Article
Surgery
Mark A. A. Healy, Oliver Peacock, Chung-Yuan Hu, Brian K. K. Bednarski, Matthew M. M. Tillman, Craig Messick, Harmeet Kaur, George J. J. Chang
Summary: This study aims to identify the rates of positive circumferential resection margin (CRM) in colon cancer surgery in the US. The results show that there is a high overall rate of CRM+ in US colon cancer cases, with variation across hospitals and many facilities having higher than expected rates. Pathologic T-category and other factors have an impact on CRM+.
Article
Oncology
Dakui Luo, Jing Li, Weijing He, Yufei Yang, Sanjun Cai, Qingguo Li, Xinxiang Li
Summary: Positive circumferential resection margin (CRM) in colon cancer surgery is associated with higher recurrence rate and worse survival. Advanced N stage, distant metastases, and poorly differentiated tumor are predictors of positive CRM. The incidence of positive CRM in our Chinese high-volume cancer center is lower compared to Western populations. Adoption of appropriate surgical techniques and multidisciplinary treatment planning can improve oncological outcomes for high-risk CRM involvement in colon cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
B. Brac, C. Dufour, H. Behal, M. Vanderbeken, J. Labreuche, E. Leteurtre, C. Mariette, C. Eveno, G. Piessen, F. Renaud
Summary: This study found that the CAP definition was more accurate in predicting prognosis and recurrence, and identified a new cutoff value for CRM based on histologic type.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Thais Reif de Paul, Knut Magne Augestad, Ravi P. Kiran, Deborah S. Keller
Summary: In patients with rectal cancer resected with clear margins but positive pathologic CRM, adjuvant chemotherapy significantly improved overall survival rates. Treatment at an academic/research facility, minimally invasive surgery, well-differentiated tumors, absence of perineural invasion, and receiving adjuvant chemotherapy were all independently associated with improved survival.
Article
Gastroenterology & Hepatology
Carla Christine Maria Marres, Marieke P. C. M. Smit, Jarmila D. W. van Der Bilt, Christianne J. Buskens, Marco W. Mundt, Paul C. M. Verbeek, Willem A. Bemelman, Anthony Willem Hendrik van de Ven
Summary: This study compared clinical and histological outcomes of laparoscopic (hybrid) wedge resection (LWR) and laparoscopic oncological colon resection (OCR) for patients with an endoscopically unresectable, suspected benign, colon polyp. The results showed that LWR was associated with significantly lower complication rates and acceptable oncological risks compared with OCR, suggesting it as a safe alternative treatment option.
COLORECTAL DISEASE
(2021)
Article
Oncology
Julia Hanevelt, Leon M. G. Moons, Judith E. K. R. Hentzen, Tess M. Wemeijer, Jelle F. Huisman, Wouter H. de Vos Tot Nederveen H. Cappel, Henderik L. van Westreenen
Summary: In the background, CAL-WR procedure is proved to be an effective and safe technique for the primary resection of suspected high-grade dysplasia or T1 colon carcinoma. A retrospective study analyzed 57 patients, and diagnosed 27 patients with pT1 colon carcinoma after CAL-WR, among which 3 cases had histological risk factors for lymph-node metastases and 70% showed deep submucosal invasion (Sm2/Sm3). The overall R0-resection rate for pT1 colon carcinoma was 88.9%, with only 1 minor complication reported.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Caroline Huynh, Stephanie Minkova, Diane Kim, Heather Stuart, Trevor D. Hamilton
Summary: The study compared the outcomes of laparoscopic versus open surgery for treating LACC and found similar overall survival and recurrence-free survival rates with both approaches, but differences in peritoneal recurrence. Careful patient selection in choosing the surgical approach is recommended.
Review
Oncology
Feng Jiang, Mengmeng Ji, Fangtong Jin, Junfeng Liu, Xiaoping Liu
Summary: This study compared the safety and efficacy of two-port laparoscopic surgery (TLS) and conventional laparoscopic surgery (CLS) for resecting sigmoid colon and upper rectal cancers. The results showed that TLS had advantages in terms of incision size and postoperative recovery.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hillary L. Simon, Thais Reif de Paula, Magda M. Profeta da Luz, Ravi P. Kiran, Deborah S. Keller
Summary: A study conducted using the National Cancer Database from 2011 to 2016 revealed a positive circumferential resection margin rate of 18.4% in rectal cancer patients, with several predictors identified for this outcome.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Medicine, Research & Experimental
Octavian Enciu, Adelaida Avino, Valentin Calu, Elena Adelina Toma, Adrian Tulin, Raluca Tulin, Iulian Slavu, Laura Raducu, Andra-Elena Balcangiu-Stroescu, Daniela-Elena Gheoca Mutu, Luminita Florentina Tomescu, Adrian Miron
Summary: Despite concerns about oncologic safety, laparoscopic surgery has been proven to be superior to open surgery for non-metastatic colon cancer. According to the study, laparoscopic surgery is not inferior to open surgery for non-metastatic colon cancer in a medium volume center in Romania.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Review
Oncology
Ross Jarrett, Nicholas P. West
Summary: Colon cancer surgery shows significant variation worldwide, leading to differences in quality measures like lymph node yield. Pathologists can assess these variables and provide feedback to improve surgical quality. The move towards complete mesocolic excision with central vascular ligation emphasizes the importance of pathological feedback for improving outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Nieun Seo, Joon Seok Lim, Taek Chung, Jong Min Lee, Byung Soh Min, Myeong-Jin Kim
Summary: The objective of this retrospective study was to predict CRM involvement on preoperative CT and assess its impact on prognosis in patients with retroperitonealized colon cancer. The study found that preoperative CT can accurately predict CRM involvement, and positive CT assessment by the primary tumor is an independent risk factor for disease-free survival and systemic recurrence.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Hong Yang, Lei Chen, Xiuxiu Wu, Chenghai Zhang, Zhendan Yao, Jiadi Xing, Ming Cui, Beihai Jiang, Xiangqian Su
Summary: This study found that distant metastasis was more common than locoregional recurrence after laparoscopic resection of rectal cancer, and there were different clinicopathological factors associated with locoregional recurrence and distant metastasis. Involved circumferential resection margin and suboptimal lymph node yield were adverse surgery-related factors of tumor recurrence that should be paid more attention to during the operation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Swapnil Patel, Mufaddal Kazi, Ashwin L. Desouza, Vivek Sukumar, Jayesh Gori, Munita Bal, Avanish Saklani
Summary: Patients with positive pCRM have high rates of local and distal relapse, with systemic relapse often being detected through follow-up surveillance, while peritoneal or local relapse is more often symptomatic.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Surgery
Erik Agger, Fredrik Joergren, Marie-Louise Lydrup, Pamela Buchwald
Summary: This study aims to evaluate the risk factor of circumferential resection margin (CRM) for distant metastasis (DM) in rectal cancer. The findings suggest that CRM <= 1.0 mm is considered to increase recurrence risk, and the risk of DM decreases with increasing CRM. Therefore, CRM is a dominant factor in discussing the risk of DM after rectal cancer surgery.