Review
Biochemistry & Molecular Biology
Alvaro Gutierrez, Hannah Demond, Priscilla Brebi, Carmen Gloria Ili
Summary: Colorectal cancer is the third most common cancer globally, and biomarkers play a crucial role in diagnosis and predicting metastasis. Key signaling pathways associated with cancer progression include the MAPK pathway, p53 pathway, and TGF-beta pathway.
Article
Multidisciplinary Sciences
Hye Eun Park, Seung-Yeon Yoo, Nam-Yun Cho, Jeong Mo Bae, Sae-Won Han, Hye Seung Lee, Kyu Joo Park, Tae-You Kim, Gyeong Hoon Kang
Summary: Studies have shown that the prognostic effect of KRAS mutations on colorectal cancers varies depending on the type of mutation, with G12D/V mutations associated with shorter recurrence-free survival. Other codon 12 mutations and codon 13 mutations exhibit different trends.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Dominik Paul Modest, Meinolf Karthaus, Stefan Kasper, Nicolas Moosmann, Verena Keitel, Alexander Kiani, Jens Uhlig, Lutz Jacobasch, Ludwig Fischer Weikersthal, Martin Fuchs, Florian Kaiser, Christian Lerchenmueller, Dagmar Sent, Christian Junghanss, Swantje Held, Sylvie Lorenzen, Klaus Kaczirek, Andreas Jung, Sebastian Stintzing, Volker Heinemann
Summary: The trial investigated the addition of panitumumab to chemotherapy in RAS wild-type colorectal cancer patients. While the experimental arm showed trends towards improved survival, the primary endpoint of progression-free survival was not met.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Medicine, Research & Experimental
Zijian Chen, Zenghong Huang, Yanxin Luo, Qi Zou, Liangliang Bai, Guannan Tang, Xiaolin Wang, Guangwen Cao, Meijin Huang, Jun Xiang, Huichuan Yu
Summary: This study found that the NTRK3 gene promoter was more frequently methylated in CRC, leading to suppressed gene expression. It was confirmed that NTRK3 promoter methylation was associated with survival outcome in CRC and a nomogram predicting survival outcome was developed. Moreover, NTRK3 promoter methylation also predicted survival outcomes in other tumors.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Yangxun Pan, Ze Yuan, Jiongliang Wang, Siegmund Ngai, Zhiwen Hu, Liyang Sun, Zhenyun Yang, Dandan Hu, Minshan Chen, Zhongguo Zhou, Yaojun Zhang
Summary: This study evaluated the efficacy and safety of postoperatively adjuvant therapy in treating uHCC patients who received FOLFOX-HAIC-based conversion therapy. The results showed that adjuvant therapy was associated with improved survival outcomes compared with non-adjuvant therapy, especially for patients with macrovascular invasion and positive hepatitis B surface antigen.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Cecilia Villegas, Rebeca Perez, Olov Sterner, Ivan Gonzalez-Chavarria, Cristian Paz
Summary: Colorectal cancer is the second leading cause of cancer death worldwide, mainly affecting men, with about 20% of cases due to hereditary syndromes. Curcumin, the main polyphenol pigment in turmeric, has antioxidant properties and synergistic effects with both anticancer and anti-inflammatory drugs in inhibiting the progression of CRC through multiple signaling pathways.
Article
Oncology
Hans-Joachim Schmoll, Julia Mann, Fabian Meinert, Benjamin Garlipp, Kersten Borchert, Arndt Vogel, Eray Goekkurt, Ulrich Kaiser, Heinz-Gert Hoeffkes, Joern Ruessel, Stephan Kanzler, Thomas Edelmann, Helmut Forstbauer, Thomas Goehler, Carla Hannig, Bert Hildebrandt, Carsten Roll, Carsten Bokemeyer, Joerg Steighardt, Franziska Cygon, Stefan Ibach, Alexander Stein, Joseph Tintelnot
Summary: The study confirms the effectiveness and tolerability of FOLFOXIRI plus bevacizumab as a first-line treatment for mCRC, but challenges remain in its clinical implementation.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Guochao Ge, Guangyao Li, Zhengjun Zhang, Yong Zhu, Wentao Wang, Lei Ren, Ziqiang Li, Mujian Teng
Summary: This study evaluated the impact of neutrophil-to-lymphocyte ratio (NLR) and preoperative prognostic nutritional index (PNI) on the prognosis of gastric cancer (GC). The findings show that a high PNI-NLR score can independently affect the worse prognosis of GC, and can be used to differentiate low risk from high risk subjects.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2023)
Article
Biochemistry & Molecular Biology
Stavros P. Papadakos, Leonidas Petrogiannopoulos, Alexandros Pergaris, Stamatios Theocharis
Summary: The EPH/ephrin system is a bidirectional signaling pathway that plays an important role in carcinogenesis. Despite advancements in the diagnosis and treatment of CRC, it remains a leading cause of global death. Recent research has provided new insights into the role of EPH/ephrins in the pathogenesis and treatment of CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Dong Dong, Runshi Zhang, Jie Shao, Aimin Zhang, Yichao Wang, Yunli Zhou, Yueguo Li
Summary: Hypermethylation of UNC5C and UNC5D genes is associated with repression in colorectal cancer, and has potential diagnostic and prognostic value. UNC5A and UNC5B show no significant methylation changes in CRC. High methylation levels of UNC5C and UNC5D are independently predictive of poor progression-free and overall survival in CRC.
CLINICAL EPIGENETICS
(2021)
Article
Genetics & Heredity
Dhouha Jamai, Raja Gargouri, Boulbaba Selmi, Abdelmajid Khabir
Summary: This study aims to evaluate the prognostic and predictive value of ERCC1 and MGMT methylation. The results suggest that the methylation of ERCC1 and MGMT is associated with the malignancy and chemotherapy response of colorectal cancer, indicating a poor prognosis and shorter overall survival.
Article
Biochemistry & Molecular Biology
Shing-Yau Tam, Md Zahirul Islam Khan, Ju-Yu Chen, Jerica Hiu-Yui Yip, Hong-Yiu Yan, Tsz-Yan Tam, Helen Ka-Wai Law
Summary: The study aimed to investigate the differences in chemotherapy responses between FOLFOX-resistant and wild-type colorectal cancer cells using proteomic profiling. FOLFOX-resistant cells (DLD1-R and HCT116-R) were developed through chronic exposure to progressive FOLFOX doses. Analysis of the proteomic profiles revealed significantly altered pathways in FOLFOX-resistant cells, with up-regulations in the ribosomal process and actin cytoskeleton. These findings suggest potential novel treatment targets for overcoming chemoresistance in colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Paula I. Escalante, Luis A. Quinones, Hector R. Contreras
Summary: The FOLFOX scheme is commonly used for metastatic colorectal cancer patients, but chemoresistance is a major challenge. EMT and overexpression of multiple genes may contribute to drug resistance.
Article
Oncology
Xin Gao, Yan Zhang, Xiangwei Li, Lina Jansen, Elizabeth Alwers, Melanie Bewerunge-Hudler, Matthias Schick, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner
Summary: Inflammation plays a role in cancer progression, where leukocytes can be estimated using DNA methylation data as prognostic markers in colorectal cancer. Among leukocytes, CD4+ T cells show the strongest association with CRC prognosis, providing independent predictive value. This suggests that DNA methylation-based leukocyte composition, particularly CD4+ T cells, can be promising independent predictors of colorectal cancer survival.
Review
Biochemistry & Molecular Biology
Gongmin Zhu, Lijiao Pei, Hongwei Xia, Qiulin Tang, Feng Bi
Summary: KRAS is a commonly mutated oncogene in colorectal cancer, leading to aberrant activation of the KRAS protein and stimulation of downstream signaling pathways, resulting in cell proliferation and survival, ultimately leading to tumorigenesis. Patients with KRAS mutations in CRC have poor prognosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyunjoo Song, Seungjae Lee, Ji Hoon Park, Hae Young Kim, Hooney Daniel Min, Jong-June Jeon, Kyoung Ho Lee
Summary: This study aimed to investigate whether patient triaging with scoring systems can reduce CT use for adolescents and young adults suspected of having appendicitis. The results showed that using clinical scoring systems for selective CT use led to a considerable loss of diagnostic accuracy, with no reduction in CT use when targeting specific sensitivity and specificity values.
Article
Radiology, Nuclear Medicine & Medical Imaging
Seunghyun Lee, Young Hun Choi, Yeon Jin Cho, Seul Bi Lee, Jung-Eun Cheon, Woo Sun Kim, Jae Sung Ko, Jaemoon Koh, Gyeong Hoon Kang
Summary: The study found that liver stiffness values on 2D-SWE can be influenced by both fibrosis and necroinflammatory grade, providing excellent diagnostic performance in different pediatric liver diseases. However, clinicians should be mindful of potential confounders, such as necroinflammatory activity or transaminase level, when performing 2D-SWE measurements for liver fibrosis staging.
BMC MEDICAL IMAGING
(2021)
Article
Gastroenterology & Hepatology
Ji Won Park, Sung-Bum Kang, Jie Hao, Seok-Byung Lim, Hyo Seong Choi, Duck-Woo Kim, Hee Jin Chang, Dae Yong Kim, Kyung Hae Jung, Tae-You Kim, Gyeong Hoon Kang, Eui Kyu Chie, Sun Young Kim, Dae Kyung Sohn, Jae-Sung Kim, Hye Seung Lee, Jee Hyun Kim, Seung-Yong Jeong, Jae Hwan Oh
Summary: The 10-year follow-up of the COREAN trial confirms the long-term oncological safety of laparoscopic surgery in patients with rectal cancer treated with preoperative chemoradiotherapy. Similar to open surgery, laparoscopic surgery does not compromise long-term survival outcomes in rectal cancer when performed by well trained surgeons.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Oncology
Jung Ho Kim, Jeong Hoon Hong, Yoon-La Choi, Ji Ae Lee, Mi-kyoung Seo, Mi-Sook Lee, Sung Bin An, Min Jung Sung, Nam-Yun Cho, Sung-Su Kim, Young Kee Shin, Sangwoo Kim, Gyeong Hoon Kang
Summary: The study revealed that NTRK-rearranged colorectal tumors develop exclusively through the serrated neoplasia pathway and can be initiated from non-dysplastic SSLs without BRAF/KRAS mutations prior to full occurrence of MSI-high/CIMP-high.
JOURNAL OF PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Hye Eun Park, Seung-Yeon Yoo, Nam-Yun Cho, Jeong Mo Bae, Sae-Won Han, Hye Seung Lee, Kyu Joo Park, Tae-You Kim, Gyeong Hoon Kang
Summary: Studies have shown that the prognostic effect of KRAS mutations on colorectal cancers varies depending on the type of mutation, with G12D/V mutations associated with shorter recurrence-free survival. Other codon 12 mutations and codon 13 mutations exhibit different trends.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Meihui Li, Younghoon Kim, Tae-Shin Kim, Nam-Yun Cho, Jeong Mo Bae, Woo Ho Kim, Gyeong Hoon Kang
Summary: The study found that gastric cancer patients with multiple protooncogene copy number gains exhibited more frequent venous invasion, lower density of tumor-infiltrating lymphocytes, and lower methylation levels. These patients also had the worst clinical outcomes in terms of both overall survival and recurrence-free survival.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Hye-Yeong Jin, Seung-Yeon Yoo, Ji-Ae Lee, Xianyu Wen, Younghoon Kim, Hye Eun Park, Yoonjin Kwak, Nam-Yun Cho, Jeong Mo Bae, Jung Ho Kim, Hye Seung Lee, Gyeong Hoon Kang
Summary: Tumor stroma and tumor-infiltrating lymphocytes (TILs) have different effects on the prognosis of colorectal cancer (CRC) patients. The combinatory statuses of tumor-stromal percentage (TSP) and TILs can provide powerful prognostic information for CRCs.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Pathology
Ji Ae Lee, Mi-Kyoung Seo, Seung-Yeon Yoo, Nam-Yun Cho, Yoonjin Kwak, Kyoungbun Lee, Jung Ho Kim, Gyeong Hoon Kang
Summary: Decreased expression of CDX2, SATB2, and KRT20 in colorectal carcinomas (CRCs) is commonly associated with microsatellite instability-high (MSI-H) and CpG island methylator phenotype-high (CIMP-H), but the specific features associated with the loss of each marker differ in CRCs.
Article
Multidisciplinary Sciences
Xianyu Wen, Hye-Yeong Jin, Meihui Li, Younghoon Kim, Nam-Yun Cho, Yoonjin Kwak, Jeong Mo Bae, Hye Seung Lee, Gyeong Hoon Kang
Summary: Through genome-wide methylation profiling, the methylation markers NCOR2, PARK2, and ZSCAN12 were found to be closely associated with the density of CD3-positive and CD8-positive cells and could serve as biomarkers for predicting the prognosis of patients with gastric carcinoma.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Sang Sik Cho, Ji Won Park, Gyeong Hoon Kang, Jung Ho Kim, Jeong Mo Bae, Sae-Won Han, Tae-You Kim, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
Summary: This study aimed to determine whether the location of lymphatic invasion, vascular invasion, and perineural invasion could affect the survival of patients with stage II colon cancer. The results showed that extramural invasion was associated with a worse prognosis, while intramural invasion was not. Therefore, pathologic reports about the location of invasion may be helpful for predicting prognosis and determining the need for adjuvant chemotherapy in stage II colon cancers.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Genetics & Heredity
Jeong Mo Bae, Ji Young Ahn, Heonyi Lee, Hoon Jang, Hyojun Han, Jaehwan Jeong, Nam-Yun Cho, Kwangsoo Kim, Gyeong Hoon Kang
Summary: DNA methylation profiling is a promising method for predicting the tissue of origin in cancer patients. By extracting genomic DNA from formalin-fixed tissues, a targeted bisulfite sequencing panel based on hybrid capture has been developed and found to be useful in clinical practice.
Review
Pathology
Younghoon Kim, Nam Yun Cho, Gyeong Hoon Kang
Summary: The association between F. nucleatum and prognosis or clinicopathological features in colorectal cancer varies among studies and may be influenced by the type of biospecimen.
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Jeong-ki Kim, Ye-Young Rhee, Jeong Mo Bae, Jung Ho Kim, Seong-Joon Koh, Hyun Jung Lee, Jong Pil Im, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park, Ji Won Park, Gyeong Hoon Kang
Summary: The optimal tumor budding cut-off number for estimating LN metastasis in submucosal CRC was determined and a composite scoring system (CSS) was developed.
Article
Pathology
Minsun Jung, Ji Ae Lee, Seung-Yeon Yoo, Jeong Mo Bae, Gyeong Hoon Kang, Jung Ho Kim
Summary: This study investigates the spatial heterogeneity of tumor-infiltrating lymphocytes (TILs) in colorectal carcinomas (CRCs) and identifies its prognostic and immunologic significance. It demonstrates that TILs density and spatial distribution have a significant impact on prognosis in CRCs. TIL-low CRCs can be divided into two subgroups with distinct prognosis and immunologic characteristics based on the spatial heterogeneity of TILs. These findings suggest that the intratumoral spatial heterogeneity of TILs can be a key element for clinically relevant immunologic subtyping of tumors.
Article
Oncology
Younghoon Kim, Gyeong Hoon Kang, Haeryoung Kim
Summary: A systematic review and meta-analysis showed that the presence of heterologous component is associated with worse overall survival in gynecologic carcinosarcoma, but not with recurrence-free survival and disease-free survival.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)