Semicontinuous Bioreactor Production of Recombinant Butyrylcholinesterase in Transgenic Rice Cell Suspension Cultures

A novel expression cassette delivers efficient production of exclusively tetrameric human butyrylcholinesterase with improved pharmacokinetics for protection against organophosphate poisoning

(2015) Stanislav Terekhov et al.   BIOCHIMIE

Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses

(2015) Oksana Lockridge   PHARMACOLOGY & THERAPEUTICS

Proline and Glutamine Improve in vitro Callus Induction and Subsequent Shooting in Rice

(2015) Bhausaheb PAWAR et al.   Rice Science

Polyproline promotes tetramerization of recombinant human butyrylcholinesterase

(2014) Marilynn A. Larson et al.   BIOCHEMICAL JOURNAL

Scaled-up manufacturing of recombinant antibodies produced by plant cells in a 200-L orbitally-shaken disposable bioreactor

(2014) Nicole Raven et al.   BIOTECHNOLOGY AND BIOENGINEERING

Oligomerization status influences subcellular deposition and glycosylation of recombinant butyrylcholinesterase inNicotiana benthamiana

(2014) Jeannine D. Schneider et al.   PLANT BIOTECHNOLOGY JOURNAL

Expression of human butyrylcholinesterase with an engineered glycosylation profile resembling the plasma-derived orthologue

(2013) Jeannine D. Schneider et al.   Biotechnology Journal

Chemical polysialylation of human recombinant butyrylcholinesterase delivers a long-acting bioscavenger for nerve agents in vivo

(2013) Denis G. Ilyushin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of polyethylene glycol conjugation on the circulatory stability of plasma-derived human butyrylcholinesterase in mice

(2012) Wei Sun et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure

(2012) Xavier Brazzolotto et al.   FEBS Journal

Drug-making plant blooms

(2012) Amy Maxmen   NATURE

Bioreactor systems for in vitro production of foreign proteins using plant cell cultures

(2011) Ting-Kuo Huang et al.   BIOTECHNOLOGY ADVANCES

Semicontinuous bioreactor production of a recombinant human therapeutic protein using a chemically inducible viral amplicon expression system in transgenic plant cell suspension cultures

(2010) Ting-Kuo Huang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Transgenic plants as a source for the bioscavenging enzyme, human butyrylcholinesterase

(2010) Brian C. Geyer et al.   PLANT BIOTECHNOLOGY JOURNAL

Fed-batch cultivation of transgenic rice cells for the production of hCTLA4Ig using concentrated amino acids

(2009) Cheon-Ik Park et al.   PROCESS BIOCHEMISTRY

A Cyclical Semicontinuous Process for Production of Human α1-Antitrypsin Using Metabolically Induced Plant Cell Suspension Cultures

(2005) Melody M. Trexler et al.   BIOTECHNOLOGY PROGRESS