Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis

Hydroxymethylation and its potential implication in DNA repair system: A review and future perspectives

(2015) Ankita Shukla et al.   GENE

Genomic, pathological, and clinical heterogeneity as drivers of personalized medicine in prostate cancer

(2015) Michael Fraser et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression

(2015) Ken-ichi Takayama et al.   Nature Communications

5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy

(2015) Aparna Vasanthakumar et al.   Cancer Genetics

5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer

(2015) Santiago Uribe-Lewis et al.   GENOME BIOLOGY

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers

(2015) Michael Christoph Haffner et al.   Oncotarget

Loss of 5-hydroxymethylcytosine in cancer: Cause or consequence?

(2014) Gabriella Ficz et al.   GENOMICS

From development to diseases: The role of 5hmC in brain

(2014) Wenjia Sun et al.   GENOMICS

CT45A1 acts as a new proto-oncogene to trigger tumorigenesis and cancer metastasis

(2014) B Shang et al.   Cell Death & Disease

DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia

(2014) Raajit Rampal et al.   Cell Reports

Intratumor DNA Methylation Heterogeneity Reflects Clonal Evolution in Aggressive Prostate Cancer

(2014) David Brocks et al.   Cell Reports

Structural insights into how 5-hydroxymethylation influences transcription factor binding

(2013) Lukas Lercher et al.   CHEMICAL COMMUNICATIONS

Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer

(2013) Sanchari Bhattacharyya et al.   NUCLEIC ACIDS RESEARCH

Alterations of 5-Hydroxymethylcytosine in Human Cancers

(2013) Christopher Mariani et al.   Cancers

Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma

(2012) Christine Guo Lian et al.   CELL

IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives

(2012) H. Yang et al.   CLINICAL CANCER RESEARCH

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary

(2012) Tarang Khare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers

(2012) Aurélien A. Sérandour et al.   NUCLEIC ACIDS RESEARCH

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

5-Hydroxymethylcytosine Is Strongly Depleted in Human Cancers but Its Levels Do Not Correlate with IDH1 Mutations

(2011) S.-G. Jin et al.   CANCER RESEARCH

Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes

(2011) C. E. Nestor et al.   GENOME RESEARCH

Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells

(2011) Yufei Xu et al.   MOLECULAR CELL

5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells

(2011) Hume Stroud et al.   GENOME BIOLOGY

Repitools: an R package for the analysis of enrichment-based epigenomic data

(2010) A. L. Statham et al.   BIOINFORMATICS

ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data

(2010) Lihua J Zhu et al.   BMC BIOINFORMATICS

Epigenetic gene silencing in the Wnt pathway in breast cancer

(2010) George J. Klarmann et al.   Epigenetics

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation

(2010) Daniele Merico et al.   PLoS One

Mutational analysis of hypoxia-related genes HIF1α and CUL2 in common human cancers

(2009) SANG WOOK PARK et al.   APMIS

Circos: An information aesthetic for comparative genomics

(2009) M. Krzywinski et al.   GENOME RESEARCH

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Silencing of Hint1, a novel tumor suppressor gene, by promoter hypermethylation in hepatocellular carcinoma

(2008) Yu-Jing Zhang et al.   CANCER LETTERS

DNA Hypomethylation Arises Later in Prostate Cancer Progression than CpG Island Hypermethylation and Contributes to Metastatic Tumor Heterogeneity

(2008) Srinivasan Yegnasubramanian et al.   CANCER RESEARCH

High-Resolution Mapping and Characterization of Open Chromatin across the Genome

(2008) Alan P. Boyle et al.   CELL

Use and misuse of the gene ontology annotations

(2008) Seung Yon Rhee et al.   NATURE REVIEWS GENETICS

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY