Article
Genetics & Heredity
Yuzhen Ding, Xiaofeng Yang, Xiaoxue Han, Meiting Shi, Lu Sun, Mengyuan Liu, Ping Zhang, Zhengrui Huang, Xiuli Yang, Ruiman Li
Summary: This study identified key molecules SRXN1 and NQO1 in the pathogenesis of preeclampsia, and found that they are closely associated with the characteristics and diagnosis of preeclampsia.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Sonia Fantone, Leonardo Ermini, Federica Piani, Nicoletta Di Simone, Greta Barbaro, Stefano Raffaele Giannubilo, Rosaria Gesuita, Giovanni Tossetta, Daniela Marzioni
Summary: Argininosuccinate synthase (ASS1) is expressed in the villous cytotrophoblast and is involved in nitric oxide production. Its expression decreases in the third trimester of pregnancy, but no differences were detected in placentas from pregnancies with preeclampsia. Additionally, ASS1 expression is decreased under hypoxic conditions and during syncytialization process.
Review
Medicine, General & Internal
Teresa M. MacDonald, Susan P. Walker, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: Preeclampsia is a pregnancy-specific disease that has a significant impact on maternal and perinatal morbidity and mortality worldwide. Currently, there are limited options for predicting and diagnosing preeclampsia, and further research is needed to identify effective tests and biomarkers.
Article
Biotechnology & Applied Microbiology
Liu Jinyu, Wang Shuying, Zheng Panchan, Chen Dan, Chen Chao, Yang Xingyu, Cheng Weiwei
Summary: The expression of BST2 and MMP2 is significantly downregulated in preeclampsia. Overexpression of BST2 can upregulate MMP2 expression and enhance the migration and invasion capacity of trophoblast cells. Knockdown of BST2 or MMP2 has opposite effects. These results suggest that the downregulation of BST2 may play a role in the pathogenesis of preeclampsia.
Article
Biochemistry & Molecular Biology
Faith Andres, Natalie J. Hannan, Susan P. Walker, Teresa M. MacDonald, Georgia P. Wong, Ciara Murphy, Ping Cannon, Manju Kandel, Joshua Masci, Tuong-Vi Nguyen, Alison Abboud, Danica Idzes, Valerie Kyritsis, Natasha Pritchard, Stephen Tong, Tuuhevaha J. Kaituu-Lino
Summary: This study found that EPCR levels were significantly increased in both the placenta and circulation of patients with preterm preeclampsia and fetal growth restriction. Hypoxia may be associated with the elevation of placental EPCR. These findings have important implications for understanding the mechanisms underlying these conditions.
Article
Cell Biology
Xiaotong Yang, Paula A. Benny, Elorri Cervera-Marzal, Biyu Wu, Cameron B. Lassiter, Joshua Astern, Lana X. Garmire
Summary: Variations in telomere length have been linked to aging, stress, and diseases. This study investigated the association between placental telomere length and preeclampsia. The results suggest that placental telomere length is not significantly different between severe preeclampsia cases and healthy controls, but it is negatively correlated with gestational age and influenced by race.
Article
Pharmacology & Pharmacy
Xiaojie Zhang, Kai Chen, Zhu Meng, Ru Jia, Feifei Lian, Feng Lin
Summary: In this study, we found that exposure to cadmium in pregnant rats can lead to the development of preeclampsia-like symptoms, including hypertension, albuminuria, and fetal growth restriction. Furthermore, cadmium exposure also inhibits the synthesis of progesterone in the placenta, which contributes to the onset of preeclampsia in pregnant rats.
Article
Peripheral Vascular Disease
Xiang Li, Nana Yang, Yue Wu, Xuegu Wang, Junpei Sun, Lei Liu, Feng Zhang, Yingying Gong, Yan Zhang, Xueting Li, Danli Du, Biao Ding
Summary: This study discovered elevated levels of lactate and histone lactylation in preeclamptic placentas. In vitro experiments further demonstrated that hypoxia induced histone lactylation through promoting lactate production. Additionally, the study identified 152 upregulated genes in response to both hypoxia exposure and sodium l-lactate treatment, with nine of these genes also upregulated in preeclamptic placentas. Notably, two fibrosis-related genes, FN1 and SERPINE1, were found to be promoted by hypoxia through histone lactylation mediated by lactate production. These findings provide new insights into the mechanism of placental dysfunction in preeclampsia.
JOURNAL OF HYPERTENSION
(2022)
Article
Biochemistry & Molecular Biology
Reinaldo Marin, Flor H. Pujol, Deliana Rojas, Luis Sobrevia
Summary: SARS-CoV-2 infection in pregnant women leads to alterations in maternal and placental function, increasing the risk of preterm birth and caesarean delivery. Placentas of infected mothers show signs of vasculopathy and inflammation. The impact of maternal infection on the fetus and postnatal health is still unclear.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Endocrinology & Metabolism
Lucy A. Bartho, Manju Kandel, Susan P. Walker, Catherine A. Cluver, Roxanne Hastie, Lina Bergman, Natasha Pritchard, Ping Cannon, Tuong-Vi Nguyen, Georgia P. Wong, Teresa M. MacDonald, Emerson Keenan, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: This study evaluated the biomarker potential of circulating chemerin to predict preeclampsia. The results showed that circulating chemerin was increased in women with early-onset preeclampsia, established preeclampsia, and preceding preeclampsia diagnosis. RARRES2, the gene coding chemerin, was dysregulated in placenta complicated by preeclampsia. Chemerin may have potential as a biomarker for preeclampsia but would need to be combined with other biomarkers.
Article
Cell Biology
Brooke Grimaldi, Hamid-Reza Kohan-Ghadr, Sascha Drewlo
Summary: Preeclampsia (PE) is a major cause of maternal-fetal morbidity and mortality worldwide. This research shows that placental activation of PPAR gamma can improve the secretion of angiogenic proteins and enhance endothelial function in PE.
Article
Peripheral Vascular Disease
Zhiyin Wang, Dan Liu, Yimin Dai, Ruotian Li, Yaowu Zheng, Guangfeng Zhao, Jingmei Wang, Zhenyu Diao, Chenrui Cao, Haining Lv, Ning Gu, Hang Zhou, Hailin Ding, Jie Li, Xiangyu Zhu, Honglei Duan, Li Shen, Qun Zhang, Jing Chen, Huilian Hu, Xiaoyan Wang, Mingming Zheng, Yan Zhou, Yali Hu
Summary: It has been found that placental miR-155 levels are elevated in preeclamptic patients. This study aims to investigate the characteristics of patients with high levels of miR-155. The preeclamptic patients were divided into a high miR-155 group (>= P95) and a normal miR-155 group based on the 95th percentile (P95) of miR-155 in controls.
Article
Biochemistry & Molecular Biology
Miira M. M. Klemetti, Sruthi Alahari, Martin Post, Isabella Caniggia
Summary: Disturbances in lipid metabolism are common in diabetes. This study compared the placental sphingolipid metabolism in type 1 and type 2 diabetic pregnancies and non-diabetic controls. The results showed that placental ceramide levels were lower in diabetic pregnancies, but higher in cases of preeclampsia and poor glycemic control. Sphingosine kinases (SPHK) and sphingoid-1-phosphates (S1P) were elevated in diabetic pregnancies, especially in cases of fetal macrosomia.
Article
Biochemistry & Molecular Biology
Lucia Perez-Roque, Elena Nunez-Gomez, Alicia Rodriguez-Barbero, Carmelo Bernabeu, Jose M. Lopez-Novoa, Miguel Pericacho
Summary: Preeclampsia is a pregnancy-specific disease characterized by hypertension, with its etiopathogenesis related to abnormal placentation and the release of soluble factors. High plasma levels of soluble endoglin (sEng) may serve as an early diagnostic and prognostic biomarker for the disease, impacting the pathophysiology of preeclampsia significantly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Sayani Banerjee, Zheping Huang, Zhengke Wang, Akitoshi Nakashima, Shigeru Saito, Surendra Sharma, Shibin Cheng
Summary: The understanding of sterile inflammation and its effects on pregnancy complications such as preeclampsia is still in its early stages. Emerging evidence suggests that sterile inflammation regulated by pathways such as the inflammasome-gasdermins-caspase-1 axis may contribute to the development of preeclampsia. Further research is needed to elucidate the mechanisms underlying these inflammatory pathways and potential therapeutic strategies for treating these complications.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)