Molecular basis for multimerization in the activation of the epidermal growth factor receptor

Quantification of Epidermal Growth Factor Receptor Expression Level and Binding Kinetics on Cell Surfaces by Surface Plasmon Resonance Imaging

(2015) Fenni Zhang et al.   ANALYTICAL CHEMISTRY

A Structural Perspective on the Regulation of the Epidermal Growth Factor Receptor

(2015) Erika Kovacs et al.   Annual Review of Biochemistry

Mechanistic Insights into R776H Mediated Activation of Epidermal Growth Factor Receptor Kinase

(2015) Zheng Ruan et al.   BIOCHEMISTRY

Class A Plexins Are Organized as Preformed Inactive Dimers on the Cell Surface

(2015) Morgan Marita et al.   BIOPHYSICAL JOURNAL

Computational Lipidomics with insane: A Versatile Tool for Generating Custom Membranes for Molecular Simulations

(2015) Tsjerk A. Wassenaar et al.   Journal of Chemical Theory and Computation

Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor

(2015) Erika Kovacs et al.   MOLECULAR AND CELLULAR BIOLOGY

Biochemical and biophysical analyses of tight junction permeability made of claudin-16 and claudin-19 dimerization

(2015) Yongfeng Gong et al.   MOLECULAR BIOLOGY OF THE CELL

Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer

(2015) Christopher C. Valley et al.   MOLECULAR BIOLOGY OF THE CELL

Subunit composition of a DEG/ENaC mechanosensory channel ofCaenorhabditis elegans

(2015) Yushu Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recruitment of the Adaptor Protein Grb2 to EGFR Tetramers

(2014) Noga Kozer et al.   BIOCHEMISTRY

Time-Resolved Fluorescence Spectroscopy Measures Clustering and Mobility of a G Protein-Coupled Receptor Opsin in Live Cell Membranes

(2014) William D. Comar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Emerging concepts in the regulation of the EGF receptor and other receptor tyrosine kinases

(2014) Nicholas F. Endres et al.   TRENDS IN BIOCHEMICAL SCIENCES

The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases

(2014) M. A. Lemmon et al.   Cold Spring Harbor Perspectives in Biology

Coarse-Grained Molecular Simulation of Epidermal Growth Factor Receptor Protein Tyrosine Kinase Multi-Site Self-Phosphorylation

(2014) John G. Koland   PLoS Computational Biology

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

Architecture and Membrane Interactions of the EGF Receptor

(2013) Anton Arkhipov et al.   CELL

Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor

(2013) Nicholas F. Endres et al.   CELL

Exploring higher-order EGFR oligomerisation and phosphorylation—a combined experimental and theoretical approach

(2013) Noga Kozer et al.   Molecular BioSystems

Mechanism for activation of mutated epidermal growth factor receptors in lung cancer

(2013) M. Red Brewer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How good is automated protein docking?

(2013) Dima Kozakov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Her2 activation mechanism reflects evolutionary preservation of asymmetric ectodomain dimers in the human EGFR family

(2013) Anton Arkhipov et al.   eLife

Negative co-operativity in the EGF receptor

(2012) Linda J. Pike   BIOCHEMICAL SOCIETY TRANSACTIONS

Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization

(2012) Yibing Shan et al.   CELL

A single ligand is sufficient to activate EGFR dimers

(2012) P. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling

(2012) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

(2011) Kathleen Aertgeerts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms

(2011) Natalia Jura et al.   MOLECULAR CELL

Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor

(2010) Diego Alvarado et al.   CELL

Spatial Structure of the Transmembrane Domain Heterodimer of ErbB1 and ErbB2 Receptor Tyrosine Kinases

(2010) Konstantin S. Mineev et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Evidence for Loose Linkage between Ligand Binding and Kinase Activation in the Epidermal Growth Factor Receptor

(2010) C. Lu et al.   MOLECULAR AND CELLULAR BIOLOGY

Spatial control of EGF receptor activation by reversible dimerization on living cells

(2010) Inhee Chung et al.   NATURE

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

(2010) Fumin Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distribution of resting and ligand-bound ErbB1 and ErbB2 receptor tyrosine kinases in living cells using number and brightness analysis

(2010) P. Nagy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

(2009) Natalia Jura et al.   CELL

The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain

(2009) Monica Red Brewer et al.   MOLECULAR CELL

Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3

(2009) N. Jura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy

(2009) Michelle A. Digman et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Predominance of activated EGFR higher-order oligomers on the cell surface

(2008) Andrew H. A. Clayton et al.   GROWTH FACTORS

The MARTINI Coarse-Grained Force Field: Extension to Proteins

(2008) Luca Monticelli et al.   Journal of Chemical Theory and Computation

The unfolded protein response signals through high-order assembly of Ire1

(2008) Alexei V. Korennykh et al.   NATURE

Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase

(2008) Chen Qiu et al.   STRUCTURE