Review
Agriculture, Dairy & Animal Science
Mario Garcia-Gonzalez, Fernando Munoz, Antonio Gonzalez-Cantalapiedra, Monica Lopez-Pena, Nikola Saulacic
Summary: Periosteal distraction osteogenesis (PDO) is a promising new technique for bone regeneration that has shown better results in animal models such as rabbits and rats compared to minipigs. The quality of studies has improved since the implementation of ARRIVE guidelines in 2010, but there is still room for enhancing transparency, comparability, and reproducibility in future research.
Article
Biotechnology & Applied Microbiology
Shahrokh Hatefi, Milad Sh Etemadi, Javad Alizargar, Venous Behdadipour, Khaled Abou-El-Hossein
Summary: The application of Distraction Osteogenesis (DO) techniques in reconstruction surgeries is advantageous with fewer side effects. However, the development of automatic devices for controlled continuous force still requires further research. A two-axis continuous distractor is proposed for mandibular reconstruction, meeting the current requirements.
BIOENGINEERING-BASEL
(2022)
Article
Engineering, Biomedical
Kazuhiro Imoto, Kensuke Yamauchi, Kenji Odashima, Shinnosuke Nogami, Yoshinaka Shimizu, Peter Kessler, Bernd Lethaus, Hidero Unuma, Tetsu Takahashi
Summary: The study evaluated the use of a polyethylene terephthalate (PET) membrane as an activation device for periosteal expansion osteogenesis (PEO), showing that membrane activation in the experimental group led to more new bone formation compared to the control group. Bone formation progressed to adjacent areas histologically, and no PET membrane-associated complications were observed in the study.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Review
Cell Biology
Ze Liu, Qi Liu, Hongbin Guo, Jieyu Liang, Yi Zhang
Summary: Distraction osteogenesis (DO) is a bone regeneration technology that promotes new bone formation through continuous and stable traction force. However, the long consolidation course of DO can lead to complications. Current treatment strategies include gene, growth factor, stem-cell, physical, and pharmacological therapies, with physical and pharmacological therapies being considered safe and effective. Recent research provides evidence for the effectiveness of physical and pharmacological therapies in promoting bone healing during DO.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Orthopedics
Ye Li, Qi Pan, Jiankun Xu, Xuan He, Helen A. Li, Derek A. Oldridge, Gang Li, Ling Qin
Summary: Various approaches have been explored to reduce the treatment duration of distraction osteogenesis (DO) with some success, but no widely accepted approach currently exists. Biometals, particularly magnesium (Mg) and its alloy, have shown promise in promoting bone formation in DO. The translational potential of utilizing Mg-based devices to accelerate DO is promising, as Mg stimulates expression of intrinsic biological factors and can aid in bone formation and consolidation.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Review
Engineering, Biomedical
Benjamin Dalisson, Baptiste Charbonnier, Ahmed Aoude, Mirko Gilardino, Edward Harvey, Nicholas Makhoul, Jake Barralet
Summary: This review article discusses different strategies for repairing massive segmental bone defects and explores emerging potential replacements for the standard treatment of fibular transplantation with a blood supply. The review highlights the importance of considering more basic approaches in bone repair and challenges the assumption that mimicry is necessary for success in repair strategies.
ACTA BIOMATERIALIA
(2021)
Article
Physiology
Kai Liu, Sulong Wang, Ainizier Yalikun, Peng Ren, Aihemaitijiang Yusufu
Summary: This study observed the effect of the accordion technique (AT) during the distraction phase on chondrogenesis and bone regeneration. It was found that low amplitude AT can enhance chondrogenesis and bone regeneration by activating the angiogenesis factor pathway and upregulating the expression of osteogenic-related biomarkers.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Engineering, Biomedical
Hanjiang Zhao, Xiangyu Wang, Anting Jin, Minjiao Wang, Zeying Wang, Xingtai Huang, Jiewen Dai, Xudong Wang, Dan Lin, Steve G. F. Shen
Summary: Rapid maxillary expansion (RME) is a common treatment for craniomaxillofacial deformity, but it often has high relapse rates and unsatisfactory therapeutic effects. In this study, a standardized rat RME model was established and a mesoporous bioactive glass/fibrin glue (MBG/FG) composite hydrogel was developed to enhance osteogenesis in the expanded palate. The results showed that the injection of 1% MBG/FG composite hydrogel significantly promoted bone formation and inhibited osteoclastogenesis in the expanded mid-palatal suture.
BIOACTIVE MATERIALS
(2022)
Article
Endocrinology & Metabolism
Feiyu Cai, Aihemaitijiang Yusufu, Kai Liu, Wenjiao Chen, Ruomei Zhao, Yanshi Liu, Yi Liu
Summary: The study evaluated the difference in bone regeneration between rats under high-fat diets (HFD) and low-fat diets (LFD) by monitoring the process of bone regeneration in distraction osteogenesis (DO) model animals. The results showed that HFD resulted in elevated blood lipids, increased adipose differentiation at the bone marrow level, and delayed bone regeneration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Feng Wang, Wenbo Wang, Lingchi Kong, Li Shi, Mengwei Wang, Yimin Chai, Jia Xu, Qinglin Kang
Summary: This study found that ADM2 accelerates bone regeneration by enhancing the osteogenic differentiation and pro-angiogenic potential of BMSCs, possibly through the NF-κB/β-catenin and AKT/β-catenin pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Physiology
Yanshi Liu, Jialin Liu, Feiyu Cai, Kai Liu, Xiaoxu Zhang, Aihemaitijiang Yusufu
Summary: Hypoxia therapy during the consolidation phase of distraction osteogenesis enhances bone regeneration by accelerating bone formation and remodeling.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Physical
Flavy Roseren, Sandrine Roffino, Martine Pithioux
Summary: This study measured the mechanical properties of calcified cartilage, trabecular bone, and cortical bone in the distracted callus during the consolidation phase. The results showed that the mechanical properties of calcified cartilage did not change over time, while trabecular bone exhibited temporal variation in elastic modulus. The study highlights the heterogeneity of mechanical properties in the distracted callus.
Review
Endocrinology & Metabolism
Nitchanant Kitcharanant, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: This review compiled and discussed the mechanisms underlying the effects of parathyroid hormone (PTH) on bone healing following distraction osteogenesis. The findings showed that PTH accelerates bone regeneration through its involvement in cell proliferation and differentiation, bone formation, and callus remodeling.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Ruisen Fu, Yili Feng, David Bertrand, Tianming Du, Youjun Liu, Bettina M. Willie, Haisheng Yang
Summary: The study proposed a distraction strategy with varying distraction rates to shorten distraction time and improve efficiency. It was found that rate-varying distraction led to faster and better healing outcomes compared to constant-rate distraction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Kensuke Yamauchi, Kazuhiro Imoto, Kenji Odajima, Hiromitsu Morishima, Yoshinaka Shimizu, Shinnosuke Nogami, Tetsu Takahashi
Summary: The study evaluates the effects of resorbable membranes and shape memory alloy mesh devices on bone formation and suggests that they can be potential alternatives for bone augmentation.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2022)
