Review
Chemistry, Multidisciplinary
Rossella Canese, Federica Vurro, Pasquina Marzola
Summary: Iron oxide nanoparticles can be used as MRI contrast agents, with applications in liver-specific contrast agents and diagnostic agents in cancer immunotherapy. In addition to diagnostic purposes, these nanoparticles may also have therapeutic effects. Furthermore, iron oxide nanoparticles have innovative applications in drug delivery and imaging techniques for tumors.
Review
Chemistry, Multidisciplinary
Shuren Wang, Yanglong Hou
Summary: Magnetic nanomaterials play a crucial role in the biomedical field and have various applications such as biosensors, drug delivery vehicles, and diagnostic agents. Researchers are continuously developing new types of magnetic nanomaterials, like iron carbide nanoparticles, to improve performance. Magnetic nanoparticles responsive to exogenous or endogenous stimuli have been developed, enhancing their applicability in more complex scenarios. These nanoparticles can respond to stimuli such as acidity, hydrogen peroxide, light, and magnetic fields.
Article
Chemistry, Inorganic & Nuclear
Sofia Khabirova, Gleb Aleshin, Evgeny Anokhin, Anna Shchukina, Anastasia Zubenko, Olga Fedorova, Aleksey Averin, Lev Trusov, Stepan Kalmykov
Summary: In this article, the first modification of nanoparticles with ligands for combined radiopharmaceuticals is reported. Nanoparticles with suitable magnetic properties can be used for both diagnostics and therapy, including magneto-mechanical therapy that is insufficiently studied. Strontium hexaferrite is a hard-magnetic material that can form stable biocompatible colloidal solutions. The nanoparticles were modified with a coupling agent and covalently linked to azacrown ether derivatives, and then radiolabeled with Bi-207. In vitro experiments showed that the complex is stable enough to be a potential theranostic radiopharmaceutical.
DALTON TRANSACTIONS
(2023)
Article
Biophysics
Maria Gabriela Montiel Schneider, Maria Florencia Favatela, Guillermo Arturo Munoz Medina, Marcela Beatriz Fernandez van Raap, Veronica Leticia Lassalle
Summary: The study synthesized multifunctional iron oxide magnetic nanoparticles for potential therapy and diagnosis applications, evaluating their capabilities as a drug carrier, antioxidant, magnetic hyperthermia agent, and MRI contrast agent. Results showed that Mag@Man/H1 could serve as a multifunctional nanoplatform for oncological diseases treatments.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Engineering, Environmental
Pankaj Bhatt, Satish Chandra Pandey, Samiksha Joshi, Parul Chaudhary, Vinay Mohan Pathak, Yaohua Huang, Xiaozhen Wu, Zhe Zhou, Shaohua Chen
Summary: Growing human interference has led to an increase in both organic and inorganic contaminants, posing a threat to ecosystems. Removing these toxic pollutants from the environment is challenging. Bioremediation combined with nanotechnology shows promise as a cost-effective method for pollutant removal. Nanomaterials have exceptional properties, such as improved catalysis and adsorption, making them of great interest. By using microbial cultures and nanomaterials, the bioremediation of toxic compounds can be facilitated. Understanding the relationship between microorganisms, contaminants, and nanoparticles is crucial. This review focuses on the removal of toxic pollutants through the combined effects of nanoparticles and microbial technology, highlighting the significance and contribution of this novel nanobioremediation technique to sustainability.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yudan Yang, Tengxiang Yang, Fangfang Chen, Cheng Zhang, Baoli Yin, Xia Yin, Linbo Han, Qingji Xie, Xiao-Bing Zhang, Guosheng Song
Summary: Theranostic agents based on magnetic ions coordinated nanoplatform show excellent multimodal imaging and photothermal therapy effects in tumors, providing a potential application for cancer treatment.
Article
Chemistry, Physical
Evelyn C. S. Santos, Jamili A. Cunha, Marcel G. Martins, Bianca M. Galeano-Villar, Richard J. Caraballo-Vivas, Pablo B. Leite, Andre L. Rossi, Flavio Garciaa, Priscilla V. Finotelli, Helen C. Ferraz
Summary: Theranostic systems based on multicore magnetic iron oxide functionalized with curcuminoids and coated with silica have been synthesized and characterized. The resulting nanoplatform exhibits expressive fluorescence, interesting magnetic and thermal properties, and negligible release of curcuminoids in sink conditions. This versatile and multifunctional nanoplatform shows potential for various biomedical applications such as image contrast, magnetic hyperthermia treatment, cell separation, and drug delivery.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Review
Nanoscience & Nanotechnology
Sumera Khizar, Nasir M. Ahmad, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid-el-salhi, Abdelhamid Elaissari
Summary: In the past few years, engineered inorganic nanoparticles have been increasingly studied and applied in the biomedical field for their potential in combining diagnosis and treatment through various approaches such as imaging, targeting, and therapy. Magnetic nanoparticles have gained attention in materials science due to their unique capabilities in targeting, imaging, therapy, and controlled drug release, among others. Decorating or functionalizing magnetic nanoparticles with different materials can enhance their biocompatibility, stability, and therapeutic efficacy.
ACS APPLIED NANO MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Guanyou Lin, Miqin Zhang
Summary: The potential of theranostic nanoparticles in tumor treatment is widely recognized due to their ability to integrate multifaceted functionalities into a single nanosystem. These nanoparticles typically consist of an inorganic core for imaging and therapeutic functions, bioinert coatings for improved biocompatibility, controlled drug-loading-release modules, and targeting ligands for specific cell uptake. The design and assembly of these functionalities require sophisticated molecular design and precise execution. Ligand chemistry plays a decisive role in translating theoretical designs into functionalized theranostic nanoparticles. This Account reviews the properties and utilities of capping ligands, drug-loading ligands, and targeting ligands in theranostic nanoparticles.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Dmitry V. Korolev, Galina A. Shulmeyster, Natalia V. Evreinova, Maria S. Syrovatkina, Maria S. Istomina, Victor N. Postnov, Ilia V. Aleksandrov, Aleksandr S. Krasichkov, Michael M. Galagudza
Summary: This paper describes the synthesis of multilayer nanoparticles for the diagnosis and treatment of ischemic injuries. The nanoparticles consist of magnetite and silica, with quinacrine used as an anti-ischemic agent. The study involves surface modification, immobilization of quinacrine, and the formation of a chitosan coating to fix fluorophores and quantum dots as secondary radiation sources. The potential theranostic platform was tested in laboratory animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Gabriela Correa Carvalho, Gabriel Davi Marena, Juliana Camila Fischer Karnopp, Juliana Jorge, Rafael Miguel Sabio, Marco Antonio Utrera Martines, Tais Maria Bauab, Marlus Chorilli
Summary: Pharmaceutical nanotechnology has significant advantages in controlling drug release. Mesoporous silica nanoparticles (MSNs) are an important system that can carry and release drugs effectively. However, the use of surfactant CTAB in the synthesis of MSNs may pose toxicity risks.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Yan Cheng, Airong Cheng, Yanlong Jia, Lin Yang, Yan Ning, Liang Xu, Yazhi Zhong, Zerui Zhuang, Jitian Guan, Xiaolei Zhang, Yan Lin, Teng Zhou, Xiusong Fan, Jianwu Li, Peng Liu, Gen Yan, Renhua Wu
Summary: The study developed a pH-sensitive theranostic nanoplatform for the precise delivery of rapamycin to ischemic brain tissues, enhancing therapeutic accuracy and enabling multimodal imaging for drug distribution monitoring. The nanoparticles showed good stability and biocompatibility, with the potential for neuroprotection in rats with transient middle cerebral artery occlusion (tMCAO). This pH-sensitive multifunctional nanoplatform could be a promising solution for the accurate in vivo imaging and treatment of acute ischemic stroke and other diseases.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Hugo Groult, Susana Carregal-Romero, David Castejon, Mikel Azkargorta, Ana-Beatriz Miguel-Coello, Krishna Reddy Pulagam, Vanessa Gomez-Vallejo, Remi Cousin, Maria Munoz-Caffarel, Charles H. Lawrie, Jordi Llop, Jean-Marie Piot, Felix Elortza, Thierry Maugard, Jesus Ruiz-Cabello, Ingrid Fruitier-Arnaudin
Summary: This study successfully prepared HEP-ESIONP probes with excellent MRI contrast using a one-pot microwave method with heparin oligosaccharides (HO) of different lengths as coatings, demonstrating anticoagulant properties and/or specific antitumor activity based on the length of HO used. In vivo distribution study showed significant changes in probe behaviors and renal clearance with shortening of HO length, while in vitro characterization of protein coronas provided insight into the crucial impact of HO length on opsonization-mediated immune response and elimination. The precise HO length identified in this study resulted in ESIONP probes with prolonged vascular lifetime, moderate tumor accumulation, low uptake by non-specific organs, and favorable urinary clearance, meeting prerequisites for advanced theranostic medical applications with dual MRI/PET hot spot capability and potential antitumor activity.
Review
Chemistry, Multidisciplinary
Peisen Zhang, Yingying Li, Wen Tang, Jie Zhao, Lihong Jing, Kevin J. McHugh
Summary: Recent advances in theranostic nanoparticles have shown promise in precision medicine, but challenges remain in terms of low bioavailability and biocompatibility. Emerging administration routes for nanomaterials offer potential benefits in bypassing biological barriers and enhancing imaging sensitivity and therapeutic efficacy.
Review
Chemistry, Inorganic & Nuclear
Neha Benedicta Fernandes, Yogendra Nayak, Sanjay Garg, Usha Y. Nayak
Summary: The field of advanced nanotechnology offers a wide range of nanotheranostics for treating malignant tumors. Among them, Mesoporous Silica Nanoparticles (MSNs) combined with upconversion nanoparticles have gained prominence in biomedicine research due to their remarkable properties in drug targeting, bio-imaging, and photodynamic/photothermal therapy. MSNs have versatile pore sizes, high drug loading efficiency, and can be functionalized to enhance their applicability. This article focuses on MSN-based hybrid nanotheranostics and their designing strategies, characterization, applications, efficacy, limitations, biotoxicity, as well as current challenges and future perspectives.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Joanna Potas, Agnieszka Zofia Wilczewska, Pawel Misiak, Anna Basa, Katarzyna Winnicka
Summary: Polyelectrolyte multilayers (PEMs) based on polyelectrolyte complex (PEC) structures are interesting materials for functionalized coatings and drug delivery platforms. This study optimized the formulation of chitosan/low-methoxy amidated pectin multilayer films and investigated their thermal properties, chemical structure, mechanical properties, and internal structure. The results showed that films with confirmed multilayer architecture are promising for buccal drug delivery and have improved thermal stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Kupinska, Maciej Michalik, Justyna Krajenta, Magda Bielicka, Karolina Halina Markiewicz, Beata Kalska-Szostko, Agnieszka Zofia Wilczewska
Summary: This study investigated the methods of preparation of zinc oxide-polypropylene nanocomposites and their antibacterial properties. Two methods of ZnO NPs syntheses were carried out and the influence of various factors on the synthesis process was examined. The fabricated PP-ZnO composite showed antibacterial properties against Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Marta Szekalska, Magdalena Wroblewska, Anna Czajkowska-Kosnik, Katarzyna Sosnowska, Pawel Misiak, Agnieszka Zofia Wilczewska, Katarzyna Winnicka
Summary: Candida species are the main causative agents of vulvovaginal candidiasis, which is difficult to cure and associated with fungal resistivity. Microparticles with larger surface area can provide short drug diffusion passage, potentially improving therapeutic efficiency. Sodium alginate, a natural polymer, possesses swelling, mucoadhesive, and gelling properties, while gelatin A, a natural polypeptide, has a high molecular weight. This study prepared microparticles using a mixture of alginate/gelatin polyelectrolyte complex and a novel antifungal drug-luliconazole. The addition of gelatin improved the particle size, encapsulation efficiency, mucoadhesiveness, drug release, and antifungal effect against Candida species.
Correction
Nanoscience & Nanotechnology
E. Piktel, K. H. Markiewicz, A. Z. Wilczewska
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Food Science & Technology
Magdalena Krekora, Karolina H. Markiewicz, Agnieszka Z. Wilczewska, Agnieszka Nawrocka
Summary: FT-Raman spectroscopy, thermogravimetry and differential scanning calorimetry were used to study the interactions between gluten proteins and flavonoids and their glycosides in the model dough. The results showed that the tested compounds caused changes in the secondary and tertiary structure of gluten proteins, mainly dependent on the molecular structure of the flavonoids. The changes caused by glycosides were related to the site of attachment of the glycosidic part to the aglycone.
JOURNAL OF CEREAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Pawel A. Grzes, Agata Sawicka, Katarzyna Niemirowicz-Laskowska, Przemyslaw Wielgat, Diana Sawicka, Halina Car, Izabella Jastrzebska
Summary: In this study, a simple and efficient methodology for the metal-promoted preparation of steroidal ethynyl selenides has been described. The compounds were characterized using various spectroscopic and analytical techniques. The synthesized compounds were then evaluated for their biocompatibility and anticancer activity, showing high hemocompatibility, lack of toxicity against cardiomyocytes, and great anti-cancer activity against estrogen-depend breast cancer cells. The mechanism of action involves the induction of cell apoptosis through overproduction of reactive oxygen species and activation of Caspase 3/7. These findings suggest that organo-selenium based compounds have great potential for breast cancer therapies.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Valery Isidorov, Adam Zalewski, Grzegorz Zambrowski, Izabela Swiecicka
Summary: Due to its medical and pharmaceutical importance, honey bee venom has been well studied, but our understanding of its composition and antimicrobial properties is still incomplete. In this study, the volatile and extractive components of dry and fresh bee venom were analyzed, and their antimicrobial activity against different pathogens was tested. The results showed that bee venom contains many new organic compounds and has strong inhibitory effects on Gram-positive bacteria, suggesting that its antimicrobial activity is not only attributed to peptides like melittin, but also low molecular weight metabolites.
Review
Microbiology
Grzegorz Krol, Kamila Fortunka, Michal Majchrzak, Ewelina Piktel, Paulina Paprocka, Angelika Mankowska, Agata Lesiak, Maciej Karasinski, Agnieszka Strzelecka, Bonita Durnas, Robert Bucki
Summary: The usage of nanotechnology in fighting parasitic diseases is in the early stages of development. It brings hopes for targeting early parasitosis stages, compensating the lack of vaccines, and finding new treatment options for drug-resistant parasites. The physicochemical properties of nanomaterials, such as size, shape, surface charge, surfactants, and shell molecules, play important roles in designing metallic nanoparticles and specific nanosystems. The development of antiparasitic drugs and diagnostic tools using nanotechnology is expected to provide new and effective methods to improve prevention and reduce morbidity and mortality caused by these diseases.
Article
Oncology
Pawel Misiak, Katarzyna Niemirowicz-Laskowska, Karolina H. Markiewicz, Przemyslaw Wielgat, Izabela Kurowska, Robert Czarnomysy, Iwona Misztalewska-Turkowicz, Halina Car, Krzysztof Bielawski, Agnieszka Z. Wilczewska
Summary: The research focuses on synthesizing polymer nanoparticles (PNPs) for doxorubicin delivery. Various block and statistical copolymers with ketoester derivative, N-isopropylacrylamide, and cholesterol were prepared. The doxorubicin-loaded PNPs demonstrated high efficacy against estrogen-dependent MCF-7 breast cancer cell lines at low doses and showed good compatibility with normal cells. The study confirms the impact of PNPs on membrane degradation, accumulation of reactive oxygen species (ROS), and cell cycle arrest, all of which are closely related to cell death.
CANCER NANOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Izabela Kurowska, Karolina H. Markiewicz, Katarzyna Niemirowicz-Laskowska, Mathias Destarac, Przemyslaw Wielgat, Iwona Misztalewska-Turkowicz, Pawel Misiak, Halina Car, Agnieszka Z. Wilczewska
Summary: This study reports on the formation of drug delivery systems using thermoresponsive block copolymers containing lipid-based segments. Two acrylate monomers derived from palmitic- or oleic-acid-based diacylglycerols were synthesized and polymerized using the RAFT method. The resulting amphiphilic block copolymers formed polymeric nanoparticles, which showed cytocompatibility with normal cells and increased cytotoxicity and apoptosis or necrosis induction in breast cancer cells compared to the free drug.
Article
Chemistry, Physical
Iwona Misztalewska-Turkowicz, Jadwiga Maj, Barbara Lessniewska, Slawomir Wojtulewski, Izabela Zglobicka, Agnieszka Z. Wilczewska
Summary: The purpose of our research was to develop heterogeneous catalysts with high activity in a water environment and easy separability. By utilizing surface-initiated polymerization (SI-RAFT/MADIX), we successfully prepared Pickering interfacial catalysts using magnetic nanoparticles covered with amphiphilic polymers, which were then modified with palladium for Suzuki-Miyaura reactions. The catalyst showed good activity in hydrophobic substances' biphasic reactions in water, eliminating the need for standard surfactants. The Pickering interfacial catalysis not only stabilized emulsions but also carried the palladium catalyst, and the pure product was obtained using non-demanding methods such as precipitation and extraction.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Genetics & Heredity
Katarzyna Leszczynska, Izabela Swiecicka, Tamara Daniluk, Dariusz Lebensztejn, Sylwia Chmielewska-Deptula, Dorota Leszczynska, Jan Gawor, Malgorzata Kliber
Summary: The study assessed the prevalence and pathogenicity of E. albertii strains in northeastern Poland and found high genetic variability and potential public health threat.
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
