Journal
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
Volume 6, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2016.00001
Keywords
hantavirus; hemorrhagic fever with renal syndrome; Bunyavirus; hantaan virus; pathogenesis
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Funding
- National Natural Science Foundation of China [81373118]
- National Basic Research Programme of China (973 Programme) [2012CB518905]
- Substantial Development Program of Technology Innovation and Clinical Research in Tangdu Hospital [2013-4241370U2]
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Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS), which is a zoonosis endemic in eastern Asia, especially in China. The reservoir host of HTNV is field mouse (Apodernus agraricus). The main manifestation of HFRS, including acute kidney injury, increases vascular permeability, and coagulation abnormalities. In this paper, we review the current knowledge of the pathogenesis of HFRS including virus factor, immunity factor and host genetic factors. Furthermore, the treatment and prevention will be discussed.
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