Real-time imaging of Huntingtin aggregates diverting target search and gene transcription

The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei

(2015) Siheng Xiang et al.   CELL

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Imaging Live-Cell Dynamics and Structure at the Single-Molecule Level

(2015) Zhe Liu et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

A general method to improve fluorophores for live-cell and single-molecule microscopy

(2015) Jonathan B Grimm et al.   NATURE METHODS

InferenceMAP: mapping of single-molecule dynamics with Bayesian inference

(2015) Mohamed El Beheiry et al.   NATURE METHODS

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

(2015) Tetsuro Murakami et al.   NEURON

Delayed emergence of subdiffraction-sized mutant huntingtin fibrils following inclusion body formation

(2015) Steffen J. Sahl et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA

(2015) A. C. Woerner et al.   SCIENCE

Large Polyglutamine Repeats Cause Muscle Degeneration in SCA17 Mice

(2015) Shanshan Huang et al.   Cell Reports

Super-Resolution Fluorescence of Huntingtin Reveals Growth of Globular Species into Short Fibers and Coexistence of Distinct Aggregates

(2014) Whitney C. Duim et al.   ACS Chemical Biology

Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells

(2014) Jiji Chen et al.   CELL

The expanding role for chromatin and transcription in polyglutamine disease

(2014) Ryan D Mohan et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Transcriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasis

(2014) Amit Kumar et al.   DRUG DISCOVERY TODAY

TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO–IKK supramolecular structures

(2014) Nadine Tarantino et al.   JOURNAL OF CELL BIOLOGY

Cerebellar abnormalities in Huntington's disease: A role in motor and psychiatric impairment?

(2014) Elin M. Rees et al.   MOVEMENT DISORDERS

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington’s disease

(2014) Bindu D. Paul et al.   NATURE

Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution

(2014) Bi-Chang Chen et al.   SCIENCE

Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

(2014) Ignacio Izeddin et al.   eLife

3D imaging of Sox2 enhancer clusters in embryonic stem cells

(2014) Zhe Liu et al.   eLife

Quantitative fluorescence loss in photobleaching for analysis of protein transport and aggregation

(2013) Daniel Wüstner et al.   BMC BIOINFORMATICS

Quantifying transcription factor kinetics: At work or at play?

(2013) Florian Mueller et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Single-molecule imaging of transcription factor binding to DNA in live mammalian cells

(2013) J Christof M Gebhardt et al.   NATURE METHODS

Real-Time Dynamics of RNA Polymerase II Clustering in Live Human Cells

(2013) I. I. Cisse et al.   SCIENCE

Huntington's disease: underlying molecular mechanisms and emerging concepts

(2013) John Labbadia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Degeneration of the Cerebellum in Huntington's Disease (HD): Possible Relevance for the Clinical Picture and Potential Gateway to Pathological Mechanisms of the Disease Process

(2012) Udo Rüb et al.   BRAIN PATHOLOGY

Significantly differential diffusion of neuropathological aggregates in the brain of transgenic mice carrying N-terminal mutant huntingtin fused with green fluorescent protein

(2012) Pei-Hsun Cheng et al.   Brain Structure & Function

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

Rational design of true monomeric and bright photoactivatable fluorescent proteins

(2012) Mingshu Zhang et al.   NATURE METHODS

Fast multicolor 3D imaging using aberration-corrected multifocus microscopy

(2012) Sara Abrahamsson et al.   NATURE METHODS

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

A benchmark for chromatin binding measurements in live cells

(2012) Davide Mazza et al.   NUCLEIC ACIDS RESEARCH

Huntingtin Fragments and SOD1 Mutants Form Soluble Oligomers in the Cell

(2012) Yang-Nim Park et al.   PLoS One

Time-lapse two-color 3D imaging of live cells with doubled resolution using structured illumination

(2012) R. Fiolka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PolyQ disease: misfiring of a developmental cell death program?

(2012) Elyse S. Blum et al.   TRENDS IN CELL BIOLOGY

Cellular Inclusion Bodies of Mutant Huntingtin Exon 1 Obscure Small Fibrillar Aggregate Species

(2012) Steffen J. Sahl et al.   Scientific Reports

Comprehensive Genome-wide Protein-DNA Interactions Detected at Single-Nucleotide Resolution

(2011) Ho Sung Rhee et al.   CELL

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

(2011) John Labbadia et al.   JOURNAL OF CLINICAL INVESTIGATION

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

A Humanized Version of Foxp2 Affects Cortico-Basal Ganglia Circuits in Mice

(2009) Wolfgang Enard et al.   CELL

Transcription Dynamics

(2009) Gordon L. Hager et al.   MOLECULAR CELL

Impaired Synaptic Plasticity and Motor Learning in Mice with a Point Mutation Implicated in Human Speech Deficits

(2008) Matthias Groszer et al.   CURRENT BIOLOGY

Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes

(2008) Arnauld Sergé et al.   NATURE METHODS

High-density mapping of single-molecule trajectories with photoactivated localization microscopy

(2008) Suliana Manley et al.   NATURE METHODS

Polyglutamine neurodegeneration: protein misfolding revisited

(2008) Aislinn J. Williams et al.   TRENDS IN NEUROSCIENCES

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY