Article
Chemistry, Applied
Ruchira Panchal, Tarun Mateti, K. Likhith, Fiona Concy Rodrigues, Goutam Thakur
Summary: This study explores the applications of cross-linked chitosan-polyvinyl alcohol-genipin films in wound healing. The results show that the cross-linked films have increased tensile strength and improved water retention capabilities, and they have a uniform continuous morphology. In vivo experiments indicate that the cross-linked films promote quick fibroblast generation and angiogenesis.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Food Science & Technology
Ana Carolina R. Goncalves, Larissa G. R. Duarte, Ana Clara T. R. Fiocco, William M. P. Alencar, Raiza Iacuzio, Nathalia C. C. Silva, Carolina S. F. Picone
Summary: Chitosan nanoparticles were prepared using two different methods: ionic cross-linking with sodium tripolyphosphate (TPP) and chemical cross-linking with genipin (GN). The nanoparticles exhibited positive zeta potentials (+46.24 mV for CS-TPP and +62.86 mV for CS-GN) and sizes ranging from 83.70 to 835.91 nm, with the ionic cross-linked nanoparticles being smaller. In vitro antibacterial tests showed effective inhibition, particularly for CS-TPP. In situ studies on O/W emulsions demonstrated that the nanoparticles improved the microbiological and oxidative stability of the emulsions. These findings highlight the relationship between particle size reduction and enhanced functional properties of biopolymers, and expand the potential applications of chitosan as a natural preservative for emulsified systems.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Duoduo Wu, Dawn Ka-Ann Lim, Blanche Xiao Hong Lim, Nathan Wong, Farhad Hafezi, Ray Manotosh, Chris Hong Long Lim
Summary: Corneal cross-linking (CXL) using riboflavin and ultraviolet A (UVA) light is a versatile treatment option for a variety of corneal diseases, including keratoconus. Recent advances include PACK-CXL for infectious keratitis and CurV customized protocols, which have generated increased interest in the field.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Shinya Watanabe, Ryuhei Hayashi, Yuzuru Sasamoto, Motokazu Tsujikawa, Bruce R. Ksander, Markus H. Frank, Andrew J. Quantock, Natasha Y. Frank, Kohji Nishida
Summary: A subpopulation of cells in hiPSC-derived corneal epithelial cell sheets, positive for ABCB5, demonstrate remarkable holoclone-forming capabilities that can be suppressed by ABCB5 blockade. These cells first emerge in 2D eye-like organoids around six weeks of differentiation and display corneal epithelial characteristics, including sustained expression of ABCB5. This study highlights the translational potential of ABCB5-enriched, hiPSC-derived corneal epithelial cell sheets for vision recovery in stem cell-deficient human eyes and represents the first report of holoclone-forming stem cells identified in an hiPSC-derived organoid.
Review
Chemistry, Multidisciplinary
Wei-Hua Han, Qing-Yu Wang, Yuan-Yi Kang, Li-Rui Shi, Yu Long, Xin Zhou, Chun-Cheng Hao
Summary: This review comprehensively discusses the cross-linking electrospinning system for the first time, including cross-linking strategies, cross-linking mechanisms, and applications of cross-linked electrospun nanofibers. The significance of cross-linking electrospinning and the challenges in constructing this system are also highlighted.
Article
Materials Science, Paper & Wood
Yt Jun Cheah, Mohd Heikal Mohd Yunus, Mh Busra Fauzi, Yasuhiko Tabata, Yosuke Hiraoka, Shou Jin Phang, Min Rui Chia, Muhamad Ramdzan Buyong, Muhammad Dain Yazid
Summary: In this study, an acellular gelatin-chitosan-cellulose nanocrystal (GCCNC) scaffold was developed as a potential wound dressing. The GCCNC scaffold showed good physiochemical properties, mechanical properties, and cellular biocompatibility, and was able to maintain normal skin physiological functions. Therefore, it could be used as a potential acellular skin substitute in managing chronic wounds.
Article
Engineering, Biomedical
Meiyan Li, Ruoyan Wei, Chang Liu, Haowei Fang, Weiming Yang, Yunzhe Wang, Yiyong Xian, Kunxi Zhang, Yong He, Xingtao Zhou
Summary: Corneal transplantation is limited by donor corneas, so developing bioadhesive corneal patches with Transparency, Epithelium & Stroma generation, Suturelessness, and Toughness is of great value. A light-curable hydrogel based on GelMA, F127DA & AF127 co-assembled bi-functional micelles, and COL I is designed for repairing damaged cornea. The hydrogel patch possesses transparent, highly tough, and strongly bio-adhesive performance after UV irradiation for 5 minutes.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Applied
Zhendong He, Changqi Liu, Jing Zhao, Fengxian Guo, Yaosong Wang
Summary: The present study found that genipin cross-linking can significantly improve the gelling properties and water holding capacity of ginkgo seed protein. Cross-linking treatment led to lower solubility, surface hydrophobicity, and promoted protein aggregation. Cross-linked gels exhibited increased hardness and water holding capacity.
Review
Biochemistry & Molecular Biology
Dong-Jin Lim
Summary: This article introduces the application of cross-linking agents to improve the performance of electrospun nanofibrous bone scaffolds in bone tissue engineering. Glutaraldehyde and genipin are two commonly used cross-linking agents, with genipin gaining attention due to its superior biocompatibility. In addition, citric acid is an emerging natural cross-linking agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Andrew R. Griswold, Hsin-Che Huang, Daniel A. Bachovchin
Summary: The study demonstrates the functional role of NLRP1 inflammasome in human corneal epithelial cells and sheds light on the mechanism through which aberrant inflammasome activation causes corneal damage.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Chemistry, Applied
Sihan Zhang, Guanglei Zhao, Wei Ma, Yanghui Song, Cheng Huang, Chong Xie, Kebing Chen, Xiaofeng Li
Summary: A porous chitosan nanofiber scaffold (CSNFS) with an extracellular matrix-like structure was prepared through a cross-linking reaction, showing high porosity and adequate micro-scale pores. CSNFS has good mechanical strength and biocompatibility, and can be used as a repair material for bone tissue engineering.
CARBOHYDRATE POLYMERS
(2022)
Article
Biotechnology & Applied Microbiology
Matteo Frigelli, Philippe Buchler, Sabine Kling
Summary: In this study, optical coherence elastography was used to investigate the effects of corneal cross-linking on refractive power and corneal biomechanics. The results showed that different cross-linking treatment patterns and energy densities resulted in different refractive corrections and axial strains. Based on the findings, personalized cross-linking treatment plans can be proposed in the future to achieve customized refractive corrections.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Elrade Rofaani, Yong He, Juan Peng, Yong Chen
Summary: This study developed a method to overcome the lack of in vivo-like basement membrane (BM) for in vitro modeling by culturing primordial lung progenitors (PLPs) on an artificial basement membrane (ABM) composed of collagen IV and laminin. The forces generated by the growing epithelial monolayer on the ABM led to geometry-dependent folding and enhanced expression of surfactant protein C and aquaporin 5 compared with a nanofiber-covered substrate. This work emphasizes the importance of recapitulating natural BM for advanced epithelial modeling.
ACTA BIOMATERIALIA
(2023)
Article
Ophthalmology
Jurriaan Brekelmans, Mor M. Dickman, Shwetabh Verma, Samuel Arba-Mosquera, Ruth Goldschmidt, Alexandra Goz, Alexander Brandis, Tos T. J. M. Berendschot, Isabelle E. Y. Saelens, Arie L. Marcovich, Avigdor Scherz, Rudy M. M. A. Nuijts
Summary: The study found that excimer laser-assisted patterned de-epithelialization allows for effective corneal cross-linking treatment. Different chromophores showed similar penetration depths and effects, but full de-epithelialization resulted in significantly lower light transmittance.
ACTA OPHTHALMOLOGICA
(2022)
Article
Biochemistry & Molecular Biology
Georgia-Persephoni Voulgaridou, Vasileios Theologidis, Maria Venetikidou, Ilias Tsochantaridis, Avgi Tsolou, Maria Koffa, Mihalis I. Panayiotidis, Aglaia Pappa
Summary: This study investigated the cytoprotective role of ALDH3A1 and its molecular mechanisms using a stable transfected HCE-2 cell line. Results showed that ALDH3A1 expression affected cell morphology, cell adhesion, and cell cycle, and reduced apoptosis and DNA damage. Additionally, ALDH3A1 upregulated phosphorylated p53 levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Ying-Chen Huang, Yen-Chang Chu, Nan-Kai Wang, Chi-Chun Lai, Kuan-Jen Chen, Yih-Shiou Hwang, Wei-Chi Wu
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2019)
Article
Ophthalmology
Ling Yeung, Wei-Chi Wu, Lan-Hsin Chuang, Nan-Kai Wang, Chi-Chun Lai
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2019)
Article
Ophthalmology
Jen-Hsiang Shen, Laura Liu, Nan-Kai Wang, Yih-Shiou Hwang, Kuan-Jen Chen, An-Ning Chao, Chi-Chun Lai, Tun-Lu Chen, Wei-Chi Wu
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2020)
Article
Ophthalmology
An-Lun Wu, Kiet-Phang Ling, Lan-Hsin Chuang, Kuan-Jen Chen, Yen-Po Chen, Ling Yeung, Nan-Kai Wang, Laura Liu, Tun-Lu Chen, Yih-Shiou Hwang, Wei-Chi Wu, Chi-Chun Lai
ACTA OPHTHALMOLOGICA
(2020)
Article
Ophthalmology
Yeo-Yang Koh, Chi-Chun Lai, Wei-Chi Wu, Yih-Shiou Hwang, Kuan-Jen Chen, Nan-Kai Wang, Tun-Lu Chen, Jerry Chien-Chieh Huang, Laura Liu, Ling Yeung
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Ethan Zhang, Joseph Ryu, Sarah R. Levi, Jin Kyun Oh, Chun Wei Hsu, Xuan Cui, Ting-Ting Lee, Nan-Kai Wang, Jose Ronaldo Lima de Carvalho, Stephen H. Tsang
Editorial Material
Ophthalmology
Chu-Yen Huang, Eugene Yu-Chuan Kang, Hung-Chou Kuo, Chiung-Mei Chen, Fu-Sung Lo, Lung-Kun Yeh, Kuan-Jen Chen, Nan-Kai Wang, Vitor K. L. Takahashi, Christine L. Xu, Stephen H. Tsang
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Nan-Kai Wang, Pei-Kang Liu, Yang Kong, Sarah R. Levi, Wan-Chun Huang, Chun-Wei Hsu, Hung-Hsi Wang, Nelson Chen, Yun-Ju Tseng, Peter M. J. Quinn, Ming-Hong Tai, Chyuan-Sheng Lin, Stephen H. Tsang
Summary: Using gene augmentation, recoverable mouse models of achromatopsia can be generated, with normal cone phototransduction maintained even with only 20% of normal CNGA3 protein levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Pei-Kang Liu, Tzu-Yu Chiu, Nan-Kai Wang, Sarah R. Levi, Ming-Ju Tsai
Summary: Obstructive sleep apnea (OSA) is a common sleep disorder that can lead to ocular consequences, clinicians should understand the eye diseases in patients with OSA and provide comprehensive care.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Kuan-Jen Chen, Ming-Hui Sun, Yen-Po Chen, Yi-Hsing Chen, Nan-Kai Wang, Laura Liu, An-Ning Chao, Wei-Chi Wu, Yih-Shiou Hwang, Chi-Chun Lai
Summary: This study retrospectively analyzed the data of 37 patients with endogenous fungal endophthalmitis and found that diabetes was the most common risk factor. Yeasts were more commonly detected than mold, and Candida spp. were the most common fungal isolates. Retinal detachment was a common complication, and better initial visual acuity was associated with superior visual outcomes.
Article
Biochemistry & Molecular Biology
Angela H. Kim, Pei-Kang Liu, Yin-Hsi Chang, Eugene Yu-Chuan Kang, Hung-Hsuan Wang, Nelson Chen, Yun-Ju Tseng, Go Hun Seo, Hane Lee, Laura Liu, An-Ning Chao, Kuan-Jen Chen, Yih-Shiou Hwang, Wei-Chi Wu, Chi-Chun Lai, Stephen H. Tsang, Meng-Chang Hsiao, Nan-Kai Wang
Summary: This study describes the clinical characteristics and genetic testing results of seven patients with CSNB in Taiwan, and discusses the significance of these findings for the molecular etiology and genotype-phenotype correlation of CSNB. Some novel variants identified in this study have not been described in previous research, but further study is needed to determine their clinical significance. The future of gene therapy for CSNB patients is also reviewed and discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Shao-Yu Sung, Laura A. Jenny, Yo-Chen Chang, Nan-Kai Wang, Pei-Kang Liu
Summary: A 25-year-old female with diabetes and hypertension developed painless blurred vision in her left eye after receiving the third dose of Pfizer-BioNTech mRNA vaccine. The diagnosis confirmed Central Retinal Vein Occlusion (CRVO) with macular edema. Anti-VEGF treatment improved visual acuity, but recurrence occurred after 6 months. This case highlights the potential association between CRVO and mRNA-based COVID-19 vaccination.
Review
Health Care Sciences & Services
Po-Yi Wu, Yuan-Kai Fu, Rey-In Lien, Ming-Chou Chiang, Chien-Chung Lee, Hung-Chi Chen, Yi-Jen Hsueh, Kuan-Jen Chen, Nan-Kai Wang, Laura Liu, Yen-Po Chen, Yih-Shiou Hwang, Chi-Chun Lai, Wei-Chi Wu
Summary: Retinopathy of prematurity (ROP) is a leading cause of childhood blindness worldwide, involving angiogenesis and cytokine-mediated inflammation. Characteristics and actions of cytokines in ROP pathogenesis are discussed, considering their time-dependent expression and differences between blood and vitreous levels. Animal models of oxygen-induced retinopathy provide valuable data. Less destructive novel therapeutics targeting signaling pathways are needed. Linking ROP-related cytokines to maternal and neonatal diseases can improve ROP management. Modulation of hypoxia-inducible factor, insulin-like growth factor (IGF)-1/IGF-binding protein 3 complex, erythropoietin and its derivatives, polyunsaturated fatty acids, and secretogranin III inhibition are potential treatments for disordered retinal angiogenesis. Emerging therapies such as gut microbiota modulation, non-coding RNAs, and gene therapies show promise for regulating ROP in preterm infants.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Eugene Yu-Chuan Kang, Tzu-Yi Lin, Sunir J. Garg, Nan-Kai Wang, Lee-Jen Chen, Pei-Wei Huang, Ming-Jen Chan, Kuan-Jen Chen, Wei-Chi Wu, Chi-Chun Lai, Yih-Shiou Hwang
Summary: This retrospective cohort study evaluated the systemic effects of three commonly used anti-vascular endothelial growth factor (VEGF) intravitreal injections in diabetes patients in Taiwan. The study found that different drugs (bevacizumab, ranibizumab, and aflibercept) had varying incidence rates of adverse events, such as ischemic stroke, major adverse lower-limb events, major bleeding, all-cause death, and all-cause admission. The study suggests that these differences may be attributed to drug variations and patient characteristics.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Medicine, General & Internal
Tsai-Hsuan Yang, Eugene Yu-Chuan Kang, Pei-Hsuan Lin, Pei-Liang Wu, Jacob Aaron Sachs, Nan-Kai Wang
Summary: Inherited retinal dystrophies are a group of diseases caused by genetic mutations that affect specific cells in the retina. Electroretinography is a diagnostic tool that measures retinal electrical activity and can assist in determining cell function. Certain types of IRDs have unique ERG features that can guide genetic testing and reduce costs.
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)