Article
Endocrinology & Metabolism
Henry S. Kahn
Summary: BMI does not provide information about the relative size of adipose tissue depots, while SAD is associated with visceral fat accumulation, which may contribute to the estimation of cardiometabolic risk. SADHtR is more strongly associated with intermediary predictors of cardiometabolic disease.
Article
Cardiac & Cardiovascular Systems
Angela McInerney, Gabriela Tirado-Conte, Josep Rodes-Cabau, Francisco Campelo-Parada, Jose D. Tafur Soto, Marco Barbanti, Erika Munoz-Garcia, Mobeena Arif, Diego Lopez, Stefan Toggweiler, Gabriela Veiga, Anna Pylko, Teresa Sevilla, Miriam Compagnone, Ander Regueiro, Vicent Serra, Manuel Carnero, Juan F. Oteo, Fernando Rivero, Henrique Barbosa Ribeiro, Leonardo Guimaraes, Anthony Matta, Natalia Giraldo Echavarria, Roberto Valvo, Federico Moccetti, Antonio J. Munoz-Garcia, Javier Lopez-Pais, Bruno Garcia del Blanco, Diego Carter Campanha Borges, Eric Dumont, Nieves Gonzalo, Enrico Criscione, Maciej Dabrowski, Fernando Alfonso, Jose M. de la Torre Hernandez, Asim N. Cheema, Ignacio J. Amat-Santos, Francesco Saia, Javier Escaned, Luis Nombela-Franco
Summary: In a study comparing short- and midterm outcomes of morbidly obese patients undergoing transcatheter aortic valve replacement, it was found that although major vascular complications were more common and device success was lower in the obese group, all-cause and cardiovascular mortality at 2 years were similar to the nonobese group. An obesity phenotype with an abdominal visceral adipose tissue:subcutaneous adipose tissue ratio >= 1 was identified as being associated with increased risk of adverse clinical outcomes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Gastroenterology & Hepatology
Wei Shen, Michael S. Middleton, Guilherme M. Cunha, Timoteo I. Delgado, Tanya Wolfson, Anthony Gamst, Kathryn J. Fowler, Adina Alazraki, Andrew T. Trout, Michael A. Ohliger, Shetal N. Shah, Mustafa R. Bashir, David E. Kleiner, Rohit Loomba, Brent A. Neuschwander-Tetri, Arun J. Sanyal, Jane Zhou, Claude B. Sirlin, Joel E. Lavine
Summary: This study investigated the relationship between reduction in adipose tissue compartment volumes and hepatic histologic improvement in adults with obesity and non-alcoholic steatohepatitis (NASH). The findings showed that reductions in deep subcutaneous adipose tissue and visceral adipose tissue volumes were associated with histologic improvement in NASH.
JOURNAL OF HEPATOLOGY
(2023)
Article
Hematology
Min Jung Lee, Hong-Kyu Kim, Eun Hee Kim, Sung Jin Bae, Kyung Won Kim, Min-Ju Kim, Jaewon Choe
Summary: A higher proportion of good quality muscle is strongly associated with a lower prevalence of significant coronary artery calcification, especially in women. Poor skeletal muscle quality may be an important risk factor for subclinical coronary atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Orthopedics
Xueqin Cao, Leilei He, Rong Sun, Siyu Chen
Summary: This study examined the relationship between abdominal adipose tissue and bone mineral density (BMD) in a nationally representative sample of middle-aged adults in the US. The findings showed that abdominal adipose tissue, regardless of its location, may have a negative impact on BMD in middle-aged men, but this relationship was not observed in women. Higher abdominal adipose mass was also found to increase the risk of low BMD. Further research is needed to confirm these findings and investigate potential underlying mechanisms.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Review
Endocrinology & Metabolism
Randa K. Saad, Malak Ghezzawi, Renee Horanieh, Assem M. Khamis, Katherine H. Saunders, John A. Batsis, Marlene Chakhtoura
Summary: This study examined the association between abdominal visceral adipose tissue (VAT) parameters and all-cause mortality risk. The findings suggest that a higher abdominal VAT area is associated with increased mortality risk in individuals aged 65 years or younger, possibly mediated by metabolic complications. However, this association becomes weaker and may even reverse in older individuals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Gastroenterology & Hepatology
Zongqian Wu, Hong Lu, Qiao Xie, Jie Cheng, Kuansheng Ma, Xiaofei Hu, Liang Tan, Huarong Zhang, Chen Liu, Xiaoming Li, Ping Cai
Summary: This study revealed a significant association between abdominal visceral and subcutaneous adipose tissue with microvascular invasion (MVI) in patients with small hepatocellular carcinoma (sHCC). The areas of abdominal SAT and VAT were found to be clinically valuable in predicting MVI status in sHCC patients.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Nutrition & Dietetics
Ming Kong, Manman Xu, Ying Zhou, Nan Geng, Ning Lin, Wenyan Song, Shanshan Li, Yuetong Piao, Zuoqing Han, Rong Guo, Chao Yang, Nan Luo, Zhong Wang, Lei Ma, Quanxiao Xu, Lili Wang, Wanchun Qiu, Junfeng Li, Daimeng Shi, Eddie C. Cheung, Rongkuan Li, Yu Chen, Zhongping Duan
Summary: This study analyzed the distribution of abdominal adipose tissue in a healthy population in northern China using abdominal CT scans. The results showed significant differences in abdominal fat distribution between men and women, with a high proportion of visceral obesity even in individuals with normal BMI.
FRONTIERS IN NUTRITION
(2022)
Review
Endocrinology & Metabolism
Tongtong Ye, Guangdong Zhang, Hangyu Liu, Junfeng Shi, Hongyan Qiu, Yongping Liu, Fang Han, Ningning Hou
Summary: PVAT plays a critical role in the development of AAAs and may serve as a therapeutic target.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Muhei Tanaka, Hiroshi Okada, Yoshitaka Hashimoto, Muneaki Kumagai, Hiromi Nishimura, Michiaki Fukui
Summary: This study found that intraperitoneal VAT (IVAT) and retroperitoneal VAT (RVAT) are differently associated with the prevalence of metabolic syndrome (MS) and its components. IVAT area index was independently associated with MS and its components, while RVAT area index was only associated with the blood pressure component.
CLINICAL NUTRITION
(2021)
Article
Surgery
Yohei Kawai, Hiroshi Banno, Tomohiro Sato, Shuta Ikeda, Takuya Tsuruoka, Masayuki Sugimoto, Kiyoaki Niimi, Akio Kodama, Kota Matsui, Shigeyuki Matsui, Kimihiro Komori
Summary: The present study found that the EATV index is associated with AAA expansion, and the initial aneurysm diameter and EATV index are predictors of the AAA expansion rate.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Materials Science, Multidisciplinary
Yuriy Snyder, Soumen Jana
Summary: Creating leaflet substrates that mimic the trilayered structure, anisotropic tensile characteristics, and elastomeric features of human heart valve leaflets is crucial to successful heart valve tissue engineering. In this study, elastomeric trilayer substrates made of a combination of polymers were developed to resemble native tissue. These substrates exhibited better cell adhesion, proliferation, extracellular matrix production, and resistance to calcification compared to non-elastomeric substrates.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Medicine, General & Internal
Xuefeng Ni, Li Jiao, Ye Zhang, Jin Xu, Yunqing Zhang, Xiaona Zhang, Yao Du, Zhaoyong Sun, Shitian Wang
Summary: The study shows a significant relationship between non-alcoholic fatty liver disease (NAFLD) and abdominal and pericardial adipose tissue, with an increase in abdominal visceral adipose tissue correlating with a higher risk of developing NAFLD.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Shivshankar Thanigaimani, Jonathan Golledge
Summary: Improved understanding of AAA pathogenesis is crucial to identify potential treatment targets. Evidence from animal and clinical studies suggests that circulating concentrations of leptin and resistin, as well as PVAT levels, may be higher in individuals with AAA compared to controls, but the exact role in aneurysm development remains unclear.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Pavel Hruska, Jan Kucera, Matej Pekar, Pavol Holeczy, Miloslav Mazur, Marek Buzga, Daniela Kuruczova, Peter Lenart, Jana Fialova Kucerova, David Potesil, Zbynek Zdrahal, Julie Bienertova-Vasku
Summary: The study compared the proteomic profiles of mature adipocytes from different adipose tissue depots, with findings showing that subcutaneous adipocytes are more active in vesicular transport, secretion, and lipid metabolism, while visceral adipocytes have higher protein expression related to mitochondrial energy metabolism and translational or biosynthetic activity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)