Journal
CURRENT RHEUMATOLOGY REPORTS
Volume 18, Issue 2, Pages -Publisher
SPRINGER
DOI: 10.1007/s11926-015-0555-7
Keywords
Systemic sclerosis; Cellular therapy; Hematopoietic stem cell transplantation; Mesenchymal stromal cells; Dendritic cells; Regulatory Tcells
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Funding
- ZonMw Translational Adult Stem Cell Research Programme [116003005]
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Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease with a high mortality and morbidity. While progress has been made in terms of identifying high-risk patients and implementing new treatment strategies, therapeutic options remain limited. In the past few decades, various cellular therapies have emerged, which have been studied in SSc and other conditions. Here, we provide a comprehensive review of currently available cellular therapies and critically assess their merit as diseasemodifying treatment for SSc. Currently, hematopoietic stem cell transplantation is the only cellular therapy that has demonstrated clinical effects on the immune system, neoangiogenesis, and fibrosis. Robust mechanistic studies as well as clinical trials are essential to move the field forward.
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