Article
Polymer Science
Charalampos Pronoitis, Minna Hakkarainen, Karin Odelius
Summary: By rational design of the microstructure of PHUs and utilizing solubility as an enabling tool, complex architectures can be realized with benign reagents and atom-economical reactions, without harsh reaction conditions and solvents. This approach expands the synthetic intricacy for PHUs and could potentially broaden their applications and opportunities in the future.
Article
Chemistry, Physical
Andrzej Puszka, Janusz W. Sikora
Summary: New segmented poly(thiourethane-urethane)s (SPTURs) with high molar masses were synthesized by reaction, showing good thermal and mechanical properties as well as adhesion. These SPTURs exhibit high resistance to hydrolysis and are hydrophilic in nature.
Article
Chemistry, Applied
Aoi Nakashima, Kaho Kohori, Kazuya Yamamoto, Jun-ichi Kadokawa
Summary: Chitin hexanoate-graft-poly(epsilon-caprolactone) (ChHex-g-PCL) was found to be thermoplastic, and the thermoplasticity was confirmed by the formation of a melt-pressed film. Chitin hexanoates were prepared by hexanoylation of chitin and then the surface-initiated ring-opening graft polymerization of epsilon-caprolactone was conducted to graft PCL chains onto the hydroxy groups of chitin hexanoates. The molar substitution and degree of polymerization of the PCL graft chains were influenced by the catalyst, reaction time, and degree of substitution.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Ying Li, Jun Shen, Siqi Zhang, Weidong Wang, Yu Chen, Lin Li
Summary: Biodegradable cationic waterborne polyurethanes (WPUs) were successfully prepared with poly(caprolactone) diol as the soft segment. Incorporating different amounts of trimethylol propane monooleate (TMPM) improved mechanical performance, adhesive strength, and water resistance of the films. The addition of TMPM decreased surface tension, increased water contact angle, and reduced water absorption, transforming the fracture mechanism from brittle to ductile. This modified cationic WPU showed excellent film-forming properties and can be used for eco-friendly applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Weslany Silverio Neto, Gabriel Victor Simoes Dutra, Maria de Sousa Brito Neta, Sacha Braun Chaves, Leonardo Fonseca Valadares, Fernando Gomes de Souza Junior, Fabricio Machado
Summary: The study developed a new magnetopolymeric fluid with potential for tumor treatment through embolization and hyperthermia. Characterization and cytotoxicity evaluation showed promising results, suggesting its potential as an embolic agent for selective and complete obstruction of blood vessels and for treatment by hyperthermia.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Polymer Science
Reihaneh Farajollah, Mir Mohammad Alavi Nikje, Ebrahim Saadat, Farid Abedin Dorkoosh
Summary: In this study, a novel three-dimensional waterborne polymer network containing a pentol star core was designed and synthesized. The polymer showed increased hydrophilicity, degradability, and biocompatibility compared to the core material. These results suggest that the prepared polymer has potential for biomedical applications in the future.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Polymer Science
Abderrahmane Nabgui, Taha El Assimi, Abdellatif El Meziane, Gerrit A. Luinstra, Mustapha Raihane, Geraldine Gouhier, Pascal Thebault, Khalid Draoui, Mohammed Lahcini
Summary: In this study, a bio-nanocomposite based on poly (epsilon-caprolactone) & bentonite nanofiller was prepared through in-situ ring opening polymerization. The resulting composite material showed improved physicochemical properties and exhibited antimicrobial activity against S. epidermidis and S. aureus.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Polymer Science
Victoria J. Barber, Meredith A. Borden, Jill W. Alty, Ly D. Tran, Hilmar Koerner, Luke A. Baldwin, Erik J. Alexanian, Frank A. Leibfarth
Summary: There is an increasing demand for degradable polymers in sustainable plastics and medical implants. To improve their usability, it is necessary to have a better understanding of degradation factors and develop new tools for modulation. In this study, poly(caprolactone) was modified through C-H xanthylation, resulting in changes in material properties and slower degradation. The interplay between molecular and materials characteristics was found to impact the degradation rate.
Article
Polymer Science
Jiafeng Su, Guangqiang Xu, Bingzhe Dong, Rulin Yang, Hongguang Sun, Qinggang Wang
Summary: Chemical upcycling of commercial plastic materials to their starting monomers is of great significance. This study demonstrates the closed-loop processes for ε-caprolactone (ε-CL) to poly(epsilon-caprolactone) (PCL) to ε-CL, and PCL to ε-CL to PCL.
Article
Chemistry, Multidisciplinary
Pawel Botwina, Magdalena Obloza, Piotr Bonarek, Krzysztof Szczubialka, Krzysztof Pyrc, Maria Nowakowska
Summary: A series of PEG-b-PSSNa copolymers were synthesized and tested for their antiviral activity against ZIKV. The copolymers effectively inhibited ZIKV replication in mammalian cells at nontoxic concentrations. Mechanistic analysis showed that the copolymers interacted with viral particles in a zipper-like manner, hindering their interaction with cells. The antiviral activity was dependent on the length of the PSSNa block, indicating the biological activity of the ionic blocks.
Article
Chemistry, Physical
Nathalia Freitas Freire, Paulo Emilio Feuser, Elena Maria Tovar Ambel, Marco Cordani, Ellen De Pieri, Ricardo Andrez Machado-de-Avila, Acacio A. F. Zielinski, Claudia Sayer, Pedro Henrique Hermes de Araujo, Guillermo Velasco Diez, Elaine Cabral Albuquerque, Rosana Lopes Lima Fialho
Summary: THC, CBD, and other natural compounds produced by Cannabis sativa have therapeutic effects on the human body. Full spectrum extracts, containing controlled amounts of different cannabinoids, are being studied for their potential use in treating diseases like cancer. However, cannabinoids have limited bioavailability due to their low solubility in water and moderate stability. Therefore, there is a need to develop novel methods of cannabinoid administration or encapsulation to improve their efficacy.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Pharmacology & Pharmacy
Tejashree Waghule, K. Laxmi Swetha, Aniruddha Roy, Ranendra Narayan Saha, Gautam Singhvi
Summary: PEGylated liposomes and lyotropic liquid crystals were developed to prolong the plasma circulation time of Temozolomide, leading to improved pharmacokinetics and biodistribution, and potential for efficient treatment of glioblastoma.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Polymer Science
Christopher B. Keller, Susan E. Walley, Curtis W. Jarand, Jibao He, Muhammad Ejaz, Daniel A. Savin, Scott M. Grayson
Summary: By grafting linear-bottlebrush amphiphilic copolymers onto the surface of silica nanoparticles, nanoparticle micelles with the ability to encapsulate and stabilize non-polar structures in aqueous media were successfully formed. These nanoparticles not only enhance oil encapsulation, but also provide an alternative dispersant system to address oil pollution in the environment.
Article
Nanoscience & Nanotechnology
Hee Ji Shin, Min Jeong Jo, Ik Sup Jin, Chun-Woong Park, Jin-Seok Kim, Dae Hwan Shin
Summary: The study aimed to develop a nanocarrier formulation incorporating FEN and RAPA for strong efficacy against A549 cancer cells. Results showed that FEN/RAPA-loaded mPEG-b-PCL micelles exhibited enhanced bioavailability and anti-tumor effects both in vitro and in vivo.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Lakshmi Narashimhan Ramana, Le N. M. Dinh, Vipul Agarwal
Summary: Surface charge of graphene quantum dots (GQDs) influences their uptake and clearance in melanoma cells, highlighting the significance of this factor in understanding the process.
NANOSCALE ADVANCES
(2021)
Review
Pharmacology & Pharmacy
Jieon Lee, Kairui Feng, Denise S. Conti, Ross Walenga, Michael Wientjes, Hezhen Wang, Bryan Newman, Liangfeng Han, Sneha Dhapare, Elizabeth Bielski, Andrew Babiskin, Fang Wu, Mark Donnelly, Myong-Jin Kim, Wenlei Jiang, Markham C. Luke, Lanyan Fang, Liang Zhao
Summary: In this article, the US FDA's current thinking, challenges, and opportunities for comparative clinical endpoint bioequivalence studies of orally inhaled drug products (OIDPs) are presented. The FDA uses an aggregate weight-of-evidence approach to demonstrate the bioequivalence of generic OIDPs to their reference listed drug. This approach includes comparative clinical endpoint studies, pharmacokinetic studies, and in vitro studies, as well as the assessment of formulation sameness and device similarity. Challenges arise in the use of forced expiratory volume in the first second (FEV1) as a clinical endpoint due to its variability and relatively flat dose-response relationship. The FDA is striving to develop alternative methods to make the bioequivalence assessment of OIDPs more efficient.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Engineering, Biomedical
Paulo Emilio Feuser, Mariana de Melo Cardoso, Nathalia Coral Galvani, Rubya Pereira Zaccaron, Ligia Milanez Venturini, Flavia Karine Rigo, Ricardo Andrez Machado-de-Avila, Paulo Cesar Lock Silveira, Claudia Sayer, Pedro Henrique Hermes de Araujo
Summary: The study aimed to evaluate the in vivo acute toxicity of Poly(thioether-ester) (PTEe) nanoparticles and poly(thioether-ester)-coated magnetic nanoparticles. Results indicated no significant alterations in biochemical parameters in different organs, suggesting good biocompatibility of both nanoparticle types.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Pharmacology & Pharmacy
Paulo Emilio Feuser, Paula Christina Matos dos Santos, Arthur Poester Cordeiro, Natalia Marceli Stefanes, Laura Otto Walter, Mariana Franzoni Maioral, Maria Claudia Santos-Silva, Pedro Henrique Hermes de Araujo, Claudia Sayer
Summary: Encapsulation of 4NC in PTEe nanoparticles enhances cytotoxicity against leukemia cells while reducing damage to peripheral blood mononuclear cells, showing a higher selectivity index compared to free 4NC.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Polymer Science
Monique J. Leite, Tamara Agner, Fabricio Machado, Brenno A. D. Neto, Pedro H. H. Araujo, Claudia Sayer
Summary: This study utilized an iron-containing imidazolium-based ionic liquid as a catalyst to efficiently catalyze the ring-opening polymerization of epsilon-caprolactone under mild reaction conditions, resulting in the synthesis of polycaprolactones with high yields and narrow molecular weight distributions.
JOURNAL OF POLYMER RESEARCH
(2022)
Article
Respiratory System
Sarah E. Ray, Vanessa Boudewyns, Christine Davis, Janice P. Tzeng, Ila Srivastava, Oluwamurewa Oguntimein, Denise S. Conti, Karen B. Feibus
Summary: This qualitative study examined patients' attitudes and perceptions towards generic dry powder inhaler (DPI) substitution, as well as their views on the quality, efficacy, design, and usability of generic products. The results showed that patients experienced a mix of positive and negative emotions when faced with unexpected generic DPI substitution, and expressed doubts about their ability to navigate differences in device design.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Fernanda Raquel Wust Schmitz, Karina Cesca, Alexsandra Valerio, Debora de Oliveira, Dachamir Hotza
Summary: Novel rapid methodologies involving colorimetric biosensors and gold nanoparticles have been developed for the detection of bacteria, specifically Pseudomonas aeruginosa. The biosensor relies on the color change of gold nanoparticles induced by NaCl after incubation with bacteria and aptamer binding. The optimized conditions for detection were found to be 5 μM aptamer concentration and 200 mM of NaCl. The detection limit for P. aeruginosa was 10(5) CFU mL(-1) by the naked eye and 10(4) CFU mL(-1) by UV-Vis spectrometry.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Nathalia Freitas Freire, Paulo Emilio Feuser, Elena Maria Tovar Ambel, Marco Cordani, Ellen De Pieri, Ricardo Andrez Machado-de-Avila, Acacio A. F. Zielinski, Claudia Sayer, Pedro Henrique Hermes de Araujo, Guillermo Velasco Diez, Elaine Cabral Albuquerque, Rosana Lopes Lima Fialho
Summary: THC, CBD, and other natural compounds produced by Cannabis sativa have therapeutic effects on the human body. Full spectrum extracts, containing controlled amounts of different cannabinoids, are being studied for their potential use in treating diseases like cancer. However, cannabinoids have limited bioavailability due to their low solubility in water and moderate stability. Therefore, there is a need to develop novel methods of cannabinoid administration or encapsulation to improve their efficacy.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Polymer Science
Fernando Elias Guckert, Karina Cesca, Claudia Sayer, Debora de Oliveira, Pedro H. Hermes de Araujo, Bruno Francisco Oechsler
Summary: This study investigated the enzymatic polycondensation of polybutylene succinate (PBS) in solution for biomedical applications. The results showed that reactions containing 5% diphenyl ether as solvent at 80°C and 90°C had the most advantageous synthesis results, with average molar masses between 2,500 and 3,350 g·mol-1. However, it was observed that diphenyl ether affected the stability of the immobilized biocatalyst, indicating the need for further research on using green solvents that maintain the stability of the catalyst.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Thayli Ramires Araujo, Daniela Bresolin, Debora de Oliveira, Claudia Sayer, Pedro Henrique Hermes de Araujo, Jose Vladimir de Oliveira
Summary: The valorization of lignin in polyurethane products enables the utilization of this biomass, which is the second most abundant natural polymer in the world. However, the complex and cross-linked molecular structure of lignin limits its use, making it necessary to develop methods to make lignin more reactive. Chemical modification and fragmentation are among the methods that have been developed, but research on the production of lignopolyols derived from enzymatic catalysis applicable to polyurethanes is lacking.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Engineering, Chemical
Tamara Agner, Amadeo Zimermann, Fabricio Machado, Brenno A. D. Neto, Pedro H. H. de Araujo, Claudia Sayer
Summary: In this study, iron-containing imidazolium-based ionic liquids were used as catalysts for the homogeneous polymerization of n-butyl vinyl ether to investigate the conditions that lead to high molecular weights. The Lewis acidic IL proved to be highly efficient, even at low catalyst concentrations, suggesting its potential for industrial applications. In contrast, the neutral iron-containing IL showed no catalytic activity.
MACROMOLECULAR REACTION ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Jeovandro Maria Beltrame, Brena Beatriz Pereira Ribeiro, Camila Guindani, Graziani Candiotto, Karina Bettega Felipe, Rodrigo Lucas, Alexandre D'Agostini Zottis, Eduardo Isoppo, Claudia Sayer, Pedro Henrique Hermes de Araujo
Summary: In this study, a biocompatible copolyester was synthesized and used to coat SPIONs, which were modified with cysteine to achieve specific interactions with tumor cells. Folic acid and the anti-cancer drug methotrexate were successfully conjugated to the nanoparticle surface, and the release of methotrexate was successfully triggered. Therefore, the SPION@PGlCLCys has a strong potential to be a model nanoplatform for less aggressive treatments and diagnosis techniques.
Article
Engineering, Chemical
Denise A. Laroque, Naomi R. de Jong, Leidiani Muller, Camila C. Paganini, Pedro H. H. de Araujo, Glaucia M. F. de Araga, Bruno A. M. Carciofi
Summary: The migration of antibacterial films made of cellulose acetate (CA) and carvacrol to fat like food simulants and their impact on the shelf life of sliced cooked ham vacuum were investigated. Mathematical models were used to describe the bacterial growth in the ham and the release kinetics of carvacrol. The results demonstrate that CA films with carvacrol have the potential to increase the shelf life of complex food matrices.
JOURNAL OF FOOD ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Junyu Ma, Chen Ma, Xiaoyu Huang, Pedro Henrique Hermes de Araujo, Amit Kumal Goyal, Guolin Lu, Chun Feng
Summary: In this study, uniform fiber-like micelles composed of a pi-conjugated oligo(p-phenylenevinylene) core and a crosslinking silica shell with grafted poly(ethylene glycol) (PEG) chains were generated using living crystalline-driven self-assembly. These micelles exhibited excellent dispersity and colloidal stability, even in different aqueous solutions and elevated temperatures. Furthermore, the micelles showed low cytotoxicity and demonstrated length-dependent cellular uptake behaviors. These findings provide a promising approach for the preparation of uniform, colloidally stable fiber-like nanostructures with tunable length and functions for biomedical applications.
FUNDAMENTAL RESEARCH
(2023)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
