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Biochemistry & Molecular Biology
Jessica Ares Blanco, Carmen Lambert, Manuel Fernandez-Sanjurjo, Paula Morales-Sanchez, Pedro Pujante, Paola Pinto-Hernandez, Eduardo Iglesias-Gutierrez, Edelmiro Menendez Torre, Elias Delgado
Summary: The aim of this study was to investigate the glucose tolerance status after 15 years of pregnancy in women diagnosed with gestational diabetes mellitus (GDM) and to assess the long-term effect of GDM on circulating miRNA profile. The study included 30 randomly selected women diagnosed with GDM during 2005-2006, and glucose tolerance was measured using the National Diabetes Data Group criteria. Four miRNAs were analyzed in the plasma of women 15 years after the diagnosis of GDM. The study found that 50% of women had some degree of glucose intolerance 15 years after the diagnosis of GDM, which was directly related to body weight and body mass index during pregnancy. Dysglycemic women also showed significantly increased levels of circulating hsa-miR-24-3p. Thus, initial weight and BMI, along with circulating expression levels of hsa-miR-24-3p, could be good predictors of the future development of dysglycemia in women with a previous diagnosis of GDM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Romana Pylypchuk, Sue Wells, Andrew Kerr, Katrina Poppe, Matire Harwood, Suneela Mehta, Corina Grey, Billy P. Wu, Vanessa Selak, Paul L. Drury, Wing Cheuk Chan, Brandon Orr-Walker, Rinki Murphy, Jim Mann, Jeremy D. Krebs, Jinfeng Zhao, Rod Jackson
Summary: A national screening programme in New Zealand led to a significant shift in the cardiovascular risk profile of patients with diabetes, with many asymptomatic patients being identified. The study found that recent diabetes screening has drastically changed the predicted cardiovascular risk in this population. The introduction of new-generation glucose-lowering medications and increasing obesity necessitate the development of updated risk prediction equations to better differentiate between low-risk and high-risk patients.
Article
Public, Environmental & Occupational Health
Kimberly A. Bertrand, Katie M. O'Brien, Lauren B. Wright, Julie R. Palmer, William J. Blot, A. Heather Eliassen, Lynn Rosenberg, Sven Sandin, Deirdre Tobias, Elisabete Weiderpass, Wei Zheng, Anthony J. Swerdlow, Minouk J. Schoemaker, Hazel B. Nichols, Dale P. Sandler
Summary: The history of gestational diabetes mellitus (GDM) is not a risk factor for breast cancer in young women. The well-established protective effect of parity on the risk of ER-positive breast cancer persists even for pregnancies complicated by GDM.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Genetics & Heredity
Heejin Jin, Sanghun Lee, Sungho Won
Summary: This study used two-sample Mendelian randomization (MR) to investigate the causal relationship between severe mental illnesses (SMIs) and type 2 diabetes (T2D). The results showed that depression has a causal effect on T2D, while bipolar disorder and schizophrenia do not. Therefore, special attention is needed for patients with depression in terms of T2D prevention and treatment.
FRONTIERS IN GENETICS
(2023)
Article
Endocrinology & Metabolism
Annika Gronberg, Daniel Espes, Per-Ola Carlsson, Johnny Ludvigsson
Summary: Children with type 1 diabetes diagnosed at a young age and with multiple autoimmune antibodies positive are more likely to experience a rapid decline in beta-cell function. Low C-peptide levels are associated with an increased risk of severe hypoglycemia and higher Hemoglobin A1C, while a high BMI standard deviation score at diagnosis predicts better preservation of beta-cell function over a 6-year follow-up period.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)
Article
Oncology
Tengteng Wang, Maryam S. Farvid, Jae H. Kang, Michelle D. Holmes, Bernard A. Rosner, Rulla M. Tamimi, Walter C. Willett, A. Heather Eliassen
Summary: This study suggests that greater adherence to a diabetes risk reduction diet after diagnosis is associated with improved survival outcomes among a large number of breast cancer survivors, indicating that postdiagnosis dietary modifications consistent with type II diabetes prevention may be crucial for breast cancer survivors.
Article
Endocrinology & Metabolism
Mary Diaz-Santana, Katie M. O'Brien, Yong-Moon Mark Park, Dale P. Sandler, Clarice R. Weinberg
Summary: This study found that a history of gestational diabetes mellitus, whether occurring once or multiple times, significantly increases the risk of developing type 2 diabetes. The risk increases steeply with each additional affected pregnancy, and although it attenuates over time after the affected pregnancies, it remains elevated for >35 years.
Article
Endocrinology & Metabolism
Mary V. Diaz-Santana, Katie M. O'Brien, Yong-Moon Mark Park, Dale P. Sandler, Clarice R. Weinberg
Summary: Gestational diabetes mellitus is strongly associated with an increased risk of type 2 diabetes, and this risk persists for over 35 years. The risk of type 2 diabetes is higher with each additional pregnancy affected by gestational diabetes mellitus, and the association weakens over time.
Article
Endocrinology & Metabolism
Jeffrey P. Krischer, Xiang Liu, Ake Lernmark, William A. Hagopian, Marian J. Rewers, Jin-Xiong She, Jorma Toppari, Anette-G Ziegler, Beena Akolkar
Summary: Children diagnosed with type 1 diabetes before the age of 6 tend to develop autoantibodies earlier and progress to diabetes more rapidly compared to those diagnosed between 6-13 years of age. The diabetes risk associated with HLA genotypes is significant in older children, while for younger children, the country of origin was a significant factor. Early onset diabetes is likely preceded by IAA autoantibodies and is more aggressive, while in older children, the progression to diabetes does not seem to be influenced by age or family history once multiple autoantibodies are present.
Editorial Material
Cardiac & Cardiovascular Systems
Irene Fernandez-Ruiz
Summary: The IAMI trial found that receiving influenza vaccination shortly after a myocardial infarction or in high-risk coronary heart disease can reduce the risk of future cardiovascular events.
NATURE REVIEWS CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Minjia Mo, Lluis Zacarias-Pons, Minh Tuan Hoang, Shayan Mostafaei, Pol Grau Jurado, Isidora Stark, Kristina Johnell, Maria Eriksdotter, Hong Xu, Sara Garcia-Ptacek
Summary: This study examines the temporal risk patterns of psychiatric disorders among patients with dementia before, at the time of, and after diagnosis. The findings highlight the significant increase in psychiatric disorders both before and after dementia diagnosis, emphasizing the importance of incorporating psychiatric preventative and management interventions for individuals with dementia across various diagnostic stages.
Article
Multidisciplinary Sciences
Yao-Chun Hsu, Chih-Cheng Chen, Wei-Hsiang Lee, Chi-Yang Chang, Fu-Jen Lee, Cheng-Hao Tseng, Tzu-Haw Chen, Hsiu J. Ho, Jaw-Town Lin, Chun-Ying Wu
Summary: The gut microbiome of HCV-infected patients is significantly different from uninfected controls, but there is no significant change in overall microbial composition shortly after HCV eradication.
SCIENTIFIC REPORTS
(2022)
Article
Obstetrics & Gynecology
Sofia Persson, Evangelia Elenis, Sahruh Turkmen, Michael S. Kramer, Eu-Leong Yong, Inger Sundstrom Poromaa
Summary: This study found that polycystic ovary syndrome is an independent risk factor for type 2 diabetes, regardless of BMI adjustment. Women with the hyperandrogenic PCOS phenotype face a higher risk of type 2 diabetes than those with the normoandrogenic PCOS phenotype.
FERTILITY AND STERILITY
(2021)
Article
Biochemistry & Molecular Biology
Ann-Kathrin Schalkamp, Kathryn J. Peall, Neil A. Harrison, Cynthia Sandor
Summary: Using accelerometry data from UK Biobank, machine learning models showed superior performance in predicting both clinically diagnosed Parkinson's disease and prodromal Parkinson's disease compared to other modalities such as genetics, lifestyle, blood biochemistry, and prodromal symptoms data.
Article
Endocrinology & Metabolism
Junghwan Suh, Hae In Lee, Myeongseob Lee, Kyungchul Song, Han Saem Choi, Ahreum Kwon, Ho-Seong Kim, Hyun Wook Chae
Summary: This study investigated the natural course of C-peptide in T1DM patients over 15 years and found that serum C-peptide levels consistently decreased since diagnosis, with a significant decline after 3 years. Patients with residual C-peptide required lower doses of insulin and had a lower risk for diabetic ketoacidosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)