Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jian Song, Nan Jiang, Xueqi Gan, Wei Zhi, Zhuoli Zhu
Summary: The study demonstrated that the local injection of argatroban can rescue bone loss in periodontal disease, while inducing osteogenic differentiation through activating the canonical Wnt signaling pathway. Therefore, argatroban has potential applications in promoting alveolar bone regeneration and remodeling based on BMSCs.
Article
Biochemistry & Molecular Biology
Jinwu Bai, Weijun Zhang, Chenwei Zhou, Guangfeng Zhao, Huiming Zhong, Kai Hang, Jianxiang Xu, Wei Zhang, Erman Chen, Jiaqi Wu, Ling Liu, Deting Xue
Summary: MFG-E8 promotes osteogenic differentiation of BMSCs by regulating the GSK3 beta/beta-catenin signaling pathway and therefore, is a potential therapeutic target. This study has important clinical significance in addressing fracture nonunion and bone defects.
Article
Agriculture, Dairy & Animal Science
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Kai Quan, Tesfaye Getachew, Joram M. M. Mwacharo, Aynalem Haile, Yutao Li, Shanhe Wang, Wei Sun
Summary: In our study, we found that CRABP2 was highly expressed in Hu sheep hair follicles, indicating its potential influence on dermal papilla cells (DPCs). Our experiments demonstrated that overexpression of CRABP2 promoted DPC proliferation and activated the Wnt/beta-catenin pathway. These findings highlight the crucial role of CRABP2 in Hu sheep DPC proliferation and shed light on its function in hair follicles.
Article
Neurosciences
Qingjiu Zhou, Qiang Fu, Mahati Shaya, Yalikun Kugeluke, Shaoshan Li, Yisireyili Dilimulati
Summary: This study found that circ_CAPG (circ_0055412) contributes to cisplatin resistance in glioma cells by stabilizing CAPG mRNA and modulating the Wnt/beta-catenin signaling pathway, providing new information for the treatment of glioma.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Zong-qing Zhao, Xiu-jie Wu, Yan-hao Cheng, Yun-fei Zhou, Xi-meng Ma, Jian Zhang, Xue-yuan Heng, Fan Feng
Summary: The study demonstrated that TROAP plays an oncogenic role in glioma by activating the Wnt/beta-Catenin signaling pathway, leading to cell proliferation, migration, invasion, and poor prognosis. Inhibition of TROAP or downstream targets of Wnt/beta-Catenin pathway could reverse the tumor-promoting effects, suggesting TROAP as a potential novel target for glioma therapy.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Medicine, Research & Experimental
So-Yeon Park, Ji-Young Kim, Gyu-Beom Jang, Jang-Hyun Choi, Jee-Heun Kim, Choong-Jae Lee, Sunjae Lee, Jeong-Heum Baek, Kwan-Kyu Park, Jin-Man Kim, Hee Jin Chang, Nam-Chul Cho, Jeong-Seok Nam
Summary: This study identified an increased expression of CD45 in CRC (EpCAM+) epithelial cells after CRT treatment. High CD45 expression promoted CRC cell survival upon 5-fluorouracil or radiation treatment, while CD45 depletion sensitized CRC cells to CRT. CD45 was found to be preferentially expressed in cancer stem-like cells (CSCs) and played a crucial role in CSC functions such as cancer initiation, repopulation, and metastasis.
Article
Cell & Tissue Engineering
Youde Liang, Xin Liu, Ruiping Zhou, Dawei Song, Yi-Zhou Jiang, Weiwei Xue
Summary: Mesenchymal stem cells (MSCs) combined with Chaetocin show enhanced osteogenic ability, reduced adipogenic ability, and improved Wnt/β-catenin signaling pathway activity, leading to promotion of bone tissue regeneration and repair.
STEM CELLS INTERNATIONAL
(2021)
Article
Oncology
Yanqiu Bao, Jingshu Cui, Yuyang Yue, Shuxia Cao, Xiangdan Li, Lan Liu
Summary: Ebp1 is highly expressed in malignant melanoma and is associated with clinical stage and lymph node metastases. Knockdown of Ebp1 inhibits cell proliferation, migration, and invasion in melanoma. Ebp1 may promote the proliferation and metastasis of melanoma cells through activation of the Wnt/β-catenin pathway.
CANCER CELL INTERNATIONAL
(2022)
Article
Neurosciences
Sheng Zhang, Yan Wang, Xiaoqing Zhu, Lanying Song, Xinhua Zhan, Edric Ma, Jennifer McDonough, Hui Fu, Franca Cambi, Judith Grinspan, Fuzheng Guo
Summary: The study reveals that TCF7l2 promotes OL differentiation by repressing BMP4 gene transcription, reducing autocrine BMP4 secretion, and dampening BMP4 signaling. Specific deletion of BMP4 can rescue arrested OL differentiation caused by TCF7l2 disruption in the oligodendroglial lineage.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Orthopedics
Yue-wen Chang, Wen-Jun Zhu, Wei Gu, Jun Sun, Zhi-qiang Li, Xiao-en Wei
Summary: The study demonstrates that neohesperidin can promote osteogenic differentiation of bone mesenchymal stem cells, which is related to the activation of the Wnt/β-catenin pathway.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Cell Biology
Bei Tao, Yi Song, Yao Wu, Xiaobo Yang, Tangming Peng, Lilei Peng, Kaiguo Xia, Xiangguo Xia, Ligang Chen, Chuanhong Zhong
Summary: This study found that a stiffer matrix can promote the stemness of glioma cells by activating the BCL9L/Wnt/beta-catenin signaling pathway. Additionally, gigantol can enhance the effectiveness of traditional chemotherapy and radiotherapy by inhibiting Wnt/beta-catenin signaling, providing a potential strategy for clinical treatment of gliomas.
Article
Biochemistry & Molecular Biology
Zhaobo Cheng, Renjie Yu, Li Li, Junhao Mu, Yijia Gong, Fan Wu, Yujia Liu, Xiangyi Zhou, Xiaohua Zeng, Yongzhong Wu, Ran Sun, Tingxiu Xiang
Summary: In our research, we identified ZNF334 as a novel tumor suppressor of triple-negative breast cancer (TNBC). ZNF334 expression was usually reduced in breast cancer tissues and TNBC cell lines, likely due to promoter hypermethylation. Ectopic expression of ZNF334 suppressed the growth and metastatic capacity of TNBC cell lines, induced cell cycle arrest at S phase and apoptosis. Additionally, re-expression of ZNF334 restored the Epithelial-Mesenchymal Transition (EMT) process and inhibited stemness by up-regulating SFRP1.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Reproductive Biology
Wenjing Hu, Min Li, Youguo Chen, Xinxian Gu
Summary: The research revealed that high expression of UBE2S in HGSOC is associated with poor prognosis. UBE2S promotes proliferation, migration, and invasion of ovarian cancer, and increases Olaparib resistance by activating the Wnt/β-catenin signaling pathway.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Environmental Sciences
Han Song, Junjun Qiu, Keqin Hua
Summary: USP14 is overexpressed in cervical cancer and is associated with clinical stage and prognosis of patients. It promotes the proliferation, migration, and invasion of cervical cancer cells by upregulating the expression of beta-catenin.
ENVIRONMENTAL TOXICOLOGY
(2023)