Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates

Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at theAtoh1promoter

(2016) Yassan Abdolazimi et al.   DEVELOPMENT

Fgf10 is required for specification of non-sensory regions of the cochlear epithelium

(2015) Lisa D. Urness et al.   DEVELOPMENTAL BIOLOGY

Where hearing starts: the development of the mammalian cochlea

(2015) Martin L. Basch et al.   JOURNAL OF ANATOMY

Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development

(2015) Yinghui Song et al.   JOURNAL OF IMMUNOLOGY

Characterization of the Transcriptome of Nascent Hair Cells and Identification of Direct Targets of the Atoh1 Transcription Factor

(2015) T. Cai et al.   JOURNAL OF NEUROSCIENCE

Making sense of Wnt signaling—linking hair cell regeneration to development

(2015) Lina Jansson et al.   Frontiers in Cellular Neuroscience

Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea

(2015) Juan C. Maass et al.   Frontiers in Cellular Neuroscience

Notch signal strength controls cell fate in the haemogenic endothelium

(2015) Leonor Gama-Norton et al.   Nature Communications

Ligand-dependent Notch signaling strength orchestrates lateral induction and lateral inhibition in the developing inner ear

(2014) J. Petrovic et al.   DEVELOPMENT

 -Catenin Is Required for Hair-Cell Differentiation in the Cochlea

(2014) F. Shi et al.   JOURNAL OF NEUROSCIENCE

The Candidate Splicing Factor Sfswap Regulates Growth and Patterning of Inner Ear Sensory Organs

(2014) Yalda Moayedi et al.   PLoS Genetics

Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states

(2014) Lauren LeBon et al.   eLife

Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochlea

(2013) T. Tateya et al.   DEVELOPMENT

Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength

(2013) Inge Van de Walle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ectopic Expression of Activated Notch or SOX2 Reveals Similar and Unique Roles in the Development of the Sensory Cell Progenitors in the Mammalian Inner Ear

(2013) W. Pan et al.   JOURNAL OF NEUROSCIENCE

Conditional Deletion of Atoh1 Reveals Distinct Critical Periods for Survival and Function of Hair Cells in the Organ of Corti

(2013) T. Cai et al.   JOURNAL OF NEUROSCIENCE

In Vivo Visualization of Notch1 Proteolysis Reveals the Heterogeneity of Notch1 Signaling Activity in the Mouse Cochlea

(2013) Zhiyong Liu et al.   PLoS One

Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cells

(2013) Jinwoong Bok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch signaling during cell fate determination in the inner ear

(2013) Amy E. Kiernan   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Negative Regulation of Notch Signaling by Xylose

(2013) Tom V. Lee et al.   PLoS Genetics

A dual function for canonical Wnt/ -catenin signaling in the developing mammalian cochlea

(2012) B. E. Jacques et al.   DEVELOPMENT

Sox2 regulation of hair cell development: incoherence makes sense

(2012) Joana Neves et al.   HEARING RESEARCH

Inner Hair Cells Are Not Required for Survival of Spiral Ganglion Neurons in the Adult Cochlea

(2012) Y. Zilberstein et al.   JOURNAL OF NEUROSCIENCE

A Mutation in EGF Repeat-8 of Notch Discriminates Between Serrate/Jagged and Delta Family Ligands

(2012) S. Yamamoto et al.   SCIENCE

Differentiation of the Lateral Compartment of the Cochlea Requires a Temporally Restricted FGF20 Signal

(2012) Sung-Ho Huh et al.   PLOS BIOLOGY

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions

(2011) I. Van de Walle et al.   BLOOD

Mechanism and Significance of cis-Inhibition in Notch Signalling

(2011) David del Álamo et al.   CURRENT BIOLOGY

Fringe benefits: Functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors

(2011) Nadia A Rana et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Jagged 1 regulates the restriction of Sox2 expression in the developing chicken inner ear: a mechanism for sensory organ specification

(2011) J. Neves et al.   DEVELOPMENT

Shaping sound in space: the regulation of inner ear patterning

(2011) A. K. Groves et al.   DEVELOPMENT

Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development

(2011) Tomoko Tateya et al.   DEVELOPMENTAL BIOLOGY

Canonical Notch Signaling Is Not Necessary for Prosensory Induction in the Mouse Cochlea: Insights from a Conditional Mutant of RBPj 

(2011) M. L. Basch et al.   JOURNAL OF NEUROSCIENCE

Localization of fatty acid binding proteins (FABPs) in the cochlea of mice

(2010) Sachiko Saino-Saito et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

A Role of Receptor Notch in Ligand cis-Inhibition in Drosophila

(2010) Isabelle Becam et al.   CURRENT BIOLOGY

Generation and characterization of Atoh1-Cre knock-in mouse line

(2010) Hua Yang et al.   GENESIS

Notch inhibition by the ligand Delta-Like 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis

(2010) Gavin Chapman et al.   HUMAN MOLECULAR GENETICS

Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate

(2010) M. Morimoto et al.   JOURNAL OF CELL SCIENCE

BMP Signaling Is Necessary for Patterning the Sensory and Nonsensory Regions of the Developing Mammalian Cochlea

(2010) T. Ohyama et al.   JOURNAL OF NEUROSCIENCE

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Notch signaling is required for the generation of hair cells and supporting cells in the mammalian inner ear

(2010) W. Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch signaling specifies prosensory domains via lateral induction in the developing mammalian inner ear

(2010) B. H. Hartman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of glycosylation of Notch in development

(2010) Hideyuki Takeuchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development

(2009) Karin Schuster-Gossler et al.   BMC DEVELOPMENTAL BIOLOGY

Notch Signalling: Receptor cis-Inhibition To Achieve Directionality

(2009) David del Álamo et al.   CURRENT BIOLOGY

Regulation of cell fate and patterning in the developing mammalian cochlea

(2009) Matthew W Kelley et al.   Current Opinion in Otolaryngology & Head and Neck Surgery

Hey2 Regulation by FGF Provides a Notch-Independent Mechanism for Maintaining Pillar Cell Fate in the Organ of Corti

(2009) Angelika Doetzlhofer et al.   DEVELOPMENTAL CELL

Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain

(2009) Jennifer L. Moran et al.   DEVELOPMENTAL DYNAMICS

Lunatic and Manic Fringe Cooperatively Enhance Marginal Zone B Cell Precursor Competition for Delta-like 1 in Splenic Endothelial Niches

(2009) Joanne B. Tan et al.   IMMUNITY

β-Catenin Up-regulatesAtoh1Expression in Neural Progenitor Cells by Interaction with anAtoh13′ Enhancer

(2009) Fuxin Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1

(2009) Junko Murata et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

More complicated than it looks: assembly of Notch pathway transcription complexes

(2008) R A Kovall   ONCOGENE