Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 126, Issue -, Pages 367-373Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2014.11.046
Keywords
Glycopolymer; Degradable; Gold nanoparticle; Self-assembly; Lectin recognition
Funding
- National Natural Science Foundation of China [51028301494, 81100014, 21174146]
- Programs and subsidized by the Special Funds for National Basic Research Program of China [2009CB930100]
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Biomimetic glycopolymers poly(gluconamidoethylmethacrylate)-b-poly(epsilon-caprolactone)-b-poly (gluconamidoethylmethacrylate) with degradable disulfide groups in the backbone (PGAMA-PCL-SS-PCL-PGAMA) were synthesized by the combination of ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP). The internal disulfide bonds were cleaved by reduction with DL-dithiothreitol to yield the corresponding thiol terminated glycopolymers. The thiol terminated glycopolymers were effectively anchored on the surface of gold nanoparticles to prepare the biomimetic glycopolymers modified gold nanoparticles (Gly@Au NPs). Moreover, the properties of the Gly@Au NPs in aqueous solution were investigated. Transmission electron microscopy (TEM) analysis revealed that the self-assembly morphology of the Gly@Au NPs can be fine-tuned, from irregular clusters to spherical aggregates, by changing the weight fraction of the hydrophobic PCL block. Furthermore, the Gly@Au NPs had specific recognition with Concanavalin A (Con A). (C) 2014 Elsevier B.V. All rights reserved.
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