Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 126, Issue -, Pages 603-606Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2015.01.015
Keywords
Magnesium; Biomaterials; Degradation; L929 cells
Funding
- National Institute for Materials Science (NIMS)
- JSPS KAKENHI [26282151]
- Grants-in-Aid for Scientific Research [26282151] Funding Source: KAKEN
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In this study, the influence of living cells (L929) on the in vitro degradation behaviour of a magnesium-calcium alloy was investigated using an electrochemical technique in the Eagle's minimum essential medium (EMEM) with 10% foetal bovine serum (PBS) under 5% CO2 atmosphere. The degradation of the alloy increased significantly in the medium containing the cells as compared to that without cells. Post-degradation analysis revealed localized degradation in the vicinity of the cells. It is suggested that the cell metabolic activity has induced local pH drop and as a result increased the alloy degradation. (C) 2015 Elsevier B.V. All rights reserved.
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