Article
Environmental Sciences
Samira Negrichi, Salima Taleb
Summary: Colorectal carcinoma (CRC) is the second most common cancer diagnosed in Algeria, with an increasing incidence and mortality rate. Factors such as high education level, family history of cancer, occupational exposures, obesity, alcohol consumption, and dietary factors were found to be associated with CRC risk in this study. Public health campaigns to raise awareness about CRC and promote healthy dietary choices may help in prevention.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Urology & Nephrology
Mark N. Brook, Holly Ni Raghallaigh, Koveela Govindasami, Tokhir Dadaev, Reshma Rageevakumar, Diana Keating, Nafisa Hussain, Andrea Osborne, Artitaya Lophatananon, Kenneth R. Muir, Zsofia Kote-Jarai, Rosalind A. Eeles
Summary: A family history of prostate cancer is associated with an increased risk of developing the disease. This study examines how the number, degree, and age of relatives with prostate cancer are related to overall survival and prostate cancer-specific survival in prostate cancer patients.
Article
Nutrition & Dietetics
June Jo Lee, John Wesley McWhorter, Gabrielle Bryant, Howard Zisser, David Miles Eisenberg
Summary: The relationship between individuals' eating habits and their overall health is widely acknowledged. However, discussions about food and nutrition have often been too focused on medical aspects. To address the impact of poor nutrition on health, it is important for healthcare providers to engage with patients about their relationship with food and recognize that these conversations go beyond nutrition and lifestyle. By incorporating questions about food relationships and motivators of eating into routine patient history taking, it can lead to better patient assessment and referrals. This broader cultural approach aims to enhance current discussions about food intake and establish a trusted foundation between patients and healthcare professionals.
Article
Agriculture, Multidisciplinary
Li-mei He, Teng-li Wang, Yu-chao Chen, Shi-shuai Ge, Kris A. G. Wyckhuys, Kong-ming Wu
Summary: The fall armyworm invaded China in December 11, 2018, impacting local maize, sorghum, and other crops. Laboratory experiments showed that the larval growth and adult reproduction of the fall armyworm strain varied significantly depending on the host crops and artificial diet used. These findings can help refine laboratory rearing protocols and guide integrated pest management in FAW-invaded areas.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2021)
Article
Medicine, General & Internal
Hyo Geun Choi, Woo Jin Bang, Jung Ki Jo, Cheol Young Oh, Myungsun Shim, Jin Seon Cho
Summary: This study found that a family history of prostate cancer in fathers posed a higher risk for patients compared to a family history in brothers. Additionally, age and hyperlipidemia were significant predictors of prostate cancer development.
Article
Family Studies
Ahmed Hassan Rakha, Adil Abalkhail, Dekheel Mohamed Albahadel
Summary: This study aims to determine the role of the family in promoting an active and healthy lifestyle for children aged 3-12 years during the COVID-19 pandemic in the Qassim region. The results showed low levels of physical activity among children, excessive use of electronic devices, and late bedtimes. However, families were knowledgeable about COVID-19 and took preventive measures. They also focused on the child's diet, education, and psychological well-being.
Article
Oncology
Justin R. Gregg, Xiaotao Zhang, Brian F. Chapin, John F. Ward, Jeri Kim, John W. Davis, Carrie R. Daniel
Summary: Adherence to the Mediterranean diet was associated with a lower risk of Gleason grade progression in men on active surveillance for localized prostate cancer, particularly in non-White men and men without diabetes.
Article
Endocrinology & Metabolism
Rachel A. Sabol, Elisa M. Ledet, Ellen Jaeger, Whitley Hatton, Marcus Moses, Anjali Lankford, Alexa Zaheria, Pedro Barata, Jodi L. Layton, Brian E. Lewis, Oliver Sartor
Summary: In men with a personal history of prostate cancer, germline pathogenic/likely pathogenic variants were associated with first degree relatives with breast or ovarian cancer, but not with a family history of prostate cancer.
Article
Multidisciplinary Sciences
Carlos Anselmo Lima, Brenda Evelin Barreto da Silva, Evania Curvelo Hora, Marcela Sampaio Lima, Erika de Abreu Costa Brito, Marceli de Oliveira Santos, Angela Maria da Silva, Marco Antonio Prado Nunes, Hugo Leite de Farias Brito, Marcia Maria Macedo Lima
Summary: Prostate cancer incidence rates in Sergipe state of Brazil sharply increased until the mid-2000s for all age groups before declining, while mortality rates increased until 2005 and then stabilized. The changes in incidence rates were associated with screening recommendations, while the increase in mortality rates appeared to be linked to age and improvements in cause of death identification. A PSA screening program may not benefit the population studied.
Article
Oncology
Danielle D. Durham, Linn A. Abraham, Megan C. Roberts, Carly P. Khan, Robert A. Smith, Karla Kerlikowske, Diana L. Miglioretti
Summary: This study found that women with a first-degree family history of breast cancer diagnosed between 40 and 49 years, who underwent screening between ages 30 and 39 or 40 and 49, had similar 5-year cumulative incidences of breast cancer as women without a family history undergoing screening between 50-59 years of age. In addition, for women with a relative diagnosed at or before age 45, initiating screening 5-8 years earlier than their relative's diagnosis age resulted in a 5-year cumulative incidence of breast cancer similar to that of an average 50-year-old woman.
Review
Oncology
Natasha Gupta, Hiten D. Patel, Jacob Taylor, James F. Borin, Kenneth Jacobsohn, Stacey A. Kenfield, Scott E. Eggener, Carrie Price, Meena Davuluri, Nataliya Byrne, Trinity J. Bivalacqua, Stacy Loeb
Summary: Plant-based diets have been found to have positive effects on the prevention and treatment of prostate cancer. Interventional studies have shown that incorporating a plant-based diet can improve oncologic outcomes, as well as general health and nutrition. Observational studies suggest that plant-based diets may lower the risk of prostate cancer.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Zhenhuang Zhuang, Yimin Zhao, Zimin Song, Wenxiu Wang, Ninghao Huang, Xue Dong, Wendi Xiao, Yueying Li, Jinzhu Jia, Zhonghua Liu, Lu Qi, Tao Huang
Summary: Screen-based sedentary activities are associated with dementia risk, and both television viewing and computer use are independent risk factors. Family history has little influence on the association between television viewing and dementia, while it has a positive additive interaction with computer use and dementia.
Article
Oncology
Huiyeon Song, Yoon Suk Jung, Thi Xuan Mai Tran, Chang Mo Moon, Boyoung Park
Summary: This study compared the risks of overall and site-specific cancers in men with and without a family history of breast cancer in female first-degree relatives. The results showed that men with a family history of breast cancer were at higher risk of pancreatic, thyroid, prostate, and breast cancers. Men with a family history in both mother and sister had even higher overall cancer risk and increased risk of thyroid cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Cardiac & Cardiovascular Systems
Florian Schnitzer, Lukas Forer, Sebastian Scho, Christian Gieger, Harald Grallert, Florian Kronenberg, Annette Peters, Claudia Lamina
Summary: This study found that both genetic risk scores and family history are relevant for the assessment of myocardial infarction (MI) risk, and they have independent contributions to the occurrence and prediction of MI. Adding both genetic risk scores and family history to a model significantly enhances the prediction of MI.
Article
Urology & Nephrology
Zhuqing Shi, Elizabeth A. Platz, Jun Wei, Rong Na, Richard J. Fantus, Chi-Hsiung Wang, Scott E. Eggener, Peter J. Hulick, David Duggan, S. Lilly Zheng, Kathleen A. Cooney, William B. Isaacs, Brian T. Helfand, Jianfeng Xu
Summary: The study suggests that genetic risk score (GRS) complements family history and rare pathogenic mutations as genetic risk measures for assessing the incidence and mortality of prostate cancer.
Review
Biochemistry & Molecular Biology
Daria S. Chulpanova, Albert A. Rizvanov, Valeriya V. Solovyeva
Summary: Cancer stem cells (CSCs) have properties similar to normal stem cells and can promote tumor progression and recurrence by resisting chemotherapy, stimulating angiogenesis, and differentiating into non-CSCs. CSCs create an immunosuppressive environment by suppressing effector immune cell activity and recruiting cells that help tumors escape immune responses. This immunosuppressive effect is mediated by receptors on the surface of CSCs and secreted molecules that transfer immunosuppressive signals to the tumor microenvironment cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ivan Y. Y. Filin, Yuri P. P. Mayasin, Chulpan B. B. Kharisova, Anna V. Gorodilova, Kristina V. V. Kitaeva, Daria S. S. Chulpanova, Valeriya V. V. Solovyeva, Albert A. A. Rizvanov
Summary: Melanoma is a highly aggressive and therapy-resistant cancer, with increasing incidence rates. Conventional methods of treatment often result in relapse. Adjuvant therapies, such as cell-based immunotherapy, can be used to reduce recurrence risk by mobilizing the immune system to kill cancer cells. This review discusses the advantages, challenges, and ongoing clinical trials of cell-based therapy for adjuvant treatment of melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Jelena Stevanovic-Silva, Jorge Beleza, Pedro Coxito, Paulo J. Oliveira, Antonio Ascensao, Jose Magalhaes
Summary: Maternal high-caloric nutrition and gestational diabetes mellitus (GDM) increase the risk of liver metabolic alterations in mothers and offspring. Exercise is recommended in GDM treatment. This study showed that gestational exercise protected mothers from diet-induced GDM metabolic consequences and ameliorated liver mitochondrial alterations in offspring.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Ines Ramos Rego, Daniela Silverio, Maria Isabel Eufrasio, Sandra Sofia Pinhancos, Bruna Lopes da Costa, Jose Teixeira, Hugo Fernandes, Yang Kong, Yao Li, Stephen H. Tsang, Paulo J. Oliveira, Rosa Fernandes, Peter M. J. Quinn, Paulo Fernando Santos, Antonio Francisco Ambrosio, Celso Henrique Alves
Summary: Age-related macular degeneration (AMD) is a major cause of visual impairment and blindness in the elderly. The damage to retinal pigment epithelium (RPE) caused by oxidative stress is a key factor in the development of AMD, and this damage is caused by the accumulation of reactive oxygen species (ROS) primarily produced by mitochondria. The protein TRAP1, found in mitochondria, helps maintain mitochondrial integrity and reduces ROS production. This study found that TRAP1 is present in human RPE cells and its levels decrease when exposed to hydrogen peroxide. Silencing TRAP1 leads to increased ROS production and decreased mitochondrial respiratory capacity in RPE cells.
Article
Biochemistry & Molecular Biology
Dilara Z. Gatina, Ilnaz M. Gazizov, Margarita N. Zhuravleva, Svetlana S. Arkhipova, Maria A. Golubenko, Marina O. Gomzikova, Ekaterina E. Garanina, Rustem R. Islamov, Albert A. Rizvanov, Ilnur I. Salafutdinov
Summary: Stimulating angiogenesis is important for treating ischemia-related diseases, and umbilical cord blood mononuclear cells (UCB-MC) have potential for gene-engineering therapy to activate angiogenesis. Adenoviral vectors were used to modify UCB-MCs, and the modified cells were found to overexpress recombinant genes and induce the formation of new vessels. This study highlights the therapeutic potential of gene-engineered UCB-MC for cardiovascular disease and diabetic cardiomyopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ilya Shulman, Tatyana Ageeva, Alexander Kostennikov, Sergei Ogurcov, Leysan Tazetdinova, Ilyas Kabdesh, Alexander Rogozhin, Ilnur Ganiev, Albert Rizvanov, Yana Mukhamedshina
Summary: Spinal cord injury (SCI) is a current medical and social problem that causes severe disability. The use of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) is a strategy to promote the recovery of spinal cord structure and function after trauma. This study evaluated the therapeutic potential of repeated intrathecal injection of autologous MSC-derived EVs in a pig model of subacute contused SCI. The results showed partial restoration of locomotor activity through remyelination of axons and timely reperfusion of nervous tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aysilu Mullagulova, Alisa Shaimardanova, Valeriya Solovyeva, Yana Mukhamedshina, Daria Chulpanova, Alexander Kostennikov, Shaza Issa, Albert Rizvanov
Summary: Metachromatic leukodystrophy (MLD) is a hereditary neurodegenerative disease caused by deficiencies of the lysosomal enzyme ARSA or the SapB protein. Current treatments are limited, but gene therapy using AAV vectors has shown promise. This study evaluates the safety and efficacy of AAV9-ARSA gene therapy administered intravenously or intrathecally in minipigs, providing insights for optimizing MLD gene therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Reem Alatrash, Maria Golubenko, Ekaterina Martynova, Ekaterina Garanina, Yana Mukhamedshina, Svetlana Khaiboullina, Albert Rizvanov, Ilnur Salafutdinov, Svetlana Arkhipova
Summary: Multiple sclerosis (MS) is a chronic autoimmune disease that cannot be cured and progressively damages the myelin sheath. Current therapy focuses on slowing neurodegeneration and suppressing the immune system. Inflammation, axon degeneration, and neurogliosis occur in the central nervous system in MS. This study explores the therapeutic potential of artificial microvesicles (MVs) derived from adipose mesenchymal stem cells (ADMSC) and expressing nerve growth factor (NGF) on a mouse model of MS. The injection of ADMSC-MVs-NGF led to a significant decrease in neurogliosis and promoted axon regeneration in the MS model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ekaterina Martynova, Timur Khaibullin, Ilnur Salafutdinov, Maria Markelova, Alexander Laikov, Leonid Lopukhov, Rongzeng Liu, Kritika Sahay, Mehendi Goyal, Manoj Baranwal, Albert A. Rizvanov, Svetlana Khaiboullina
Summary: Multiple sclerosis (MS) is a chronic disease with unknown causes, limited treatment options, and seasonal exacerbation of symptoms. This study used targeted metabolomics analysis to identify seasonal changes in metabolites in MS patients and found that ceramides play a central role in disease pathogenesis, glucose metabolism shifts to glycolysis, and histidine pathways are involved in relapse during spring and fall seasons. The study also revealed a higher number of affected metabolites in spring and fall, potentially relating to symptom relapse in these seasons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alisa A. Shaimardanova, Valeriya V. Solovyeva, Shaza S. Issa, Albert A. Rizvanov
Summary: Sphingolipidoses are a group of hereditary diseases resulting from gene mutations that cause enzyme deficiency and accumulation of sphingolipids. The nervous system is typically affected. Gene therapy, particularly using adeno-associated viral vectors or genetically modified hematopoietic stem cells, shows promise for the treatment of sphingolipidoses. Currently, there are no known effective methods for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Virology
Ayushi Sehgal, Sanya Mehta, Kritika Sahay, Ekaterina Martynova, Albert Rizvanov, Manoj Baranwal, Sara Chandy, Svetlana Khaiboullina, Emmanuel Kabwe, Yuriy Davidyuk
Summary: Hemorrhagic Fever with Renal Syndrome (HFRS) is a common zoonotic infection in Asia, caused by exposure to virus-contaminated aerosols. Hantaan, Puumala, and Seoul viruses are the most common orthohantaviruses causing this disease. Orthohantaviruses are endemic in China, South Korea, Japan, and have been recently found in Thailand and India. This review summarizes the current data on orthohantaviruses in Asia, including their history, diversity, clinical presentation, pathogenesis, and approaches for prevention and treatment.
Review
Cell Biology
Shaza S. Issa, Alisa A. Shaimardanova, Valeriya V. Solovyeva, Albert A. Rizvanov
Summary: Despite the advancements in gene and cell therapy, some diseases still lack effective treatment. Adeno-associated viruses (AAVs) have enabled the development of effective gene therapy methods for various diseases. Numerous AAV-based gene therapy medications are undergoing trials and entering the market. This article provides a review of AAV discovery, properties, serotypes, tropism, and their applications in gene therapy for different diseases of organs and systems.
Review
Chemistry, Medicinal
Mario P. Marques, Laura Mendonca, Beatriz G. Neves, Carla Varela, Paulo Oliveira, Celia Cabral
Summary: This review investigates the traditional applications of Lamiaceae medicinal plants used by local communities in the Iberian Peninsula for wound healing. The information from Iberian ethnobotanical surveys is summarized, and the pharmacological evidence for eight out of twenty-nine Lamiaceae species is presented. Future studies should focus on isolating and identifying the active molecules of these plants, followed by robust clinical trials to confirm their safety and effectiveness in wound healing.
Article
Biochemistry & Molecular Biology
Sirina V. V. Kurbangaleeva, Valeriia Y. Y. Syromiatnikova, Angelina E. E. Prokopeva, Aleksey M. M. Rogov, Artur A. A. Khannanov, Albert A. A. Rizvanov, Marina O. O. Gomzikova
Summary: The yield of naturally occurring extracellular vesicles (EVs) and cytochalasin B-induced membrane vesicles (CIMVs) from MSCs was compared. It was found that the use of cytochalasin B treatment and vortexing resulted in the production of a more homogeneous population of membrane vesicles with a larger size than EVs. EVs-like particles remained in the FBS, leading to inaccuracies in calculating EVs yield, so serum-free medium was used for EVs isolation. The number of CIMVs significantly exceeded the number of EVs after each step of centrifugation (2300x g, 10,000x g, and 100,000x g) by up to 5, 9, and 20 times, respectively.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sara Boussaha, Somia Lassed, Ahmed B. Abdelwahab, Adel Krid, Muhammed Altun, Pr. Pierre Chalard, Pr. Jean Claude Chalchat, Gilles Figueredo, Pr. Djamila Zama, Pr. Ibrahim Demirtas, Pr. Samir Benayache, Pr. Fadila Benayache
Summary: In this study, the chemical composition of Perralderia coronopifolia essential oils was analyzed, and their anticancer and antioxidant activities were investigated. The major compounds in the essential oils showed inhibitory effects on cell proliferation and protected DNA against oxidative damage. Molecular docking study revealed the inhibitory mechanisms of the compounds, and ADMET properties evaluation and DFT calculations provided insights for designing new cancer drugs.
CHEMISTRY & BIODIVERSITY
(2023)
