi, Nosrat O. Mahmoodi, Asieh Yahyazadeh, Md Lutfor Rahman, Mohd Sani Sarjadi
Summary: Two different nanoformulations, LTSP micellar/liposomal and TSP micellar/niosomal, were prepared using the thin-film hydration method. These nanoformulations showed potential for delivering SSZ, improving its bioavailability, and exhibited increased cell toxicity.
ALEXANDRIA ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Yachao Ren, Bingchuan Yuan, Shenghua Hou, Yilei Sui, Tinghui Yang, Meilin Lv, Yulong Zhou, Hui Yu, Sen Li, Haisheng Peng, Naidan Chang, Yang Liu
Summary: Modified liposomes can achieve higher targeted therapeutic effects in vivo, with better efficacy against colorectal cancer, and may also induce autophagy.
JOURNAL OF DRUG TARGETING
(2021)
Article
Pharmacology & Pharmacy
Sushil Yadaorao Raut, Kengyen Fu, Huang Taichun, Avinash Gahane, Dasharath Chaudhari, Varun Kushwah, Renuka Suresh Managuli, Aswathi R. Hegde, Sanyog Jain, Guruprasad Kalthur, Manjunath Bandu Joshi, Hsin-I. Chang, Niann-Tzyy Dai, Srinivas Mutalik
Summary: To address the issue of female infertility, researchers have developed an oral formulation of follicle stimulating hormone (FSH) using nanostructured lipid carriers (NLCs) and liposomes as carriers to improve the oral bioavailability and efficacy of the drug. Through a series of experiments and studies, they demonstrated the stability and effectiveness of the developed formulations in vivo.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Jilai Tian, Shixiao Wan, Jing Tian, Liming Liu, Jintao Xia, Yunfeng Hu, Zhen Yang, Huanhuan Zhao, Haixiang Wang, Yichen Guo, Jun Guo
Summary: Lipid-encapsulated oxygen nanobubbles were prepared and modified with a protein to enhance tumor targeting and induce tumor apoptosis. The study found that these oxygen nanobubbles improved the efficiency of photodynamic therapy and alleviated tumor hypoxia.
Article
Pharmacology & Pharmacy
Maryam Ebrahimi Nik, Mahmoud Reza Jaafari, Mohammad Mashreghi, Sara Nikoofal-Sahlabadi, Mohamadreza Amin, Hamid Reza Sadeghnia, Mehrdad Iranshahi, Jamshid Gholizadeh Navashenaq, Bizhan Malaekeh-Nikouei
Summary: The study developed new liposomal formulations to enhance the anti-cancer therapeutic application of Galbanic acid, and demonstrated that RGD peptide decoration could improve targeted delivery to tumor vasculature. The results showed that the targeted liposomes could enhance receptor-mediated endocytosis both in vitro and in vivo, leading to increased accumulation in colon tumors.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Na Qi, Shangqian Zhang, Xiantai Zhou, Wenjuan Duan, Duan Gao, Jianfang Feng, Aimin Li
Summary: The study demonstrated the significant advantages of RGD-Lf-LP in cellular uptake and tumor spheroid penetration, with both in vitro and in vivo experiments confirming its strong targeting effects for brain orthotopic gliomas. The dual modification of RGD and Lf is a promising combination for brain targeting delivery.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yue Zhi, Junyi Che, Haofang Zhu, Rui Liu, Yuanjin Zhao
Summary: In this study, a novel GA liposomes encapsulated microcapsules delivery system was developed for inflammatory wound repair. The GA liposomes could be controllably released from the microcapsules, promoting M2 macrophage polarization and regulating their responses in the inflammatory wound microenvironment. The results demonstrated that the GA liposomes encapsulated microcapsules delivery system exhibited anti-inflammatory and immunomodulatory effects for diabetic wound healing.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Mohamed Nilam, Shreya Karmacharya, Werner M. Nau, Andreas Hennig
Summary: This study demonstrates a significant increase in sensitivity of supramolecular chemosensors by encapsulating them inside liposomes and exposing them to a pH gradient. The enhanced sensors can effectively detect multiple biologically relevant analytes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Food Science & Technology
Vera Lavelli, Jolanta Sereikaite
Summary: This article primarily discusses the development of nano- and micro-structures for the encapsulation of β-carotene, and their role in improving its bioavailability and stability. The results show that these structures can provide better protection for β-carotene compared to natural matrices, and the use of materials with antioxidant activity can further increase its stability.
Article
Biochemistry & Molecular Biology
Jibing Zhang, Xiao Cui, Yujiao Huang, Xiangdong Xu, Changshun Feng, Jun Li
Summary: Breast cancer is a common and serious health threat worldwide. Innate immunity, particularly the STING pathway, has attracted attention in antitumor research. In this study, diABZI-encapsulated liposomes (dLNPs) were prepared and shown to effectively suppress tumor growth in breast cancer therapy.
Review
Pharmacology & Pharmacy
N. Bhagya, K. R. Chandrashekar
Summary: Autophagy serves as a double-edged sword in cancer, exerting both tumor promoting and inhibiting effects. While normal autophagy degrades damaged cell organelles and debris, enhancing autophagy can induce apoptosis and programmed cell death, making it significant in cancer therapy. Liposome-based drug delivery systems offer advantages in manipulating autophagy pathway and are discussed in the review, including drug uptake and its role in autophagy-mediated cancer cell death. Challenges and translational difficulties of liposome-based chemotherapeutic drugs in clinical trials and biomedical applications are also addressed.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Zhiyang Li, Jiaqi Lu, Baolan Tang, Yuesen Shi, Li Hai, Li Guo, Yong Wu
Summary: Liposomes decorated with multi-branched RGD ligand show promise in the treatment of glioma, as they have enhanced targeting ability for the blood-brain barrier and glioma cells.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Hamad Alrbyawi, Sai H. S. Boddu, Ishwor Poudel, Manjusha Annaji, Nur Mita, Robert D. Arnold, Amit K. Tiwari, R. Jayachandra Babu
Summary: This study developed a co-delivery system of daunorubicin and cardiolipin encapsulated in thermosensitive liposomes for the treatment of breast cancer. The liposomes exhibited high drug encapsulation efficiency, small size, and rapid release under mild hyperthermia, resulting in significantly higher cytotoxicity against breast cancer cells compared to daunorubicin or conventional liposomes. This research lays the foundation for future development of liposomal co-delivery systems for breast cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Huanli Yin, Qi Yan, Yuan Liu, Lan Yang, Yang Liu, Yujie Luo, Tianyu Chen, Ningxi Li, Min Wu
Summary: A dual-loaded multi-targeted drug delivery nanosystem was successfully developed to selectively target tumor sites and release multiple drugs, demonstrating a significantly better inhibitory effect compared to free drugs.
Article
Critical Care Medicine
Seyedeh-Sara Hashemi, Zohreh Saadatjo, Reza Mahmoudi, Hamdollah Delaviz, Hassan Bardania, Seyedeh-Somayeh Rajabi, Alireza Rafati, Mohammad M. Zarshenas, Mehrzad Jafari Barmak
Summary: This study investigates the potential application of electrospun polycaprolactone/chitosan/oak fruit (Jaft) internal layer as skin scaffolds. The combination of synthetic polymers, natural polymers, and Jaft provides the fabricated scaffolds with good mechanical properties, water absorption capacity, surface hydrophilicity, and cell viability.
Article
Chemistry, Multidisciplinary
Fatemeh Najarnia, Fatemeh Ahmadpoor, Samaneh Sahebian, Jacqueline A. Johnson, Saeed Kamali, Seyed Abbas Shojaosadati
Summary: This study investigated the thermal stability and decomposition kinetics of Ha center dot gg iron carbide nanoparticles synthesized via a wet chemical method. The results showed that the transformation activation energy of the nanoparticles was high, and the degradation kinetics was determined to be a three-dimensional diffusion type.
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
(2022)
Article
Immunology
Zohreh Safari, Majid Sadeghizadeh, Golareh Asgaritarghi, Hassan Bardania, Dina Sadeghizadeh, Sara Soudi
Summary: This study found that M13 phages can polarize macrophages towards the M2 phenotype by inducing anti-inflammatory cytokine production and reducing inflammatory cytokine levels. This suggests the potential of M13 phages in immunotherapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Marzieh Baneshi, Shayessteh Dadfarnia, Ali Mohammad Haji Shabani, Seyyed Kazem Sabbagh, Hassan Bardania
Summary: A pH-sensitive nano-graphene oxide (nGO)-based delivery system was designed for delivering Cur to MCF cancerous cells. The system effectively loaded and released Cur, showing potential for cancer treatment. The functionalized nano-carrier with AS1411 aptamer demonstrated improved efficiency in inhibiting the growth of specific cancer cells.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Vahid Eskandari, Hossein Sahbafar, Leila Zeinalizad, Reza Mahmoudi, Farzad Karimpour, Amin Hadi, Hassan Bardania
Summary: In this study, surface-enhanced Raman scattering (SERS) was used to investigate the presence of the chemotherapy drug Doxorubicin (DOX) in healthy blood plasma. The researchers successfully detected and evaluated the enhancement of Raman signals using silver nanoparticles (AgNPs) coated on glass fiber substrates.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Toxicology
Zahra Barmoudeh, Maryam Tajali Ardakani, Amir Hossein Doustimotlagh, Hassan Bardania
Summary: The effects of hydroalcoholic extracts of Thymus daenensis Celak and Stachys pilifera Benth on HepG2 cell line were investigated. The extracts showed high cytotoxicity and antioxidant capacity, making them potentially useful for medicinal purposes.
JOURNAL OF TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Khosravani, Hamed Mir, Ali Mirzaei, Farzad Kobarfard, Hassan Bardania, Ebrahim Hosseini
Summary: This study aimed to prepare arginine-glycine-aspartic acid (RGD)-decorated nanoliposomes (NLPs) containing Erlo and ATO (NLPs-ATO-Erlo-RGD) to increase the solubility and reduce the toxicity of Erlo and ATO for cancer treatment. The results showed that NLPs-ATO-Erlo-RGD demonstrated considerable toxicity against the alpha v beta 3 overexpressing PC3 cell line and induced apoptosis. Furthermore, treatment with NLPs-ATO-Erlo-RGD significantly reduced EGFR level.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Hamdam Hourfar, Farhang Aliakbari, Shabboo Rahimi Aqdam, Zahra Nayeri, Hassan Bardania, Daniel E. Otzen, Dina Morshedi
Summary: The blood-brain barrier (BBB) controls the movement of biomolecules and protects the brain, but it can be compromised by the accumulation of alpha-synuclein aggregates (alpha SN-AGs) seen in Parkinson's disease (PD). In this study, in vitro co-culturing models were used to investigate how alpha SN-AGs affect the BBB. The results showed that alpha SN-AGs compromised the endothelial cells, leading to decreased viability, membrane potential, wound healing activity, TEER value, and increased permeability. However, co-culturing with astrocytes or dopaminergic neurons, or treatment with their conditioned media, increased resistance against alpha SN-AGs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemical Research Methods
Mahshid Azizi, Ghasem Ghalamfarsa, Fatemeh Khosravani, Hassan Bardania, Shahriar Azizi
Summary: This study developed a nanoliposome-based curcumin and Bilhar extract codelivery system, which demonstrated improved anticancer activity and sustainable release after loading onto nanoliposomes.
IET NANOBIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zahra Barmoudeh, Mohamad Hassan Fouani, Zahra Moslemi, Mahdokht Azizi, Amir Hossein Doustimotlagh, Hassan Bardania
Summary: The therapeutic effectiveness of co-loaded liposomes of metformin (Met) and melatonin (Mel) was investigated on cholestasis induced by bile duct ligation (BDL) in male rats. The results showed that liposomal form of Mel and Met had a stronger effect in reducing inflammation and bile duct proliferation compared to their free forms. Moreover, liposomal treatment resulted in lower levels of aspartate aminotransferase (AST) and bilirubin, and downregulation of inflammatory cytokine genes TNF-α and IL-1. Overall, liposomal co-administration of Met and Mel had a better therapeutic effect on liver injury by improving histological changes, reducing biochemical markers, and favoring oxidant-antioxidant balance.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Fatemeh Khosravani, Fatemeh Amiri, Rouzbeh Mahmoudi, Dina Morshedi, Farzad Kobarfard, Mohsen Alipour, Ebrahim Hosseini, Hassan Bardania
Summary: This study developed a co-delivery system using liposomes modified with RGD peptide to enhance the treatment of prostate cancer cells. The liposomes co-loaded with curcumin and arsenic trioxide showed good stability and demonstrated a strong anti-proliferative effect and apoptosis induction on PC3 cells. Furthermore, the co-delivery system significantly reduced EGFR gene expression level in the treated cells. These findings suggest that the NLPs-RGD-Cur-ATO co-delivery system holds promise for prostate cancer therapy.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Marjan Bagherinajafabad, Hassan Bardania, Elham Moazamian, Seyed Sajjad Khoramrooz
Summary: Conventional techniques for microbial detection are time-consuming, expensive, and unsuitable. Gold nanoparticles have been used as a promising detector for rapid and low-cost identification of microbes with high sensitivity. In this study, gold nanoparticles-probes were used to identify Pseudomonas aeruginosa and Acinetobacter baumannii genomic DNA.
Article
Nanoscience & Nanotechnology
Azadeh Kordzadeh, Hassan Bardania, Esmaeil Behmard, Amin Hadi
Summary: In this study, 55 different RGD dimer motifs were investigated to find the three peptides with the strongest binding energy to the Integrin alpha v133 receptor. The results showed that a sequence with RGD at the beginning and end, and tryptophan (TRP) at the end, had strong interactions with the receptor and significantly changed its conformation.
ADVANCES IN NANO RESEARCH
(2023)
Article
Integrative & Complementary Medicine
Behzad Fazli, Soussan Irani, Hassan Bardania, Mahdieh-Sadat Moosavi, Bita Rohani
Summary: It was found in this study that curcumin-loaded niosomes can effectively prevent the development of severe forms of dysplasia and inhibit the growth of oral cancer cells. The dose of 16 μg showed promising results in vitro. Injectable curcumin niosomes were observed to significantly prevent the development of severe forms of dysplasia in animal experiments.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Biotechnology & Applied Microbiology
Parisa Salehi Najafabadi, Hamdollah Delaviz, Arash Asfaram, Mehrzad Jafari Barmak, Amir Ghanbari, Mohsen Alipour, Parastou Rad, Hassan Bardania
Summary: This study demonstrates that RGD-modified nano-liposomes can significantly improve drug retention time in the blood of rats.
IRANIAN JOURNAL OF BIOTECHNOLOGY
(2022)
